Abstract
WHILE the production of antibodies by explanted tissues or cells from immunized animals is readily demonstrable, most attempts to initiate antibody formation in vitro have met with failure. Only recently has the original claim for success1 been substantiated by the observations of Stevens and McKenna2, who found that normal rabbit spleen produced antibody to bovine γ-globulin after exposure to this antigen in vitro, but only if either the rabbit or the spleen had previously been treated with S. typhi endotoxin.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Carrel, A., and Ingebrigtsen, R., J. Exp. Med., 15, 287 (1912).
Stevens, K. M., and McKenna, J. M., J. Exp. Med., 107, 537 (1958).
Sawyer, W. D., Smith, R. M., and Wood, W. B., J. Exp. Med., 100, 417 (1954).
Trowell, O. A., Exp. Cell. Res., 9, 258 (1955).
Boyden, S. V., J. Exp. Med., 93, 107 (1951).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FISHMAN, M. Antibody Formation in Tissue Culture. Nature 183, 1200–1201 (1959). https://doi.org/10.1038/1831200a0
Issue Date:
DOI: https://doi.org/10.1038/1831200a0
This article is cited by
-
What history tells us XXXIV. The complex history of the selective model of antibody formation
Journal of Biosciences (2014)
-
Effect of aurantin on phagocytosis and induction of synthesis of hemolysins
Bulletin of Experimental Biology and Medicine (1970)
-
Stochastic Model for the Production of Antibody-forming Cells
Nature (1969)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.