Abstract
HIGHER animals may change in their response to drugs because of a decrease in the sensitivity of drug receptor sites in the organism, or because of accelerated drug metabolism. The latter has been explained1 on the basis of drug induced stimulation of liver microsomal enzymes, for example, many compounds have been listed which induce microsomal oxidizing enzymes in rats, and phenobarbital has been shown to stimulate the metabolism of the anti-coagulant coumarin in man2. We now report the induced enzyme metabolism of nicotine in man by tobacco smoking.
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Remmer, H., Proc. Europ. Soc. for the Study of Drug Toxicity, 4, 57 (1964).
Dayton, P. G., Tarcan, Y., Chenkin, T., and Weiner, M., J. Clin. Invest., 40, 1797 (1961).
Beckett, A. H., and Triggs, E. J., Nature, 211, 1415 (1966).
Beckett, A. H., and Rowland, M., J. Pharm. Pharmacol., 17, 628 (1965).
Beckett, A. H., and Rowland, M., J. Pharm. Pharmacol., 17, suppl., 109S (1965).
Beckett, A. H., and Wilkinson, G. R., J. Pharm. Pharmacol., 17, suppl., 107S (1965).
Triggs, E. J., thesis, Univ. London, 1967.
Okamoto, T., Nisshin Igaku, 16, 1835, 1993 (1927); ibid., 17, 421, 594 (1927).
Werle, E., and Uschold, E., Biochem. Zschr., 318, 531 (1948).
Rottenstein, H., Pierce, G., Russ, E., Felder, D., and Montgomery, H., Ann. NY Acad. Sci., 90, 102 (1960).
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BECKETT, A., TRIGGS, E. Enzyme Induction in Man caused by Smoking. Nature 216, 587 (1967). https://doi.org/10.1038/216587a0
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DOI: https://doi.org/10.1038/216587a0
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