The rhizobacterial strain BJ3 showed 16S rDNA sequence similarity to species within the Burkholderia genus. Its complete genome sequence revealed a 97% match with Burkholderia contaminans and uncovered gene clusters essential for plant-growth-promoting traits (PGPTs). These clusters include genes responsible for producing indole acetic acid (IAA), osmolytes, non-ribosomal peptides (NRPS), volatile organic compounds (VOCs), siderophores, lipopolysaccharides, hydrolytic enzymes, and spermidine. Additionally, the genome contains genes for nitrogen fixation and phosphate solubilization, as well as a gene encoding 1-aminocyclopropane-1-carboxylate (ACC) deaminase. The treatment with BJ3 enhanced root architecture, boosted vegetative growth, and accelerated early flowering in Arabidopsis. Treated seedlings also showed increased lignin production and antioxidant capabilities, as well as notably increased tolerance to water deficit and high salinity. An RNA-seq transcriptome analysis indicated that BJ3 treatment significantly activated genes related to immunity induction, hormone signaling, and vegetative growth. It specifically activated genes involved in the production of auxin, ethylene, and salicylic acid (SA), as well as genes involved in the synthesis of defense compounds like glucosinolates, camalexin, and terpenoids. The expression of AP2/ERF transcription factors was markedly increased. These findings highlight BJ3’s potential to produce various bioactive metabolites and its ability to activate auxin, ethylene, and SA signaling in Arabidopsis, positioning it as a new Burkholderia strain that could significantly improve plant growth, stress resilience, and immune function. Full article

An increasing number of individuals are eating out due to work and study commitments. This trend directly influences people’s food choices, especially those who frequently rely on snacks and pre-packaged foods. Consuming these foods can lead to long-term health consequences. Adding functional foods to vending machines could lead to healthier choices. Our aim is to evaluate the acceptability and willingness to pay (WTP) of workers and students for a snack pack of novel functional biscuits (FBs) made with high amylose contents. We found that the experimental flour used is effective in preventing various non-communicable diseases; two phases of analysis were carried out on 209 participants. The participants blindly tested the products and only after the sensory evaluation were they informed about the biscuits’ health contents. Firstly, the blind investigation highlighted the acceptability of the FBs compared to the conventional biscuits. Secondly, the finite mixture model on WTP revealed that some consumers are interested in the health benefits associated with high-amylose test blends and others are focused on hedonistic taste. The design of a communication strategy and industry approach should aim to assist consumers in comprehending the health benefits and sensory aspects of novel functional foods available on the market. Full article

In order to effectively solve the problems of the complex growth state of dragon fruit and how the picking process is mostly manual, this study designed a picking and selecting integrated remote-operation-type dragon-fruit-picking device. Based on SOLIDWORKS 2020 software for the three-dimensional digital design and overall assembly of key components, the structure and working theory of the machine are introduced. By improving the high-recognition-rate dragon fruit target detection algorithm based on YOLOv5, better recognition and locating effects were achieved for targets with a small size and high density, as well as those in bright-light scenes. Serial communication, information acquisition, and the precise control of each picking action were realized by building the software and hardware platforms of the picking device control system. By analyzing the working principle of the mechanical system and the mechanics of the machine picking process, the critical factors affecting the net picking rate and damage rate of the dragon-fruit-picking device were confirmed. Based on the force and parameter analysis of the test results, it was confirmed that the machine had an optimal picking influence when the flexible claw closing speed was 0.029 m/s, the electric cylinder extending speed was 0.085 m/s, and the mechanical arm moving speed was 0.15 m/s. The net picking rate of the device reached 90.5%, and the damage rate reached 2.9%. The picking device can complete the picking of a single dragon fruit, as well as a plurality of fruits grown at a growing point, and integrates the integration of picking fruits, removing bad fruits, and sorting fruits, which can improve the efficiency of dragon fruit harvesting and replace manual work. Full article

