Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Structure of vitamin D-dependent calcium-binding protein from bovine intestine

Nature volume 294, pages 327–332 (1981)Cite this article

Abstract

The structure of vitamin D-dependent calcium-binding protein from bovine intestine, determined crystallographically to 2.3 Å, contains a pair of calcium-binding domains similar to those in parvalbumin, but one domain has a longer and rearranged calcium-binding loop. This result has implications for structure predictions of other calcium-binding proteins such as calmodulin and S-100.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Rasmussen, H., Goodman, D. B. P. & Tenenhouse, A. CRC crit. Rev. Biochem. 1, 95–148 (1972).

    Article  CAS  Google Scholar 

  2. Rasmussen, H., Jensen, P., Lake, W., Friedmann, N. & Goodman, D. B. P. Adv. Cyclic Nucleotide Res. 5, 375–394 (1974).

    Google Scholar 

  3. Kretsinger, R. H. A. Rev. Biochem. 45, 239–266 (1976).

    Article  CAS  Google Scholar 

  4. Cheung, W. Y. Science 207, 19–27 (1980).

    Article  ADS  CAS  Google Scholar 

  5. Wasserman, R. H., Fullmer, C. S. & Taylor, A. N. in Vitamin D (ed. Lawson, D. E. M.) 133–136 (Academic, New York, 1978).

    Google Scholar 

  6. Fullmer, C. S. & Wasserman, R. H. J. biol. Chem. 256, 5669–5674 (1981).

    CAS  PubMed  Google Scholar 

  7. Taylor, A. N. in Calcium Binding Proteins: Structure and Function (eds Siegel, F. L. et al.) 393–400 (Elsevier, New York, 1980).

    Google Scholar 

  8. Thomasset, M., Cuisinier-Gleizers, P. & Mathieu, H. FEBS Lett. 107, 91–94 (1979).

    Article  CAS  Google Scholar 

  9. Wasserman, R. H. in Calcium Binding Proteins: Structure and Function (eds Siegel, F. L. et al.) 357–361 (Elsevier, New York, 1980).

    Google Scholar 

  10. Kretsinger, R. H. & Nockolds, C. E. J. biol. Chem. 248, 3313–3326 (1973).

    CAS  Google Scholar 

  11. Moews, P. C. & Kretsinger, R. H. J. molec. Biol. 91, 201–228 (1975).

    Article  CAS  Google Scholar 

  12. Tufty, R. M. & Kretsinger, R. H. Science 187, 167–169 (1975).

    Article  ADS  CAS  Google Scholar 

  13. Kretsinger, R. H. in Calcium Binding Proteins and Calcium Function (eds Wasserman, R. H. et al.) 63–72 (Elsevier, New York, 1977).

    Google Scholar 

  14. Kretsinger, R. H. CRC crit. Rev. Biochem. 8, 119–174 (1980).

    Article  CAS  Google Scholar 

  15. Fullmer, C. S. & Wasserman, R. H. Biochim. biophys. Acta 317, 172–186 (1973).

    Article  CAS  Google Scholar 

  16. Moffat, K., Fullmer, C. S. & Wasserman, R. H. J. molec. Biol. 97, 661–664 (1975).

    Article  CAS  Google Scholar 

  17. Blundell, T. L. & Johnson, L. N. Protein Crystallography (Academic, London, 1976).

    Google Scholar 

  18. Blow, D. M. & Crick, F. H. C. Acta crystallogr. 12, 794–802 (1959).

    Article  CAS  Google Scholar 

  19. Matthews, B. W. Acta crystallogr. 20, 82–86 (1966).

    Article  CAS  Google Scholar 

  20. Schevitz, R. W. et al. Nature 278, 188–190 (1979).

    Article  ADS  CAS  Google Scholar 

  21. Agard, D. A. & Stroud, R. M. Acta. crystallogr. (in the press).

  22. Richards, F. M. J. molec. Biol. 37, 225–230 (1968).

    Article  CAS  Google Scholar 

  23. Huang, W.-Y., Cohn, D. V., Hamilton, J. W., Fullmer, C. S. & Wasserman, R. H. J. biol. Chem. 250, 7647–7655 (1975).

    CAS  PubMed  Google Scholar 

  24. Dorrington, K. J., Hin, A., Hofmann, T., Hitchman, A. J. W. & Harrison, J. E. J. biol. Chem. 249, 199–204 (1974).

    CAS  PubMed  Google Scholar 

  25. Birdsall, W. J. et al. in Calcium Binding Proteins: Structure and Function (eds Siegel, F. L. et al.) 405–406 (Elsevier, New York, 1980).

    Google Scholar 

  26. Jones, A. J. S., Szebenyi, D. M. & Moffat, K. in Calcium Binding Proteins: Structure and Function (eds Siegel, F. L. et al.) 413–416 (Elsevier, New York, 1980).

    Google Scholar 

  27. Remington, S. J. & Matthews, B. W. J. molec. Biol. 140, 77–99 (1980).

    Article  CAS  Google Scholar 

  28. Fullmer, C. S. & Wasserman, R. H. in Calcium Binding Proteins and Calcium Function (eds Wasserman, R. H. et al.) 303–312 (Elsevier, New York, 1977).

    Google Scholar 

  29. Goodman, M. in Calcium Binding Proteins: Structure and Function (eds Siegel, F. L. et al.) 347–354 (Elsevier, New York, 1980).

    Google Scholar 

  30. Isobe, T. & Okuyama, T. Eur. J. Biochem. 116, 79–86 (1981).

    Article  CAS  Google Scholar 

  31. Calissano, P., Alemá, S. & Fasella, P. Biochemistry 13, 4553–4560 (1974).

    Article  CAS  Google Scholar 

  32. Kretsinger, R. H. & Barry, C. D. Biochim. biophys. Acta 405, 40–52 (1975).

    Article  CAS  Google Scholar 

  33. Bernstein, F. C. et al. J. molec. Biol. 112, 535–542 (1977).

    Article  CAS  Google Scholar 

  34. Nockolds, C. E., Kretsinger, R. H., Coffee, C. J. & Bradshaw, R. A. Proc. natn. Acad. Sci. U.S.A. 69, 581–584 (1972).

    Article  ADS  CAS  Google Scholar 

  35. Collins, J. H., Potter, J. D., Horn, M. J., Wilshire, G. & Jackman, N. FEBS Lett. 36, 268–272 (1973).

    Article  CAS  Google Scholar 

  36. Watterson, D. M., Sharief, F. S. & Vanaman, T. C. J. biol. Chem. 255, 962–971 (1980).

    CAS  PubMed  Google Scholar 

  37. Isobe, T. & Okuyama, T. Eur. J. Biochem. 89, 379–388 (1978).

    Article  CAS  Google Scholar 

  38. Bricogne, G. Acta crystallogr. A32, 832–847 (1976).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Biochemistry, Molecular and Cell Biology, Clark Hall, Cornell University, Ithaca, New York, 14853, USA

    D. M. E. Szebenyi, S. K. Obendorf & K. Moffat

Authors
  1. D. M. E. Szebenyi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. K. Obendorf
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. Moffat
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Szebenyi, D., Obendorf, S. & Moffat, K. Structure of vitamin D-dependent calcium-binding protein from bovine intestine. Nature 294, 327–332 (1981). https://doi.org/10.1038/294327a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/294327a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing