The 2023 MDPI Annual Report has
been released!
 
11 pages, 5989 KiB  
Article
The Effect of Heat Treatment on the Microstructure and Mechanical Properties of Al0.6CoFeNi2V0.5 High Entropy Alloy
by Hui Liang, Jinxin Hou, Li Jiang, Zhaoxin Qi, Min Zhang and Zhiqiang Cao
Coatings 2024, 14(6), 658; https://doi.org/10.3390/coatings14060658 (registering DOI) - 23 May 2024
Abstract
Al0.6CoFeNi2V0.5 high entropy alloy was successfully designed and prepared via the nonconsumable arc-melting process, and it was annealed at 600 °C, 800 °C, and 1000 °C for 4 h. Its microstructure and mechanical properties were studied. The as-cast [...] Read more.
Al0.6CoFeNi2V0.5 high entropy alloy was successfully designed and prepared via the nonconsumable arc-melting process, and it was annealed at 600 °C, 800 °C, and 1000 °C for 4 h. Its microstructure and mechanical properties were studied. The as-cast alloy consisted of FCC and BCC phases, and no phase transformation occurred during annealing at 600 °C. Hard Al3V-type metal compounds precipitated during annealing at 800 °C, and BCC particles precipitated in the FCC matrix during annealing at 1000 °C. After annealing, the strength and hardness of Al0.6CoFeNi2V0.5 high-entropy alloy both showed a decreasing trend, because the annealing process eliminated the internal stress in this alloy. However, as the annealing temperature increased, the strength and hardness of the Al0.6CoFeNi2V0.5 high-entropy alloy samples gradually increased. This is because the hard Al3V metal compounds precipitated when the annealing temperature was 800 °C, which produced the “second phase strengthening” effect. At 1000 °C, the larger volume fraction of the hard and fine BCC phase (21.81%) diffusely precipitated; the precipitation of this BCC phase not only produced a “second phase strengthening” effect, which also resulted in “solid solution strengthening”, ultimately exhibiting enhanced hardness and strength. These findings have important theoretical reference value for the study of the microstructure and mechanical properties of high-entropy alloys. And, this study plays a significant role in promoting the research and development of new component materials that bear compressive loads, such as columns in large factory buildings, supports for cranes, and clamping bolts for rolling mills in practical mechanical engineering. Full article
(This article belongs to the Section Surface Characterization, Deposition and Modification)
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16 pages, 1986 KiB  
Article
Reducing Driving Risk Factors in Adolescents with Attention Deficit Hyperactivity Disorder (ADHD): Insights from EEG and Eye-Tracking Analysis
by Anat Keren, Orit Fisher, Anwar Hamde, Shlomit Tsafrir and Navah Z. Ratzon
Sensors 2024, 24(11), 3319; https://doi.org/10.3390/s24113319 (registering DOI) - 23 May 2024
Abstract
Adolescents with attention deficit hyperactivity disorder (ADHD) face significant driving challenges due to deficits in attention and executive functioning, elevating their road risks. Previous interventions targeting driving safety among this cohort have typically addressed isolated aspects (e.g., cognitive or behavioral factors) or relied [...] Read more.
Adolescents with attention deficit hyperactivity disorder (ADHD) face significant driving challenges due to deficits in attention and executive functioning, elevating their road risks. Previous interventions targeting driving safety among this cohort have typically addressed isolated aspects (e.g., cognitive or behavioral factors) or relied on uniform solutions. However, these approaches often overlook this population’s diverse needs. This study introduces the “Drive-Fun” innovative intervention (DFI), aimed at enhancing driving skills among this vulnerable population. The intervention was tested in a pilot study including 30 adolescents aged 15–18, comparing three groups: DFI, an educational intervention, and a control group with no treatment. Assessments included a driving simulator, EEG, and Tobii Pro Glasses 2. Evaluation was conducted pre- and post-intervention and at a 3-month follow-up. Results indicated that the DFI group significantly improved in the simulated driving performance, attentional effort, and focused gaze time. The findings underscore that holistic strategies with personalized, comprehensive approaches for adolescents with ADHD are particularly effective in improving driving performance. These outcomes not only affirm the feasibility of the DFI but also highlight the critical role of sensor technologies in accurately measuring and enhancing simulator driving performance in adolescents with ADHD. Outcomes suggest a promising direction for future research and application. Full article
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49 pages, 36963 KiB  
Article
Combining “Deep Learning” and Physically Constrained Neural Networks to Derive Complex Glaciological Change Processes from Modern High-Resolution Satellite Imagery: Application of the GEOCLASS-Image System to Create VarioCNN for Glacier Surges
by Ute C. Herzfeld, Lawrence J. Hessburg, Thomas M. Trantow and Adam N. Hayes
Remote Sens. 2024, 16(11), 1854; https://doi.org/10.3390/rs16111854 (registering DOI) - 23 May 2024
Abstract
The objectives of this paper are to investigate the trade-offs between a physically constrained neural network and a deep, convolutional neural network and to design a combined ML approach (“VarioCNN”). Our solution is provided in the framework of a cyberinfrastructure that includes a [...] Read more.
