The 2023 MDPI Annual Report has
been released!
 
23 pages, 11417 KiB  
Article
Orthologs of NOX5 and EC-SOD/SOD3: dNox and dSod3 Impact Egg Hardening Process and Egg Laying in Reproductive Function of Drosophila melanogaster
by Eva Louise Steinmetz, Annika Scherer, Célestine Calvet and Uli Müller
Int. J. Mol. Sci. 2024, 25(11), 6138; https://doi.org/10.3390/ijms25116138 (registering DOI) - 2 Jun 2024
Abstract
The occurrence of ovarian dysfunction is often due to the imbalance between the formation of reactive oxygen species (ROS) and the ineffectiveness of the antioxidative defense mechanisms. Primary sources of ROS are respiratory electron transfer and the activity of NADPH oxidases (NOX) while [...] Read more.
The occurrence of ovarian dysfunction is often due to the imbalance between the formation of reactive oxygen species (ROS) and the ineffectiveness of the antioxidative defense mechanisms. Primary sources of ROS are respiratory electron transfer and the activity of NADPH oxidases (NOX) while superoxide dismutases (SOD) are the main key regulators that control the levels of ROS and reactive nitrogen species intra- and extracellularly. Because of their central role SODs are the subject of research on human ovarian dysfunction but sample acquisition is low. The high degree of cellular and molecular similarity between Drosophila melanogaster ovaries and human ovaries provides this model organism with the best conditions for analyzing the role of ROS during ovarian function. In this study we clarify the localization of the ROS-producing enzyme dNox within the ovaries of Drosophila melanogaster and by a tissue-specific knockdown we show that dNox-derived ROS are involved in the chorion hardening process. Furthermore, we analyze the dSod3 localization and show that reduced activity of dSod3 impacts egg-laying behavior but not the chorion hardening process. Full article
(This article belongs to the Special Issue Drosophila: A Versatile Model in Biology and Medicine)
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27 pages, 4362 KiB  
Article
Enhancing Resource Utilization Efficiency in Serverless Education: A Stateful Approach with Rofuse
by Xinxi Lu, Nan Li, Lijuan Yuan and Juan Zhang
Electronics 2024, 13(11), 2168; https://doi.org/10.3390/electronics13112168 (registering DOI) - 2 Jun 2024
Abstract
Traditional container orchestration platforms often suffer from resource wastage in educational settings, and stateless serverless services face challenges in maintaining container state persistence during the teaching process. To address these issues, we propose a stateful serverless mechanism based on Containerd and Kubernetes, focusing [...] Read more.
Traditional container orchestration platforms often suffer from resource wastage in educational settings, and stateless serverless services face challenges in maintaining container state persistence during the teaching process. To address these issues, we propose a stateful serverless mechanism based on Containerd and Kubernetes, focusing on optimizing the startup process for container groups. We first implement a checkpoint/restore framework for container states, providing fundamental support for managing stateful containers. Building on this foundation, we propose the concept of “container groups” to address the challenges in educational practice scenarios characterized by a large number of similar containers on the same node. We then propose the Rofuse optimization mechanism, which employs delayed loading and block-level deduplication techniques. This enables containers within the same group to reuse locally cached file system data at the block level, thus reducing container restart latency. Experimental results demonstrate that our stateful serverless mechanism can run smoothly in typical educational practice scenarios, and Rofuse reduces the container restart time by approximately 50% compared to existing solutions. This research provides valuable exploration for serverless practices in the education domain, contributing new perspectives and methods to improve resource utilization efficiency and flexibility in teaching environments. Full article
(This article belongs to the Special Issue Machine Intelligent Information and Efficient System)
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19 pages, 9762 KiB  
Article
Graph Search-Based Path Planning for Automatic Ship Berthing
by Xiaocheng Liu, Zhihuan Hu, Ziheng Yang and Weidong Zhang
J. Mar. Sci. Eng. 2024, 12(6), 933; https://doi.org/10.3390/jmse12060933 (registering DOI) - 2 Jun 2024
Abstract
Ship berthing is one of the most challenging operations for crews, involving optimal trajectory generation and intricate harbor maneuvering at low speed. In this paper, we present a practical path-planning method that generates smooth trajectories for an underactuated surface vehicle (USV) traveling in [...] Read more.
Ship berthing is one of the most challenging operations for crews, involving optimal trajectory generation and intricate harbor maneuvering at low speed. In this paper, we present a practical path-planning method that generates smooth trajectories for an underactuated surface vehicle (USV) traveling in a confined harbor environment. Our approach introduces a Generalized Voronoi Diagram (GVD)-based path planner to handle the unberthing phase. The hybrid A* search-based path finding method is used for the transportation phase. A simple planner based on a Bézier curve is proposed for the berthing phase. To track the target path, an adaptive pure pursuit method and proportional-derivative (PD) controller is used. The performance of the given method is tested numerically and experimentally on a catamaran with a pair of non-steerable thrusters. The results demonstrate that the proposed algorithm can achieve a successful berthing operation through static obstacle handling and smooth trajectory generation. Full article
(This article belongs to the Special Issue Motion Control and Path Planning of Marine Vehicles—2nd Edition)
20 pages, 16972 KiB  
Article
Sideband Vibro-Acoustics Suppression and Numerical Prediction of Permanent Magnet Synchronous Motor Based on Markov Chain Random Carrier Frequency Modulation
by Yong Chen, Bingxiao Yan, Liming Zhang, Kefu Yao and Xue Jiang
Appl. Sci. 2024, 14(11), 4808; https://doi.org/10.3390/app14114808 (registering DOI) - 2 Jun 2024
Abstract
This paper presents a Markov chain random carrier frequency modulation (MRCFM) technique for suppressing sideband vibro-acoustic responses caused by discontinuous pulse-width modulation (DPWM) in permanent magnet synchronous motors (PMSMs) for new energy vehicles. Firstly, the spectral and order distributions of the sideband current [...] Read more.
This paper presents a Markov chain random carrier frequency modulation (MRCFM) technique for suppressing sideband vibro-acoustic responses caused by discontinuous pulse-width modulation (DPWM) in permanent magnet synchronous motors (PMSMs) for new energy vehicles. Firstly, the spectral and order distributions of the sideband current harmonics and radial electromagnetic forces introduced by DPWM are characterized and identified. Then, the principle and implementation method of three-state Markov chain random number generation are proposed, and particle swarm optimization (PSO) algorithm is chosen to quickly find the key parameters of transition probability and random gain. A Simulink and JMAG multi-physics field co-simulation model is built to simulate and predict the suppression effect of the MRCFM method on the sideband vibro-acoustic response. Finally, a 12-slot-10-pole PMSM test platform is built for experimental testing. The results show that the sideband current harmonics and vibro-acoustic response are effectively suppressed after the optimization of Markov chain algorithm. The constructed multi-physics field co-simulation model can accurately predict the amplitude characteristics of the sideband current harmonics and vibro-acoustic response. Full article
(This article belongs to the Section Acoustics and Vibrations)
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18 pages, 4146 KiB  
Article
The Spatial Shifts and Vulnerability Assessment of Ecological Niches under Climate Change Scenarios for Betula luminifera, a Fast-Growing Precious Tree in China
by Xian-Ge Hu, Jiahui Chen, Qiaoyun Chen, Ying Yang, Yiheng Lin, Zilun Jin, Luqiong Sha, Erpei Lin, El-Kassaby Yousry and Huahong Huang
Plants 2024, 13(11), 1542; https://doi.org/10.3390/plants13111542 (registering DOI) - 2 Jun 2024
Abstract
The spatial shifts and vulnerability assessments of ecological niches for trees will offer fresh perspectives for sustainable development and preservation of forests, particularly within the framework of rapid climate change. Betula luminifera is a fast-growing native timber plantation species in China, but the [...] Read more.
The spatial shifts and vulnerability assessments of ecological niches for trees will offer fresh perspectives for sustainable development and preservation of forests, particularly within the framework of rapid climate change. Betula luminifera is a fast-growing native timber plantation species in China, but the natural resources have been severely damaged. Here, a comprehensive habitat suitability model (including ten niche-based GIS modeling algorithms) was developed that integrates three types of environmental factors, namely, climatic, soil, and ultraviolet variables, to assess the species contemporary and future distribution of suitable habitats across China. Our results suggest that the habitats of B. luminifera generally occur in subtropical areas (about 1.52 × 106 km2). However, the growth of B. luminifera is profoundly shaped by the nuances of its local environment, the most reasonable niche spaces are only 1.15 × 106 km2 when limiting ecological factors (soil and ultraviolet) are considered, generally considered as the core production region. Furthermore, it is anticipated that species-suitable habitats will decrease by 10 and 8% with climate change in the 2050s and 2070s, respectively. Our study provided a clear understanding of species-suitable habitat distribution and identified the reasons why other niche spaces are unsuitable in the future, which can warn against artificial cultivation and conservation planning. Full article
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21 pages, 11367 KiB  
Article
Analysis of Shafting System Vibration Characteristics for Mixed-Flow Hydropower Units Considering Sand Wear on Turbine Blades
by Wenhua Chen, Shuo Wang, Haifeng Chen, Weiliang Zhang, Jianfeng Ma and Jun Pan
Appl. Sci. 2024, 14(11), 4806; https://doi.org/10.3390/app14114806 (registering DOI) - 2 Jun 2024
Abstract
Addressing the issue of increased shaft-system vibration in high-altitude mixed-flow hydropower generating units due to sand wear on turbine blades, a three-dimensional model of a specific mixed-flow water turbine was constructed. CFD numerical simulations were employed to analyze the fluid exciting force acting [...] Read more.
Addressing the issue of increased shaft-system vibration in high-altitude mixed-flow hydropower generating units due to sand wear on turbine blades, a three-dimensional model of a specific mixed-flow water turbine was constructed. CFD numerical simulations were employed to analyze the fluid exciting force acting on the turbine runner under varying degrees of blade wear. An approximate analytical model was then established for the variation of fluid exciting force in the turbine runner system using the Fourier harmonic analysis method. A multi-degree-of-freedom mathematical model of flexural and inclined coupling vibration of a hydropower unit’s shafting, considering blade wear, was constructed. The nonlinear dynamic model was numerically calculated by the Runge–Kutta method. The vibration responses of the shafting of hydropower units under different wear degrees were obtained by means of a time-domain diagram, frequency-domain diagram, axis-locus diagram, phase-locus diagram, and Poincare mapping. Based on the formula for calculating the wear amount of the blade material, the runner amplitude degradation trajectory model was established, and the pseudo-failure time of turbine blades was determined according to the allowable value of amplitude. Full article
(This article belongs to the Section Mechanical Engineering)
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19 pages, 1277 KiB  
Article
An Accelerated Dual-Integral Structure Zeroing Neural Network Resistant to Linear Noise for Dynamic Complex Matrix Inversion
by FeiXiang Yang, TingLei Wang and Yun Huang
Axioms 2024, 13(6), 374; https://doi.org/10.3390/axioms13060374 (registering DOI) - 2 Jun 2024
Abstract
The problem of inverting dynamic complex matrices remains a central and intricate challenge that has garnered significant attention in scientific and mathematical research. The zeroing neural network (ZNN) has been a notable approach, utilizing time derivatives for real-time solutions in noiseless settings. However, [...] Read more.
