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Pressure Reversal of Anaesthesia

Abstract

The application of high hydrostatic pressure will remove, at least partially, the effects of general anaesthetics in both newts and mice. This feature seems to be common to all general anaesthetics and a simple model could explain this antagonism.

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References

  1. Johnson, F. H., and Flagler, E. A., Science, 112, 91 (1950).

    Article  ADS  CAS  Google Scholar 

  2. Fenn, W. O., in The Physiology and Medicine of Diving (edit. by Bennett, P. B., and Elliot, D. H.), 36 (Baillière, Tindall and Cassell, London, 1969).

    Google Scholar 

  3. Regnard, P., Recherches Expérimentales sur les Conditions Physiques de la Vie dans les Eaux (Masson, Paris, 1891).

    Google Scholar 

  4. Cattell, M., Biol. Rev., 11, 441 (1936).

    Article  CAS  Google Scholar 

  5. Miller, K. W., Paton, W. D. M., Streett, W. B., and Smith, E. B., Science, 157, 97 (1967).

    Article  ADS  CAS  Google Scholar 

  6. Brauer, R. W., Way, R. O., and Perry, R. A., in Toxicity of Anaesthetics (edit. by Fink, B. R.), 241 (Williams and Wilkins, Baltimore, 1968).

    Google Scholar 

  7. Lever, M. J., Miller, K. W., Paton, W. D. M., Streett, W. B., and Smith, E. B., Proc. Fourth Symp. Underwater Physiol. (edit. by Lambertsen, C. J. (in the press).

  8. MacInnis, J., Dickson, J. G., and Lambertson, C. J., J. Appl. Physiol., 22, 694 (1967).

    Article  CAS  Google Scholar 

  9. Miller, K. W., Paton, W. D. M., and Smith, E. B., Nature, 206, 574 (1965).

    Article  ADS  CAS  Google Scholar 

  10. Miller, K. W., Paton, W. D. M., and Smith, E. B., Brit. J. Anaesthesiol., 39, 910 (1967).

    Article  CAS  Google Scholar 

  11. Eger, E. I., Lundgren, C., Miller, S. L., and Stevens, W. C., Anesthesiology, 30, 129 (1969).

    PubMed  Google Scholar 

  12. Pauling, L., Science, 134, 15 (1961).

    Article  ADS  CAS  Google Scholar 

  13. Miller, S. L., Proc. US Nat. Acad. Sci., 47, 1515 (1961).

    Article  ADS  CAS  Google Scholar 

  14. Meyer, K. H., Trans. Faraday Soc., 33, 1062 (1937).

    Article  CAS  Google Scholar 

  15. Mullins, L. B., Chem. Rev., 54, 289 (1954).

    Article  CAS  Google Scholar 

  16. Forsythe, W. E., Smithsonian Physical Tables, ninth ed. (Smithsonian Institute, Washington DC, 1956).

    Google Scholar 

  17. International Critical Tables, Nat. Res. Council US (McGraw-Hill, New York, 1926).

  18. Brink, F., and Posternak, J. M., J. Cell. Comp. Physiol., 32, 211 (1948).

    Article  CAS  Google Scholar 

  19. Miller, K. W., Paton, W. D. M., and Smith, E. B., Proc. Journées Intern. d'Hyperbarie et de Physiologie Subaquatique, in Bulletin de Société Française de Médecine Subaquatique et Hyperbare (in the press).

  20. Walkley, J., and Jenkins, W. I., Trans. Faraday Soc., 64, 19 (1968).

    Article  CAS  Google Scholar 

  21. Cherkin, A., and Catchpool, J. F., Science, 144, 1460 (1964).

    Article  ADS  CAS  Google Scholar 

  22. Meyer, H. M., Arch. Exp. Pathol. Pharm., 46, 338 (1901).

    Article  Google Scholar 

  23. Spyropolous, C., J. Gen. Physiol., 40, 848 (1957).

    Google Scholar 

  24. Fraser, M. J., Kaplan, J. L., and Schulman, J. H., Disc. Faraday Soc., 20, 44 (1955).

    Article  Google Scholar 

  25. Bott, J., Johnson, F. H., and Morales, M. F., J. Cell. Comp. Physiol., 37, 247 (1951).

    Article  Google Scholar 

  26. Johnson, S. M., and Bangham, A. D., Biochim. Biophys. Acta, 193, 92 (1969).

    Article  CAS  Google Scholar 

  27. Johnson, S. M., and Miller, K. W., Nature, 228, 75 (1970).

    Article  ADS  CAS  Google Scholar 

  28. Lillie, R. S., Protoplasmic Action and Nervous Action (University of Chicago Press, 1923).

    Book  Google Scholar 

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LEVER, M., MILLER, K., PATON, W. et al. Pressure Reversal of Anaesthesia. Nature 231, 368–371 (1971). https://doi.org/10.1038/231368a0

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