The objectives of this paper are to investigate the trade-offs between a physically constrained neural network and a deep, convolutional neural network and to design a combined ML approach (“VarioCNN”). Our solution is provided in the framework of a cyberinfrastructure that includes a +newly designed ML software, GEOCLASS-image (v1.0), modern high-resolution satellite image data sets (Maxar WorldView data), and instructions/descriptions that may facilitate solving similar spatial classification problems. Combining the advantages of the physically-driven connectionist-geostatistical classification method with those of an efficient CNN, VarioCNN provides a means for rapid and efficient extraction of complex geophysical information from submeter resolution satellite imagery. A retraining loop overcomes the difficulties of creating a labeled training data set. Computational analyses and developments are centered on a specific, but generalizable, geophysical problem: The classification of crevasse types that form during the surge of a glacier system. A surge is a glacial catastrophe, an acceleration of a glacier to typically 100–200 times its normal velocity. GEOCLASS-image is applied to study the current (2016-2024) surge in the Negribreen Glacier System, Svalbard. The geophysical result is a description of the structural evolution and expansion of the surge, based on crevasse types that capture ice deformation in six simplified classes. Full article
(This article belongs to the Special Issue Remote Sensing of the Cryosphere II)
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37 pages, 23753 KiB  
Article
May the Force Be with You... Gesturality of the Barcelonians Associated with Mockery, Insult and Protection
by Mar Forment and Cristina Illamola
Languages 2024, 9(6), 191; https://doi.org/10.3390/languages9060191 (registering DOI) - 23 May 2024
Abstract
The aim of the article is to inventory gestures related to mockery, insult, attracting good luck, or warding off bad luck that a group of informants from Barcelona have performed. The data come from the application of the survey from the Atlas de [...] Read more.
The aim of the article is to inventory gestures related to mockery, insult, attracting good luck, or warding off bad luck that a group of informants from Barcelona have performed. The data come from the application of the survey from the Atlas de Gestos, whose task is to collect gestures from the Pan-Hispanic context to describe the gestural repertoire of each territory and conduct comparative studies. The results, interpreted based on social factors (gender, age, and level of instruction), confirm the wide range of gestures for different functions (10 for mockery, 11 for insult and attracting good luck, and 9 for warding off bad luck). Regarding differences based on social variables, the results allow for indicating trends, namely, while the most used gesture to express mockery is sticking out the tongue, young people prefer the gesture of pointing and laughing, and informants over 55 years old only prefer laughing. Concerning insults, the use of peineta is widespread, although differences in behavior between men and women are observed. As for attracting good luck, Barcelona informants opt for crossing fingers, although older generations use gestures with more religious connotations, such as clasping hands. Finally, to ward off bad luck, Barcelona locals mention the gesture of crossing made with the index fingers of each hand. Full article
(This article belongs to the Special Issue Advances in Non-Verbal Communication in the 21st Century)
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21 pages, 3862 KiB  
Article
Identification and Evaluation of Olive Phenolics in the Context of Amine Oxidase Enzyme Inhibition and Depression: In Silico Modelling and In Vitro Validation
by Tom C. Karagiannis, Katherine Ververis, Julia J. Liang, Eleni Pitsillou, Siyao Liu, Sarah M. Bresnehan, Vivian Xu, Stevano J. Wijoyo, Xiaofei Duan, Ken Ng, Andrew Hung, Erik Goebel and Assam El-Osta
Molecules 2024, 29(11), 2446; https://doi.org/10.3390/molecules29112446 (registering DOI) - 23 May 2024
Abstract
The Mediterranean diet well known for its beneficial health effects, including mood enhancement, is characterised by the relatively high consumption of extra virgin olive oil (EVOO), which is rich in bioactive phenolic compounds. Over 200 phenolic compounds have been associated with Olea europaea [...] Read more.
The Mediterranean diet well known for its beneficial health effects, including mood enhancement, is characterised by the relatively high consumption of extra virgin olive oil (EVOO), which is rich in bioactive phenolic compounds. Over 200 phenolic compounds have been associated with Olea europaea, and of these, only a relatively small fraction have been characterised. Utilising the OliveNetTM library, phenolic compounds were investigated as potential inhibitors of the epigenetic modifier lysine-specific demethylase 1 (LSD1). Furthermore, the compounds were screened for inhibition of the structurally similar monoamine oxidases (MAOs) which are directly implicated in the pathophysiology of depression. Molecular docking highlighted that olive phenolics interact with the active site of LSD1 and MAOs. Protein–peptide docking was also performed to evaluate the interaction of the histone H3 peptide with LSD1, in the presence of ligands bound to the substrate-binding cavity. To validate the in silico studies, the inhibitory activity of phenolic compounds was compared to the clinically approved inhibitor tranylcypromine. Our findings indicate that olive phenolics inhibit LSD1 and the MAOs in vitro. Using a cell culture model system with corticosteroid-stimulated human BJ fibroblast cells, the results demonstrate the attenuation of dexamethasone- and hydrocortisone-induced MAO activity by phenolic compounds. The findings were further corroborated using human embryonic stem cell (hESC)-derived neurons stimulated with all-trans retinoic acid. Overall, the results indicate the inhibition of flavin adenine dinucleotide (FAD)-dependent amine oxidases by olive phenolics. More generally, our findings further support at least a partial mechanism accounting for the antidepressant effects associated with EVOO and the Mediterranean diet. Full article
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13 pages, 693 KiB  
Article
Walking and Running of Children with Decreased Femoral Torsion
by Christos Tsagkaris, Marry E. Hamberg, Christina Villefort, Thomas Dreher and Britta K. Krautwurst
Children 2024, 11(6), 617; https://doi.org/10.3390/children11060617 - 22 May 2024
Abstract
Understanding the implications of decreased femoral torsion on gait and running in children and adolescents might help orthopedic surgeons optimize treatment decisions. To date, there is limited evidence regarding the kinematic gait deviations between children with decreased femoral torsion and typically developing children, [...] Read more.