The problem of inverting dynamic complex matrices remains a central and intricate challenge that has garnered significant attention in scientific and mathematical research. The zeroing neural network (ZNN) has been a notable approach, utilizing time derivatives for real-time solutions in noiseless settings. However, real-world disturbances pose a significant challenge to a ZNN’s convergence. We design an accelerated dual-integral structure zeroing neural network (ADISZNN), which can enhance convergence and restrict linear noise, particularly in complex domains. Based on the Lyapunov principle, theoretical analysis proves the convergence and robustness of ADISZNN. We have selectively integrated the SBPAF activation function, and through theoretical dissection and comparative experimental validation we have affirmed the efficacy and accuracy of our activation function selection strategy. After conducting numerous experiments, we discovered oscillations and improved the model accordingly, resulting in the ADISZNN-Stable model. This advanced model surpasses current models in both linear noisy and noise-free environments, delivering a more rapid and stable convergence, marking a significant leap forward in the field. Full article
(This article belongs to the Special Issue Differential Equations and Inverse Problems)
18 pages, 1567 KiB  
Article
Phytoremediation Potential of Flax Grown on Multimetal Contaminated Soils: A Field Experiment
by Danai Kotoula, Eleni G. Papazoglou, Garifalia Economou, Panayiotis Trigas and Dimitris L. Bouranis
Plants 2024, 13(11), 1541; https://doi.org/10.3390/plants13111541 (registering DOI) - 2 Jun 2024
Abstract
The aim of this study was to assess the phytoremediation potential of fiber flax (Linum usitatissimatum L., var. Calista) cultivated in a soil contaminated with multiple metals, under real field conditions. A two-year (2022 and 2023) field experiment was conducted in a [...] Read more.
The aim of this study was to assess the phytoremediation potential of fiber flax (Linum usitatissimatum L., var. Calista) cultivated in a soil contaminated with multiple metals, under real field conditions. A two-year (2022 and 2023) field experiment was conducted in a site contaminated with elevated concentrations of Cd, Ni, Cu, Pb, and Zn due to mining and metallurgical activities. Three different nitrogen fertilization levels were tested (N0: 0 kg N ha−1, N1: 30 kg N ha−1, N2: 60 kg N ha−1), and both spring and winter sowings were conducted. At full maturity, growth parameters and yields were measured. The phytoremediation potential of flax was assessed in terms of the metal concentrations in the above-ground biomass and of the metal uptake (i.e., the potential removal of the soil metals in g ha−1 and per year). Flax demonstrated a shorter growth cycle, with shorter and thicker plants and higher yields when sown in spring compared to winter sowing. Plant growth and productivity were not evidently influenced by additional nitrogen fertilization during plant growth. The cadmium bioaccumulation factor was 1.06, indicating that flax accumulates this metal. For Ni, Cu, Pb, and Zn, the corresponding values were 0.0, 0.04, 0.004, and 0.02, suggesting that this crop excludes these metals. The order of the higher uptake in plant tissues was as follows: Zn > Pb > Cd > Cu > Ni. In conclusion, flax demonstrated tolerance to heavy metals in the soil, effectively supporting soil restoration through cultivation. Additionally, flax showed potential as a cadmium accumulator while excluding nickel, copper, lead, and zinc. Full article
(This article belongs to the Section Plant–Soil Interactions)
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19 pages, 2565 KiB  
Review
Measurements of Nuclear Magnetic Shielding in Molecules
by Karol Jackowski and Marcin Wilczek
Molecules 2024, 29(11), 2617; https://doi.org/10.3390/molecules29112617 (registering DOI) - 2 Jun 2024
Abstract
The origin of nuclear magnetic shielding in diamagnetic molecules is discussed, pointing out various contributions to the shielding from electrons and the effects of intra- and intermolecular interactions. In NMR practice, chemical shifts are determined first as the measure of shielding in observed [...] Read more.
The origin of nuclear magnetic shielding in diamagnetic molecules is discussed, pointing out various contributions to the shielding from electrons and the effects of intra- and intermolecular interactions. In NMR practice, chemical shifts are determined first as the measure of shielding in observed samples. The descriptions of shielding and chemical shifts are not fully consistent. Gas phase studies permit the withdrawal of intermolecular contributions from shielding and obtaining the magnetic shielding data in isolated molecules. The shielding determination in molecules is possible using at least three methods delivering the reference shielding standards for selected nuclei. The known shielding of one magnetic nucleus can be transferred to other nuclei if the appropriate nuclear magnetic moments are available with satisfactory accuracy. It is possible to determine the nuclear magnetic dipole moments using the most advanced ab initio shielding calculations jointly with the NMR frequencies measurements for small-sized isolated molecules. Helium-3 gas is postulated as all the molecules’ primary and universal reference standard of shielding. It can be easily applied using common deuterium lock solvents as the secondary reference standards. The measurements of absolute shielding are available for everyone with the use of standard NMR spectrometers. Full article
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20 pages, 5797 KiB  
Article
Fault Detection and Diagnosis of Three-Wheeled Omnidirectional Mobile Robot Based on Power Consumption Modeling
by Bingtao Wang, Liang Zhang and Jongwon Kim
Mathematics 2024, 12(11), 1731; https://doi.org/10.3390/math12111731 (registering DOI) - 2 Jun 2024
Abstract
Three-wheeled omnidirectional mobile robots (TOMRs) are widely used to accomplish precise transportation tasks in narrow environments owing to their stability, flexible operation, and heavy loads. However, these robots are susceptible to slippage. For wheeled robots, almost all faults and slippage will directly affect [...] Read more.
Three-wheeled omnidirectional mobile robots (TOMRs) are widely used to accomplish precise transportation tasks in narrow environments owing to their stability, flexible operation, and heavy loads. However, these robots are susceptible to slippage. For wheeled robots, almost all faults and slippage will directly affect the power consumption. Thus, using the energy consumption model data and encoder data in the healthy condition as a reference to diagnose robot slippage and other system faults is the main issue considered in this paper. We constructed an energy model for the TOMR and analyzed the factors that affect the power consumption in detail, such as the position of the gravity center. The study primarily focuses on the characteristic relationship between power consumption and speed when the robot experiences slippage or common faults, including control system faults. Finally, we present the use of a table-based artificial neural network (ANN) to indicate the type of fault by comparing the modeled data with the measured data. The experiments proved that the method is accurate and effective for diagnosing faults in TOMRs. Full article
(This article belongs to the Section Engineering Mathematics)
19 pages, 6161 KiB  
Review
Advancements in Neuroendocrine Neoplasms: Imaging and Future Frontiers
by Luigi Asmundo, Francesco Rizzetto, Michael Blake, Mark Anderson, Amirkasra Mojtahed, William Bradley, Anuradha Shenoy-Bhangle, Carlos Fernandez-del Castillo, Motaz Qadan, Cristina Ferrone, Jeffrey Clark, Valentina Ambrosini, Maria Picchio, Paola Mapelli, Laura Evangelista, Doris Leithner, Konstantin Nikolaou, Stephan Ursprung, Stefano Fanti, Angelo Vanzulli and Onofrio Antonio Catalanoadd Show full author list remove Hide full author list
J. Clin. Med. 2024, 13(11), 3281; https://doi.org/10.3390/jcm13113281 (registering DOI) - 2 Jun 2024
Abstract
Neuroendocrine neoplasms (NENs) are a diverse group of tumors with varying clinical behaviors. Their incidence has risen due to increased awareness, improved diagnostics, and aging populations. The 2019 World Health Organization classification emphasizes integrating radiology and histopathology to characterize NENs and create personalized [...] Read more.
Neuroendocrine neoplasms (NENs) are a diverse group of tumors with varying clinical behaviors. Their incidence has risen due to increased awareness, improved diagnostics, and aging populations. The 2019 World Health Organization classification emphasizes integrating radiology and histopathology to characterize NENs and create personalized treatment plans. Imaging methods like CT, MRI, and PET/CT are crucial for detection, staging, treatment planning, and monitoring, but each of them poses different interpretative challenges and none are immune to pitfalls. Treatment options include surgery, targeted therapies, and chemotherapy, based on the tumor type, stage, and patient-specific factors. This review aims to provide insights into the latest developments and challenges in NEN imaging, diagnosis, and management. Full article
(This article belongs to the Section Nuclear Medicine & Radiology)
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31 pages, 1992 KiB  
Article
Securing Data Exchange with Elliptic Curve Cryptography: A Novel Hash-Based Method for Message Mapping and Integrity Assurance
by Younes Lahraoui, Saiida Lazaar, Youssef Amal and Abderrahmane Nitaj
Cryptography 2024, 8(2), 23; https://doi.org/10.3390/cryptography8020023 (registering DOI) - 2 Jun 2024
Abstract
To ensure the security of sensitive data, elliptic curve cryptography (ECC) is adopted as an asymmetric method that balances security and efficiency. Nevertheless, embedding messages into elliptic curve (EC) points poses a significant challenge. The intricacies of this process can greatly affect the [...] Read more.
To ensure the security of sensitive data, elliptic curve cryptography (ECC) is adopted as an asymmetric method that balances security and efficiency. Nevertheless, embedding messages into elliptic curve (EC) points poses a significant challenge. The intricacies of this process can greatly affect the overall security and efficiency of the cryptosystem, reflecting security vulnerabilities observed in many existing schemes that utilize ElGamal ECC-based encryption. In this paper, we introduce an innovative hash-based technique for securely embedding messages into EC points before encryption. A random parameter and a shared secret point generated through the EC Diffie–Hellman protocol are used to bolster the scheme’s security. The security of the proposed method is evaluated against various attack models; moreover, the complexity, and sensitivity of the encryption scheme, as well as its inputs, are analyzed. The randomness assessment of the ciphertext was performed using the NIST statistical test suite. Additionally, we propose a mechanism to ensure the integrity of the message by securely appending a tag to the ciphertext. As a consequence, a comprehensive analysis of our scheme demonstrates its effectiveness in maintaining data security and integrity against various attack models. The algorithm also meets more criteria such as the strict avalanche criterion, linear complexity, and operability. Full article
23 pages, 12637 KiB  
Article
Mechanical Properties of Raw Filaments and Printed Specimens: Effects of Fiber Reinforcements and Process Parameters
by Daniel Vieweger, Sergej Diel, Hans-Georg Schweiger and Ulrich Tetzlaff
Polymers 2024, 16(11), 1576; https://doi.org/10.3390/polym16111576 (registering DOI) - 2 Jun 2024
Abstract
Fused Deposition Modeling (FDM) is a well-established manufacturing method for producing both prototype and functional components. This study investigates the mechanical properties of FDM components by material and process-related influencing variables. Tensile tests were conducted on seven different materials in their raw filament [...] Read more.
Fused Deposition Modeling (FDM) is a well-established manufacturing method for producing both prototype and functional components. This study investigates the mechanical properties of FDM components by material and process-related influencing variables. Tensile tests were conducted on seven different materials in their raw filament form, two of which were fiber-reinforced, to analyze their material-related influence. To cover a wide range from standard to advanced materials relevant for load-carrying components as well as their respective variations, polylactic acid (PLA), 30% wood-fiber-reinforced PLA, acrylonitrile butadiene styrene (ABS), polycarbonate (PC), a blend of ABS and PC, Nylon, and 30% glass-fiber-reinforced Nylon were selected. The process-related influencing variables were studied using the following process parameters: layer thickness, nozzle diameter, build orientation, nozzle temperature, infill density and pattern, and raster angle. The first test series revealed that the addition of wood fibers significantly worsened the mechanical behavior of PLA due to the lack of fiber bonding to the matrix and significant pore formation. The polymer blend of ABS and PC only showed improvements in stiffness. Significant strength and stiffness improvements were found by embedding glass fibers in Nylon, despite partially poor fiber–matrix bonding. The materials with the best properties were selected for the process parameter analysis. When examining the impact of layer thickness on part strength, a clear correlation was evident. Smaller layer thicknesses resulted in higher strength, while stiffness did not appear to be affected. Conversely, larger nozzle diameters and lower nozzle temperatures only positively impacted stiffness, with little effect on strength. The part orientation did alter the fracture behavior of the test specimens. Although an on-edge orientation resulted in higher stiffness, it failed at lower stresses. Higher infill densities and infill patterns aligned with the load direction led to the best mechanical results. The raster angle had a significant impact on the behavior of the printed bodies. An alternating raster angle resulted in lower strengths and stiffness compared to a unidirectional raster angle. However, it also caused significant stretching due to the rotation of the beads. Full article
(This article belongs to the Section Polymer Processing and Engineering)
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19 pages, 249 KiB  
Article
Africa, ChatGPT, and Generative AI Systems: Ethical Benefits, Concerns, and the Need for Governance
by Kutoma Wakunuma and Damian Eke
Philosophies 2024, 9(3), 80; https://doi.org/10.3390/philosophies9030080 (registering DOI) - 2 Jun 2024
Abstract
This paper examines the impact and implications of ChatGPT and other generative AI technologies within the African context while looking at the ethical benefits and concerns that are particularly pertinent to the continent. Through a robust analysis of ChatGPT and other generative AI [...] Read more.
This paper examines the impact and implications of ChatGPT and other generative AI technologies within the African context while looking at the ethical benefits and concerns that are particularly pertinent to the continent. Through a robust analysis of ChatGPT and other generative AI systems using established approaches for analysing the ethics of emerging technologies, this paper provides unique ethical benefits and concerns for these systems in the African context. This analysis combined approaches such as anticipatory technology ethics (ATE), ethical impact assessment (EIA), and ethical issues of emerging ICT applications with AI (ETICA) with specific issues from the literature. The findings show that ChatGPT and other generative AI systems raise unique ethical concerns such as bias, intergenerational justice, exploitation of labour and cultural diversity in Africa but also have significant ethical benefits. These ethical concerns and benefits are considered crucial in shaping the design and deployment of ChatGPT and similar technologies responsibly. It further explores the potential applications of ChatGPT in critical domain areas such as education, agriculture, and healthcare, thereby demonstrating the transformative possibilities that these technologies can have on Africa. This paper underscores the critical role of AI governance as Africa increasingly adopts ChatGPT and similar AI systems. It argues that a comprehensive understanding of AI governance is essential not only for maximising the benefits of generative AI systems but also for facilitating a global dialogue. This dialogue aims to foster shared knowledge and insights between the Global North and the Global South, which is important for the development and creation of inclusive and equitable AI policies and practices that can be beneficial for all regions. Full article
(This article belongs to the Special Issue The Ethics of Modern and Emerging Technology)
12 pages, 3682 KiB  
Communication
Assessment of Alginate Gel Films as the Orodispersible Dosage Form for Meloxicam
by Barbara Jadach, Martyna Kowalczyk and Anna Froelich
Gels 2024, 10(6), 379; https://doi.org/10.3390/gels10060379 (registering DOI) - 2 Jun 2024
Abstract
The aim of this study was to obtain films based on sodium alginate (SA) for disintegration in the oral cavity. The films were prepared with a solvent-casting method, and meloxicam (MLX) as the active ingredient was suspended in a 3% sodium alginate solution. [...] Read more.
