Cueva de Los Postes is located in the southern part of the Spanish Extremadura region, in the Fuentes de León municipality. This study analyzed pottery found during archaeological excavations in Cueva de Los Postes. The aim was to determine whether the raw materials had common or separate origins and determine whether or not the origin of the pottery raw material was regional. In this regard, several pottery fragments were found in different phases (Neolithic and Copper Age) of the Holocene occupation of Cueva de Los Postes. These were analyzed using ATR-FTIR (Fourier Transform Infrared spectroscopy). The analyzed samples demonstrated no strong differences in their composition. In order to identify a possible origin for the kaolinite of the analyzed pottery, six samples of clay sediments were taken from inside and around the cave and subjected to ATR-FTIR. This was done to compare their compositions and check for a possible correlation with the pottery. The analyzed pottery, from different stratigraphic units, shows homogeneity in raw material. This finding, and the analyses made of the regional sediments, confirm that the raw material was regional and that there was a continuous use of it. Full article

Safety from crime is a fundamental human need. In Maslow’s hierarchy, safety is one of the foundational needs of well-being. The built environment should be safe to use at all times of the day and for all groups of people. After dark, the appearance of the outdoor environment changes dramatically, and this could impact the opportunities for crime. This study investigated the impact of daylight on the rates of different types of crime by comparing the crime rates during selected periods of daylight and darkness. The study used records of crime data from the Metropolitan Police Service. By studying crimes in the week on either side of the twice-yearly clock change, it is possible to compare periods that are dark in one week and light in the other at the same clock time. Where the time at which the crime took place was known, and using the GPS coordinates of the specific crime, the solar altitude was calculated and used to determine if it was light or dark at the time of the crime. A similar calculation was used to see if the crime would have been in the dark or light in the week on the other side of the clock change. The headline result is that there was 4.8% (OR 1.07) more crime in the dark periods than the light ones. However, this increase was not uniform across all crime types, and there were some further complications in some results due to potential changes in the behavior of some victims after dark. For the crimes of theft from a person and robbery of personal property, there was a significant increase during the dark period. The availability of light had an impact on the rate of certain crimes. Whilst this does not provide any information about the impact of street lighting on crime, it does provide some idea of by how much crime could be reduced if better lighting was provided. Full article

The demographic profile of patients transitioning from chronic kidney disease to kidney replacement therapy is changing, with a higher prevalence of aging patients with multiple comorbidities such as diabetes mellitus and heart failure. Cardiovascular disease remains the leading cause of mortality in this population, exacerbated by the cardiovascular stress imposed by the HD procedure. The first year after transitioning to hemodialysis is associated with increased risks of hospitalization and mortality, particularly within the first 90–120 days, with greater vulnerability observed among the elderly. Based on data from clinics in Fresenius Medical Care Europe, Middle East, and Africa NephroCare, this review aims to optimize hemodialysis procedures to reduce mortality risk in stable incident and prevalent patients. It addresses critical aspects such as treatment duration, frequency, choice of dialysis membrane, dialysate composition, blood and dialysate flow rates, electrolyte composition, temperature control, target weight management, dialysis adequacy, and additional protocols, with a focus on mitigating prevalent intradialytic complications, particularly intradialytic hypotension prevention. Full article

There are studies on the effect of general nutrition education on diet quality and anthropometric measurements, while studies showing the effectiveness of sustainable nutrition education, which also addresses the effect of food on the environment, are quite limited. This study aimed to investigate the effects of sustainable nutrition education on diet quality, anthropometric measurements, and the carbon footprint (CFP) and water footprint (WFP) of diet. A total of 160 university students received 1 h of sustainable nutrition education for 6 weeks. Before, at the end of, and 2 months after the courses, 24 h food consumption records were taken to assess diet quality and CFP and WFP values of diet, and Mediterranean diet (MedDiet) and Healthy Eating Index (HEI)-2020 scores were evaluated. The results of the study showed that sustainable nutrition education increased MedDiet score by 1.86 points and HEI-2020 score by 7.38 points. This education program also decreased body weight, body mass index (BMI), fat mass, and neck circumference. Sustainability education has a positive impact on calcium, potassium, and magnesium intakes, a negative impact on vitamin B12 and zinc intakes, and no effect on total protein intake. Education resulted in a 22% reduction in CFP and a 10% reduction in WFP. Full article