Objectives: Our purpose was to examine the effectiveness of pattern scanning laser trabeculoplasty (PSLT) as an additional treatment for patients of open-angle glaucoma (OAG) receiving maximized ocular hypotensive medications (OHM). Methods: A total of 40 eyes of 33 patients (average age 72.7 ± 10.7 years) who had not previously undergone open glaucoma surgery or laser trabeculoplasty and were treated with maximized OHM between June 2018 and March 2022 were included. A 360-degree PSLT was conducted, and postoperative intraocular pressure (IOP) and survival curves at 1, 3, 6, 9, and 12 months were evaluated. Results: According to the Kaplan–Meier survival analysis, the average survival time was 8.1 months and the survival rate at 12 months was 0.55, with death defined as postoperative IOP reduction of less than 10% or requiring additional treatment. The average survival time was 4.9 months and the survival rate at 12 months was 0.28, with death defined as postoperative IOP reduction of less than 20% or requiring additional treatment. Nine eyes showed increased IOP (three eyes) or worsened visual field (six eyes) during the course and underwent additional open glaucoma surgery. In the 31 eyes which received no additional treatment after PSLT, the mean preoperative IOP was 18.5 ± 3.9 mmHg, which reduced to 15.3 ± 4.1 mmHg (p = 1.62 × 10⁻⁶), 15.5 ± 3.4 mmHg (p = 1.51 × 10⁻⁵), 15.7 ± 4.0 mmHg (p = 1.75 × 10⁻⁵), 14.7 ± 4.38 (p = 2.89 × 10⁻⁶), and 15.0 ± 4.0 mmHg (p = 5.74 × 10⁻⁹) at 1, 3, 6, 9, and 12 months after PSLT, respectively. The IOP reduction rate one year after PSLT was 18.7%. Of the 31 eyes, 13 (42%) achieved a 20% reduction in IOP compared to the baseline. Conclusions: Adjunctive treatment with PSLT in OAG patients receiving maximized OHM may be effective over 12 months of follow-up. Full article

The root system plays a decisive role in the growth and development of plants. The water requirement of a root system depends strongly on the plant species. Potatoes are an important food and vegetable crop grown worldwide, especially under irrigation in arid and semi-arid regions. However, the expected impact of global warming on potato yields calls for an investigation of genes related to root development and drought resistance signaling pathways in potatoes. In this study, we investigated the molecular mechanisms of different drought-tolerant potato root systems in response to drought stress under controlled water conditions, using potato as a model. We analyzed the transcriptome and proteome of the drought-sensitive potato cultivar Atlantic (Atl) and the drought-tolerant cultivar Qingshu 9 (Q9) under normal irrigation (CK) and weekly drought stress (D). The results showed that a total of 14,113 differentially expressed genes (DEGs) and 5596 differentially expressed proteins (DEPs) were identified in the cultivars. A heat map analysis of DEGs and DEPs showed that the same genes and proteins in Atl and Q9 exhibited different expression patterns under drought stress. Weighted gene correlation network analysis (WGCNA) showed that in Atl, Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG)-enriched pathways were related to pyruvate metabolism and glycolysis, as well as cellular signaling and ion transmembrane transporter protein activity. However, GO terms and KEGG-enriched pathways related to phytohormone signaling and the tricarboxylic acid cycle were predominantly enriched in Q9. The present study provides a unique genetic resource to effectively explore the functional genes and uncover the molecular regulatory mechanism of the potato root system in response to drought stress. Full article

Granular computing (GrC) is a methodology for reducing the complexity of problem solving and includes two basic aspects: granulation and granular-based computing. Strongly connected components (SCCs) are a significant subgraph structure in digraphs. In this paper, two new granulation strategies were devised to improve the efficiency of computing SCCs. Firstly, four SCC correlations between the vertices were found, which can be divided into two classes. Secondly, two granulation strategies were designed based on correlations between two classes of SCCs. Thirdly, according to the characteristics of the granulation results, the parallelization of computing SCCs was realized. Finally, a parallel algorithm based on granulation strategy for computing SCCs of simple digraphs named GPSCC was proposed. Experimental results show that GPSCC performs with higher computational efficiency than algorithms. Full article