The aim of this study was to obtain films based on sodium alginate (SA) for disintegration in the oral cavity. The films were prepared with a solvent-casting method, and meloxicam (MLX) as the active ingredient was suspended in a 3% sodium alginate solution. Two different solid-dosage-form additives containing different disintegrating agents, i.e., VIVAPUR 112® (MCC; JRS Pharma, Rosenberg, Germany) and Prosolve EASYtabs SP® (MIX; JRS Pharma, Rosenberg, Germany), were used, and four different combinations of drying time and temperature were tested. The influence of the used disintegrant on the properties of the ODFs (orodispersible films) was investigated. The obtained films were studied for their appearance, elasticity, mass uniformity, water content, meloxicam content and, finally, disintegration time, which was studied using two different methods. The films obtained with the solvent-casting method were flexible and homogeneous in terms of MLX content. Elasticity was slightly better when MIX was used as a disintegrating agent. However, these samples also revealed worse uniformity and mechanical durability. It was concluded that the best properties of the films were achieved using the mildest drying conditions. The type of the disintegrating agent had no effect on the amount of water remaining in the film after drying. The water content depended on the drying conditions. The disintegration time was not affected by the disintegrant type, but some differences were observed when various drying conditions were applied. However, regardless of the formulation type and manufacturing conditions, the analyzed films could not be classified as fast disintegrating films, as the disintegration time exceeded 30 s in all of the tested formulations. Full article
(This article belongs to the Special Issue Chemical Properties and Application of Gel Materials)
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20 pages, 11871 KiB  
Article
Smart Wireless Transducer Dedicated for Use in Aviation Laboratories
by Tomasz Kabala and Jerzy Weremczuk
Sensors 2024, 24(11), 3585; https://doi.org/10.3390/s24113585 (registering DOI) - 2 Jun 2024
Abstract
Reliable testing of aviation components depends on the quality and configuration flexibility of measurement systems. In a typical approach to test instrumentation, there are tens or hundreds of sensors on the test head and test facility, which are connected by wires to measurement [...] Read more.
Reliable testing of aviation components depends on the quality and configuration flexibility of measurement systems. In a typical approach to test instrumentation, there are tens or hundreds of sensors on the test head and test facility, which are connected by wires to measurement cards in control cabinets. The preparation of wiring and the setup of measurement systems are laborious tasks requiring diligence. The use of smart wireless transducers allows for a new approach to test preparation by reducing the number of wires. Moreover, additional functionalities like data processing, alarm-level monitoring, compensation, or self-diagnosis could improve the functionality and accuracy of measurement systems. A combination of low power consumption, wireless communication, and wireless power transfer could speed up the test-rig instrumentation process and bring new test possibilities, e.g., long-term testing of moving or rotating components. This paper presents the design of a wireless smart transducer dedicated for use with sensors typical of aviation laboratories such as thermocouples, RTDs (Resistance Temperature Detectors), strain gauges, and voltage output integrated sensors. The following sections present various design requirements, proposed technical solutions, a study of battery and wireless power supply possibilities, assembly, and test results. All presented tests were carried out in the Components Test Laboratory located at the Łukasiewicz Research Network–Institute of Aviation. Full article
(This article belongs to the Special Issue Feature Papers in Intelligent Sensors 2024)
17 pages, 1723 KiB  
Article
Design and Validation of MEDOC, a Tool to Assess the Combined Adherence to Mediterranean and Western Dietary Patterns
by Camilla Barbero Mazzucca, Lorenza Scotti, Davide Raineri, Giuseppe Cappellano and Annalisa Chiocchetti
Nutrients 2024, 16(11), 1745; https://doi.org/10.3390/nu16111745 (registering DOI) - 2 Jun 2024
Abstract
The Mediterranean diet (MD) and Western diet (WD) are poles apart as dietary patterns. Despite the availability of epidemiological tools to estimate the adherence to MD, to date, there is a lack of combined scores. We developed MEDOC, a food frequency questionnaire (FFQ) [...] Read more.
The Mediterranean diet (MD) and Western diet (WD) are poles apart as dietary patterns. Despite the availability of epidemiological tools to estimate the adherence to MD, to date, there is a lack of combined scores. We developed MEDOC, a food frequency questionnaire (FFQ) designed to calculate a combined adherence score for both diets and validated it on 213 subjects. The test–retest reliability revealed all frequency questions falling within the acceptable range of 0.5 to 0.7 (Pearson correlation coefficient) in younger (<30 years old) subjects, while 1 question out of 39 fell below the range in older (>30 years old) participants. The reproducibility for portion size was less satisfying, with, respectively, 38.2% and 70.5% of questions falling below 0.5 (Cohen’s Kappa index) for younger and older subjects. The good correlation (R = 0.63, p < 0.0001 for subjects younger than 30 years and R = 0.54, p < 0.0001 for subjects older than 30 years, Pearson’s correlation coefficient) between the MEDOC score and the MediDietScore (MDS) confirmed the validity of the MEDOC score in identifying patients who adhere to the MD. Harnessing the capabilities of this innovative tool, we aim to broaden the existing perspective to study complex dietary patterns in nutritional epidemiology studies. Full article
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24 pages, 2415 KiB  
Systematic Review
Towards Zero: A Review on Strategies in Achieving Net-Zero-Energy and Net-Zero-Carbon Buildings
by Hoi-Lam Lou and Shang-Hsien Hsieh
Sustainability 2024, 16(11), 4735; https://doi.org/10.3390/su16114735 (registering DOI) - 2 Jun 2024
Abstract
The establishment of net-zero-energy and net-zero-carbon buildings can offer significant opportunities to reduce environmental impact in the building sector. Several successful net-zero-energy buildings highlight the feasibility of reducing energy consumption via energy-efficient strategies and the use of renewable energy technologies. To comprehend the [...] Read more.