The emergence of antibiotic-resistant bacteria necessitates the development of novel, sustainable, and biocompatible antibacterial agents. This study addresses cytotoxicity and environmental concerns associated with traditional silver nanoparticles (AgNPs) by exploring lignin, a readily available and renewable biopolymer, as a platform for AgNPs. We present a novel one-pot synthesis method for lignin-based AgNPs (AgNPs@AL) nanocomposites, achieving rapid synthesis within 5 min. This method utilizes various organic solvents, demonstrating remarkable adaptability to a wide range of lignin-dissolving systems. Characterization reveals uniform AgNP size distribution and morphology influenced by the chosen solvent. This adaptability suggests the potential for incorporating lignin-loaded antibacterial drugs alongside AgNPs, enabling combined therapy in a single nanocomposite. Antibacterial assays demonstrate exceptional efficacy against both Gram-negative and Gram-positive bacteria, with gamma-valerolactone (GVL)-assisted synthesized AgNPs exhibiting the most potent effect. Mechanistic studies suggest a combination of factors contributes to the antibacterial activity, including direct membrane damage caused by AgNPs and sustained silver ion release, ultimately leading to bacterial cell death. This work presents a straightforward, adaptable, and rapid approach for synthesizing biocompatible AgNPs@AL nanocomposites with outstanding antibacterial activity. These findings offer a promising and sustainable alternative to traditional antibiotics, contributing to the fight against antibiotic resistance while minimizing environmental impact. Full article

The rapid advancement of autonomous vehicle technology has brought into focus the critical need for enhanced road safety systems, particularly in the areas of road damage detection and surface classification. This paper explores these two essential components, highlighting their importance in autonomous driving. In the domain of road damage detection, this study explores a range of deep learning methods, particularly focusing on one-stage and two-stage detectors. These methodologies, including notable ones like YOLO and SSD for one-stage detection and Faster R-CNN for two-stage detection, are critically analyzed for their efficacy in identifying various road damages under diverse conditions. The review provides insights into their comparative advantages, balancing between real-time processing and accuracy in damage localization. For road surface classification, the paper investigates the classification techniques based on both environmental conditions and material road composition. It highlights the role of different convolutional neural network architectures and innovations at the neural level in enhancing classification accuracy under varying road and weather conditions. The main finding of this work is that it offers a comprehensive overview of the current state of the art, showcasing significant strides in utilizing deep learning for road analysis in autonomous vehicle systems. The study concludes by underscoring the importance of continued research in these areas to further refine and improve the safety and efficiency of autonomous driving. Full article

Dynamic reserves evaluation is crucial for the development and assessment of gas reservoirs. However, ultra-deep fractured tight sandstone gas reservoirs pose unique challenges due to their abnormally high pressure, tight matrix, and complex fracture distribution. This paper proposes a simplified forward calculation method that incorporates the fracture length for the rapid estimation of dynamic reserves in fractured tight sandstone gas reservoirs. This method was based on the pressure change rate equation and considered the unique characteristics of fractured gas reservoirs. Numerical simulations were conducted to analyze the sensitivity of the proposed method. The proposed method was applied to estimate the dynamic reserves of a fractured gas reservoir, and the results closely approximate the well group method, indicating its accuracy. The main advantage of this method lies in its simplicity, allowing field engineers to perform rapid dynamic reserve evaluations. Full article

Addressing the issues of low harvesting efficiency and high losses in current pod pepper harvesters, this study presents the design of a bionic comb finger pod pepper picking device and an inclined double-spiral bell pepper harvester to improve the harvest rate and reduce loss rate. Through the utilization of discrete element simulation software EDEM, a discrete element model for pod peppers is established. Additionally, a simulation platform for ground drop loss during pod pepper picking is developed, enabling exploration of the movement trajectory and velocity changes of the pod pepper elements. The study also conducts an analysis on the impact of the speed of the picking rollers X₁, the feeding speed of pod peppers X₂, and the spacing between the two picking rollers X₃ on ground drop losses. Based on the results of the single-factor test, the Box–Behnken response surface test was used to optimize the working parameters of the picking device, which resulted in the optimal combination of the working parameters of the picking device: the speed of the picking rollers was 680.41 rpm, the feeding speed of the pod peppers was 0.5 m/s, and the spacing between the two picking rollers was 12 mm, which resulted in the loss rate of pod peppers on the floor of the ground being 3.526%. Full article

The United States is suffering from an epidemic associated with high-risk strains of the Human Papillomavirus (HPV) predominantly responsible for the development of head and neck squamous cell carcinoma (HNSCC). Treatment with immune checkpoint inhibitors targeting programmed death 1 (PD-1) or its ligand PD-L1 has shown poor efficacy in HNSCC patients, observing only a 20–30% response. Therefore, biological marker identification associated with PD-1 blockade response is important to improve prognosis and define novel therapeutics for HNSCC patients. Therapy response was associated with increased frequencies of activated CD27⁺T cells, activated CD79a⁺ B cells, antigen-presenting CD74⁺ dendritic and B cells, and PD-L1⁺ and PD-L2⁺ myeloid-derived suppressor cells (MDSCs). The oral microbiota composition differed significantly in mice bearing tongue tumors and treated with anti-PD-1. A higher abundance of Allobaculum, Blautia, Faecalibacterium, Dorea, or Roseburia was associated with response to the therapy. However, an increase in Enterococcus was attributed to tongue tumor-bearing non-responding mice. Our findings indicate that differences in immune phenotypes, protein expression, and bacterial abundance occur as mice develop tongue tumors and are treated with anti-PD-1. These results may have a clinical impact as specific bacteria and immune phenotype could serve as biomarkers for treatment response in HNSCC. Full article

Solid organ injury (SOI) is common in children who experience abdominal trauma, and the management of such injuries has evolved significantly over the past several decades. In 2000, the American Pediatric Surgical Association (APSA) published the first societal guidelines for the management of blunt spleen and/or liver injury (BLSI), advocating for optimized resource utilization while maintaining patient safety. Nonoperative management (NOM) has become the mainstay of treatment for SOI, and since the publication of the APSA guidelines, numerous groups have evaluated how invasive procedures, hospitalization, and activity restrictions may be safely minimized in children with SOI. Here, we review the current evidence-based management guidelines in place for the treatment of injuries to the spleen, liver, kidney, and pancreas in children, including initial evaluation, inpatient management, and long-term care, as well as gaps that exist in the current literature that may be targeted for further optimization of protocols for pediatric SOI. Full article

Faba bean is an important legume crop worldwide, which is grown both for food and feed. As for many legume crops, postemergence weed control is difficult. The aim of this work was to assess the potential of intercropping in weed management by assessing the effect of mixing faba bean with different crops (wheat, barley, and pea) on weeds in the South of Spain. Four field trials were conducted over four consecutive seasons, and the results found that the addition of alternate intercropping of faba bean and barley achieved high levels of weed control, both for coverage and biomass (92.7% and 76.6%, respectively). Intercropping with wheat did not reduce weed coverage but did decrease weed biomass by 46.1% as compared with the faba bean monocrop. Intercropping with pea did not provide significant reductions in weed coverage or weed biomass. The diversity of the weed community was not altered by the different crop combinations tested. Additional experiments under controlled conditions were carried out to determine the possible role of barley allelopathy in weed suppression. A strong allelopathic effect entailing a reduction in the number of plants and biomass was detected for four weeds including Sinapis arvensis, Polypogon monspeliensis, Matricaria camomilla, and Medicago truncatula. It can be concluded that intercropping faba bean with barley is an excellent strategy for weed control in Southern Spain. Full article

This study subjected nuclear-grade 20# pipeline steel to cyclic freeze–thaw ice plugging tests, simulating the plastic deformation experienced by pipes during ice plug removal procedures. Subsequently, the dislocation morphology and mechanical properties of the specimens post cyclic ice plugging were examined. The cyclic ice plugging process led to an increase in the dislocation density within the specimens. After 20 and 40 cycles of ice plugging, the internal dislocation structures evolved from individual dislocation lines and dislocation tangles to high-density dislocation walls and dislocation cells. These high-density dislocation walls and cells hindered dislocation motion, giving rise to strain hardening phenomena, thereby resulting in increased strength and hardness of the specimens with an increasing number of ice plugging cycles. In addition, a large stress field was generated around the dislocation buildup, which reduced the pipe material’s plastic toughness. The findings elucidate the effects of cyclic ice plugging on the microstructure and properties of nuclear-grade 20# pipeline steel, aiming to provide a theoretical basis for the safe and stable application of ice plugging technology in nuclear piping systems. Full article