Understanding the implications of decreased femoral torsion on gait and running in children and adolescents might help orthopedic surgeons optimize treatment decisions. To date, there is limited evidence regarding the kinematic gait deviations between children with decreased femoral torsion and typically developing children, as well as the implications of the same on the adaptation of walking to running. A three-dimensional gait analysis study was undertaken to compare gait deviations during running and walking among patients with decreased femoral torsion (n = 15) and typically developing children (n = 11). Linear mixed models were utilized to establish comparisons within and between the two groups and investigate the relationship between clinical examination, spatial parameters, and the difference in hip rotation between running and walking. Patients exhibited increased external hip rotation during walking in comparison to controls, accompanied by higher peaks for the same as well as for knee valgus and external foot progression angle. A similar kinematic gait pattern was observed during running, with significant differences noted in peak knee valgus. In terms of variations from running to walking, patients internally rotated their initially externally rotated hip by 4°, whereas controls maintained the same internal hip rotation. Patients and controls displayed comparable kinematic gait deviations during running compared to walking. The passive hip range of motion, torsions, and velocity did not notably influence the variation in mean hip rotation from running to walking. This study underlines the potential of 3D gait kinematics to elucidate the functional implications of decreased FT and, hence, may contribute to clinical decision making. Full article
(This article belongs to the Special Issue Clinical Gait Analysis in Children: Progress and Relevance)
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11 pages, 873 KiB  
Article
Integrating Ataxia Evaluation into Tumor-Induced Hearing Loss Model to Comprehensively Study NF2-Related Schwannomatosis
by Simeng Lu, Zhenzhen Yin, Jie Chen, Limeng Wu, Yao Sun, Xing Gao, Peigen Huang, Justin T. Jordan, Scott R. Plotkin and Lei Xu
Cancers 2024, 16(11), 1961; https://doi.org/10.3390/cancers16111961 (registering DOI) - 22 May 2024
Abstract
NF2-related Schwannomatosis (NF2-SWN) is a disease that needs new solutions. The hallmark of NF2-SWN, a dominantly inherited neoplasia syndrome, is bilateral vestibular schwannomas (VSs), which progressively enlarge, leading to sensorineural hearing loss, tinnitus, facial weakness, and pain that translates to social impairment and [...] Read more.
NF2-related Schwannomatosis (NF2-SWN) is a disease that needs new solutions. The hallmark of NF2-SWN, a dominantly inherited neoplasia syndrome, is bilateral vestibular schwannomas (VSs), which progressively enlarge, leading to sensorineural hearing loss, tinnitus, facial weakness, and pain that translates to social impairment and clinical depression. Standard treatments for growing VSs include surgery and radiation therapy (RT); however, both carry the risk of further nerve damage that can result in deafness and facial palsy. The resultant suffering and debility, in combination with the paucity of therapeutic options, make the effective treatment of NF2-SWN a major unmet medical need. A better understanding of these mechanisms is essential to developing novel therapeutic targets to control tumor growth and improve patients’ quality of life. Previously, we developed the first orthotopic cerebellopontine angle mouse model of VSs, which faithfully mimics tumor-induced hearing loss. In this model, we observed that mice exhibit symptoms of ataxia and vestibular dysfunction. Therefore, we further developed a panel of five tests suitable for the mouse VS model and investigated how tumor growth and treatment affect gait, coordination, and motor function. Using this panel of ataxia tests, we demonstrated that both ataxia and motor function deteriorated concomitantly with tumor progression. We further demonstrated that (i) treatment with anti-VEGF resulted in tumor size reduction, mitigated ataxia, and improved rotarod performance; (ii) treatment with crizotinib stabilized tumor growth and led to improvements in both ataxia and rotarod performance; and (iii) treatment with losartan did not impact tumor growth nor ameliorate ataxia or motor function. Our studies demonstrated that these methods, paired with hearing tests, enable a comprehensive evaluation of tumor-induced neurological deficits and facilitate the assessment of the effectiveness of novel therapeutics to improve NF2 treatments. Full article
(This article belongs to the Special Issue Hot Topics in Neuro-Oncology)
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21 pages, 1687 KiB  
Article
Comparative Analysis of Energy Efficiency between Battery Electric Buses and Modular Autonomous Vehicles
by Ioan-Tudor Oargă, Gabriel Prunean, Bogdan Ovidiu Varga, Dan Moldovanu and Dan Doru Micu
Appl. Sci. 2024, 14(11), 4389; https://doi.org/10.3390/app14114389 (registering DOI) - 22 May 2024
Abstract
This paper presents the initial steps taken in analysing the benefits of connected autonomous vehicles (CAVs), especially Modular Autonomous Vehicles (MAVs), in search of sustainable solutions for reducing energy consumption per passenger in air transport. For this particular case, a Mobility-as-a-Service (MaaS) solution [...] Read more.
This paper presents the initial steps taken in analysing the benefits of connected autonomous vehicles (CAVs), especially Modular Autonomous Vehicles (MAVs), in search of sustainable solutions for reducing energy consumption per passenger in air transport. For this particular case, a Mobility-as-a-Service (MaaS) solution is proposed, correlating airside transport with landside transport, as an urban mobility alternative. To better understand the benefits of the proposal, this paper studies the impact on energy consumption conceptual differences between a conventional public transport fleet using Battery Electric Buses (BEBs) and an MAV fleet. Simulations for simple public transport tasks are performed to highlight the advantages of the modular vehicle concept, in which routes are assigned dynamically based on the requested passenger carrying capacity and travel distance, aiming to optimize the efficiency of the entire system. With a proven reduction in energy consumption due to better use of available passenger capacity and reduced travel times in which the vehicle is driving with a number of passengers less than half of its capacity, the concept can be addressed further in developing a predictive system that processes public transport data and delivers an optimized schedule for the entire fleet. The main goal being to improve overall operational efficiency and total cost of ownership, the second part of the paper studies the impact of weight distribution on efficiency parameters such as energy consumption, range, and overall performance of an electric bus. The impact on dynamic elements such as acceleration, braking, and cornering performance is analyzed, to assess the viability and safety of all types of electric bus operations. Full article
(This article belongs to the Special Issue Virtual Models for Autonomous Driving Systems)
18 pages, 2224 KiB  
Article
Research on Miniaturized UHF Sensing Technology for PD Detection in Power Equipment Based on Symmetric Cut Theory
by Bowen Xu, Chaoqian Duan, Jiangfan Wang, Lei Zhang, Guozhi Zhang, Guoguang Zhang and Guangke Li
Sensors 2024, 24(11), 3313; https://doi.org/10.3390/s24113313 (registering DOI) - 22 May 2024
Abstract
In answer to the demand for high sensitivity and miniaturization of ultra-high frequency (UHF) sensors for partial discharge (PD) detection in power equipment, this paper proposes research on miniaturized UHF-sensing technology for PD detection in power equipment based on symmetric cut theory. The [...] Read more.