The establishment of net-zero-energy and net-zero-carbon buildings can offer significant opportunities to reduce environmental impact in the building sector. Several successful net-zero-energy buildings highlight the feasibility of reducing energy consumption via energy-efficient strategies and the use of renewable energy technologies. To comprehend the existing innovatory designs, techniques, and practices employed to achieve net-zero-energy buildings, this research aims to review the up-to-date advancements in net-zero-energy building practices. The utilization of embodied carbon assessments to achieve the net-zero status of buildings is explored. The findings indicate an escalating global interest and participation in the field of study, and reveal three major areas related to net-zero-energy buildings: multidisciplinary approaches, energy systems, and guidance, which together cover thirteen subfields. The role of life cycle assessment in buildings is emphasized, offering insights into the role of embodied emissions relative to operational emissions over the entire life cycle of a building. In the end, possible future study directions are outlined, including balancing energy efficiency with sustainability, and assessing the impact of design on emissions and economic outcomes. These areas collectively contribute to transforming sustainable building concepts into reality. Full article
(This article belongs to the Special Issue Sustainable Building Environment)
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11 pages, 1082 KiB  
Article
Resilience of Canola to Plasmodiophora brassicae (Clubroot) Pathotype 3H under Different Resistance Genes and Initial Inoculum Levels
by Rui Wen, Tao Song, Nazmoon Naher Tonu, Coreen Franke and Gary Peng
Plants 2024, 13(11), 1540; https://doi.org/10.3390/plants13111540 (registering DOI) - 2 Jun 2024
Abstract
In this study, we explored the resilience of a clubroot resistance (CR) stacking model against a field population of Plasmodiophora brassicae pathotype 3H. This contrasts with our earlier work, where stacking CRaM and Crr1rutb proved only moderately resistant to pathotype X. Canola varieties [...] Read more.
In this study, we explored the resilience of a clubroot resistance (CR) stacking model against a field population of Plasmodiophora brassicae pathotype 3H. This contrasts with our earlier work, where stacking CRaM and Crr1rutb proved only moderately resistant to pathotype X. Canola varieties carrying Rcr1/Crr1rutb and Rcr1 + Crr1rutb were repeatedly exposed to 3H at low (1 × 104/g soil) and high (1 × 107/g soil) initial resting spore concentrations over five planting cycles under controlled environments to mimic intensive canola production. Initially, all resistant varieties showed strong resistance. However, there was a gradual decline in resistance over time for varieties carrying only a single CR gene, particularly with Crr1rutb alone and at the high inoculum level, where the disease severity index (DSI) increased from 9% to 39% over five planting cycles. This suggests the presence of virulent pathotypes at initially low levels in the 3H inoculum. In contrast, the variety with stacked CR genes remained resilient, with DSI staying below 3% throughout, even at the high inoculum level. Furthermore, the use of resistant varieties, carrying either a single or stacked CR genes, reduced the total resting spore numbers in soil over time, while the inoculum level either increased or remained high in soils where susceptible Westar was continuously grown. Our study demonstrates greater resistance resilience for stacking Rcr1 and Crr1rutb against the field population of 3H. Additionally, the results suggest that resistance may persist even longer in fields with lower levels of inoculum, highlighting the value of extended crop rotation (reducing inoculum) alongside strategic CR-gene deployment to maximize resistance resilience. Full article
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13 pages, 5758 KiB  
Article
The Influence of Microstructure on TCR for Inkjet-Printed Resistive Temperature Detectors Fabricated Using AgNO3/Ethylene-Glycol-Based Inks
by Aziz Radwan, Yongkun Sui and Christian Zorman
Micromachines 2024, 15(6), 749; https://doi.org/10.3390/mi15060749 (registering DOI) - 2 Jun 2024
Abstract
This study investigated the influence of microstructure on the performance of Ag inkjet-printed, resistive temperature detectors (RTDs) fabricated using particle-free inks based on a silver nitrate (AgNO3) precursor and ethylene glycol as the ink solvent. Specifically, the temperature coefficient of resistance [...] Read more.
This study investigated the influence of microstructure on the performance of Ag inkjet-printed, resistive temperature detectors (RTDs) fabricated using particle-free inks based on a silver nitrate (AgNO3) precursor and ethylene glycol as the ink solvent. Specifically, the temperature coefficient of resistance (TCR) and sensitivity for sensors printed using inks that use monoethylene glycol (mono-EG), diethylene glycol (di-EG), and triethylene glycol (tri-EG) and subjected to a low-pressure argon (Ar) plasma after printing were investigated. Scanning electron microscopy (SEM) confirmed previous findings that microstructure is strongly influenced by the ink solvent, with mono-EG inks producing dense structures, while di- and tri-EG inks produce porous structures, with tri-EG inks yielding the most porous structures. RTD testing revealed that sensors printed using mono-EG ink exhibited the highest TCR (1.7 × 10−3/°C), followed by di-EG ink (8.2 × 10−4/°C) and tri-EG ink (7.2 × 10−4/°C). These findings indicate that porosity exhibits a strong negative influence on TCR. Sensitivity was not strongly influenced by microstructure but rather by the resistance of RTD. The highest sensitivity (0.84 Ω/°C) was observed for an RTD printed using mono-EG ink but not under plasma exposure conditions that yield the highest TCR. Full article
(This article belongs to the Special Issue Microstructured Sensors: From Design to Application)
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10 pages, 1999 KiB  
Article
The Effect of Storage Time and Temperature on Quality Changes in Freeze-Dried Snacks Obtained with Fruit Pomace and Pectin Powders as a Sustainable Approach for New Product Development
by Magdalena Karwacka, Agnieszka Ciurzyńska, Sabina Galus and Monika Janowicz
Sustainability 2024, 16(11), 4736; https://doi.org/10.3390/su16114736 (registering DOI) - 2 Jun 2024
Abstract
The study aimed to evaluate the effect of storage temperature on quality changes in freeze-dried carrot–orange–ginger (COG) snacks obtained with 2% of apple (AP) or blackcurrant (BP) pomace powder or 1.5% of pectin (LMP). The material was stored at 4, 25 and 40 [...] Read more.