During the overall design phase of solar-powered unmanned aerial vehicles (UAVs), a large amount of high-fidelity (HF) propeller aerodynamic performance data is required to enhance design performance, but the acquisition cost is prohibitively expensive. To improve model accuracy and reduce modeling costs, this paper constructs a multi-fidelity aerodynamic data fusion model by associating data with different fidelity. This model utilizes a low-fidelity computational method to quickly determine the design space. The constrained Latin hypercube sampling based on the successive local enumeration (SLE-CLHS) method and the expected improvement (EI) criterion were adopted to achieve the efficient initialization and fastest convergence of the Co-Kriging surrogate model within the design space. This modeling framework was applied to acquire the aerodynamic performance of high-altitude propellers, and the model was evaluated using various performance indicators. The results demonstrate that the proposed model has excellent predictive performance. Specifically, when the surrogate model was constructed using 350 high-fidelity samples, there were improvements of 13.727%, 12.241%, and 5.484% for thrust, torque, and efficiency compared with the surrogate model constructed from low-fidelity samples. Full article

The integration of Internet of Things (IoT) technology into agriculture has revolutionized farming practices by using connected devices and sensors to optimize processes and facilitate sustainable execution. Because most IoT devices have limited resources, the vital requirement to efficiently manage data traffic while ensuring data security in agricultural IoT solutions creates several challenges. Therefore, it is important to study the data amount that IoT protocols generate for resource-constrained devices, as it has a direct impact on the device performance and overall usability of the IoT solution. In this paper, we present a comprehensive study that focuses on optimizing data transmission in agricultural IoT solutions with the use of compression algorithms and secure technologies. Through experimentation and analysis, we evaluate different approaches to minimize data traffic while protecting sensitive agricultural data. Our results highlight the effectiveness of compression algorithms, especially Huffman coding, in reducing data size and optimizing resource usage. In addition, the integration of encryption techniques, such as AES, provides the security of the transmitted data without incurring significant overhead. By assessing different communication scenarios, we identify the most efficient approach, a combination of Huffman encoding and AES encryption, to strike a balance between data security and transmission efficiency. Full article

Glutathione transferases (GSTs) are the primary catalysts protecting from reactive electrophile attack. In this review, the quantitative levels and distribution of glutathione transferases in relation to physiological function are discussed. The catalytic properties (random sequential) tell us that these enzymes have evolved to intercept reactive intermediates. High concentrations of enzymes (up to several hundred micromolar) ensure efficient protection. Individual enzyme molecules, however, turn over only rarely (estimated as low as once daily). The protection of intracellular protein and DNA targets is linearly proportional to enzyme levels. Any lowering of enzyme concentration, or inhibition, would thus result in diminished protection. It is well established that GSTs also function as binding proteins, potentially resulting in enzyme inhibition. Here the relevance of ligand inhibition and catalytic mechanisms, such as negative co-operativity, is discussed. There is a lack of knowledge pertaining to relevant ligand levels in vivo, be they exogenous or endogenous (e.g., bile acids and bilirubin). The stoichiometry of active sites in GSTs is well established, cytosolic enzyme dimers have two sites. It is puzzling that a third of the site’s reactivity is observed in trimeric microsomal glutathione transferases (MGSTs). From a physiological point of view, such sub-stoichiometric behavior would appear to be wasteful. Over the years, a substantial amount of detailed knowledge on the structure, distribution, and mechanism of purified GSTs has been gathered. We still lack knowledge on exact cell type distribution and levels in vivo however, especially in relation to ligand levels, which need to be determined. Such knowledge must be gathered in order to allow mathematical modeling to be employed in the future, to generate a holistic understanding of reactive intermediate protection. Full article