Reliance on groundwater is outpacing natural replenishment, a growing imbalance that requires detailed and multi-faceted water resource understanding. This study integrated water-stable isotopes and hydrogeochemical species to examine hydrogeochemical processes during groundwater recharge and evolution in the Lake Malawi basin aquifer systems. The findings provide insights into groundwater source provenance, with non-evaporated modern precipitation dominating recharge inputs. Grouped hydrochemical facies exhibit five groundwater water types, prominently featuring Ca-Mg-HCO₃. Modelled hydrogeochemical data underscore dominant silicate dissolution reactions with the likely precipitation of calcite and/or high-Mg dolomitic carbonate constrained by ion exchange. Isotope hydrology reinforces water resource system conceptualisation. Coupled isotopic-hydrogeochemical lines of evidence reveal a discernible spatial-seasonal inhomogeneity in groundwater chemical character, revealing a complex interplay of meteoric water input, evaporative effects, recharge processes, and mixing dynamics. Findings show that measurable nitrate across Malawi highlights a widespread human impact on groundwater quality and an urgent need for detailed modelling to predict future trends of nitrate in groundwater with respect to extensive fertiliser use and an ever-increasing number of pit latrines and septic systems arising from rapid population growth. This study not only refined the Lake Malawi basin aquifer systems conceptualisation but also provided isotopic evidence of groundwater and lake water mixing. This study sets a base for groundwater management and policy decisions in support of the Integrated Water Resources Management principles and Sustainable Development Goal 6 objectives for groundwater sustainability in the transboundary Lake Malawi basin. Full article

The aim of this paper was to determine the efficiency of a rainwater treatment installation located near the farm buildings of Roztocze National Park (RNP), Poland. The rainwater treatment system, consisting of two polypropylene filters, one activated carbon filter and a UV lamp, was examined. Samples of raw and treated rainwater were collected once a month from June to December 2023. The study shows that average efficiency of pollutant removal in the analysed rainwater treatment system was not very high and amounted to 38.8% for ammonia, 29.6% for turbidity, 27.9% for NO₂, 19.8% for NO₃, and 6.9% for copper. The low efficiency values can be explained by the low concentration of these parameters in rainwater from the tanks. The efficiency of removing microbiological contaminants was very high and ranged from approximately 98% to 100%. It was shown that the UV lamp ensures very good disinfection of rainwater. The study shows that rainwater treated using filtration and disinfection (UV lamp) can be used for watering the Polish Konik horses living in the park, as well as for washing vehicles, watering green areas, or flushing toilets. The present findings can be used in the design of a new system for managing rainwater that is planned to be built in the RNP’s Animal Breeding Centre, as well as to prepare other rainwater systems, especially in protected areas. Full article

The physical integrity of the Ngerengere River and its three tributaries drains within Morogoro Municipality were evaluated by assessing the variations in land-use–land cover (LULC) in the river’s buffer zone, the discharge, and the contamination of river water and sediment from nutrients and heavy metals. Integrated geospatial techniques were used to classify the LULC in the river’s buffer zone. In contrast, the velocity area method and monitoring data from the Wami-Ruvu Basin were used for the discharge measurements. Furthermore, atomic absorption spectrophotometry was used during the laboratory analysis to determine the level of nutrients and heavy metals in the water and river sediment across the 13 sampling locations. The LULC assessment in the river’s buffer during the sampling year of 2023 showed that bare land and built-up areas dominate the river’s buffer, with a coverage of 28% and 38% of the area distribution. The higher discharge across the sampling stations was in the upstream reaches at 3.73 m³/s and 2.36 m³/s at the confluences. The highest concentrations of heavy metals in the water for the dry and wet seasons were 0.09 ± 0.01, 0.25 ± 0.01, 0.03 ± 0.02, 0.73 ± 0.04, 4.07 ± 0.08, and 3.07 ± 0.04 mg/L, respectively, for Pb, Cr, Cd, Cu, Zn, and Ni. The order of magnitude of the heavy metal concentration in the sediments was Zn > Ni > Cr > Cu > Cd > Pb, while the highest NO₂⁻, NO₃⁻_, NH₃, and PO₄³⁻ in the water and sediment were 2.05 ± 0.01, 0.394 ± 0.527 0.66 ± 0.05, and 0.63 ± 0.01 mg/L, and 2.64 ± 0.03, 0.63 ± 0.01, 2.36 ± 0.01, and 48.16 ± 0.01 mg/kg, respectively, across all sampling seasons. This study highlights the significant impact of urbanization on river integrity, revealing elevated levels of heavy metal contamination in both water and sediment, the variability of discharge, and alterations in the LULC in the rivers’ buffer. This study recommends the continuous monitoring of the river water quality and quantity of the urban rivers, and the overall land-use plans for conserving river ecosystems. Full article

Net-zero carbon reduction has become a global supply chain development trend, and the EU has established CBAM regulations. Industries that fail to effectively reduce carbon emissions will face operational challenges under these regulations. For SMEs, carbon reduction is crucial for sustainable operations. To address this challenge, governments worldwide are formulating relevant policies and investing resources to help SMEs enhance their competitiveness. In Taiwan, the metal industry has an export ratio exceeding 45%, making it a significant global production base for metal products. This study conducted a green operational transformation survey on 230 SMEs in Taiwan’s metal industry. The Taiwanese government has devised a comprehensive carbon reduction approach for the metal industry, which includes environmental facilities, digital technology introduction, process and production technology improvement, resource recycling, and energy conversion as strategies and tools for promoting carbon reduction. According to this study, the aforementioned five promotion strategies have become essential tools for SMEs in their carbon reduction efforts. This study utilized a one-way ANOVA, Pearson correlation analysis, and simple regression analysis, all of which demonstrated significant correlations among these tools. These findings can serve as a reference for other partner countries, accelerating the global industry’s transition toward green operations. Full article

The technology to jet print metal lines with precise shape fidelity on diverse substrates is gaining higher interest across multiple research fields. It finds applications in additively manufactured flexible electronics, environmentally friendly and sustainable electronics, sensor devices for medical applications, and fabricating electrodes for solar cells. This paper provides an experimental investigation to deepen insights into the non-contact printing of solder lines using StarJet technology, eliminating the need for surface activation, substrate heating, curing, or post-processing. Moreover, it employs bulk metal instead of conventional inks or pastes, leading to cost-effective production and enhanced conductivity. The effect of molten metal temperature, substrate temperature, standoff distance, and printing velocity was investigated on polymer foils (i.e., PET sheets). Robust printing parameters were derived to print uniform, bulge-free, bulk metal lines suitable for additive manufacturing applications. The applicability of the derived parameters was extended to 3D-printed PLA, TPU, PA-GF, and PETG substrates having a much higher surface roughness. Additionally, a high aspect ratio of approx. 16:1 wall structure has been demonstrated by printing multiple metal lines on top of each other. While challenges persist, this study contributes to advancing additively manufactured electronic devices, highlighting the capabilities of StarJet metal jet-printing technology. Full article

Rock strength is an essential parameter in the design of any underground excavation, and it has become even more relevant as the focus increasingly shifts to sustainable excavations. The heterogeneous nature of rock material makes characterising the strength of rocks a difficult and challenging task. The research results presented in this article compare the impact on the strength when the classic stress paths in laboratory experiments are applied versus when in situ stress paths would be applied. In most laboratory experiments, the rock specimens are free of stress at the beginning of the tests, and the load is increased systematically until failure occurs. Opposite paths occur around an underground excavation; that is, the rock is in equilibrium under a triaxial stress state and at least one stress component decreases while another component may increase. Based on discrete element simulations, the research shows that different stress paths result in different failure envelopes. The impact of this finding is evaluated in the application of wellbore stability (e.g., the minimum or maximum mud weight), whereby it is concluded that failure envelopes, based on stress paths closer to the in situ stress paths, result in a more accurate design. Although the most critical location along the circumference is not different, the required density of the mud is significantly different if the rock strength criteria are based on the more realistic in situ stress paths. This means that a change in the way the strength of rocks is characterised improves the sustainable design of all underground excavations. Full article

This study presents the measurements of exposure to electromagnetic fields, carried out comparatively following standard methods from fixed sites using a broadband meter and using a smartphone on which an App designed for this purpose has been installed. The results of two measurement campaigns carried out on the campus of the University of Alcalá over an area of 1.9 km² are presented. To characterize the exposure, 20 fixed points were measured in the first case and 860 points along the route made with a bicycle in the last case. The results obtained indicate that there is proportionality between the two methods, making it possible to use the smartphone for comparative measurements. The presented methodology makes it possible to characterize the exposure in the area under study in four times less time than that required with the traditional methodology. Full article

Studies on chronic myeloid leukemia (CML) in the Gulf region are scarce, consisting of a survey and expert meeting that included 15 experts in 2023 which discussed CML diagnosis, testing, treatment objectives, toxicities, and discontinuation in the Gulf region. Most patients were reported to be in first-line therapy, and the most common treatments were imatinib/imatinib generic in first-line and dasatinib in second- and third-lines. Mutation analysis was not reported to be routinely performed at the time of diagnosis but rather in case of progression to accelerated/blast phase or any sign of loss of response. While all participants were aware that BCR-ABL should be monitored every three months during the first year of treatment, 10% reported monitoring BCR-ABL every six months in practice due to test cost and lab capability. The most important first-line therapy objective was “achievement of major molecular response” (MMR) in younger patients and “overall survival” in older ones. The most important treatment objectives were “MMR” and “early molecular response followed by prolongation of overall survival” in the short term and “treatment-free remission” in the long term. The current practices in CML in the Gulf region appear to be similar to global figures. Full article

Oxidation–reduction post-translational modifications (redox-PTMs) are chemical alterations to amino acids of proteins. Redox-PTMs participate in the regulation of protein conformation, localization and function, acting as signalling effectors that impact many essential biochemical processes in the cells. Crucially, the dysregulation of redox-PTMs of proteins has been implicated in the pathophysiology of numerous human diseases, including neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. This review aims to highlight the current gaps in knowledge in the field of redox-PTMs biology and to explore new methodological advances in proteomics and computational modelling that will pave the way for a better understanding of the role and therapeutic potential of redox-PTMs of proteins in neurodegenerative diseases. Here, we summarize the main types of redox-PTMs of proteins while providing examples of their occurrence in neurodegenerative diseases and an overview of the state-of-the-art methods used for their detection. We explore the potential of novel computational modelling approaches as essential tools to obtain insights into the precise role of redox-PTMs in regulating protein structure and function. We also discuss the complex crosstalk between various PTMs that occur in living cells. Finally, we argue that redox-PTMs of proteins could be used in the future as diagnosis and prognosis biomarkers for neurodegenerative diseases. Full article

Domestic heating systems across northern Europe are responsible for a substantial fraction of their countries’ carbon footprints. In the UK, the vast majority of home space heating is via natural gas boilers with `wet’ hydronic radiator systems. Most of those use TRVs (thermostatic radiator valves) for micro-zoning, to avoid overheating, improve comfort and save energy. To meet Net Zero targets, 20 million such UK gas systems may be retrofitted with heat pumps. Heat pump system designers and installers are cautious about retaining TRVs in such systems in part because of worries that TRV temperature setbacks that lower heat demand may raise heat pump electricity demand in a “bad setback effect”, thus wasting energy. This paper presents a new view of heat pump control and provides the first exploration of this issue through the development of a simple physics-based model. The model tests an installation industry claim about the negative effect of TRVs, and finds that though real it should not apply to typical UK retrofits with weather compensation. The energy efficiency benefits of TRVs for older and partly occupied homes, and to keep bedrooms cooler, remain valid. Comfort-seeking householders and installers should know that setting `stiff’ temperature regulation may invoke the bad setback effect and cost dearly in energy and carbon footprint. Full article

Bacteriophages (phages) are viruses that infect the bacteria within which their reproduction cycle takes place, a process that ends in the lysis and death of the bacterial cell. Some phages are also able to destroy bacterial biofilms. Due to increased antibiotics resistance, Pseudomonas aeruginosa, another biofilm-forming pathogen, is a problem in many parts of the world. Zinc oxide (ZnO) and other metal nanoparticles (NPs) are biologically active and also possess anti-biofilm properties. ZnO-NPs were prepared by the green synthesis method using orange peels. The vibrational peaks of the ZnO-NPs were analyzed using FTIR analysis, and their size and morphological properties were determined using scanning electron microscopy (SEM). The ability of the ZnO-NPs to reduce or eliminate P. aeruginosa biofilm alone or in combination with phages PB10 and PA19 was investigated. The P. aeruginosa cells were effectively killed in the preformed 48 h biofilms during a 24 h incubation with the ZnO-NP–phage combination, in comparison with the control or ZnO-NPs alone. The treatments on growing biofilms were most efficient in the final stages of biofilm development. All five treatment groups showed a significant biofilm reduction compared to the control group (p < 0.0001) at 48 h of incubation. The influence of the ZnO-NPs and phages on the quorum sensing system of P. aeruginosa was monitored by quantitative real-time PCR (qRT-PCR) of the autoinducer biosynthesis gene lasI. While the ZnO-NPs repressed the lasI gene transcription, the phages slightly activated it at 24 and 48 h of incubation. Also, the effect of the ZnO-NPs and phage PA19 on the viability of HFF2 cells was investigated and the results showed that the combination of NPs with PA19 reduced the toxic effect of ZnO-NPs and also stimulated the growth in normal cells. Full article

Long-term regional vegetation dynamics is essential for the understanding of past land cover changes. High-resolution pollen analysis of a 1020 cm core from a large lake, Lake Yangzonghai (YZH), in central Yunnan, SW China, was conducted to reveal regional vegetation dynamics in the lake catchment over the past 13,400 years. Pollen record, principal component analysis (PCA) of pollen percentages of major arboreal taxa, and plant abundances estimated from the “Regional Estimates of VEgetation Abundance from Large Sites” (REVEALS) model show five successional stages of vegetation dynamics since 13,400 cal. a BP: regional vegetation with high coverages in the lateglacial (13,400–11,400 cal. a BP) was dominated by evergreen broadleaved forest (EBF) and deciduous broadleaved forest (DBF), together with some grass meadows and marshes; pine forest and alder forest expanded in the early Holocene (11,400–9000 cal. a BP) when vegetation coverages were still high; regional vegetation with low coverages was dominated by sweetgum forest, together with some pine forest during the mid-Holocene (9000–4200 cal. a BP); more pine forest, grass meadows and marshes occupied the lake catchment during the late Holocene (4200–800 cal. a BP), when vegetation coverages were higher than the average of the past 13,400 years; regional vegetation with low coverage was dominated by grass meadows and marshes, great deforestation happened in the last 800 years. Regional vegetation dynamics over the past 13,400 years in the Lake YZH catchment was the result of regional vegetation response to climate changes during the lateglacial and early–mid Holocene, and to human activities mainly during the late Holocene. Full article

Studies on obligate halophytes combining eco-physiological techniques and proteomic analysis are crucial for understanding salinity tolerance mechanisms but are limited. We thus examined growth, water relations, ion homeostasis, photosynthesis, oxidative stress mitigation and proteomic responses of an obligate halophyte Suaeda fruticosa to increasing salinity under semi-hydroponic culture. Most biomass parameters increased under moderate (300 mmol L⁻¹ of NaCl) salinity, while high (900 mmol L⁻¹ of NaCl) salinity caused some reduction in biomass parameters. Under moderate salinity, plants showed effective osmotic adjustment with concomitant accumulation of Na⁺ in both roots and leaves. Accumulation of Na⁺ did not accompany nutrient deficiency, damage to photosynthetic machinery and oxidative damage in plants treated with 300 mmol L⁻¹ of NaCl. Under high salinity, plants showed further decline in sap osmotic potential with higher Na⁺ accumulation that did not coincide with a decline in relative water content, Fv/Fm, and oxidative damage markers (H₂O₂ and MDA). There were 22, 54 and 7 proteins in optimal salinity and 29, 46 and 8 proteins in high salinity treatment that were up-regulated, down-regulated or exhibited no change, respectively, as compared to control plants. These data indicate that biomass reduction in S. fruticosa at high salinity might result primarily from increased energetic cost rather than ionic toxicity. Full article

Industrialization and increased energy use are leading to a greater influence of environmental and climate challenges on human existence and progress. China’s emissions in 2023 totaled 12.6 gigatons, representing 35% of global emissions, establishing it as the top carbon emitter globally. Combined with China’s industrial structure, it is essential to investigate carbon reduction in the building sector due to its significant contribution to carbon emissions. This study introduces a third-party organization into the relationship between stakeholders, based on traditional government regulation. It constructs a three-party dynamic evolution model involving the government, environmental protection organization, and construction enterprise. The study analyzes the evolution process of the three-party strategy selection using evolutionary game theory. We analyze the elements influencing decision-making for the three parties through simulation analysis and provide appropriate recommendations. The study’s findings indicate that low-carbon construction in China’s construction sector is an intricate system involving several stakeholders, each guided by their own interests when determining their behavioral methods. Government penalties and financial subsidies can influence construction enterprises to adopt low-carbon production practices to some degree, but excessive rewards and punishments may not support system stability. Full article

Natural plants contain numerous chemical compounds that are beneficial to human health. The berries from the Lycium genus are widely consumed and are highly nutritious. Moreover, their chemical constituents have attracted attention for their health-promoting properties. In East Asia, there are three varieties of the Lycium genus (Lycium barbarum L., Lycium chinense Miller, and L. ruthenicum Murray) that possess medicinal value and are commonly used for treating chronic diseases and improving metabolic disorders. These varieties are locally referred to as “red Goji berries” or “black Goji berries” due to their distinct colors, and they differ in their chemical compositions, primarily in terms of carotenoid and anthocyanin content. The pharmacological functions of these berries include anti-aging, antioxidant, anti-inflammatory, and anti-exercise fatigue effects. This review aims to analyze previous and recent studies on the active ingredients and pharmacological activities of these Lycium varieties, elucidating their signaling pathways and assessing their impact on the gut microbiota. Furthermore, the potential prospects for using these active ingredients in the treatment of COVID-19 are evaluated. This review explores the potential targets of these Lycium varieties in the treatment of relevant diseases, highlighting their potential value in drug development. Full article

Polymer microspheres with temperature and salt resistance were synthesized using the anti-suspension polymerization method, incorporating the functional monomers AMPS, AM, and AA. To enhance their self-gelling properties, the microspheres were designed with a core–shell structure. The shell is composed of a polymeric surfactant, fatty alcohol polyoxyethylene ether methacrylate (AEOMA), which serves as a thermosensitive crosslinking agent, enabling self-crosslinking upon shell decomposition, addressing compatibility with reservoir pore throat dimensions. Comprehensive characterizations including infrared spectroscopy, scanning electron microscopy, optical microscopy, and laser particle size analysis were conducted. The microspheres exhibited successful synthesis, a nanoscale size, and regular spherical morphology. They demonstrated excellent temperature and salt resistance, making them suitable for high-temperature, high-salinity reservoir profile control. With a stable three-dimensional network structure, the microspheres displayed good expansion behavior due to hydrophilic groups along the polymer chains, resulting in favorable water affinity. Even after aging, the microspheres maintained their gelling state with a distinct and stable microscopic network skeleton. They exhibited superior plugging performance in low-permeability reservoirs, while effectively improving water absorption profiles in reservoirs with permeability contrasts of 10 to 80, thereby enhancing oil recovery. Full article