In answer to the demand for high sensitivity and miniaturization of ultra-high frequency (UHF) sensors for partial discharge (PD) detection in power equipment, this paper proposes research on miniaturized UHF-sensing technology for PD detection in power equipment based on symmetric cut theory. The symmetric cut theory is applied for the first time to the miniaturization of PD UHF sensors for power equipment. A planar monopole UHF sensor with a size of only 70 mm × 70 mm × 1.6 mm is developed using an exponential asymptotic feed line approach, which is a 50% size reduction. The frequency–response characteristics of the sensor are simulated, optimized and tested; the results show that the standing wave ratio of the sensor developed in this paper is less than 2 in the frequency band from 427 MHz to 1.54 GHz, and less than 5 in the frequency band from 300 MHz to 1.95 GHz; in the 300 MHz~1.5 GHz band; the maximum and average gains of the sensor E-plane are 4.76 dB and 1.02 dB, respectively. Finally, the PD simulation experiment platform for power equipment is built to test the sensor’s sensing performance; the results show that the sensor can effectively detect the PD signals; the sensing sensitivity is improved by about 95% relative to an elliptical monopole UHF sensor. Full article
(This article belongs to the Section Fault Diagnosis & Sensors)
9 pages, 557 KiB  
Article
ChatGPT’s Efficacy in Queries Regarding Polycystic Ovary Syndrome and Treatment Strategies for Women Experiencing Infertility
by Belgin Devranoglu, Tugba Gurbuz and Oya Gokmen
Diagnostics 2024, 14(11), 1082; https://doi.org/10.3390/diagnostics14111082 (registering DOI) - 22 May 2024
Abstract
This study assesses the efficacy of ChatGPT-4, an advanced artificial intelligence (AI) language model, in delivering precise and comprehensive answers to inquiries regarding managing polycystic ovary syndrome (PCOS)-related infertility. The research team, comprising experienced gynecologists, formulated 460 structured queries encompassing a wide range [...] Read more.
This study assesses the efficacy of ChatGPT-4, an advanced artificial intelligence (AI) language model, in delivering precise and comprehensive answers to inquiries regarding managing polycystic ovary syndrome (PCOS)-related infertility. The research team, comprising experienced gynecologists, formulated 460 structured queries encompassing a wide range of common and intricate PCOS scenarios. The queries were: true/false (170), open-ended (165), and multiple-choice (125) and further classified as ‘easy’, ‘moderate’, and ‘hard’. For true/false questions, ChatGPT-4 achieved a flawless accuracy rate of 100% initially and upon reassessment after 30 days. In the open-ended category, there was a noteworthy enhancement in accuracy, with scores increasing from 5.53 ± 0.89 initially to 5.88 ± 0.43 at the 30-day mark (p < 0.001). Completeness scores for open-ended queries also experienced a significant improvement, rising from 2.35 ± 0.58 to 2.92 ± 0.29 (p < 0.001). In the multiple-choice category, although the accuracy score exhibited a minor decline from 5.96 ± 0.44 to 5.92 ± 0.63 after 30 days (p > 0.05). Completeness scores for multiple-choice questions remained consistent, with initial and 30-day means of 2.98 ± 0.18 and 2.97 ± 0.25, respectively (p > 0.05). ChatGPT-4 demonstrated exceptional performance in true/false queries and significantly improved handling of open-ended questions during the 30 days. These findings emphasize the potential of AI, particularly ChatGPT-4, in enhancing decision-making support for healthcare professionals managing PCOS-related infertility. Full article
(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
14 pages, 13155 KiB  
Article
Optimizing Variational Quantum Neural Networks Based on Collective Intelligence
by Zitong Li, Tailong Xiao, Xiaoyang Deng, Guihua Zeng and Weimin Li
Mathematics 2024, 12(11), 1627; https://doi.org/10.3390/math12111627 (registering DOI) - 22 May 2024
Abstract
Quantum machine learning stands out as one of the most promising applications of quantum computing, widely believed to possess potential quantum advantages. In the era of noisy intermediate-scale quantum, the scale and quality of quantum computers are limited, and quantum algorithms based on [...] Read more.
