The 2023 MDPI Annual Report has
been released!
 
24 pages, 3088 KiB  
Article
Exploring the Survival Determinants in Recurrent Ovarian Cancer: The Role of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
by Katarzyna Gęca, Jakub Litwiński, Tomasz Ostrowski, Izabela Świetlicka, Wojciech P. Polkowski and Magdalena Skórzewska
Cancers 2024, 16(11), 2150; https://doi.org/10.3390/cancers16112150 (registering DOI) - 5 Jun 2024
Abstract
Background: Recurrent ovarian cancer (ROC) significantly challenges gynecological oncology due to its poor outcomes. This study assesses the impact of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) on ROC survival rates. Materials and Methods: Conducted at the Medical University of Lublin [...] Read more.
Background: Recurrent ovarian cancer (ROC) significantly challenges gynecological oncology due to its poor outcomes. This study assesses the impact of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) on ROC survival rates. Materials and Methods: Conducted at the Medical University of Lublin from April 2011 to November 2022, this retrospective observational study involved 71 patients with histologically confirmed ROC who underwent CRS and subsequent HIPEC. Results: The median overall survival (OS) was 41.1 months, with 3-year and 5-year survival rates post-treatment of 0.50 and 0.33, respectively. Patients undergoing radical surgery for primary ovarian cancer had a median OS of 61.9 months. The key survival-related factors included the Peritoneal Carcinomatosis Index (PCI) score, AGO score, platinum sensitivity, and ECOG status. Conclusions: The key factors enhancing ROC patients’ survival include radical surgery, optimal performance status, platinum sensitivity, a positive AGO score, and a lower PCI. This study highlights the predictive value of the platinum resistance and AGO score in patient outcomes, underlining their role in treatment planning. Further prospective research is needed to confirm these results and improve patient selection for this treatment approach. Full article
(This article belongs to the Section Cancer Survivorship and Quality of Life)
17 pages, 2597 KiB  
Article
Spatiotemporal Variation of Correlated Color Temperature in the Tunnel Access Zone
by Yangjian Yu, Yuwei Zhang, Shaofeng Wang, Ziyi Guo, Zhikai Ni and Peng Xue
Sustainability 2024, 16(11), 4838; https://doi.org/10.3390/su16114838 (registering DOI) - 5 Jun 2024
Abstract
A scientific and logical tunnel entrance lighting environment is an important guarantee for the safety of drivers entering tunnels as well as an essential element for the sustainable development of the tunnel. At present, most of the highway tunnel entrance lighting environment focuses [...] Read more.
A scientific and logical tunnel entrance lighting environment is an important guarantee for the safety of drivers entering tunnels as well as an essential element for the sustainable development of the tunnel. At present, most of the highway tunnel entrance lighting environment focuses on the road surface luminance and does not consider the variation of correlated color temperatures (CCT) on the driver’s vision in the tunnel access zone. This study analyzes the temporal and spatial variation of the ambient CCT in the driver’s 20° field of view during the approach to the tunnel through field dynamic tests of existing tunnels in the Beijing area. As a result, the CCT received by the driver’s eyes when approaching the tunnel peaks at the midpoint of the tunnel access zone, after which it decreases slowly up to the tunnel portal. Moreover, a calculation model of the CCT outside the tunnel with the solar irradiance, the distance from the tunnel portal, and the CCT of tunnel interior lighting as the input parameters is established. The modeling methodology was validated in a new tunnel, and the calculation model’s average absolute error is within 5%, which could provide guidance for the selection of the tunnel interior lighting CCT and a basis for the design of intelligent control of sustainable lighting systems in tunnels. Full article
(This article belongs to the Section Green Building)
13 pages, 1015 KiB  
Article
Immunological Insights: A Multicenter Longitudinal Study on Humoral Response to COVID-19 Vaccines in Greece
by Eleni Makri, Ekatherina Charvalos, Elisavet Stavropoulou, Constantina Skanavis, Areti Lagiou and Anastasia Barbounis
Acta Microbiol. Hell. 2024, 69(2), 101-113; https://doi.org/10.3390/amh69020011 (registering DOI) - 5 Jun 2024
Abstract
Vaccination has emerged as the most effective tool in the battle against COVID-19. To optimize vaccination protocols, a deeper understanding of the immune response to vaccination, including influential factors and its duration, is essential. This study aimed to assess the humoral response in [...] Read more.
Vaccination has emerged as the most effective tool in the battle against COVID-19. To optimize vaccination protocols, a deeper understanding of the immune response to vaccination, including influential factors and its duration, is essential. This study aimed to assess the humoral response in vaccinated individuals with or without prior SARS-CoV-2 infection. A prospective observational study was conducted across 14 private healthcare structures in Greece. Anti-spike IgG titers were measured at different timepoints following the initial vaccination and booster doses of the BNT162b2, mRNA-1273, ChAdOx1 nCoV-19, and Ad26.COV2.S vaccines. A total of 505 participants were included in the first phase, evaluating the humoral response after the initial vaccination, and 311 participants were involved in the second phase, assessing the effects of booster vaccination. All vaccines elicited high anti-S IgG titers initially, followed by a subsequent decline that was addressed by the booster vaccination. The humoral response was sustained up to one year after the booster vaccination. mRNA vaccines induced higher anti-S IgG titers compared to vector vaccines, with mRNA-1273 eliciting higher titers than BNT162b2. Vaccination resulted in higher antibody titers than natural infection alone; however, convalescent patients who received vaccination had significantly higher anti-S IgG titers compared to those who received the booster vaccine without previous SARS-CoV-2 infection. Lower antibody titers were observed in men and older patients (>51.5 years old), as well as smokers, although the decline rate was lower in these subgroups. These results underscore the importance of booster doses and reveal the potential influence of age, gender, smoking habits, and vaccine type on varying humoral responses. Long-term monitoring of antibody persistence, evaluation of cellular immune responses, and assessment of vaccine efficacy against emerging variants should be considered to enhance our understanding of immunity dynamics and inform vaccine development and deployment strategies. Full article
(This article belongs to the Special Issue Feature Papers in Medical Microbiology in 2024)
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10 pages, 538 KiB  
Article
A Clinical Perspective on Plasma Cell Leukemia: A Single-Center Experience
by Andrew Y. Li, Farin Kamangar, Noa G. Holtzman, Aaron P. Rapoport, Mehmet H. Kocoglu, Djordje Atanackovic and Ashraf Z. Badros
Cancers 2024, 16(11), 2149; https://doi.org/10.3390/cancers16112149 (registering DOI) - 5 Jun 2024
Abstract
Circulating plasma cells (CPCs) are detected in most multiple myeloma (MM) patients, both at diagnosis and on relapse. A small subset, plasma cell leukemia (PCL), represents a different biology and has a poor prognosis. In this retrospective analysis, we evaluated patients with primary [...] Read more.
Circulating plasma cells (CPCs) are detected in most multiple myeloma (MM) patients, both at diagnosis and on relapse. A small subset, plasma cell leukemia (PCL), represents a different biology and has a poor prognosis. In this retrospective analysis, we evaluated patients with primary (pPCL, n = 35) or secondary (sPCL, n = 49), with ≥5% CPCs and a smaller subset with lower CPCs of 1–4% (n = 20). The median age was 61 years; 45% were men and 54% were Black. High-risk cytogenetics were found in 87% and extramedullary disease in 47%. For the entire cohort, 75% received a proteasome inhibitor, 70% chemotherapy, 54% an immunomodulatory drug, 24% a daratumumab-based regimen and 26% an autologous stem cell transplant (ASCT). The treatments marginally improved the overall survival (OS) for pPCL vs. sPCL (13 vs. 3.5 months p = 0.002). However, the 5-year survival for the whole cohort was dismal at 11%. High-risk cytogenetics, low platelets, extramedullary disease and high LDH were independently associated with poor outcomes. Further research is urgently needed to expand the treatment options and improve the outcomes in PCL. Full article
(This article belongs to the Section Clinical Research of Cancer)
21 pages, 2281 KiB  
Article
The Logistics of Volkswagen Development Center Applies Operations Research to Optimize Transshipments
by Bastian Vorwerk and Sebastian Trojahn
Appl. Sci. 2024, 14(11), 4917; https://doi.org/10.3390/app14114917 (registering DOI) - 5 Jun 2024
Abstract
Volkswagen Technical Development (TE) is responsible for all prototype development and prototype production for the Volkswagen brand and has its own logistics department (TE-Logistics). In the logistics of prototype parts in the automotive industry, new versions of prototype parts (henceforth referred to as [...] Read more.
Volkswagen Technical Development (TE) is responsible for all prototype development and prototype production for the Volkswagen brand and has its own logistics department (TE-Logistics). In the logistics of prototype parts in the automotive industry, new versions of prototype parts (henceforth referred to as updating parts) are repeatedly assembled in finished prototype vehicles. These updating parts are stored in warehouses and provided to an assembly site to ensure a timely assembly of the associated prototype vehicles. As the internal warehouse on the company site is not large enough for the high variety of parts, an additional external warehouse in the logistics network is needed. However, since prototype parts are unique, the allocation of the parts in suitable warehouses is particularly important. Currently, the various warehouses and the short-term demands repeatedly lead to reactive transshipments between the warehouses. To this end, we developed an approach for proactive transshipments based on a machine learning forecast and a mixed-integer linear programming model for planning proactive transshipments of parts between the warehouses to minimize transport costs. The model is based on a probability estimation of future demands to anticipate the expected optimal warehouse. After the model had revealed high improvement potential through a case study with real-world data in terms of costs and availability time compared to the current reactive process, we derived decision rules and developed a rule-based heuristic algorithm that leads to the optimal solution for the industrial use case. We implemented the heuristic with a spreadsheet-based decision support system (DSS) for daily transshipment planning. After successful test implementation, TE-Logistics estimated the annual cost savings for transport to be approximately 10%. Full article
10 pages, 378 KiB  
Article
A Quality and Completeness Assessment of Testicular Cancer Health Information on TikTok
by Hoi Pong Nicholas Wong, Lee Jing Yang, Vikneshwaren SO Senthamil Selvan, Jamie Yong Qi Lim, Wei Zheng So, Vineet Gauhar and Ho Yee Tiong
Soc. Int. Urol. J. 2024, 5(3), 182-191; https://doi.org/10.3390/siuj5030028 (registering DOI) - 5 Jun 2024
Abstract
TikTok has become a hub for easily accessible medical information. However, the quality and completeness of this information for testicular cancer has not been examined. Our study aims to assess the quality and completeness of testicular cancer information on TikTok. A search was [...] Read more.
TikTok has become a hub for easily accessible medical information. However, the quality and completeness of this information for testicular cancer has not been examined. Our study aims to assess the quality and completeness of testicular cancer information on TikTok. A search was performed on TikTok using the search terms “Testicular Cancer” and “Testicle Cancer”. Inclusion criteria encompassed videos about testicular cancer in English. We excluded non-English videos, irrelevant videos, and videos without audio. We evaluated these videos using the DISCERN instrument and a completeness assessment. A total of 361 videos were considered for screening and 116 videos were included. Of these, 57 were created by healthcare professionals (HCPs). The median video length was 40 s (5–277 s), with >25 million cumulative views and a median of 446,400 views per video. The average DISCERN score was 29.0 ± 5.7, with HCPs providing higher-quality videos than non-HCPs (30.8 vs. 5.5, p < 0.05). HCPs also had more reliable videos (21.2 vs. 18.1, p < 0.05). Overall quality levels were mostly poor or very poor (97.4%), with none being good or excellent. Most HCP videos were poor (63.2%), whilst many non-HCP videos were very poor (61.0%). The most viewed video had 2,800,000 views but scored a 31 on the DISCERN tool and one on the completeness assessment. The highest DISCERN score had 11,700 views. HCP videos better defined the disease and were more complete (p < 0.05). Most videos discussed self-assessment but were lacking in definitions, risk factors, symptoms, evaluation, management, and outcomes. Most of TikTok’s testicular cancer information lacks quality and completeness, whilst higher-quality videos have limited reach. Full article
23 pages, 660 KiB  
Article
The Dynamics of Rewards and Penalties: Governmental Impact on Green Packaging Adoption in Logistics
by Xingyi Yang, Xiaopei Dai and Hou Bin
Sustainability 2024, 16(11), 4835; https://doi.org/10.3390/su16114835 (registering DOI) - 5 Jun 2024
Abstract
The widespread use of traditional packaging materials poses significant environmental challenges. Adopting green packaging is essential for reducing pollution and conserving natural resources. This paper aims to examine the effectiveness of government incentives and penalties in promoting the adoption of green packaging by [...] Read more.
The widespread use of traditional packaging materials poses significant environmental challenges. Adopting green packaging is essential for reducing pollution and conserving natural resources. This paper aims to examine the effectiveness of government incentives and penalties in promoting the adoption of green packaging by logistics companies. We developed an evolutionary game theory model that involves governments and logistics companies, comparing the impacts of static and dynamic reward and penalty policies. The results indicate that (1) static policies often lead to oscillatory adoption rates of green packaging without achieving a stable equilibrium, while dynamic policies generally promote steadier adoption of sustainable practices. (2) Different combinations of dynamic policies have varying influences on logistics companies’ propensity to adopt green packaging solutions. Specifically, dynamic rewards and static penalties are particularly effective at encouraging logistics companies to adopt green packaging. (3) A combination of dynamic rewards and penalties tends to facilitate more rapid and consistent adoption of green packaging by logistics companies. (4) An increase in government supervision costs is associated with reduced regulatory actions and a lower prevalence of green packaging. These insights are critical for policymakers aiming to craft regulations that successfully encourage sustainability within logistics operations. Full article
28 pages, 6815 KiB  
Article
A Hardware Security Protection Method for Conditional Branches of Embedded Systems
by Qiang Hao, Dongdong Xu, Yusen Qin, Ruyin Li, Zongxuan Zhang, Yunyan You and Xiang Wang
Micromachines 2024, 15(6), 760; https://doi.org/10.3390/mi15060760 (registering DOI) - 5 Jun 2024
Abstract
The branch prediction units (BPUs) generally have security vulnerabilities, which can be used by attackers to tamper with the branches, and the existing protection methods cannot defend against these attacks. Therefore, this article proposes a hardware security protection method for conditional branches of [...] Read more.
The branch prediction units (BPUs) generally have security vulnerabilities, which can be used by attackers to tamper with the branches, and the existing protection methods cannot defend against these attacks. Therefore, this article proposes a hardware security protection method for conditional branches of embedded systems. This method calculates the number of branch target buffer (BTB) updates every 80 clock cycles. If the number exceeds the set threshold, the BTB will be locked and prevent any process from tampering with the BTB entries, thereby resisting branch prediction analysis (BPA) attacks. Moreover, to prevent attackers from stealing the critical information of branches, the method designs the hybrid arbiter physical unclonable function (APUF) circuit to encrypt and decrypt the directions, addresses, and indexes of branches. This circuit combines the advantages of double APUF and Feed-Forward APUF, which can enhance the randomness of output response and resist machine learning attacks. If attackers still successfully tamper with the branches and disrupt the control flow integrity (CFI), this method detects tampering with the instruction codes, jump addresses, and jump directions in a timely manner through dynamic and static label comparison. The proposed method is implemented and tested on FPGA. The experimental results show that this method can achieve fine-grained security protection for conditional branches, with about 5.4% resource overhead and less than 5.5% performance overhead. Full article
(This article belongs to the Section D1: Semiconductor Devices)
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10 pages, 384 KiB  
Article
Increased Expression of Orexin-A in Patients Affected by Polycystic Kidney Disease
by Ersilia Nigro, Daniela D’Arco, Fiorenzo Moscatelli, Antonio Pisani, Maria Amicone, Eleonora Riccio, Ivana Capuano, Francesca Argentino, Marcellino Monda, Giovanni Messina, Aurora Daniele and Rita Polito
Int. J. Mol. Sci. 2024, 25(11), 6243; https://doi.org/10.3390/ijms25116243 (registering DOI) - 5 Jun 2024
Abstract
Orexin-A is a neuropeptide product of the lateral hypothalamus that acts on two receptors, OX1R and OX2R. The orexinergic system is involved in feeding, sleep, and pressure regulation. Recently, orexin-A levels have been found to be negatively correlated with renal function. Here, we [...] Read more.
Orexin-A is a neuropeptide product of the lateral hypothalamus that acts on two receptors, OX1R and OX2R. The orexinergic system is involved in feeding, sleep, and pressure regulation. Recently, orexin-A levels have been found to be negatively correlated with renal function. Here, we analyzed orexin-A levels as well as the incidence of SNPs in the hypocretin neuropeptide precursor (HCRT) and its receptors, HCRTR1 and HCRTR2, in 64 patients affected by autosomal dominant polycystic kidney disease (ADPKD) bearing truncating mutations in the PKD1 or PKD2 genes. Twenty-four healthy volunteers constituted the control group. Serum orexin-A was assessed by ELISA, while the SNPs were investigated through Sanger sequencing. Correlations with the main clinical features of PKD patients were assessed. PKD patients showed impaired renal function (mean eGFR 67.8 ± 34.53) and a statistically higher systolic blood pressure compared with the control group (p < 0.001). Additionally, orexin-A levels in PKD patients were statistically higher than those in healthy controls (477.07 ± 69.42 pg/mL vs. 321.49 ± 78.01 pg/mL; p < 0.001). Furthermore, orexin-A inversely correlated with blood pressure (p = 0.0085), while a direct correlation with eGFR in PKD patients was found. None of the analyzed SNPs showed any association with orexin-A levels in PKD. In conclusion, our data highlights the emerging role of orexin-A in renal physiology and its potential relevance to PKD. Further research is essential to elucidate the intricate mechanisms underlying orexin-A signaling in renal function and its therapeutic implications for PKD and associated cardiovascular complications Full article
(This article belongs to the Special Issue New Insights into Kidney Diseases)
17 pages, 10384 KiB  
Article
In Situ Thermal Interactions of Cu-Based Anti-Corrosion Coatings on Steel Implemented by Surface Alloying
by Huda Hanif Khan, Tong Wang, Lihong Su, Huijun Li, Qiang Zhu, Ana Yang, Zigang Li, Wei Wang and Hongtao Zhu
Coatings 2024, 14(6), 722; https://doi.org/10.3390/coatings14060722 (registering DOI) - 5 Jun 2024
Abstract
Incorporating expensive alloying elements into bulk steel for corrosion protection is undesirable, considering that only the surfaces are exposed to aggressive environments. Therefore, this work focused on developing and optimizing a new surface functioning technology through in situ observation of thermal interactions between [...] Read more.
Incorporating expensive alloying elements into bulk steel for corrosion protection is undesirable, considering that only the surfaces are exposed to aggressive environments. Therefore, this work focused on developing and optimizing a new surface functioning technology through in situ observation of thermal interactions between the metallic powders at elevated temperatures. The study revealed that the Cu-Ni powder mixture, with 12.5 wt% Ni, began to melt at 1099.5 °C and was fully melted at 1175 °C, significantly different from the Cu-Ni solid solution and bulk Cu or Ni. As a result of high-temperature reactions, copper penetration of up to 35 µm for pure copper and 55 µm for copper-chromium composite coatings occurred due to liquid metal corrosion. In contrast, the copper-nickel composite coating exhibited a cupronickel solution microstructure with FeNi dendrites and a nickel-rich transition layer. This cupronickel coating, with a chemical composition of 89.3 wt% Cu, 6.2 wt% Ni, and 4.5 wt% Fe, demonstrated uniform thickness, superior surface morphology, and continuous coverage on the steel substrate. Furthermore, the Ni-rich transition layer played a vital role in preventing copper penetration along the grain boundary of the steel matrix while forming a chemical binding between the coating and the substrate. The practicality of the coating was further confirmed through the hot-rolling procedure and subsequent electrochemical corrosion tests, which resulted in a 44% improvement in corrosion resistance. Full article
(This article belongs to the Special Issue Surface Science of Degradation and Surface Protection)
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14 pages, 14702 KiB  
Article
The Effect of Deposition Temperature on TiN Thin Films for the Electrode Layer of 3D Capacitors Prepared by Atomic Layer Deposition
by Xingyu Chen, Jing Zhang, Lingshan Gao, Faqiang Zhang, Mingsheng Ma and Zhifu Liu
Coatings 2024, 14(6), 724; https://doi.org/10.3390/coatings14060724 (registering DOI) - 5 Jun 2024
Abstract
The TiN thin film is considered a promising electrode layer for 3D capacitors. In this study, TiN thin films were prepared on Si substrates using atomic layer deposition (ALD) at various temperatures from 375 °C to 475 °C. The crystallization behavior, microstructure, and [...] Read more.
