The precise calculation and effective control of the horizontal displacement of deep foundation pit retaining structures are critical for foundation pit support design and construction. Based on stress‒strain linear elastomer theory and considering the deformation coordination between an enclosure wall and its internal support member, a formula for the redundant restraint force acting on the retaining wall was derived through the unit load method and the principle of elastic superposition. Moreover, a method for calculating the horizontal displacement of the retaining structure of a deep foundation pit was formulated, which is convenient for engineering applications. The method can also be used to calculate the horizontal displacement of cantilevered and anchored retaining structures when the loading conditions of the deep foundation pit and the relevant parameters of the enclosure structure are known. A case study was conducted on a standard section with an excavation width H of 19.3 m and an excavation depth h of 17.8 m. The structural parameters of the enclosure wall, along with the elastic support stiffness coefficient and soil layer parameters of the pit, were inputted into a MATLAB calculation code. Then, four internal support constraint forces F_i and the calculated values for the horizontal displacement of the enclosure wall were obtained after running the code. The calculated curve closely matched the curve of values measured in the field. The horizontal displacements of the top of the wall of several cement–soil gravity enclosure structures mentioned in the literature were also calculated. The results of these calculations were then compared with the measured data and corresponding data from the literature. The examples provided clear evidence demonstrating that the proposed method is highly reliable for calculating the horizontal displacement of deep foundation pit enclosure structures. Full article

The wide use of boronic compounds, especially boronic acids and benzoxaboroles, in virtually all fields of chemistry is related to their specific properties. The most important of them are the ability to form cyclic esters with diols and the complexation of anions. In both cases, the equilibrium of the reaction depends mainly on the acidity of the compounds, although other factors must also be taken into account. Quantification of the acidity (pK_a value) is a fundamental factor considered when designing new compounds of practical importance. The aim of the current work was to collect available values of the acidity constants of monosubstituted phenylboronic acids, critically evaluate these data, and supplement the database with data for missing compounds. Measurements were made using various methods, as a result of which a fast and reliable method for determining the pK_a of boronic compounds was selected. For an extensive database of monosubstituted phenylboronic acids, their correlation with their Brønsted analogues—namely carboxylic acids—was examined. Compounds with ortho substituents do not show any correlation, which is due to the different natures of both types of acids. Nonetheless, both meta- and para-substituted compounds show excellent correlation. From a practical point of view, acidity constants are best determined from the Hammett equation. Computational approaches for determining acidity constants were also analyzed. In general, the reported calculated values are not compatible with experimental ones, providing comparable results only for selected groups of compounds. Full article

To address the difficulty in conducting fire tests to verify the fire-resistance limit of large one-way slabs with heavy loads in a metro, a scale fire test method is proposed based on the bearing capacity calculation of the one-way slab under fire. The scale fire test method adapted the hypothesis that the deflection of the one-way slab under fire is close to a half-sine function and the plane section hypothesis. The validity of this hypothesis is verified through fire tests and finite element simulations. The scale fire test method achieves a similar temperature field and mechanical behavior between the scaled model and full-scale model of the one-way slab. The results of the fire tests showed that the temperature field and mechanical behavior of the scaled model were consistent with those of the full-scale model, with an error in fire resistance of 4.7%. The calculation results and fire test results are essentially consistent, with an error of 6.5%, and according to the calculation of the one-way slab fire-resistance limit, the key factor affecting the fire resistance of the one-way slab under fire is the temperature of the bottom rebars. Using the scale fire test method, the size effect of the one-way slab under fire still exists, and larger slabs have a greater deformation capacity. Full article

Nutritional bars (NBs) are gaining popularity among healthy and athletic individuals, but postprandial antioxidative response has not been investigated. Therefore, the current study examined the postprandial alterations in total phenolic content (TPC), total antioxidant capacity (T-AOC), malondialdehyde (MDA), and Superoxide dismutase (SOD) in the plasma of healthy individuals after the ingestion of 140 g (510 Kcal) from formulated date-based bars (DBBs) or fruit-based bars (FBBs). Firstly, the free and bound phenolic contents (PCs) were determined to be 10.15 and 12.98 and 6.19 and 3.57 mg GAE g⁻¹, respectively. FBBs were significantly higher in free PC than DBBs, while DBBs were considerably higher in bound PC than FBBs. Secondly, twenty participants with age, height, weight, body mass index (BMI), fat mass, and fat-free mass averages of 21.4 years, 170.0 cm, 66.3 kg, 22.9 kg m², 14.5, and 29.2 kg, respectively, were subjected to metabolic experiments (ISRCTN19386758). Ingestion of 140 g of FBB or DBB resulted in 288.50 or 302.14 µg TPC mL⁻¹ blood, respectively. Postprandial TPC content increased with time progression and peaked after 120 min. T-AOC contents averaged 22.63 and 23.61 U mL⁻¹ before ingestion of FBBs or DBBs, respectively. The T-AOC content increased significantly 120 and 180 min after ingestion of DBBs, while no significant change was noted after consuming FBBs. A significant decrease in MDA content was observed 180 min after consuming DBBs, while no significant change was noted after consuming FBBs. SOD concentrations ranged from 193.99 to 201.07 U L⁻¹ in FBBs and DBBs, respectively. No considerable response was noted up to 3 h after ingestion of FBBs. On the contrary, a significant response was found 120 min after consuming DBBs. Pearson’s correlation coefficient indicated a highly significant positive correlation coefficient (p < 0.01) between T-AOC and either MDA or SOD, as well as between MDA and SOD. The principal component analysis demonstrated a strong and positive relationship between SOD and TPC at 60 and 120 min after DBB ingestion. In conclusion, the relative changes in postprandial responses in T-AOC and MDA did not significantly (p > 0.05) differ between DBBs and FBBs, except for TPC (p = 0.04, paired t-test) and SOD (p = 0.003, paired t-test). Further studies with an extended experimental time are needed to confirm the current findings. Full article

This study aimed to explore how dark personality traits influence the interplay between embitterment and jealousy. We first assessed the appropriateness of the scales used to assess jealousy, personality, and embitterment for our study population, examining their performance across different relationship statuses and ensuring their reliability. Then, through correlation, regression, and moderation analyses, we investigated the relationships among these measures. Our results revealed that Machiavellianism and narcissism act as moderators in the embitterment–jealousy relationship. Specifically, Machiavellianism moderated associations between overall embitterment and its psychological state and behavioral jealousy, while narcissism moderated connections between total embitterment and its psychological state, behavioral jealousy, cognitive jealousy, and overall jealousy. Furthermore, the combined influence of a longer relationship duration and higher levels of embitterment and Machiavellianism contributed to total jealousy scores. These findings deepen our comprehension of jealousy’s intricacies and the underlying factors at play. Full article

We developed a novel machine-learning algorithm to augment the clinical diagnosis of prostate cancer utilizing first and second-order texture analysis metrics in a novel application of machine-learning radiomics analysis. We successfully discriminated between significant prostate cancers versus non-tumor regions and provided accurate prediction between Gleason score cohorts with statistical sensitivity of 0.82, 0.81 and 0.91 in three separate pathology classifications. Tumor heterogeneity and prediction of the Gleason score were quantified using two feature selection approaches and two separate classifiers with tuned hyperparameters. There was a total of 71 patients analyzed in this study. Multiparametric MRI, incorporating T₂WI and ADC maps, were used to derive radiomics features. Recursive feature elimination (RFE), the least absolute shrinkage and selection operator (LASSO), and two classification approaches, incorporating a support vector machine (SVM) (with randomized search) and random forest (RF) (with grid search), were utilized to differentiate between non-tumor regions and significant cancer while also predicting the Gleason score. In T₂WI images, the RFE feature selection approach combined with RF and SVM classifiers outperformed LASSO with SVM and RF classifiers. The best performance was achieved by combining LASSO and SVM into a model that used both T₂WI and ADC images. This model had an area under the curve (AUC) of 0.91. Radiomic features computed from ADC and T₂WI images were used to predict three groups of Gleason score using two kinds of feature selection methods (RFE and LASSO), RF and SVM classifier models with tuned hyperparameters. Using combined sequences (T₂WI and ADC map images) and combined radiomics (1st and GLCM features), LASSO, with a feature selection method with RF, was able to predict G3 with the highest sensitivity at a level AUC of 0.92. To predict G3 for single sequence (T₂WI images) using GLCM features, LASSO with SVM achieved the highest sensitivity with an AUC of 0.92. Full article

This study aims to support designers in developing transformative solutions in the engineering discipline using the Design-by-Analogy ideation method. Design-by-Analogy involves drawing inspiration from the source domain and applying it to the target domain. Based on the conceptual distance between the two domains, analogies are classified as biological—(natural), cross—(distant-engineering), and within—(near-engineering) domain analogies. Real-world scenarios involve designers selecting analogies after seeking them across multiple domains. These selected analogies significantly influence the produced designs. However, the selection criteria of the analogy domain are unexplored in design research. We address this gap by investigating: (a) the influence of analogy domains on their selection frequency; and (b) the relationship between the frequency of selecting analogies from specific domains and the novelty of designs. The experiment involved twenty-six teams of novice product designers, who solved design problems aided by one analogical source from each domain. The results showed that biological analogies were frequently selected. While biological-domain analogies significantly increased the novelty of designs compared to the within-domain ones; no significant difference was found between the biological- and cross-domain analogies, suggesting that middle-domain analogies can be as effective as far-domain ones. The findings can support technological innovation by aiding the development of analogy search databases. Full article

Maritime shipping is a crucial method of transporting goods internationally and is vital in supporting global trade. However, due to its global scope, the international shipping market is susceptible to political and economic disturbances. The recent escalation in the Israeli–Palestinian conflict has severely impacted the international shipping market, particularly in the tense Red Sea region. Previous research has neglected the significance of evaluating international shipping companies, particularly their origins, within their evaluation frameworks. A fuzzy multi-attribute decision-making (MADM) approach is necessary to address the complexity of evaluating shipping companies with unclear criteria and uncertain expert opinions. Symmetry is crucial in various mathematical fields, with recent applications in hesitant fuzzy sets (HFSs) and neutrosophic sets (NSs), which are frequently employed to solve complex MADM problems. The consideration of symmetry in decision-making processes can enhance the robustness and fairness of evaluations, ensuring a balanced and unbiased approach. The neutrosophic–hesitant fuzzy set (NHFS) considers both the uncertainty of membership degrees of elements (hesitancy in HFSs) and the performance of membership degrees in the true, false, and neutral aspects (the ternary relation in NSs). NHFSs can be seen as a generalization of HFSs and NSs, providing a flexible mathematical framework to more effectively describe and analyze the uncertainties, hesitancies, and fuzziness involved in MADM problems. This study presents single-valued neutrosophic power Hamy mean (SVNPHM) operators and single-valued neutrosophic weighted power Hamy mean (SVNWPHM) operators, which are derived from power aggregation operators (AOs) and the Hamy mean (HM), within the framework of single-valued neutrosophic sets (SVNS). Some properties were investigated via these operators. Furthermore, SVNWPHM operators were employed to address single-valued neutrosophic MADM issues. The proposed methodology was validated by conducting a case study on international shipping provider selection, showcasing the methodology’s relevance and efficiency. Full article

The utilization of ammonia for hydrogen storage relies on the implementation of efficient decomposition techniques, and the membrane reactor, which allows simultaneous ammonia decomposition and hydrogen recovery, can be regarded as a promising technology. While Pd-based membranes show the highest performance for hydrogen separation, their applicability for NH₃-sensitive applications, such as proton exchange membrane (PEM) fuel cells, demands relatively thick, and therefore expensive, membranes to meet the purity targets for hydrogen. To address this challenge, this study proposes a solution involving the utilization of a downstream hydrogen purification unit to remove residual ammonia, thereby enabling the use of less selective, therefore more cost-effective, membranes. Specifically, a carbon molecular sieve membrane was prepared on a tubular porous alumina support and tested for ammonia decomposition in a membrane reaction setup. Operating at 5 bar and temperatures ranging from 450 to 500 °C, NH₃ conversion rates exceeding 90% were achieved, with conversion approaching thermodynamic equilibrium at temperatures above 475 °C. Simultaneously, the carbon membrane facilitated the recovery of hydrogen from ammonia, yielding recoveries of 8.2–9.8%. While the hydrogen produced at the permeate side of the reactor failed to meet the purity requirements for PEM fuel cell applications, the implementation of a downstream hydrogen purification unit comprising a fixed bed of zeolite 13X enabled the production of fuel cell-grade hydrogen. Despite performance far from being comparable with the ones achieved in the literature with Pd-based membranes, this study underscores the viability of carbon membranes for fuel cell-grade hydrogen production, showcasing their competitiveness in the field. Full article

Tonsillectomy has been suggested as a potential intervention to resolve psoriasis; however, its preventive effects on the development of psoriasis remain unclear. This study aimed to investigate the risk of developing late-onset psoriasis among a Korean adult population who had undergone tonsillectomy. Data from the Korean National Health Insurance Service-Health Screening Cohort between 2002 and 2019 were utilized. Out of a total of 514,866 participants, 1082 participants aged 40 years or older who had undergone tonsillectomy were matched with 4328 control participants using overlap weighting adjustment based on the propensity score. The incidence and hazard ratio (HR) of psoriasis were calculated for both tonsillectomy and control groups. The incidence rates of psoriasis were 1.30% in the tonsillectomy group and 1.20% in the control group. The incidence of psoriasis (overlap-weighted HR = 1.08, 95% confidence of interval = 0.69–1.69, and p = 0.732) did not differ significantly between the patients who underwent tonsillectomy and those in the control group. The cumulative probability of developing psoriasis was not different between the two groups (Log-rank test: p = 0.440). These findings were consistent across subgroups divided by age, sex, income, and region of residence. We found that tonsillectomy did not confer a preventive effect on the development of late-onset psoriasis in the Korean adult population. Full article

In open-cut assembled subway tunnels, foundation pit enclosure piles are typically cast in place. However, this conventional approach limits the functionality of the piles to serving as retaining structures during excavation, resulting in resource inefficiency and the underutilization of prefabrication techniques. To address this issue, a fully prefabricated pile-wall composite scheme is proposed for cut-and-cover tunnels to optimize the retaining effect of the piles and leverage the benefits of prefabricated technology. In this scheme, the retaining pile and lining are both prefabricated. The pile is the temporary retaining structure during pit excavation and a part of the sidewall. This scheme was researched and applied in Jinan, China. Field monitoring and numerical simulation were used to investigate the load transfer within the fully prefabricated pile-wall composite structure (PPWS) and its mechanical response, respectively. The results show: (1) The development of lateral earth pressures on the PPWS experienced three stages. The lateral earth pressure distribution indicates that the PPWS can fully activate the retaining effect of precast piles. (2) Following the backfilling of the joints, the horizontal displacement at the bottom of the precast pile reduced by 0.39 mm. Numerical simulation results indicate the effectiveness of precast pile restraint in PPWS. (3) The PPWS exhibited uniform deformation transition at the joints. The joints play a crucial role in coordinating deformation between the precast piles and sidewalls, utilizing the restraining effect of the precast piles. Full article

This study examined the impact of temperature optimization on indium tin oxide (ITO) films in monolithic HJT/perovskite tandem solar cells. ITO films were deposited using magnetron sputtering at temperatures ranging from room temperature (25 °C) to 250 °C. The sputtering target was ITO, with a mass ratio of In₂O₃ to SnO₂ of 90% to 10%. The effects of temperature on the ITO film were analyzed using X-ray diffraction (XRD), spectroscopic ellipsometry, and sheet resistance measurements. Results showed that all ITO films exhibited a polycrystalline morphology, with diffraction peaks corresponding to planes (211), (222), (400), (440), and (622), indicating a cubic bixbyite crystal structure. The light transmittance exceeded 80%, and the sheet resistance was 75.1 Ω/sq for ITO deposited at 200 °C. The optical bandgap of deposited ITO films ranged between 3.90 eV and 3.93 eV. Structural and morphological characterization of the perovskite solar cell was performed using XRD and FE-SEM. Tandem solar cell performance was evaluated by analyzing current density-voltage characteristics under simulated sunlight. By optimizing the ITO deposition temperature, the tandem cell achieved a power conversion efficiency (PCE) of 16.74%, resulting in enhanced tandem cell efficiency. Full article

Coordinated regional development is an important issue for China in the new era, and the influence of innovation ability on regional economic development is increasing, but the current regional innovation is characterized by an increasingly obvious “dualization” effect. In this paper, by constructing innovation efficiency, science and technology innovation, innovation culture, and innovation policy as the four key subsystems of regional innovation effect, and using system dynamics to establish a regional innovation effect model, Wuhan and Enshi as the representatives of central city and non-central city, selecting the data from 2014 to 2021, and adopting different parameters to simulate the evolution trend of the innovation effect, it is concluded that the growth rate of industrial enterprises and the intensity of R&D expenditures have increased, and the innovation effect has become more and more obvious, which is the most important issue in the new era of China’s development. It is also concluded that the growth rate of industrial enterprises and the intensity of R&D expenditure are the key factors influencing the innovation effect of central and non-central cities, and suggestions are made for optimizing the “dualization” effect of regional innovation. Full article

This article attempts to elucidate the Deleuzian philosophy of the event between The Logic of Sense and A Thousand Plateaus, where it acquires clearly political nuances. With regard to The Logic of Sense, I show that (i) it takes up the definition of the event of Difference and Repetition, identifying it with that redistribution of pre-individual singularities or individuating differences at the level of the univocal being which defines the conditions of problems; (ii) the event is henceforth also the instance that makes possible the “communication” of the heterogeneous series of bodies and propositions from which the production of sense in language follows; and (iii) the counter-effectuation should be understood in this book as an ethics of the event. With regard to A Thousand Plateaus, I emphasize (i) the “return” to The Logic of Sense that the concept of assemblage entails, (ii) the reformulation of the notion of event that takes place in the new theoretical framework, and (iii) that of the counter-effectuation, which must henceforth be understood as a politics of the event. Full article

We aimed to understand the changes in nutritional parameters and performance of beef cows during the peripartum, whether receiving or not receiving protein supplements. Forty cows were used, divided into two treatments: CON—mineral mix and SUP—protein supplementation. Digestibility trial was performed at 45, 30, and 15 days (d) before the parturition and at 20 and 40 d of lactation. The ADG of cows pre- and postpartum was recorded along with the BCS in gestational (GT) and maternal (MT) tissues in the prepartum. There was an effect of treatment and period (p ≤ 0.044) for intakes of DM and CP. The forage intake was similar (p > 0.90) but varied with the effect of days related to parturition (p < 0.001). There was a 14.37% decrease in DM intake from d −30 to d −15 of prepartum. In the postpartum, at 20 d of lactation, there was an increase of 72.7% in relation to d −15 of prepartum. No differences were observed in postpartum ADG or BCS at parturition and postpartum (p ≥ 0.12). However, higher total and MT ADG (p ≤ 0.02) were observed in animals receiving supplementation, while ADG in GT remained similar (p > 0.14). In conclusion, there is a decrease in intake for pregnant cows close to parturition and greater performance of animals supplemented in prepartum. Full article

Azorella compacta (A. compacta) is a shrub of the Andean Altiplano of Bolivia, Chile and Peru, consumed by local communities as a traditional medicine for several maladies such as diabetes, hepatic and inflammatory diseases. A. compacta is rich in mulinane- and azorellane-type diterpenoids. For two of these, acute hypoglycemic effects have been described, but the impact of A. compacta diterpenoids on fatty liver disease has not been investigated. Therefore, A. compacta organic fractions were prepared using petroleum ether, dichloromethane and methanol. Their content was characterized by UHPLC/MS, revealing the presence of ten diterpenoids, mainly mulinic acid, azorellanol and mulin-11,13-diene. Next, mice fed with a high-fat diet (HFD), a model of metabolic dysfunction-associated fatty liver disease (MAFLD), received one of the fractions in drinking water for two weeks. After this treatment, hepatic parameters were evaluated. The A. compacta fractions did not reduce hyperglycemia or body weight in the HFD-fed mice but increased the serum levels of hepatic transaminases (AST and ALT), reduced albumin and increased bilirubin, indicating hepatic damage, while histopathological alterations such as steatosis, inflammation and necrosis generated by the HFD were, overall, not ameliorated by the fractions. These results suggest that organic A. compacta extracts may generate hepatic complications in patients with MAFLD. Full article

This study aims at the identification and characterization of five actinobacterial strains with presumed belonging to the species Curtobacterium flaccumfaciens isolated from tomato and pepper plants, and establishing the potential role of both plants as natural reservoirs of this phytopathogen. Species identification was performed via MALDI-ToF MS, 16S rDNA sequencing and PCR. The strains were Gram-positive with a coryneform cell shape having yellow/orange-pigmented colonies; positive for catalase and esculin, and starch and casein hydrolysis; oxidase-, urease-, indole- and nitrate-reduction-negative and were strictly aerobic. All isolates produced antimicrobial substances against various phytopathogenic bacteria. Tomato and pepper plants were artificially infected with newly isolated strains in order to establish their role as natural reservoirs of the bacteria. Morphological alterations were observed only in the tomato plants, with defoliation of the first two to four leaves at the 28th day. Then, viable coryneform bacterial isolates (n = 73) were successfully re-isolated only from the stems of the infected plants. The similarity between the re-isolates and the respective initial isolates was confirmed phenotypically and genotypically by RAPD-PCR, confirming that solanaceous vegetables can act as reservoirs of C. flaccumfaciens. This is the first report of C. flaccumfaciens in Bulgaria. Full article

Comprehending the regulatory mechanisms influencing blood pressure control is pivotal for continuous monitoring of this parameter. Implementing a personalized machine learning model, utilizing data-driven features, presents an opportunity to facilitate tracking blood pressure fluctuations in various conditions. In this work, data-driven photoplethysmograph features extracted from the brachial and digital arteries of 28 healthy subjects were used to feed a random forest classifier in an attempt to develop a system capable of tracking blood pressure. We evaluated the behavior of this latter classifier according to the different sizes of the training set and degrees of personalization used. Aggregated accuracy, precision, recall, and F1-score were equal to 95.1%, 95.2%, 95%, and 95.4% when 30% of a target subject’s pulse waveforms were combined with five randomly selected source subjects available in the dataset. Experimental findings illustrated that incorporating a pre-training stage with data from different subjects made it viable to discern morphological distinctions in beat-to-beat pulse waveforms under conditions of cognitive or physical workload. Full article

Chimerism analysis after allogeneic hematopoietic stem cell transplantation serves to confirm engraftment, indicate relapse of hematologic malignancy, and attribute graft failure to either immune rejection or poor graft function. Short tandem repeat PCR (STR-PCR) is the prevailing method, followed by quantitative real-time PCR (qPCR), with detection limits of 1–5% and 0.1%, respectively. Chimerism assays using digital PCR or next-generation sequencing, both of which are more sensitive than STR-PCR, are increasingly used. Stable mixed chimerism is usually not associated with poor outcomes in non-malignant diseases, but recipient chimerism may foretell relapse of hematologic malignancies, so higher detection sensitivity may be beneficial in such cases. Thus, the need for and the type of intervention, e.g., immunosuppression regimen, donor lymphocyte infusion, and/or salvage second transplantation, should be guided by donor chimerism in the context of the feature and/or residual malignant cells of the disease to be treated. Full article

The COVID-19 pandemic has accelerated the integration of online learning into primary and secondary education. However, gaps persist in academic research, particularly in understanding its impact on educational equity within the third-type digital divide. This study conducted an equity-focused review to assess online learning’s impact on primary and secondary education within this context. It developed a theoretical framework integrating elements from schooling and home environments to explore equity implications in online learning. Building on this, the study proposed and validated a conceptual model using structural equation modeling (SEM), analyzing data from 1236 students in Shenzhen, China. The study found that both school investment and family involvement indirectly influence students’ online learning outcomes through complete mediating effects on students’ online learning engagement. Family investment slightly outweighs school education in its influence on outcomes. Consequently, online education within the environmental divide potentially hinders educational equity, necessitating caution with large-scale online education initiatives. This study fills research gaps on the digital divide in the third environment, leveraging China’s pandemic experience with online education. It also integrates school education and family input to examine the impact of large-scale online learning and its associated strategies on educational equity, providing insights into the promotion of educational equity. Full article

Pain is a multifaceted, multisystem disorder that adversely affects neuro-psychological processes. This study compares the effectiveness of central stimulation (transcranial direct current stimulation—tDCS over F3/F4) and peripheral stimulation (transcutaneous electrical nerve stimulation—TENS over the median nerve) in pain inhibition during a cognitive task in healthy volunteers and to observe potential neuro-cognitive improvements. Eighty healthy participants underwent a comprehensive experimental protocol, including cognitive assessments, the Cold Pressor Test (CPT) for pain induction, and tDCS/TENS administration. EEG recordings were conducted pre- and post-intervention across all conditions. The protocol for this study was categorized into four groups: G1 (control), G2 (TENS), G3 (anodal-tDCS), and G4 (cathodal-tDCS). Paired t-tests (p < 0.05) were conducted to compare Pre-Stage, Post-Stage, and neuromodulation conditions, with t-values providing insights into effect magnitudes. The result showed a reduction in pain intensity with TENS (p = 0.002, t-value = −5.34) and cathodal-tDCS (p = 0.023, t-value = −5.08) and increased pain tolerance with TENS (p = 0.009, t-value = 4.98) and cathodal-tDCS (p = 0.001, t-value = 5.78). Anodal-tDCS (p = 0.041, t-value = 4.86) improved cognitive performance. The EEG analysis revealed distinct neural oscillatory patterns across the groups. Specifically, G2 and G4 showed delta-power reductions, while G3 observed an increase. Moreover, G2 exhibited increased theta-power in the occipital region during CPT and Post-Stages. In the alpha-band, G2, G3, and G4 had reductions Post-Stage, while G1 and G3 increased. Additionally, beta-power increased in the frontal region for G2 and G3, contrasting with a reduction in G4. Furthermore, gamma-power globally increased during CPT1, with G1, G2, and G3 showing reductions Post-Stage, while G4 displayed a global decrease. The findings confirm the efficacy of TENS and tDCS as possible non-drug therapeutic alternatives for cognition with alleviation from pain. Full article

Common bean production is constrained by a multitude of biotic constraints including bean flies and Fusarium wilt in tropical and subtropical farming systems globally. As these pests and diseases attack the crop beneath the soil, excessive applications of synthetic pesticides are frequently used for their control. The use of plant-based pesticides could be a more sustainable management approach; however, few studies have investigated their application for controlling soil-borne pests and diseases. This study aimed to evaluate the efficacy of pesticidal plants and soil fertility management for controlling bean fly (Ophiomyia spp.) and Fusarium wilt (Fusarium spp.) using extracts and pastes of Azadirachta indica, Tephrosia vogelii, Tagetes minuta, Lippia javanica, Cymbopogon citratus and Ocimum gratissimum. To protect against Fusarium wilt and bean fly, pesticidal plants were applied as a seed coating and/or foliar spray, and demonstrated that common bean seeds coated with T. vogelii resulted in higher yields than other pesticidal plants and the synthetic pesticide control treatment. Treatments to target bean fly damage showed no significant difference between application methods on the oviposition rate of bean fly. An integrated treatment of T. minuta with 2 g Diammonium phosphate fertilizer and high compost led to higher yields than other treatments. Our results indicate that key soil-borne pests and pathogens of common bean can be effectively managed without synthetic pesticide inputs, while seed ball pastes of pesticidal plants combined with soil fertility management can increase crop yields using cost-beneficial agroecological farming systems. Full article