Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

A Germplasm-transmitted Alteration of Histocompatibility in the Progeny of Homograft Tolerant Mice

Abstract

THE in vivo co-existence of cells of two genotypes achieved in the state of actively acquired tolerance inspired this investigation to determine if any detectable changes occurred in progeny of tolerant mice secondary to the exposure of maturing germ cells to a chimæric environment.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Billingham, R. E., Brent, L., and Medawar, P. B., Nature, 172, 603 (1953).

    Article  ADS  CAS  Google Scholar 

  2. Barrett, M. K., and Deringer, M. K., J. Nat. Cancer Inst., 11, 51 (1950).

    CAS  PubMed  Google Scholar 

  3. Haldane, J. B. S., Nature, 132, 265 (1933).

    Article  ADS  Google Scholar 

  4. Little, C. C., in The Biology of the Laboratory Mouse, edit. by Snell, G. D., 279 (The Blakiston Co., Philadephia, 1953).

    Google Scholar 

  5. Owen, R. D., Science, 102, 400 (1945).

    Article  ADS  CAS  Google Scholar 

  6. Stone, W. H., Berman, D. T., Tyler, W. J., and Irwin, M. R., J. Hered., 51, 136 (1960).

    Article  Google Scholar 

  7. Owen, R. D. (personal communication).

  8. Fox, A. S., Yoon, S., and Mead, C. G., Proc. U.S. Nat. Acad. Sci., 48, 546 (1962).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

GUTTMANN, R., AUST, J. A Germplasm-transmitted Alteration of Histocompatibility in the Progeny of Homograft Tolerant Mice. Nature 197, 1220–1221 (1963). https://doi.org/10.1038/1971220a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1971220a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing