The 2023 MDPI Annual Report has
been released!
 
9 pages, 489 KiB  
Article
Detection of KPC-216, a Novel KPC-3 Variant, in a Clinical Isolate of Klebsiella pneumoniae ST101 Co-Resistant to Ceftazidime-Avibactam and Cefiderocol
by Maria Giufrè, Giulia Errico, Maria Del Grosso, Michela Pagnotta, Bernardetta Palazzotti, Milva Ballardini, Annalisa Pantosti, Marcello Meledandri and Monica Monaco
Antibiotics 2024, 13(6), 507; https://doi.org/10.3390/antibiotics13060507 (registering DOI) - 29 May 2024
Abstract
Background: Carbapenemase-producing Klebsiella pneumoniae (CP-KP) represents a global threat to public health, with limited antimicrobial therapeutic options. In this study, we analyzed a ceftazidime/avibactam (CAZ-AVI)-resistant K. pneumoniae isolate obtained from a patient previously exposed to CAZ-AVI expressing a novel K. pneumoniae carbapenemase (KPC)-3 [...] Read more.
Background: Carbapenemase-producing Klebsiella pneumoniae (CP-KP) represents a global threat to public health, with limited antimicrobial therapeutic options. In this study, we analyzed a ceftazidime/avibactam (CAZ-AVI)-resistant K. pneumoniae isolate obtained from a patient previously exposed to CAZ-AVI expressing a novel K. pneumoniae carbapenemase (KPC)-3 variant. Methods: Antimicrobial susceptibility testing was performed using reference broth microdilution. Whole-genome sequencing (WGS) was performed using Illumina and Nanopore Technologies. Short- and long-reads were combined with Unicycler. Assemblies were investigated for multilocus sequence typing (MLST), antimicrobial resistance genes, porins, and plasmids. Results: The K. pneumoniae isolate (KP_RM_1) was resistant to CAZ-AVI, expanded-spectrum cephalosporins, amikacin, ertapenem, and cefiderocol (FDC) but was susceptible to tigecycline, colistin, trimethoprim/sulfamethoxazole, meropenem–vaborbactam, and imipenem–relebactam. WGS revealed that the KP_RM_1 genome is composed of a single chromosome of 5 Mbp and five circular plasmids. Further analysis showed the presence of novel blaKPC-216 located on a 72 kb plasmid. KPC-216 differs from KPC-3 by a Lysin (K) insertion at position 168 (+K168). Conclusions: We report the identification of a new KPC-3 variant associated with CAZ-AVI resistance. The KPC variants associated with CAZ-AVI resistance should be determined to promptly inform clinicians and start the appropriate antimicrobial therapy. Full article
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13 pages, 4860 KiB  
Article
Development of Macro-Encapsulated Phase-Change Material Using Composite of NaCl-Al2O3 with Characteristics of Self-Standing
by Shenghao Liao, Xin Zhou, Xiaoyu Chen, Zhuoyu Li, Seiji Yamashita, Chaoyang Zhang and Hideki Kita
Processes 2024, 12(6), 1123; https://doi.org/10.3390/pr12061123 (registering DOI) - 29 May 2024
Abstract
Developing thermal storage materials is crucial for the efficient recovery of thermal energy. Salt-based phase-change materials have been widely studied. Despite their high thermal storage density and low cost, they still face issues such as low thermal conductivity and easy leaks. Therefore, a [...] Read more.
Developing thermal storage materials is crucial for the efficient recovery of thermal energy. Salt-based phase-change materials have been widely studied. Despite their high thermal storage density and low cost, they still face issues such as low thermal conductivity and easy leaks. Therefore, a new type of NaCl-Al2O3@SiC@Al2O3 macrocapsule was developed to address these drawbacks, and it exhibited excellent rapid heat storage and release capabilities and was extremely stable, significantly reducing the risk of leakage at high temperatures for industrial waste heat recovery and in concentrated solar power systems above 800 °C. Thermal storage macrocapsules consisted of a double-layer encapsulation of silicon carbide and alumina and a self-standing core of NaCl-Al2O3. After enduring over 1000 h at a high temperature of 850 °C, the encapsulated phase-change material exhibited an extremely low weight loss rate of less than 5% compared with NaCl@Al2O3 and NaCl-Al2O3@Al2O3 macrocapsules, for which the weight loss rate was reduced by 25% and 10%, respectively, proving their excellent leakage prevention. The SiC powder layer, serving as an intermediate coating, further prevented leakage, while the use of Al2O3 ceramics for encapsulation enhanced the overall mechanical strength. It was innovatively discovered that the Al2O3 particles formed a network structure around the molten NaCl, playing an important role in maintaining the shape and preventing leakage of the composite thermal storage phase-change material. Furthermore, the addition of Al2O3 significantly enhanced the rapid heat storage and release rate of NaCl-Al2O3 compared to pure NaCl. This encapsulated phase-change material demonstrated outstanding durability and rapid heat storage and release performance, offering an innovative approach to the application of salt phase-change materials in the field of high temperature rapid heat storage and release and encapsulating NaCl as a high-temperature thermal storage material in a packed bed system. Compared with conventional salt-based phase-change materials, the developed product is expected to significantly improve the reliability and thermal efficiency of thermal storage systems. Full article
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15 pages, 1004 KiB  
Article
Enhancing Structural Capacity Assessment with a Novel Failure Decision Function for Rectangular Reinforced Concrete Columns
by Petros Christou, Marios Charalambides, Demetris Nicolaides and Georgios Xekalakis
Inventions 2024, 9(3), 63; https://doi.org/10.3390/inventions9030063 (registering DOI) - 29 May 2024
Abstract
This study introduces the Failure Decision Function, a novel approach for evaluating the structural capacity of rectangular reinforced concrete columns under axial forces and moments, both uniaxial and biaxial. The method simplifies existing practices, enhancing accuracy and integration into design software. The methodology [...] Read more.
This study introduces the Failure Decision Function, a novel approach for evaluating the structural capacity of rectangular reinforced concrete columns under axial forces and moments, both uniaxial and biaxial. The method simplifies existing practices, enhancing accuracy and integration into design software. The methodology hinges on deriving exact biaxial bending failure surfaces, utilizing integral expressions based on material properties and cross-sectional geometry. This direct integration process uncovers failure surface characteristics previously undocumented. Results confirm the utility of the Failure Decision Function through comparative analysis with established literature, showcasing its potential for simplifying and improving structural capacity assessments. The analytic procedure developed enables efficient computation of failure surfaces, streamlining the inclusion of these functions in structural engineering software in two key ways: (1) compiling a library of pre-calculated functions for quick capacity checks and (2) creating a dynamic application that generates these functions based on specific design parameters, allowing users to explore various load and moment scenarios. In conclusion, the Failure Decision Function represents a significant advancement in structural engineering design, offering an accurate and user-friendly method for assessing column performance under critical loading conditions. Full article
21 pages, 639 KiB  
Article
A High-Performance Non-Indexed Text Search System
by Binh Kieu-Do-Nguyen, Tuan-Kiet Dang, Nguyen The Binh, Cuong Pham-Quoc, Huynh Phuc Nghi, Ngoc-Thinh Tran, Katsumi Inoue, Cong-Kha Pham and Trong-Thuc Hoang
Electronics 2024, 13(11), 2125; https://doi.org/10.3390/electronics13112125 (registering DOI) - 29 May 2024
Abstract
Full-text search has a wide range of applications, including tracking systems, computer vision, and natural language processing. Standard methods usually implement a two-phase procedure: indexing and retrieving, with the retrieval performance entirely dependent on the index efficiency. In most cases, the more powerful [...] Read more.
Full-text search has a wide range of applications, including tracking systems, computer vision, and natural language processing. Standard methods usually implement a two-phase procedure: indexing and retrieving, with the retrieval performance entirely dependent on the index efficiency. In most cases, the more powerful the index algorithm, the more memory and processing time are required. The amount of time and memory required to index a collection of documents is proportional to its overall size. In this paper, we propose a full-text search hardware implementation without the indexing phase, thus removing the time and memory requirements for indexing. Additionally, we propose an efficient design to leverage the parallel architecture of High Bandwidth Memory (HBM). To our knowledge, few (if not zero) researchers have integrated their full-text search system with an effective data access control on HBM. The functionality of the proposed system is verified on the Xilinx Alveo U50 Field-Programmable Gate Array (FPGA). The experimental results show that our system achieved a throughput of 8 Gigabytes per second, about 6697× speed-up compared to other software-based approaches. Full article
(This article belongs to the Section Microelectronics)
11 pages, 824 KiB  
Article
Effectiveness of Erythrocyte Morphology Observation as an Indicator for the Selection and Qualification of Blood in a Mechanically Induced Hemolysis Test
by Jeonghwa Kim, Taeho Kim, Sekyung Kim, Joonho Eom and Taewon Kim
Appl. Sci. 2024, 14(11), 4695; https://doi.org/10.3390/app14114695 (registering DOI) - 29 May 2024
Abstract
Background: This study was conducted to confirm the reliability of an in vitro mechanically induced hemolysis test (ISO 10993-4:2017), which is essential for ensuring the safety of blood pumps. Methods: For appropriate anticoagulant selection, porcine blood was prepared in anticoagulant citrate dextrose solution [...] Read more.
Background: This study was conducted to confirm the reliability of an in vitro mechanically induced hemolysis test (ISO 10993-4:2017), which is essential for ensuring the safety of blood pumps. Methods: For appropriate anticoagulant selection, porcine blood was prepared in anticoagulant citrate dextrose solution A (ACD-A), heparin, and citrate phosphate dextrose adenine (CPDA-1), respectively, according to the ASTM F1830 standard. Anticoagulant-treated porcine and bovine blood were circulated in a mock circulatory loop (MCL) for 6 h to observe the rate of plasma-free hemoglobin (pfHb) and RBCs with morphological integrity. Results: A morphological loss of red blood cells (RBCs) was observed over time. While there were differences in morphological loss depending on the anticoagulant, no consistent trend could be identified. The pfHb concentration was significantly higher in bovine than in porcine blood. Conversely, the number of RBCs with morphological integrity decreased over time in both, but the ratio of RBCs with morphological integrity was similar across all timepoints. Conclusions: The percentage of RBCs with morphological integrity can be used as a reliable indicator for the interpretation of mechanically induced hemolysis results in different blood types. Furthermore, the reliability of the in vitro mechanically induced hemolysis test (ISO 10993-4:2017) was assessed. Full article
12 pages, 1113 KiB  
Article
Concentration of Microparticles/Cells Based on an Ultra-Fast Centrifuge Virtual Tunnel Driven by a Novel Lamb Wave Resonator Array
by Wei Wei, Zhaoxun Wang, Bingnan Wang, Wei Pang, Qingrui Yang and Xuexin Duan
Biosensors 2024, 14(6), 280; https://doi.org/10.3390/bios14060280 (registering DOI) - 29 May 2024
Abstract
The µTAS/LOC, a highly integrated microsystem, consolidates multiple bioanalytical functions within a single chip, enhancing efficiency and precision in bioanalysis and biomedical operations. Microfluidic centrifugation, a key component of LOC devices, enables rapid capture and enrichment of tiny objects in samples, improving sensitivity [...] Read more.
The µTAS/LOC, a highly integrated microsystem, consolidates multiple bioanalytical functions within a single chip, enhancing efficiency and precision in bioanalysis and biomedical operations. Microfluidic centrifugation, a key component of LOC devices, enables rapid capture and enrichment of tiny objects in samples, improving sensitivity and accuracy of detection and diagnosis. However, microfluidic systems face challenges due to viscosity dominance and difficulty in vortex formation. Acoustic-based centrifugation, particularly those using surface acoustic waves (SAWs), have shown promise in applications such as particle concentration, separation, and droplet mixing. However, challenges include accurate droplet placement, energy loss from off-axis positioning, and limited energy transfer from low-frequency SAW resonators, restricting centrifugal speed and sample volume. In this work, we introduce a novel ring array composed of eight Lamb wave resonators (LWRs), forming an Ultra-Fast Centrifuge Tunnel (UFCT) in a microfluidic system. The UFCT eliminates secondary vortices, concentrating energy in the main vortex and maximizing acoustic-to-streaming energy conversion. It enables ultra-fast centrifugation with a larger liquid capacity (50 μL), reduced power usage (50 mW) that is one order of magnitude smaller than existing devices, and greater linear speed (62 mm/s), surpassing the limitations of prior methods. We demonstrate successful high-fold enrichment of 2 μm and 10 μm particles and explore the UFCT’s potential in tissue engineering by encapsulating cells in a hydrogel-based micro-organ with a ring structure, which is of great significance for building more complex manipulation platforms for particles and cells in a bio-compatible and contactless manner. Full article
(This article belongs to the Special Issue Application of Microfluidics in Cell Manipulation and Biosensing)
22 pages, 2529 KiB  
Article
Harnessing the Cloud: A Novel Approach to Smart Solar Plant Monitoring
by Mohammad Imran Ali, Shahi Dost, Khurram Shehzad Khattak, Muhammad Imran Khan and Riaz Muhammad
Future Internet 2024, 16(6), 191; https://doi.org/10.3390/fi16060191 (registering DOI) - 29 May 2024
Abstract
Renewable Energy Sources (RESs) such as hydro, wind, and solar are merging as preferred alternatives to fossil fuels. Among these RESs, solar energy is the most ideal solution; it is gaining extensive interest around the globe. However, due to solar energy’s intermittent nature [...] Read more.
Renewable Energy Sources (RESs) such as hydro, wind, and solar are merging as preferred alternatives to fossil fuels. Among these RESs, solar energy is the most ideal solution; it is gaining extensive interest around the globe. However, due to solar energy’s intermittent nature and sensitivity to environmental parameters (e.g., irradiance, dust, temperature, aging and humidity), real-time solar plant monitoring is imperative. This paper’s contribution is to compare and analyze current IoT trends and propose future research directions. As a result, this will be instrumental in the development of low-cost, real-time, scalable, reliable, and power-optimized solar plant monitoring systems. In this work, a comparative analysis has been performed on proposed solutions using the existing literature. This comparative analysis has been conducted considering five aspects: computer boards, sensors, communication, servers, and architectural paradigms. IoT architectural paradigms employed have been summarized and discussed with respect to communication, application layers, and storage capabilities. To facilitate enhanced IoT-based solar monitoring, an edge computing paradigm has been proposed. Suggestions are presented for the fabrication of edge devices and nodes using optimum compute boards, sensors, and communication modules. Different cloud platforms have been explored, and it was concluded that the public cloud platform Amazon Web Services is the ideal solution. Artificial intelligence-based techniques, methods, and outcomes are presented, which can help in the monitoring, analysis, and management of solar PV systems. As an outcome, this paper can be used to help researchers and academics develop low-cost, real-time, effective, scalable, and reliable solar monitoring systems. Full article
(This article belongs to the Section Internet of Things)
13 pages, 3181 KiB  
Article
Effects of Exogenous Brassinosteroid and Reduced Leaf Source on Source–Sink Relationships and Boll Setting in Xinjiang Cotton
by Shanwei Lou, Hui Jiang, Jie Li, Liwen Tian, Mingwei Du, Tengfei Ma, Lizhen Zhang and Pengzhong Zhang
Agronomy 2024, 14(6), 1168; https://doi.org/10.3390/agronomy14061168 (registering DOI) - 29 May 2024
Abstract
Xinjiang cotton is characterized by high-density planting, which easily leads to competition between the source and sink, the shading of leaves and reproductive organs, and yield reduction. Balancing the relationship between source and sink can promote high and stable cotton yield. In this [...] Read more.
Xinjiang cotton is characterized by high-density planting, which easily leads to competition between the source and sink, the shading of leaves and reproductive organs, and yield reduction. Balancing the relationship between source and sink can promote high and stable cotton yield. In this study, field experiments were conducted by combining the exogenous application of brassinosteroid with a reduction in leaf source to study their effects on the physiological and yield attributes of cotton. The results indicate that brassinosteroid application increased the yield, with a maximum yield increase of 6.3%. The number of bolls per plant increased by 1.3 nos. The photosynthetic rate and dry matter accumulation were enhanced, and the proportion of reproductive organs in the dry matter increased by >4%. Under the reduced leaf source, brassinosteroid application increased the number of new leaves by 20%, delayed the shedding of reproductive organs by 5–10 days, and reduced the average shedding rate by 8.9%. Additionally, the number of bolls increased in the middle and upper parts and at the edge of the plant. The number of bolls increased by 19.4% on the 4th–8th fruiting branches and 60.7% at the edge. Under leaf reduction treatment, brassinosteroid application could generally increase yield. After brassinosteroid application and removing half the leaves of fruiting branches and all leaves of the vegetive branches, the yield was higher than that of the control. Thus, brassinosteroid application could improve the efficiency of the leaf source and promote dry matter accumulation in sinks. Moreover, it could optimize boll distribution and increase yield by reducing reproductive organ shedding. Under the high-density planting of cotton in Xinjiang, leaf source is a slight surplus, and a moderate reduction in plant density is conducive to increasing yield. Full article
(This article belongs to the Section Agroecology Innovation: Achieving System Resilience)
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19 pages, 469 KiB  
Article
Core Legal Challenges for Medical 3D Printing in the EU
by Ante B. V. Pettersson, Rosa Maria Ballardini, Marc Mimler, Phoebe Li, Mika Salmi, Timo Minssen, Ian Gibson and Antti Mäkitie
Healthcare 2024, 12(11), 1114; https://doi.org/10.3390/healthcare12111114 (registering DOI) - 29 May 2024
Abstract
3D printing has been adopted into routine use for certain medical applications, but more widespread usage has been hindered by, among other things, unclear legislation. We performed an analysis, using legal doctrinal study and legal informatics, of relevant EU legislation and case law [...] Read more.
3D printing has been adopted into routine use for certain medical applications, but more widespread usage has been hindered by, among other things, unclear legislation. We performed an analysis, using legal doctrinal study and legal informatics, of relevant EU legislation and case law in four issues relevant to medical 3D printing (excluding bioprinting or pharmacoprinting): pre-market approval, post-market liability, intellectual property rights, and data protection. Several gaps and uncertainties in the current legislation and interpretations were identified. In particular, we regard the current EU regulatory framework to be quite limiting and inflexible, exemplifying a cautionary approach common in EU law. Though the need to establish high safety standards in order to protect patients as a disadvantaged population is understood, both legal uncertainties and overregulation are seen as harmful to innovation. Hence, more adaptive legislation is called for to ensure continuous innovation efforts and enhanced patient outcomes. Full article
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19 pages, 515 KiB  
Article
Factors Affecting the Waste of Selected Agricultural Products with an Emphasis on the Marketing Mix
by Mehdi Mahmoudi, Hosein Mohammadi, Sayed Saghaian and Alireza Karbasi
Agriculture 2024, 14(6), 857; https://doi.org/10.3390/agriculture14060857 (registering DOI) - 29 May 2024
Abstract
Unusual levels of agricultural product waste are becoming one of the issues and dangers that human societies face in their efforts to achieve food security. Therefore, reducing agricultural product waste is one of the main strategies for the optimal use of production resources [...] Read more.
Unusual levels of agricultural product waste are becoming one of the issues and dangers that human societies face in their efforts to achieve food security. Therefore, reducing agricultural product waste is one of the main strategies for the optimal use of production resources and support food security. In this study, a multilevel Bayesian technique was used to examine the characteristics of customers and the effects of marketing mix on the waste of selected agricultural products—a subgroup of fruits and vegetables in Mashhad, Iran. Based on this, 368 consumers (at the first level), 53 fruit and vegetable markets (at the second level), and 3 main supply centers of fruit and vegetables in the city (at the third level) were evaluated using the Bayesian multilevel model. The results showed that approximately 56% of food waste variance was caused by differences between consumers, 29% is due to the differences between fruit and vegetable markets, and almost 14% is due to the differences between the main supply centers of Mashhad. Also, the effects of the marketing mix showed that the place of distribution of agricultural products always has an increasing effect on the waste of agricultural products. Moreover, increasing the price of agricultural products reduces waste by consumers and keeps the consumer away from unnecessary purchases. The product factor also has an increasing effect on the waste of agricultural products, and consumers are encouraged to consume more and create more waste. A good way to reduce agricultural product waste is to use solutions that slow down the spoilage process and extend the shelf life of fruit and vegetables. Using an appropriate marketing mix and considering the characteristics of consumers can also control the waste of agricultural products. Full article
(This article belongs to the Section Agricultural Economics, Policies and Rural Management)
13 pages, 929 KiB  
Article
Assessment of Vitamin Concentrations in Patients with Hashimoto’s Thyroiditis and Their Relationships with Thyroid Function, Biochemical Status, and Anthropometric Parameters—A Preliminary Study
by Aniceta Ada Mikulska-Sauermann, Matylda Resztak, Marta Karaźniewicz-Łada, Dorota Filipowicz, Marek Ruchała and Franciszek K. Główka
Nutrients 2024, 16(11), 1694; https://doi.org/10.3390/nu16111694 (registering DOI) - 29 May 2024
Abstract
Hashimoto’s thyroiditis (HT) is the leading cause of hypothyroidism, affecting mainly the female population. Many patients with HT have metabolic disorders and nutritional deficiencies. The aim of this study was to evaluate vitamin D, A, E, B2, and B6 concentrations, thyroid function, metabolic [...] Read more.
Hashimoto’s thyroiditis (HT) is the leading cause of hypothyroidism, affecting mainly the female population. Many patients with HT have metabolic disorders and nutritional deficiencies. The aim of this study was to evaluate vitamin D, A, E, B2, and B6 concentrations, thyroid function, metabolic profile, and anthropometric parameters of patients with Hashimoto’s thyroiditis. In 81 female patients with HT (study group), vitamin A and B2 concentrations were significantly lower than in 34 healthy women (control group). No differences were noted in vitamin D, E, and B6 concentrations between groups. Moreover, HT patients had similar anthropometric parameters, lipid profiles, and glucose and insulin concentrations compared to controls. This study showed some relationships between vitamin concentrations and anthropometric or biochemical profiles in HT patients. Among others, in the HT group, the concentration of vitamin D was positively correlated with the level of HDL and negatively correlated with BMI, total fat mass, and insulin level, which influence cardiovascular risk. The results indicate that patients with HT should be routinely tested for vitamin concentrations to prevent nutritional deficiencies. Further studies are also needed on the role of vitamins in the development and progression of HT and the presence of metabolic complications in this population. Full article
(This article belongs to the Special Issue The Role of Natural Compounds in Autoimmune Diseases)
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15 pages, 900 KiB  
Review
Meta-Analysis of Internet Gaming Disorder Prevalence: Assessing the Impacts of DSM-5 and ICD-11 Diagnostic Criteria
by Ruoyu Zhou, Nobuaki Morita, Yasukazu Ogai, Tamaki Saito, Xinyue Zhang, Wenjie Yang and Fan Yang
Int. J. Environ. Res. Public Health 2024, 21(6), 700; https://doi.org/10.3390/ijerph21060700 (registering DOI) - 29 May 2024
Abstract
With the inclusion of Internet gaming disorder (IGD) in both the DSM-5 and ICD-11, understanding the prevalence and diagnostic discrepancies is crucial for developing appropriate interventions. This study presents a meta-analysis of the prevalence of IGD based on two diagnostic criteria. We systematically [...] Read more.
With the inclusion of Internet gaming disorder (IGD) in both the DSM-5 and ICD-11, understanding the prevalence and diagnostic discrepancies is crucial for developing appropriate interventions. This study presents a meta-analysis of the prevalence of IGD based on two diagnostic criteria. We systematically searched the PubMed and Web of Science databases. A total of 22 studies were included in the final analysis. The analysis incorporated studies employing the DSM-5 and ICD-11 criteria and focused on the impact of various factors, including study location, sample characteristics, sample size, and quality score, on the reported prevalence rates using a random-effects model. The pooled prevalence of IGD is 6.7% (95% CI: 5.7–7.7%). The subgroup analysis indicated significant differences in the prevalence rates of IGD (DSM-5 criteria) and GD (ICD-11 criteria) (Q b = 38.46, p < 0.01). There were also significant differences in IGD prevalence rates between different scales (Q b = 54.23, p < 0.001). Our findings indicate that different diagnostic criteria and different assessment scales have a significant impact on the prevalence of IGD. This underscores the importance of adopting standardized methodologies to guide public health interventions. However, given the limited research based on ICD-11 diagnostic criteria, further investigation is necessary to determine the variations in prevalence rates of IGD under different diagnostic standards. Full article
(This article belongs to the Section Behavioral and Mental Health)
10 pages, 611 KiB  
Article
Vitamin D Deficiency in Professional Football Players during Competitive Season of Italian First Division (Serie A)
by Marco Alfonso Perrone, Massimo Pieri, Giuseppe Caminiti, Wahid Ali, Sergio Bernardini, Attilio Parisi, Ferdinando Iellamo, Rosario Barone and Pasquale Farsetti
Sports 2024, 12(6), 153; https://doi.org/10.3390/sports12060153 (registering DOI) - 29 May 2024
Abstract
Background: Data in the literature have demonstrated the crucial role that vitamin D plays in the human organism, and recent studies also emphasize this essential role of vitamin D in athletes. Indeed, vitamin D acts on the skeletal muscles and plays a fundamental [...] Read more.
Background: Data in the literature have demonstrated the crucial role that vitamin D plays in the human organism, and recent studies also emphasize this essential role of vitamin D in athletes. Indeed, vitamin D acts on the skeletal muscles and plays a fundamental role in numerous physiological processes involved in immune function. Many factors such as sun exposure, skin tone, body mass index and chronic illness affect vitamin D levels. The aim of the study is to evaluate vitamin D levels in professional football players in Italy and investigate the variations in vitamin D values in footballers who train at different latitudes. Methods: The study performed is a retrospective observational study analyzing 25-OH vitamin D values in professional football players of the Italian First Division (Serie A). Two teams during the competitive season were selected: team A (latitude of 41° N in southern Italy) and team B (latitude of 45° N in northern Italy). Three time periods were identified and were classified as follows: the first quarter (May, June, July, and August), the second quarter (September, October, November, and December) and the third quarter (January, February, March, and April). The purpose of this was to study the average values of vitamin D during the year corresponding to different levels of sunlight exposure. Each athlete was subjected to at least one sampling during the three quarters of the competitive season. Results: Both vitamin D insufficiency (10.1%) and overt deficiency (1.93%) were found in Italian Serie A players. Insufficient vitamin D values are between 20 ng/mL and 29 ng/mL and overt deficiency values <20 ng/mL. At the same time, the data demonstrated a significant variation in vitamin D values depending on the period of the competitive season and the latitude of the cities of the two teams. In detail, there was no significant difference in the first quarter, while there was a significant increase in vitamin D values in team B in the second and third quarter, at p < 0.01 and p < 0.05, respectively. Conclusions: Latitude and seasons have a significant impact on vitamin D levels. Therefore, it is essential to measure vitamin D in professional football players, especially during the spring and winter months, so as to monitor changes in levels in relation to the season and latitude and evaluate any supplements. Further studies should be performed to evaluate the relationship between vitamin D deficiency and football players’ athletic performance. Full article
13 pages, 1225 KiB  
Article
Impact of Multiple Grid-Connected Solar PV Inverters on Harmonics in the High-Frequency Range
by Kasun Peiris, Sean Elphick, Jason David and Duane Robinson
Energies 2024, 17(11), 2639; https://doi.org/10.3390/en17112639 (registering DOI) - 29 May 2024
Abstract
In recent years, integration of solar photovoltaic (PV) systems into distribution networks has been increasing rapidly, as it has become the most promising renewable energy source (RES) in the transition of power generation from centralised to decentralised systems. With the power electronic (PE) [...] Read more.
In recent years, integration of solar photovoltaic (PV) systems into distribution networks has been increasing rapidly, as it has become the most promising renewable energy source (RES) in the transition of power generation from centralised to decentralised systems. With the power electronic (PE) interfaces that use high-frequency internal switching, all renewable energy sources are considered to be harmonic emitters, especially near switching frequencies, i.e., above 2 kHz. This paper evaluates the behaviour of high-frequency harmonics in the 2–20 kHz range due to the parallel operation of multiple solar PV inverters connected to a low-voltage (LV) network. The circulation current component that flows within the installation due to the low impedance paths at higher frequencies is analysed. Summation of high-frequency harmonic currents is observed with phase diversity analysis. The circulating current component can become 14 times higher than the grid current component at higher frequencies. Full article
10 pages, 871 KiB  
Article
First Broad-Range Serological Survey of Crimean–Congo Hemorrhagic Fever among Hungarian Livestock
by Nóra Deézsi-Magyar, Béla Dénes, Bereniké Novák, Gyula Zsidei, Dániel Déri, Judit Henczkó, Bernadett Pályi and Zoltán Kis
Viruses 2024, 16(6), 875; https://doi.org/10.3390/v16060875 (registering DOI) - 29 May 2024
Abstract
(1) Background: Crimean–Congo hemorrhagic fever (CCHF) is an emerging tick-borne disease endemic in Africa, Asia, the Middle East, and the Balkan and Mediterranean regions of Europe. Although no human CCHF cases have been reported, based on vector presence, serological evidence among small vertebrates, [...] Read more.
(1) Background: Crimean–Congo hemorrhagic fever (CCHF) is an emerging tick-borne disease endemic in Africa, Asia, the Middle East, and the Balkan and Mediterranean regions of Europe. Although no human CCHF cases have been reported, based on vector presence, serological evidence among small vertebrates, and the general human population, Hungary lies within high evidence consensus for potential CCHF introduction and future human infection. Thus, the aim of our pilot serosurvey was to assess CCHF seropositivity among cattle and sheep as indicator animals for virus circulation in the country. (2) Methods: In total, 1905 serum samples taken from free-range cattle and sheep in 2017 were tested for the presence of anti-CCHF virus IgG antibodies using commercial ELISA and commercial and in-house immunofluorescent assays. (3) Results: We found a total of eleven reactive samples (0.58%) from five administrative districts of Hungary comprising 8 cattle and 3 sheep. The most affected regions were the south–central and northwestern parts of the country. (4) Conclusions: Based on these results, more extended surveillance is advised, especially in the affected areas, and there should be greater awareness among clinicians and other high-risk populations of the emerging threat of CCHF in Hungary and Central Europe. Full article
(This article belongs to the Special Issue Tick-Borne Viruses: Transmission and Surveillance)
12 pages, 226 KiB  
Review
Global Initiative for Children’s Surgery (GICS) Pediatric Trauma Care Initiative: A Call for a Comprehensive Approach to a Global Problem
by Abdelbasit E. Ali, Adesoji Ademuyiwa, Simone Abib, Charles Carapinha, Fazal Nouman Wahid, Udo Rolle and Kokila Lakhoo
Children 2024, 11(6), 666; https://doi.org/10.3390/children11060666 (registering DOI) - 29 May 2024
Abstract
Introduction: Trauma is a major problem which has a significant health, social, and economic impact. Particularly, pediatric trauma carries substantial mortality and morbidity. This is a great concern for subspecialized general and pediatric surgeons. Therefore, a global initiative for pediatric trauma care is [...] Read more.
Introduction: Trauma is a major problem which has a significant health, social, and economic impact. Particularly, pediatric trauma carries substantial mortality and morbidity. This is a great concern for subspecialized general and pediatric surgeons. Therefore, a global initiative for pediatric trauma care is warranted and should be initiated. Aim: The international association “Global Initiative for Children’s Surgery” (GICS) would like to propose and organize a children’s trauma care (CTC) initiative. This initiative should comprehensively address pediatric trauma management globally, especially in low- and middle-income countries (LMICs). The initiative seeks to achieve a structured cooperation and collaboration with respective sister organizations and local stakeholders. Methods: The initiative will address these relevant aspects: 1. first aid; 2. prehospital primary trauma care; 3. hospital primary trauma care; 4. advanced care (ATLS); 5. diagnostic facilities; 6. operation room (OR) equipment; 7. specialized surgical services; 8. rehabilitation; 9. registry, research, and auditing; 10. specialization in pediatric trauma; 11. capacity and confidence building in pediatric trauma; 12. prevention. The GICS CTC provided activities have been recorded and evaluated in a structured manner. This statement paper is based on data of a narrative review as well as expert opinions. Results: The Trauma Working Group of GICS provided specialized trauma prevention leaflets available for translation to different languages. A one-day children’s primary trauma course has been designed to be delivered at the physical GICS meetings. Exercising advocacy, the group addressed several meetings on prevention of pediatric trauma, which included the 75th United Nations General Assembly (UNGA) (2020), GICS IVth meeting in Johannesburg (2020), Norwich (UK) Joint SPRINT Symposium on Pediatric Surgery for Pediatricians (2021), the second online Pan African Pediatric Surgical Association (PAPSA) meeting (2021), the seventh World Congress of the World Federation of Associations of Pediatric Surgeons (WOFAPS) in Prague (2022), and GICS pediatric trauma webinar (2023). Additionally, the working group participated in the preparations of a pediatric trauma module for the World Health Organization (WHO) and published several related studies. The contents of the selected articles added relevant information to the categories stated above. Conclusions: The CTC initiative of GICS is proposed as a mean to address pediatric trauma comprehensively through a process of collaboration and advocacy with existing organizations to achieve awareness, health education, prevention, health, and training. Further, it will support the provision of suitable facilities to health institutions. The establishment of a specialization in pediatric trauma is encouraged. GICS CTC initiative aims to improve pediatric trauma care in LMICs by developing injury prevention strategies; optimizing the use of locally available resources; obtaining commitment by LMICs governments; improvement in all fields of hospital care; improvements in infrastructure, education and training, and attention to data registry and research. Full article
(This article belongs to the Section Pediatric Surgery)
14 pages, 983 KiB  
Article
Extraction of Geolocations from Site Maps in the Context of Traffic Counting
by Johannes Schering, Pascal Säfken and Jorge Marx Gómez
Sustainability 2024, 16(11), 4631; https://doi.org/10.3390/su16114631 (registering DOI) - 29 May 2024
Abstract
The further promotion of cycling is a key component for each city to reach its sustainability goals. To make decisions to improve comfort or safety for cyclists, the amount of motorized traffic should be taken into account. Therefore, traffic data play a crucial [...] Read more.
The further promotion of cycling is a key component for each city to reach its sustainability goals. To make decisions to improve comfort or safety for cyclists, the amount of motorized traffic should be taken into account. Therefore, traffic data play a crucial role not only in the construction of roads but also in cycling planning. This data source provides insights essential for road infrastructure development and optimizing various modes of transportation, such as bike paths. However, processing municipal traffic data becomes a challenge when stationary traffic-counting stations lack geo-referencing in relational databases. In this case, the locations of traffic counters are solely displayed on a PDF-based site map without inherent geo-referencing, and the geo-coordinates are not stored in any relational database. The absence of geo-references poses a significant hurdle for traffic-planning experts in decision-making processes. Hence, this study aims to address this issue by finding a suitable approach to extract the geo-coordinates from the site maps. Several potential solutions are discussed and compared in terms of time dimension, usability, extensibility, error treatment and the accuracy of results. Leveraging the open-source tool QGIS, geo-coordinates may be successfully extracted from the PDF-based site maps, resulting in the creation of a GeoTIFF file incorporating coordinates and the rotated site map. Geo-coordinates can then be derived from the GeoTIFF files using x and y coordinates, computed through the rotation matrix formula. Over 1400 measurement locations may be extracted based on the preferred approach, facilitating more informed decision-making in traffic planning. Full article
21 pages, 1191 KiB  
Review
Evolution, Current Trends, and Latest Advances of Endoscopic Spine Surgery
by Sharvari Gunjotikar, Malcolm Pestonji, Masato Tanaka, Tadashi Komatsubara, Shashank J. Ekade, Ahmed Majid Heydar and Huynh Kim Hieu
J. Clin. Med. 2024, 13(11), 3208; https://doi.org/10.3390/jcm13113208 (registering DOI) - 29 May 2024
Abstract
Background: The aging of the population in developing and developed countries has led to a significant increase in the health burden of spinal diseases. These elderly patients often have a number of medical comorbidities due to aging. The need for minimally invasive [...] Read more.
Background: The aging of the population in developing and developed countries has led to a significant increase in the health burden of spinal diseases. These elderly patients often have a number of medical comorbidities due to aging. The need for minimally invasive techniques to address spinal disorders in this elderly population group cannot be stressed enough. Minimally invasive spine surgery (MISS) has several proven benefits, such as minimal muscle trauma, minimal bony resection, lesser postoperative pain, decreased infection rate, and shorter hospital stay. Methods: A comprehensive search of the literature was performed using PubMed. Results: Over the past 40 years, constant efforts have been made to develop newer techniques of spine surgery. Endoscopic spine surgery is one such subset of MISS, which has all the benefits of modern MISS. Endoscopic spine surgery was initially limited only to the treatment of lumbar disc herniation. With improvements in optics, endoscopes, endoscopic drills and shavers, and irrigation pumps, there has been a paradigm shift. Endoscopic spine surgery can now be performed with high magnification, thus allowing its application not only to lumbar spinal stenosis but also to spinal fusion surgeries and cervical and thoracic pathology as well. There has been increasing evidence in support of these newer techniques of spine surgery. Conclusions: For this report, we studied the currently available literature and outlined the historical evolution of endoscopic spine surgery, the various endoscopic systems and techniques available, and the current applications of endoscopic techniques as an alternative to traditional spinal surgery. Full article
(This article belongs to the Special Issue Neurosurgery and Spine Surgery: From Up-to-Date Practitioners)
20 pages, 4102 KiB  
Article
Numerical and Analytical Estimation of the Wind Speed Causing Overturning of the Fast-Erecting Crane—Part II
by Marcin Augustyn and Marek Barski
Appl. Sci. 2024, 14(11), 4694; https://doi.org/10.3390/app14114694 (registering DOI) - 29 May 2024
Abstract
The currently presented work is a continuation of the previous one, where the estimation of the forces induced by the wind flow acting on the fast-erecting crane. In that work, the values of the aerodynamic forces were determined experimentally and numerically for the [...] Read more.
The currently presented work is a continuation of the previous one, where the estimation of the forces induced by the wind flow acting on the fast-erecting crane. In that work, the values of the aerodynamic forces were determined experimentally and numerically for the sectional models of the tower and jib. Next, the obtained results were compared with the appropriate standards. Now, the main aim is to determine the critical wind speed causing the overturning of the whole structure. At the very beginning, the numerical analysis of the simplified model of the crane on the real scale is studied. The computations are performed with the use of the ANSYS FLUENT R22. The simulations are performed for three different wind profiles, namely: urban terrain, village terrain, and open terrain. Moreover, the various geometric configurations of the crane in the wind direction are studied. The k-ε model of turbulent flow is exploited. The obtained critical values of the wind speed are confronted with those that are obtained from standards and estimations based on the results obtained from previous investigations performed for sectional models. The influence of the load carried by the crane is also taken into consideration in the overturning of the structure. Full article
(This article belongs to the Special Issue Structural Wind Engineering, 2nd Edition)
23 pages, 1131 KiB  
Article
Evaluating Online Security Behavior: Development and Validation of a Personal Cybersecurity Awareness Scale for University Students
by László Bognár and László Bottyán
Educ. Sci. 2024, 14(6), 588; https://doi.org/10.3390/educsci14060588 (registering DOI) - 29 May 2024
Abstract
As the digital age permeates higher education, the cybersecurity awareness of university students has emerged as a pressing concern. This study examines the behavioral factors influencing students’ cybersecurity practices, developing a robust, empirically validated survey. Our research applies a comprehensive framework employing both [...] Read more.
As the digital age permeates higher education, the cybersecurity awareness of university students has emerged as a pressing concern. This study examines the behavioral factors influencing students’ cybersecurity practices, developing a robust, empirically validated survey. Our research applies a comprehensive framework employing both exploratory and confirmatory factor analyses (EFA; CFA) to affirm the survey’s ability to capture the intricate dimensions of students’ cybersecurity awareness. A structural equation model (SEM) has been developed to delineate and scrutinize five key dimensions of cybersecurity behaviors within the student body. Post-validation, we utilized this model to conduct a thorough comparative analysis of cybersecurity behaviors among members of the varied student demographic that participated in the survey. The investigation included an examination of behavior across genders, age groups, academic disciplines, and cultural backgrounds, shedding light on the diverse cybersecurity behaviors that define the modern student experience. Our research ultimately strives to contribute to the enhancement of digital security in educational environments, aligning student online practices with robust security measures and nurturing a cybersecurity-aware culture in academia. Full article
(This article belongs to the Special Issue Cybersecurity and Online Learning in Tertiary Education)
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14 pages, 2398 KiB  
Article
Design of Ratio-Fluorescence Nanohybrid Based on Radix Hedysari Green-Synthesized CDs and GSH-AuNCs for Sensitive Detection of Cefodizime Sodium in Urine Sample
by Yan-Xin Guo, Xin-Ran Guo and Xin-Yue Chen
Int. J. Mol. Sci. 2024, 25(11), 5971; https://doi.org/10.3390/ijms25115971 (registering DOI) - 29 May 2024
Abstract
A dual-emission ratio-fluorescent sensing nanohybrid based on Radix Hedysari green-synthesized carbon quantum dots (CDs) and glutathione-functionalized gold nanoclusters (GSH-AuNCs) had been developed for the determination of cefodizime sodium (CDZM). The designed fluorescence nanohybrid had two significant fluorescence emission peaks at 458 nm and [...] Read more.
A dual-emission ratio-fluorescent sensing nanohybrid based on Radix Hedysari green-synthesized carbon quantum dots (CDs) and glutathione-functionalized gold nanoclusters (GSH-AuNCs) had been developed for the determination of cefodizime sodium (CDZM). The designed fluorescence nanohybrid had two significant fluorescence emission peaks at 458 nm and 569 nm when excited at 360 nm, which was attributed to the CDs and GSH-AuNCs. With the addition of CDZM, the fluorescence at 458 nm was slightly weakened while the fluorescence at 569 nm was enhanced obviously. Based on the relationship between the I569/I458 fluorescence intensity ratio and the concentration of CDZM, the designed nanohybrid exhibited a good linearity range of 1.0–1000.0 μM and the limit of detection (LOD) was 0.19 μM. The method was finally applied in the detection of CDZM in urine, showing the potential applications in complicated biological samples. Full article
(This article belongs to the Special Issue Recent Advances in Luminescence: From Mechanisms to Applications)
16 pages, 1984 KiB  
Article
Hydrodynamic Simulation of Urban Waterlogging Based on an Improved Vertical Flow Exchange Method
by Xi Jin and Yan Mu
Water 2024, 16(11), 1563; https://doi.org/10.3390/w16111563 (registering DOI) - 29 May 2024
Abstract
In the 1D–2D coupled simulation of urban waterlogging, the calculation process of vertical flow exchange is independent from the 1D hydraulic calculation, resulting in a failure to consider the node head and pipe flow during the exchange flow calculation, which may lead to [...] Read more.
In the 1D–2D coupled simulation of urban waterlogging, the calculation process of vertical flow exchange is independent from the 1D hydraulic calculation, resulting in a failure to consider the node head and pipe flow during the exchange flow calculation, which may lead to irrational results and further affect the stability of the model calculation. However, setting an upper limit for the exchange flow may introduce excessive subjective factors into the simulation process. In this study, a vertical flow exchange method based on the water balance of nodes is proposed. When a node is in an overloaded state, the calculation of vertical flow exchange at the node is integrated into the 1D hydraulic simulation process, thus taking into consideration the influence of the node head and pipe flow when calculating vertical flow exchange. Additionally, the iterative solution method used in the 1D hydraulic model ensures numerical harmony between the vertical flow exchange, node head and pipe flow, thus ensuring the stability of the coupled calculation. For the non-overloaded nodes, the calculation of the vertical flow exchange was conducted using a variable-head orifice discharge formula, enabling the consideration of changes in the surface water depth during the calculation of the node backflow. Using the InfoWorks ICM model as a benchmark, a comparative analysis of case simulation results demonstrated that the improved vertical flow exchange method was able to accurately and stably simulate the process of vertical flow exchange. When used with the improved vertical exchange method, the coupled model gave simulation results that closely matched those of the benchmark model. Full article
(This article belongs to the Special Issue Advanced Research on Hydraulic Engineering and Hydrological Modelling)
44 pages, 11001 KiB  
Article
A Logical–Algebraic Approach to Revising Formal Ontologies: Application in Mereotopology
by Gonzalo A. Aranda-Corral, Joaquín Borrego-Díaz, Antonia M. Chávez-González and Nataliya M. Gulayeva
AI 2024, 5(2), 746-789; https://doi.org/10.3390/ai5020039 (registering DOI) - 29 May 2024
Abstract
In ontology engineering, reusing (or extending) ontologies poses a significant challenge, requiring revising their ontological commitments and ensuring accurate representation and coherent reasoning. This study aims to address two main objectives. Firstly, it seeks to develop a methodological approach supporting ontology extension practices. [...] Read more.
In ontology engineering, reusing (or extending) ontologies poses a significant challenge, requiring revising their ontological commitments and ensuring accurate representation and coherent reasoning. This study aims to address two main objectives. Firstly, it seeks to develop a methodological approach supporting ontology extension practices. Secondly, it aims to demonstrate its feasibility by applying the approach to the case of extending qualitative spatial reasoning (QSR) theories. Key questions involve effectively interpreting spatial extensions while maintaining consistency. The framework systematically analyzes extensions of formal ontologies, providing a reconstruction of a qualitative calculus. Reconstructed qualitative calculus demonstrates improved interpretative capabilities and reasoning accuracy. The research underscores the importance of methodological approaches when extending formal ontologies, with spatial interpretation serving as a valuable case study. Full article
(This article belongs to the Section AI Systems: Theory and Applications)

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