Quantum machine learning stands out as one of the most promising applications of quantum computing, widely believed to possess potential quantum advantages. In the era of noisy intermediate-scale quantum, the scale and quality of quantum computers are limited, and quantum algorithms based on fault-tolerant quantum computing paradigms cannot be experimentally verified in the short term. The variational quantum algorithm design paradigm can better adapt to the practical characteristics of noisy quantum hardware and is currently one of the most promising solutions. However, variational quantum algorithms, due to their highly entangled nature, encounter the phenomenon known as the “barren plateau” during the optimization and training processes, making effective optimization challenging. This paper addresses this challenging issue by researching a variational quantum neural network optimization method based on collective intelligence algorithms. The aim is to overcome optimization difficulties encountered by traditional methods such as gradient descent. We study two typical applications of using quantum neural networks: random 2D Hamiltonian ground state solving and quantum phase recognition. We find that the collective intelligence algorithm shows a better optimization compared to gradient descent. The solution accuracy of ground energy and phase classification is enhanced, and the optimization iterations are also reduced. We highlight that the collective intelligence algorithm has great potential in tackling the optimization of variational quantum algorithms. Full article
(This article belongs to the Special Issue Advances in Quantum Key Distribution and Quantum Information)
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22 pages, 1568 KiB  
Review
Clinical Validation of Digital Healthcare Solutions: State of the Art, Challenges and Opportunities
by Mar Gomis-Pastor, Jesús Berdún, Alicia Borrás-Santos, Anna De Dios López, Beatriz Fernández-Montells Rama, Óscar García-Esquirol, Mònica Gratacòs, Gerardo D. Ontiveros Rodríguez, Rebeca Pelegrín Cruz, Jordi Real, Jordi Bachs i Ferrer and Adrià Comella
Healthcare 2024, 12(11), 1057; https://doi.org/10.3390/healthcare12111057 (registering DOI) - 22 May 2024
Abstract
Digital health technologies (DHTs) at the intersection of health, medical informatics, and business aim to enhance patient care through personalised digital approaches. Ensuring the efficacy and reliability of these innovations demands rigorous clinical validation. A PubMed literature review (January 2006 to July 2023) [...] Read more.
Digital health technologies (DHTs) at the intersection of health, medical informatics, and business aim to enhance patient care through personalised digital approaches. Ensuring the efficacy and reliability of these innovations demands rigorous clinical validation. A PubMed literature review (January 2006 to July 2023) identified 1250 papers, highlighting growing academic interest. A focused narrative review (January 2018 to July 2023) delved into challenges, highlighting issues such as diverse regulatory landscapes, adoption issues in complex healthcare systems, and a plethora of evaluation frameworks lacking pragmatic guidance. Existing frameworks often omit crucial criteria, neglect empirical evidence, and clinical effectiveness is rarely included as a criterion for DHT quality. The paper underscores the urgency of addressing challenges in accreditation, adoption, business models, and integration to safeguard the quality, efficacy, and safety of DHTs. A pivotal illustration of collaborative efforts to address these challenges is exemplified by the Digital Health Validation Center, dedicated to generating clinical evidence of innovative healthcare technologies and facilitating seamless technology transfer. In conclusion, it is necessary to harmonise evaluation approaches and frameworks, improve regulatory clarity, and commit to collaboration to integrate rigorous clinical validation and empirical evidence throughout the DHT life cycle. Full article
15 pages, 941 KiB  
Article
Impact of Land Use and Climate Change on Streamflow: An Assessment Using a Semi-Empirical Model in the Guishui Watershed of North China
by Chunni Gao, Mark Honti, Jinhua Cheng and Tao Wang
Land 2024, 13(6), 725; https://doi.org/10.3390/land13060725 (registering DOI) - 22 May 2024
Abstract
Land-use change may significantly influence streamflow. The semi-empirical model PhosFate was used to analyze the impact of land use and climate change on streamflow by choosing the Guishui watershed as a pilot site and then expanding, applying it to all of North China. [...] Read more.
Land-use change may significantly influence streamflow. The semi-empirical model PhosFate was used to analyze the impact of land use and climate change on streamflow by choosing the Guishui watershed as a pilot site and then expanding, applying it to all of North China. The Guishui watershed (North Beijing, China) has experienced a dramatic decline in its streamflow in recent decades. Parallel to this, significant land-use change has happened in this area; afforestation programs have increased forest cover from 41% (1980) to 59% (2013) and a similar increase in forest cover can also be observed in North China. Managing flow decline requires separating climatic and direct human-influenced effects. The results showed the following: (1) Afforestation is a major factor that decreased total flow in the Guishui watershed from 1996 to 2014; total flow increased by around 24% more than the actual dataset in the constant scenario (no afforestation) and decreased by 5% more than the actual dataset in the forest scenario (all agriculture land use transferred to forests). (2) When forest coverage increases, the Qinghai–Tibet Plateau and the Loess Plateau are the most sensitive areas regarding total flow in North China; the total flow change rate increased by up to 25% in these two areas when land use shifted from sparse vegetation to mixed forests. After analyzing the contributions of these two factors, we formulated recommendations on future afforestation practices for North China. In the central–north and northwest districts, the annual precipitation is under 520 mm and 790 mm, respectively, and the practice of afforestation should be more carefully planned to prevent severe damage to streams. This research also proved that the PhosFate model can be used in North China, which would be a practical tool for watershed management. Full article
(This article belongs to the Section Land Environmental and Policy Impact Assessment)
16 pages, 7436 KiB  
Article
Microparticle Hybrid Target Simulation for keV X-ray Sources
by Rolf Behling, Christopher Hulme, Panagiotis Tolias, Gavin Poludniowski and Mats Danielsson
Instruments 2024, 8(2), 32; https://doi.org/10.3390/instruments8020032 - 22 May 2024
Abstract
The spatiotemporal resolution of diagnostic X-ray images obtained with rotating-anode X-ray tubes has remained limited as the development of rigid, high-performance target materials has slowed down. However, novel imaging techniques using finer detector pixels and orthovolt cancer therapy employing narrow X-ray focal spots [...] Read more.
