SFX by Ex Libris Inc.

Title:	In silicoandin vitroevaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization
Source:	Nucleic Acids Research [0305-1048] Kamola, Piotr yr:2015

Basic

Full text

Full text available via PubMed Central

Year:

Volume:

Issue:

Start Page:

Document delivery

Request document via Library/Bibliothek

Users interested in this article also expressed an interest in the following:
description	1.	Kondo, J. "The crystal structure of a 2',4'-BNA(NC)[N-Me]-modified antisense gapmer in complex with the target RNA." Chemical communications (London. 1996) 52.11 (2016): 2354-2357.
description	2.	Nishina K, K. "DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing." Nature communications 6.1 (2015): 7969-7969.
description	3.	Kasuya, T. "Ribonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotides." Scientific Reports 6.1 (2016): 30377-30377.
description	4.	Ji, Y. "Photochemical regulation of gene expression using caged siRNAs with single terminal Vitamin E modification." Angewandte Chemie (International ed.) 55.6 (2016): 2152-2156.
description	5.	Osawa, T. "Synthesis and Properties of the 5-Methyluridine Derivative of 3,4-Dihydro-2H-pyran-Bridged Nucleic Acid (DpNA)." Journal of organic chemistry 80.21 (2015): 10474-10481.
description	6.	Ahmed, K. "Self-assembly into nanoparticles is essential for receptor mediated uptake of therapeutic antisense oligonucleotides." Nano letters 15.7 (2015): 4294967295-73.
description	7.	Prakash, P. "Efficient synthesis and biological evaluation of 5’–GalNAc conjugated antisense oligonucleotides." Bioconjugate chemistry 26.8 (2015): 4294967295-1455.
description	8.	Di Martino, Maria T. "In Vitro and In Vivo Activity of a Novel Locked Nucleic Acid (LNA)-Inhibitor-miR-221 against Multiple Myeloma Cells." PLoS ONE 9.2 (2014).
description	9.	Prakash, Thazha P. "Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity." Nucleic acids research 43.6 (2015): 2993-3011.
description	10.	Khvorova, A. "The chemical evolution of oligonucleotide therapies of clinical utility." Nature Biotechnology 35.3 (2017): 238-248.
description	11.	Yu, L. "Photo/pH dual-responsive biocompatible poly(methacrylic acid)-based particles for triggered drug delivery." Journal of applied polymer science 133.39 (2016).
description	12.	Jones, G. "Investigation of some properties of oligodeoxynucleotides containing 4'- thio-2'-deoxynucleotides: duplex hybridization and nuclease sensitivity." Nucleic acids research 24.21 (1996): 4117-4122.
description	13.	Wu, Z. "N-dots as a photoluminescent probe for the rapid and selective detection of Hg2+ and Ag+ in aqueous solution." Journal of Materials Chemistry B: Materials for biology and medicine 4.12 (2016): 2086-2089.
description	14.	Prakash, Thazha P. "Comprehensive Structure-Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes." Journal of medicinal chemistry 59.6 (2016): 2718-2733.
description	15.	Tibbitt, Mark W. "Emerging Frontiers in Drug Delivery." Journal of the American Chemical Society 138.3 (2016): 704-717.
description	16.	Prakash, Thazha P. "Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice." Nucleic acids research 42.13 (2014): 8796-807.
description	17.	Ikejiri, M. "Synthesis and fluorescence properties of 4-diarylmethylene analogues of the green fluorescent protein chromophore." Tetrahedron 71.30 (2015): 4987-4998.
description	18.	Ding, M. "Total Synthesis of (+)-Chimonanthine, (+)-Folicanthine, and (-)-Calycanthine." Journal of organic chemistry 80.20 (2015): 10309-10316.
description	19.	Govan, Jeane M. "Optically Triggered Immune Response through Photocaged Oligonucleotides." Tetrahedron letters 56.23 (2015): 3639-3642.
description	20.	Boisguérin, P. "Delivery of therapeutic oligonucleotides with cell penetrating peptides." Advanced drug delivery reviews 87.C (2015): 52-67.