Abstract
ROSENTHAL1 has shown that when the anaerobic conversion of fructose to lactic acid by the Jensen rat sarcoma is studied by Warburg's method, a spontaneous increase in the rate of acid production , which he ascribes to the anaerobic formation of an activator, occurs about forty minutes after the manometric vessels are put into the thermostat at 38° C. We have been able to show that this spontaneous increase may also be demonstrated when glucose is the substrate, although here the pre-activation period is shorter; and we find that with both sugars the pre-activation period is abolished when sodium pyruvate is present in 10−3 M concentration.
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References
Z. Krebsforschung, 32, 220; 1930.
Klin. Woch., 10, 118; 1931.
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DICKENS, F., GREVILLE, G. Anaerobic Activation of Glycolysis in Tumour Tissue. Nature 130, 206 (1932). https://doi.org/10.1038/130206a0
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DOI: https://doi.org/10.1038/130206a0
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