The TiN thin film is considered a promising electrode layer for 3D capacitors. In this study, TiN thin films were prepared on Si substrates using atomic layer deposition (ALD) at various temperatures from 375 °C to 475 °C. The crystallization behavior, microstructure, and conductance properties of those TiN thin films were investigated. The resistivity of TiN thin films deposited on Si wafers can reach as low as 128 μΩ·cm. TiN thin films showed lower resistivity and worse uniformity with the deposition temperature increasing. In addition, the aging of TiN thin films may weaken the device performance. Optimized deposition parameters were found and full-coverage deposition of thin films on the wall of deep holes with an aspect ratio of approximately 14 has been successfully achieved. The results would be a good reference for the development of 3D capacitors and other microelectronics components. Full article
(This article belongs to the Special Issue Thin-Film Synthesis, Characterization and Properties)
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27 pages, 13721 KiB  
Article
Influence of Incident Shock on Fuel Mixing in Scramjet
by Chao Wang, Hongbo Wang, Yixin Yang and Xu Liu
Appl. Sci. 2024, 14(11), 4916; https://doi.org/10.3390/app14114916 (registering DOI) - 5 Jun 2024
Abstract
During the operation of hypersonic vehicles, a reciprocal coupling effect is manifested between the inlet and the combustion chamber. This results in an unavoidable non-uniformity of conditions at the combustion chamber’s entrance, which, in turn, influences the fuel mixing within the chamber. The [...] Read more.
During the operation of hypersonic vehicles, a reciprocal coupling effect is manifested between the inlet and the combustion chamber. This results in an unavoidable non-uniformity of conditions at the combustion chamber’s entrance, which, in turn, influences the fuel mixing within the chamber. The present study employed the Reynolds-averaged Navier–Stokes (RANS) equations to perform a numerical simulation of an X-51-like vehicle, with a focus on examining the impact of isolation section length and multi-injection strategies on the fuel mixing characteristics within the combustion chamber under conditions of non-uniform inflow. The findings indicated that a supersonic non-uniform inlet triggers incident shock waves, leading to a non-uniform pressure distribution across the flow section. Moreover, the position of injection was found to be pivotal in regulating penetration depth and mixing efficiency. The incident shock wave, bow shock, and boundary layer separation shock interacted with each other to increase local pressure. The coupling of high and low pressures generated an adverse pressure gradient that led to boundary layer separation, which further enhanced fuel penetration depth. Full article
(This article belongs to the Special Issue Application of Aerodynamics in Aerospace)
18 pages, 809 KiB  
Review
The Integration of Advanced Drug Delivery Systems into Conventional Adjuvant Therapies for Peri-Implantitis Treatment
by Iria Seoane-Viaño, Mariola Seoane-Gigirey, Carlos Bendicho-Lavilla, Luz M. Gigirey, Francisco J. Otero-Espinar and Santiago Seoane-Trigo
Pharmaceutics 2024, 16(6), 769; https://doi.org/10.3390/pharmaceutics16060769 (registering DOI) - 5 Jun 2024
Abstract
Despite the high success rates of dental implants, peri-implantitis is currently the most common complication in dental implantology. Peri-implantitis has an inflammatory nature, it is associated with the accumulation of plaque in the peri-implant tissues, and its evolution can be progressive depending on [...] Read more.