The spatiotemporal resolution of diagnostic X-ray images obtained with rotating-anode X-ray tubes has remained limited as the development of rigid, high-performance target materials has slowed down. However, novel imaging techniques using finer detector pixels and orthovolt cancer therapy employing narrow X-ray focal spots demand improved output from brilliant keV X-ray sources. Since its advent in 1929, rotating-anode technology has become the greatest bottleneck to improvement. To overcome this limitation, the current authors have devised a novel X-ray generation technology based on tungsten microparticle targets. The current study investigated a hybrid solution of a stream of fast tungsten microparticles and a rotating anode to both harvest the benefits of the improved performance of the new solution and to reuse known technology. The rotating anode captures energy that may pass a partially opaque microparticle stream and thereby contributes to X-ray generation. With reference to fast-rotating anodes and a highly appreciated small focal spot of a standardized size of 0.3 for an 8° target angle (physical: 0.45 mm × 4.67 mm), we calculated a potential output gain of at least 85% for non-melting microparticles and of 124% if melting is envisioned. Microparticle charging can be remediated by electron backscattering and electron field emission. The adoption of such a solution enables substantially improved image resolution. Full article
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22 pages, 11504 KiB  
Article
Identifying the Morphological and Molecular Features of a Cell-Based Orthotopic Pancreatic Cancer Mouse Model during Growth over Time
by Felista L. Tansi, Andrea Schrepper, Michael Schwarzer, Ulf Teichgräber and Ingrid Hilger
Int. J. Mol. Sci. 2024, 25(11), 5619; https://doi.org/10.3390/ijms25115619 - 22 May 2024
Abstract
Pancreatic ductal adenocarcinoma (PDAC), characterized by hypovascularity, hypoxia, and desmoplastic stroma is one of the deadliest malignancies in humans, with a 5-year survival rate of only 7%. The anatomical location of the pancreas and lack of symptoms in patients with early onset of [...] Read more.
Pancreatic ductal adenocarcinoma (PDAC), characterized by hypovascularity, hypoxia, and desmoplastic stroma is one of the deadliest malignancies in humans, with a 5-year survival rate of only 7%. The anatomical location of the pancreas and lack of symptoms in patients with early onset of disease accounts for late diagnosis. Consequently, 85% of patients present with non-resectable, locally advanced, or advanced metastatic disease at diagnosis and rely on alternative therapies such as chemotherapy, immunotherapy, and others. The response to these therapies highly depends on the stage of disease at the start of therapy. It is, therefore, vital to consider the stages of PDAC models in preclinical studies when testing new therapeutics and treatment modalities. We report a standardized induction of cell-based orthotopic pancreatic cancer models in mice and the identification of vital features of their progression by ultrasound imaging and histological analysis of the level of pancreatic stellate cells, mature fibroblasts, and collagen. The results highlight that early-stage primary tumors are secluded in the pancreas and advance towards infiltrating the omentum at week 5–7 post implantation of the BxPC-3 and Panc-1 models investigated. Late stages show extensive growth, the infiltration of the omentum and/or stomach wall, metastases, augmented fibroblasts, and collagen levels. The findings can serve as suggestions for defining growth parameter-based stages of orthotopic pancreatic cancer models for the preclinical testing of drug efficacy in the future. Full article
(This article belongs to the Section Molecular Oncology)
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17 pages, 1496 KiB  
Article
Empowering Self-Help Groups: The Impact of Financial Inclusion on Social Well-Being
by Madan Survase and Atmajitsinh Gohil
J. Risk Financial Manag. 2024, 17(6), 217; https://doi.org/10.3390/jrfm17060217 - 22 May 2024
Abstract
Financial inclusion (FI) relates to the access and availability of financial services to society, especially in low-income groups. FI is pivotal in achieving 7 of the 17 Sustainable Development Goals (SDGs). This paper explores the level of FI in the rural areas of [...] Read more.
Financial inclusion (FI) relates to the access and availability of financial services to society, especially in low-income groups. FI is pivotal in achieving 7 of the 17 Sustainable Development Goals (SDGs). This paper explores the level of FI in the rural areas of Maharashtra and measures the impact of FI on the social conditions of Self-Help Groups (SHGs) prevalent in these areas. The study is based on a 424 SHGs survey conducted in the Pune, Thane, and Palghar districts of Maharashtra, India. The impact of FI on SHGs is evaluated using a Structural Equation Model (SEM). The results of the study show that physical banking services, Business Facilitators (BFs), and Business Correspondents (BCs) improve the social conditions of rural SHGs. Additionally, BCs and BFs mediate the relationship between physical banking services and social conditions. The study also reveals an insignificant association between BCs and BFs and insurance services. The present study highlights the importance of increasing the awareness of insurance policies through financial literacy programs and making timely availability and accessibility of BCs and BFs to enhance financial inclusion in rural areas. Full article
(This article belongs to the Special Issue Fintech, Business, and Development)
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10 pages, 2521 KiB  
Article
Less Is More: Selective-Atom-Removal-Derived Defective MnOx Catalyst for Efficient Propane Oxidation
by Wenfan Xu, Limei Zhou, Lining Liu, Huimei Duan, Haoxi Ben, Sheng Chen and Xingyun Li
Nanomaterials 2024, 14(11), 907; https://doi.org/10.3390/nano14110907 - 22 May 2024
Abstract
Defect manipulation in metal oxide is of great importance in boosting catalytic performance for propane oxidation. Herein, a selective atom removal strategy was developed to construct a defective manganese oxide catalyst, which involved the partial etching of a Mg dopant in MnOx [...] Read more.
Defect manipulation in metal oxide is of great importance in boosting catalytic performance for propane oxidation. Herein, a selective atom removal strategy was developed to construct a defective manganese oxide catalyst, which involved the partial etching of a Mg dopant in MnOx. The resulting MgMnOx-H catalysts exhibited superior low-temperature catalytic activity (T50 = 185 °C, T90 = 226 °C) with a propane conversion rate of 0.29 μmol·gcat.−1·h−1 for the propane oxidation reaction, which is 4.8 times that of pristine MnOx. Meanwhile, a robust hydrothermal stability was guaranteed at 250 °C for 30 h of reaction time. The comprehensive experimental characterizations revealed that the catalytic performance improvement was closely related to the defective structures including the abundant (metal and oxygen) vacancies, distorted crystals, valence imbalance, etc., which prominently weakened the Mn-O bond and stimulated the mobility of surface lattice oxygen, leading to the elevation in the intrinsic oxidation activity. This work exemplifies the significance of defect engineering for the promotion of the oxidation ability of metal oxide, which will be valuable for the further development of efficient non-noble metal catalysts for propane oxidation. Full article
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14 pages, 235 KiB  
Article
Mediator Role of Dissociative Experiences in the Effect of Childhood Traumas on Emotion Regulation Difficulty and Parental Child-Containing Function
by Elif Yöyen, Fatih Bal, Tülay Güneri Barış, Meryem Selva Arslan and Gülşen Filazoğlu Çokluk
Children 2024, 11(6), 618; https://doi.org/10.3390/children11060618 (registering DOI) - 22 May 2024
Abstract
The aim of this study is to examine the mediating role of dissociation in emotional regulation and parental child-containing function skills of mothers exposed to childhood trauma. The research was conducted with 400 mothers between the ages of 20–60 who had childhood trauma [...] Read more.
The aim of this study is to examine the mediating role of dissociation in emotional regulation and parental child-containing function skills of mothers exposed to childhood trauma. The research was conducted with 400 mothers between the ages of 20–60 who had childhood trauma and currently have children between the ages of 0–18. The relational screening model, one of the general screening models, was used in the research. The sample of the research was selected using the convenient sampling method and the simple random method. Research data were collected with the Sociodemographic Information Form, Childhood Trauma Scale (CTS), Parental Child-Containing Function Scale (PCCFS), Emotion Regulation Difficulty Scale (ERDS), and Dissociative Experiences Scale (DES). According to the results obtained in the study, physical abuse (β = 0.197; 95% CI [0.124; 0.268]), physical neglect (β = 0.232; 95% CI [0.161; 0.306]), emotional abuse (β = 0.238; 95% CI [0.169; 0.309]), emotional neglect (β = 0.210; 95% CI [0.150; 0.275]), and sexual abuse (β = 0.139; 95% CI [0.058; 0.220]) were found to have a significant indirect effect on emotion regulation difficulties through dissociative experiences. In addition, physical abuse (β = 0.122; 95% CI [0.071; 0.181]), physical neglect (β = 0.151; 95% CI [0.084; 0.228]), emotional abuse (β = 0.158; 95% CI [0.086; 0.238]), emotional neglect (β = 0.159; 95% CI [0.093; 0.235]), and sexual abuse (β = 0.086; 95% CI [0.039; 0.150] was found to have a significant indirect effect on parental child-containing function skills through dissociative experiences. Full article
(This article belongs to the Special Issue Psychological Health of Children and Adolescents in Times of Crises)
10 pages, 912 KiB  
Article
Comparison of Psychometric Functions Measured Using Remote Testing and Laboratory Testing
by Nirmal Srinivasan, Chhayakanta Patro, Radhika Kansangra and Angelica Trotman
Audiol. Res. 2024, 14(3), 469-478; https://doi.org/10.3390/audiolres14030039 - 22 May 2024
Abstract
The use of remote testing to collect behavioral data has been on the rise, especially after the COVID-19 pandemic. Here we present psychometric functions for a commonly used speech corpus obtained in remote testing and laboratory testing conditions on young normal hearing listeners [...] Read more.
The use of remote testing to collect behavioral data has been on the rise, especially after the COVID-19 pandemic. Here we present psychometric functions for a commonly used speech corpus obtained in remote testing and laboratory testing conditions on young normal hearing listeners in the presence of different types of maskers. Headphone use for the remote testing group was checked by supplementing procedures from prior literature using a Huggins pitch task. Results revealed no significant differences in the measured thresholds using the remote testing and laboratory testing conditions for all the three masker types. Also, the thresholds measured obtained in these two conditions were strongly correlated for a different group of young normal hearing listeners. Based on the results, excellent outcomes on auditory threshold measurements where the stimuli are presented both at levels lower than and above an individual’s speech-recognition threshold can be obtained by remotely testing the listeners. Full article
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17 pages, 8810 KiB  
Article
Effect of Skin Pigmentation and Finger Choice on Accuracy of Oxygen Saturation Measurement in an IoT-Based Pulse Oximeter
by Shyqyri Haxha, Chike Nwibor, Mian Ali, Mohamed Sakel, Karen Saunders, Vladimir Dyo and Shakira Nabakooza
Sensors 2024, 24(11), 3301; https://doi.org/10.3390/s24113301 (registering DOI) - 22 May 2024
Abstract
Pulse oximeters are widely used in hospitals and homes for measurement of blood oxygen saturation level (SpO2) and heart rate (HR). Concern has been raised regarding a possible bias in obtaining pulse oximeter measurements from different fingertips and the potential effect [...] Read more.
Pulse oximeters are widely used in hospitals and homes for measurement of blood oxygen saturation level (SpO2) and heart rate (HR). Concern has been raised regarding a possible bias in obtaining pulse oximeter measurements from different fingertips and the potential effect of skin pigmentation (white, brown, and dark). In this study, we obtained 600 SpO2 measurements from 20 volunteers using three UK NHS-approved commercial pulse oximeters alongside our custom-developed sensor, and used the Munsell colour system (5YR and 7.5YR cards) to classify the participants’ skin pigmentation into three distinct categories (white, brown, and dark). The statistical analysis using ANOVA post hoc tests (Bonferroni correction), a Bland–Altman plot, and a correlation test were then carried out to determine if there was clinical significance in measuring the SpO2 from different fingertips and to highlight if skin pigmentation affects the accuracy of SpO2 measurement. The results indicate that although the three commercial pulse oximeters had different means and standard deviations, these differences had no clinical significance. Full article
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21 pages, 16825 KiB  
Article
Study on the Load-Bearing Characteristics Analysis Model of Non-Pneumatic Tire with Composite Spokes
by Muyang Sun, Weidong Liu, Qiushi Zhang, Yuxi Chen, Jianshan Jiang and Xiaotong Liu
Machines 2024, 12(6), 358; https://doi.org/10.3390/machines12060358 - 22 May 2024
Abstract
This study aims to analyze the load-bearing characteristics of non-pneumatic tires with composite spokes using experimental and finite element simulation methods and to establish a mechanical analysis model based on the Timoshenko beam theory. Subsequently, experiments were conducted on carbon fiber-reinforced plastics and [...] Read more.