Psychotherapy for individuals with psychosis is an effective treatment that promotes recovery in various ways. While there is strong quantitative evidence across modalities, less is known from the patient’s perspective. There are many varied forms of psychotherapy, and gaining the patient’s perspective can improve understanding of salient elements of psychotherapy and increase engagement, ultimately improving recovery rates. The purpose of this review is to identify and integrate data from published studies of patient perspectives of psychotherapy for psychosis to understand essential elements across approaches, differences between approaches, and how psychotherapy impacts recovery. We aimed to understand further: what are the perceptions about individual psychotherapy from the perspective of individuals with psychosis? The current study was a systematic review using PRISMA guidelines of studies that included qualitative interviews with persons with experiences of psychosis who participated in psychotherapy. All three authors participated in the literature search using Pubmed, APA PsycInfo, and Psychiatry Online. We identified N = 33 studies. Studies included cognitive therapies, acceptance and mindfulness approaches, trauma therapies, metacognitive therapy, and music therapy. All studies reported participants’ perceived benefit with the therapeutic relationship as especially salient. Participants described diverse aspects of objective (e.g., symptoms, functioning) and subjective (e.g., self-experience or quality of life) recovery improvements, with perceived mechanisms of change, and with music therapy having some unique benefits. Participants also reported challenges and suggestions for improvement. Study findings highlight the salient aspects of psychotherapy identified by patients that may help therapists to individualize and improve approaches to psychotherapy when working with individuals experiencing psychosis. Overall, findings support the potential for integrative psychotherapy approaches for maximal treatment personalization. Full article

N-aryl-substituted pyrrolidines are important moieties widely found in bioactive substances and drugs. Herein, we present a practical reductive amination of diketones with anilines for the synthesis of N-aryl-substituted pyrrolidines in good to excellent yields. In this process, the N-aryl-substituted pyrrolidines were furnished via successive reductive amination of diketones via iridium-catalyzed transfer hydrogenation. The scale-up performance, water as a solvent, simple operation, as well as derivation of drug molecules showcased the potential application in organic synthesis. Full article

Multiple Sclerosis (MS) is a demyelinating and chronic disease with variable neurological symptoms. There are different scales that score the level of disability, but only few papers have taken into consideration the 5-times sit-to-stand (5STS) test and the 30 s chair stand test (30CST), which are valid and easily obtainable indicators of other neurological diseases. The aim of our research is to verify the validity, reproducibility, and responsiveness of these tests. Patients afflicted with MS were enrolled in the AISM outpatient facility. The inclusion criterion was an EDSS score less than 6.5. We performed the 5STS, 30CST, and timed 25-foot walk (T25-FW) tests and recorded EDSS scores in the first evaluation. Then, we recorded the performance after 5 days (conducted by a second blind operator to ensure test–retest reproducibility), and the last evaluation was made after 12 sessions of physiotherapy. We recruited 38 patients diagnosed with MS. The results show significant data regarding validity, reproducibility, and responsiveness for both scales. The data argue in favor of adding these tests to the relevant clinical assessments. These two tests are simple, reliable, and easy to administer, and the data confirm that they can be included in the evaluation of patients with MS. Full article

Sorghum grain contains high levels and a diverse profile of polyphenols (PPs), which are antioxidants known to reduce oxidative stress when consumed in the diet. Oxidative stress leading to amyloid-β (Aβ) aggregation, neurotoxicity, and mitochondrial dysfunction is implicated in the pathogenesis of Alzheimer’s disease (AD). Thus, PPs have gained attention as possible therapeutic agents for combating AD. This study aimed to (a) quantify the phenolic compounds (PP) and antioxidant capacities in extracts from six different varieties of sorghum grain and (b) investigate whether these PP extracts exhibit any protective effects on human neuroblastoma (BE(2)-M17) cells against Aβ- and tau-induced toxicity, Aβ aggregation, mitochondrial dysfunction, and reactive oxygen species (ROS) induced by Aβ and tert-butyl hydroperoxide (TBHP). PP and antioxidant capacity were quantified using chemical assays. Aβ- and tau-induced toxicity was determined using the 3-(4,5-dimenthylthiazol-2-yl)-2,5-dimethyltetrazolium bromide (MTS) assay. The thioflavin T (Th-T) assay assessed anti-Aβ aggregation. The dichlorodihydrofluorescein diacetate (DCFDA) assay determined the levels of general ROS and the MitoSOX assay determined the levels of mitochondrial superoxide. Sorghum varieties Shawaya short black-1 and IS1311C possessed the highest levels of total phenolics, total flavonoids, and antioxidant capacity, and sorghum varieties differed significantly in their profile of individual PPs. All extracts significantly increased cell viability compared to the control (minus extract). Variety QL33 (at 2000 µg sorghum flour equivalents/mL) showed the strongest protective effect with a 28% reduction in Aβ-toxicity cell death. The extracts of all sorghum varieties significantly reduced Aβ aggregation. All extracts except that from variety B923296 demonstrated a significant (p ≤ 0.05) downregulation of Aβ-induced and TBHP-induced ROS and mitochondrial superoxide relative to the control (minus extract) in a dose- and variety-dependent manner. We have demonstrated for the first time that sorghum polyphenolic extracts show promising neuroprotective effects against AD, which indicates the potential of sorghum foods to exert a similar beneficial property in the human diet. However, further analysis in other cellular models and in vivo is needed to confirm these effects. Full article