The study aimed to evaluate the effect of storage temperature on quality changes in freeze-dried carrot–orange–ginger (COG) snacks obtained with 2% of apple (AP) or blackcurrant (BP) pomace powder or 1.5% of pectin (LMP). The material was stored at 4, 25 and 40 °C for 1, 3, 6 and 12 months in pouches impermeable to vapour, oxygen and light. Water content and activity, texture, colour, total polyphenol content and antioxidant activity were examined to evaluate the products’ quality. During storage, water content and activity fluctuations were noted, but no critical values were exceeded. Texture properties remained stable in snacks with pomace powders compared to those with pectin, the hardness of which significantly decreased when stored at ambient and elevated temperatures. However, the product with pectin was found to change colour the least over time. The results obtained for chemical properties were not clear, but they strongly indicated the occurrence of the transformation of some chemical compounds. Overall, a lowered temperature helped to maintain the quality of the freeze-dried snacks for the longest time. The presented research contributes to the general knowledge of the behaviour of innovative products with the addition of nonconventional but sustainable compounds, revealing the potential for quality and stability improvements. Full article
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34 pages, 10341 KiB  
Review
Advances in Aptamer-Based Conjugate Recognition Techniques for the Detection of Small Molecules in Food
by Xin Deng, Biao Ma, Yunfei Gong, Jiali Li, Yuxin Zhou, Tianran Xu, Peiying Hao, Kai Sun, Zhiyong Lv, Xiaoping Yu and Mingzhou Zhang
Foods 2024, 13(11), 1749; https://doi.org/10.3390/foods13111749 (registering DOI) - 2 Jun 2024
Abstract
Small molecules are significant risk factors for causing food safety issues, posing serious threats to human health. Sensitive screening for hazards is beneficial for enhancing public security. However, traditional detection methods are unable to meet the requirements for the field screening of small [...] Read more.
Small molecules are significant risk factors for causing food safety issues, posing serious threats to human health. Sensitive screening for hazards is beneficial for enhancing public security. However, traditional detection methods are unable to meet the requirements for the field screening of small molecules. Therefore, it is necessary to develop applicable methods with high levels of sensitivity and specificity to identify the small molecules. Aptamers are short−chain nucleic acids that can specifically bind to small molecules. By utilizing aptamers to enhance the performance of recognition technology, it is possible to achieve high selectivity and sensitivity levels when detecting small molecules. There have been several varieties of aptamer target recognition techniques developed to improve the ability to detect small molecules in recent years. This review focuses on the principles of detection platforms, classifies the conjugating methods between small molecules and aptamers, summarizes advancements in aptamer−based conjugate recognition techniques for the detection of small molecules in food, and seeks to provide emerging powerful tools in the field of point−of−care diagnostics. Full article
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14 pages, 2632 KiB  
Article
Rhodamine 19 Alkyl Esters as Effective Antibacterial Agents
by Pavel A. Nazarov, Vladislav S. Maximov, Alexander M. Firsov, Marina V. Karakozova, Veronika Panfilova, Elena A. Kotova, Maxim V. Skulachev and Yuri N. Antonenko
Int. J. Mol. Sci. 2024, 25(11), 6137; https://doi.org/10.3390/ijms25116137 (registering DOI) - 2 Jun 2024
Abstract
Mitochondria-targeted antioxidants (MTAs) have been studied quite intensively in recent years as potential therapeutic agents and vectors for the delivery of other active substances to mitochondria and bacteria. Their most studied representatives are MitoQ and SkQ1, with its fluorescent rhodamine analog SkQR1, a [...] Read more.
Mitochondria-targeted antioxidants (MTAs) have been studied quite intensively in recent years as potential therapeutic agents and vectors for the delivery of other active substances to mitochondria and bacteria. Their most studied representatives are MitoQ and SkQ1, with its fluorescent rhodamine analog SkQR1, a decyl ester of rhodamine 19 carrying plastoquinone. In the present work, we observed a pronounced antibacterial action of SkQR1 against Gram-positive bacteria, but virtually no effect on Gram-negative bacteria. The MDR pump AcrAB-TolC, known to expel SkQ1, did not recognize and did not pump out SkQR1 and dodecyl ester of rhodamine 19 (C12R1). Rhodamine 19 butyl (C4R1) and ethyl (C2R1) esters more effectively suppressed the growth of ΔtolC Escherichia coli, but lost their potency with the wild-type E. coli pumping them out. The mechanism of the antibacterial action of SkQR1 may differ from that of SkQ1. The rhodamine derivatives also proved to be effective antibacterial agents against various Gram-positive species, including Staphylococcus aureus and Mycobacterium smegmatis. By using fluorescence correlation spectroscopy and fluorescence microscopy, SkQR1 was shown to accumulate in the bacterial membrane. Thus, the presentation of SkQR1 as a fluorescent analogue of SkQ1 and its use for visualization should be performed with caution. Full article
(This article belongs to the Special Issue Advanced Research of Mitochondria-Targeted Antioxidants)
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