This study aims to analyze the load-bearing characteristics of non-pneumatic tires with composite spokes using experimental and finite element simulation methods and to establish a mechanical analysis model based on the Timoshenko beam theory. Subsequently, experiments were conducted on carbon fiber-reinforced plastics and rubbers to establish the corresponding constitutive model. A finite element model of the non-pneumatic tires with composite spokes was also developed. The main structural and material parameters were selected, and their correlation with the vertical stiffness of the non-pneumatic tires with composite spokes was studied using response surface methodology. The stiffness characteristics of the composite spokes were simplified, and a load-bearing characteristic analysis model was established. The results indicated that among the parameters of the reinforcement plate structure and rubber, the constitutive parameter C10 of the rubber in the spokes had the greatest impact, with a comprehensive influence value of 319.83 N/mm. Under a load of 5000 N, the load-bearing characteristic analysis model results were consistent with those of the finite element simulation, with a maximum relative error of 7.49%. The proposed load-bearing characteristic analysis model can assist in the rapid design and performance prediction of non-pneumatic tires with composite spokes. Full article
(This article belongs to the Section Vehicle Engineering)
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20 pages, 3449 KiB  
Article
Seasonal Dynamics and Damage of Halyomorpha halys in Italian Vineyards
by Davide Scaccini, Diego Fornasiero, Paola Tirello, Simone Vincenzi, Massimo Cecchetto, Ilirjan Allgjata, Carlo Duso and Alberto Pozzebon
Insects 2024, 15(6), 378; https://doi.org/10.3390/insects15060378 (registering DOI) - 22 May 2024
Abstract
The brown marmorated stink bug, Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), is an invasive polyphagous pest often observed in vineyards. In Europe, a gap needs to be filled in the knowledge on H. halys seasonal dynamics and damage on grapes. With this study, we [...] Read more.
The brown marmorated stink bug, Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), is an invasive polyphagous pest often observed in vineyards. In Europe, a gap needs to be filled in the knowledge on H. halys seasonal dynamics and damage on grapes. With this study, we described the seasonal dynamics of H. halys and its distribution in multi-cultivar vineyards, and we evaluated the damage on grape clusters induced by different pest densities. In vineyards, the seasonal occurrence of H. halys varied across time and grape cultivars, and the pest was more abundant on Cabernet Franc, Merlot and, to a lesser extent, Pinot gris. Moreover, higher densities of H. halys were found on red berry cultivars than on white ones, and on cultivars ripening late in the season. An edge effect was also detected in pest distribution within vineyards, with more stink bugs observed in the borders. In the study on pest infestation density, H. halys caused damage on berries, showing differences in susceptibility among different cultivars and with regard to the time of infestation (i.e., plant phenological stages). Halyomorpha halys infestation induced an increase in Botrytis cinerea and sour rot incidence, which probably represents the main issue related to the impact of brown marmorated stink bug on grapevine. Full article
(This article belongs to the Section Insect Pest and Vector Management)
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25 pages, 35547 KiB  
Review
A Systematic Review of the Vertical Green System for Balancing Ecology and Urbanity
by Jiayu Zhao, Qiuyi Rao, Chuanhao Sun, Rana Muhammad Adnan Ikram, Chengliang Fan, Jianjun Li, Mo Wang and Dongqing Zhang
Water 2024, 16(11), 1472; https://doi.org/10.3390/w16111472 - 22 May 2024
Abstract
Skyrise greenery, including green roofs and vertical gardens, has emerged as an indispensable tool for sustainable urban planning with multiple ecological and economic benefits. A bibliometric analysis was used to provide a systematic review of the functions associated with skyrise greenery in urban [...] Read more.
Skyrise greenery, including green roofs and vertical gardens, has emerged as an indispensable tool for sustainable urban planning with multiple ecological and economic benefits. A bibliometric analysis was used to provide a systematic review of the functions associated with skyrise greenery in urban landscapes. Key research tools, including the “Bibliometrix” R package and “CiteSpace” 6.2 R4, highlight the depth and breadth of the literature covering skyrise greenery. In 2000–2022, a total of 1474 original journal articles were retrieved. Over this period, there was an exponential increase in the number of publications, reflecting both enhanced knowledge and increasing concerns regarding climate change, the urban heat island, and urbanization. Of the total, ~58% of the articles originated from China, followed by the USA, Italy, Australia, and Canada. The research themes, such as urban heat islands, carbon sequestration, hydrology, and air quality, have been identified as the frontier in this fields. Furthermore, researchers from developed countries contributed the most publications to this domain, while developing countries, such as China, play an increasing role in the design and performance evaluation of vertical greenery. Key benefits identified in vertical green systems (e.g., green roofs and walls) include thermal regulation, sustainable water management, air-quality improvement, noise reduction, and biodiversity enhancement. In addition, several potential future research prospectives are highlighted. This review provides a comprehensive insight into exploring the pivotal role of skyrise greenery in shaping sustainable, resilient urban futures, coupled with sustainable urban planning. Full article
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