Urban parks serve as vital spaces for leisure, social interaction, and nature engagement. At the same time, climate change disproportionately impacts densely populated megacities. While extensive research exists on climate change’s effects on mortality, agriculture, and economic activities, less is known about its impact on urban park usage. Understanding their temporal usage and how temperature changes affect park visitation is crucial for maximizing park benefits and building resiliency. This study analyzes long-term, hourly park visitation data on Dallas, Texas, using digital trace data from SafeGraph (San Francisco, CA, USA), which covers mobile records from approximately 10% of U.S. devices. We focus on five established parks in Dallas and examine their historical temperature data from 2018 to 2022. Descriptive statistics and scatter graphs are utilized to analyze temperature- and demographic-specific visitation patterns. The results of the study highlight the impact of climate change on park visitation and reveal how extreme temperatures influence visitation patterns across parks in Dallas. Additionally, this study explores the differences in visitation based on weekdays versus weekends and highlights demographic disparities. Notably, we examine the implications of nighttime park usage during extreme heat conditions. Our work is informative for urban planners seeking to improve park facilities and comfort amid climate change, ultimately enhancing the resilience and well-being of urban communities. Full article

The scarcity of water resources, climate change, and water-wasting behavior have contributed to a worsening water crisis in many countries. This has raised concerns among farmers and increased pressure on governments. Digital technologies provide effective solutions to reduce resource waste; therefore, exploring farmers’ willingness to implement water-smart farming technologies to reduce waste, especially in developing countries, requires further analysis. To address this gap, this paper aims to investigate the factors that influence farmers’ intention to minimize water waste in Algeria. The theory of planned behavior was extended with the constructs of perceived usefulness of water-smart farming and knowledge of water waste reduction. Primary data were collected from 202 farmers to test the model. The empirical evidence suggests that attitudes, knowledge about water waste reduction, perceived usefulness, and perceived behavioral control significantly predict farmers’ intention to reduce waste. These factors explained 54.6% of the variation in intention. However, social influence was not found to be a significant antecedent of intentions. This paper’s findings can provide useful insights for various stakeholders on how to encourage farmers to reduce water waste and offer guidance on strategies for achieving sustainability in agriculture. Full article

Cavitary corpora lutea are commonly observed during the estrous cycle in bovines. Since the quality of the corpus luteum (CL) is extremely important during embryo transfer when embryos are implanted into the recipient, the ultrasonographic examination of the CL is becoming more and more important in terms of the outcome of the procedure. In the present study, a total of 2477 ultrasonographic transrectal diagnoses were performed, and data were collected between the years of 2018 and 2020 in a large-scale Holstein Friesian dairy farm in Hungary. In 91.1% (n = 2257) and in 8.9% (n = 220) of the cases, compact CLs and cavitary CLs, respectively, were diagnosed at pregnancy diagnosis. The presence of a cavitary CL on the ovary at pregnancy diagnosis increased the odds of remaining open after pregnancy by 21 times compared to the presence of a compact CL (OR = 21.0, p < 0.001) in the cows. The presence of cavitary CL was not influenced either by month or season. Ovarian cysts were detected in 196 cases (8.0%) in the examined animals. The presence of a cavitary CL decreased by 9 times when an ovarian cyst was also diagnosed (OR = 9.0, 1.6% vs. 9.5%, p < 0.001). The presence of an ovarian cyst decreased the odds of established pregnancy by 81 times (OR = 81.1, p < 0.001). Based on our results, the presence of a cavitary CL between days 31 and 42 after artificial insemination is associated with a smaller chance of conception in Holstein Friesian cows. The presence of an ovarian cyst decreases the occurrence of cavitary CL and the chance of conception. Full article