Despite the high success rates of dental implants, peri-implantitis is currently the most common complication in dental implantology. Peri-implantitis has an inflammatory nature, it is associated with the accumulation of plaque in the peri-implant tissues, and its evolution can be progressive depending on various factors, comorbidities, and poor oral health. Prophylaxis and different treatment methods have been widely discussed in recent decades, and surgical and non-surgical techniques present both advantages and disadvantages. In this work, a literature review of different studies on the application of adjuvant treatments, such as local and systemic antibiotics and antiseptic treatments, was conducted. Positive outcomes have been found in the short (up to one year after treatment) and long term (up to ten years after treatment) with combined therapies. However, there is still a need to explore new therapies based on the use of advanced drug delivery systems for the effective treatment of peri-implantitis in the long term and without relapses. Hence, micro- and nanoparticles, implants, and injectable hydrogels, among others, should be considered in future peri-implantitis treatment with the aim of enhancing overall therapy outcomes. Full article
(This article belongs to the Special Issue Advanced Materials Science and Technology in Drug Delivery)
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11 pages, 423 KiB  
Review
Breaking Barriers: Unveiling Sex-Related Differences in Cerebrospinal Fluid Analysis—A Narrative Review
by Raffaella Candeloro, Caterina Ferri, Tiziana Bellini, Maura Pugliatti and Massimiliano Castellazzi
Biology 2024, 13(6), 420; https://doi.org/10.3390/biology13060420 (registering DOI) - 5 Jun 2024
Abstract
(1) Background: The recent emphasis on sexual and gender diversity’s impact on human health underscores the need for tailored diagnostic and therapeutic approaches in neurology. The aim of this article is to conduct a narrative review of the available scientific literature on sex [...] Read more.
(1) Background: The recent emphasis on sexual and gender diversity’s impact on human health underscores the need for tailored diagnostic and therapeutic approaches in neurology. The aim of this article is to conduct a narrative review of the available scientific literature on sex differences in cerebrospinal fluid analysis. (2) Methods: The literature search encompassed PubMed databases, focusing on cerebrospinal fluid analysis and sex differences, considering parameters like cerebrospinal fluid protein content, cell count, albumin quotient (QAlb) and intrathecal IgG synthesis. (3) Results: Nine articles from the past two decades were identified, revealing limited research in this area. Males consistently exhibited higher cerebrospinal fluid protein content and albumin quotient values across various pathologies and age groups. Consequently, males more frequently manifested blood–cerebrospinal fluid barrier dysfunction than females. No significant sex differences were observed in cerebrospinal fluid leukocyte count or intrathecal IgG synthesis. (4) Conclusions: This review highlights the dearth of research on sex differences in cerebrospinal fluid analysis, despite consistent findings of higher protein content and albumin quotient values in males. Revisiting current diagnostic thresholds based on sex is crucial for accurate prognosis and personalised treatment strategies in neurological disorders. Moving towards sex-specific approaches in clinical practice is imperative for advancing personalised medicine. Full article
9 pages, 254 KiB  
Brief Report
An Observational Study Suggests That Natural HAdV-36 Infection Decreases Blood Glucose Levels without Affecting Insulin Levels in Obese Young Subjects
by Inés Matia-Garcia, Jorge Adalberto Ocampo-Galeana, José Francisco Muñoz-Valle, José Guadalupe Soñanez-Organis, Ramón A. González, Iris Paola Guzmán-Guzmán, Linda Anahi Marino-Ortega and Isela Parra-Rojas
Viruses 2024, 16(6), 922; https://doi.org/10.3390/v16060922 (registering DOI) - 5 Jun 2024
Abstract
Human adenovirus-36 (HAdV-36) infection has been linked to obesity, low lipid levels, and improvements in blood glucose levels and insulin sensitivity in animal models and humans, although epidemiological studies remain controversial. Therefore, this study investigated the relationship between HAdV-36 seropositivity and glycemic control [...] Read more.
Human adenovirus-36 (HAdV-36) infection has been linked to obesity, low lipid levels, and improvements in blood glucose levels and insulin sensitivity in animal models and humans, although epidemiological studies remain controversial. Therefore, this study investigated the relationship between HAdV-36 seropositivity and glycemic control in youths. This observational study examined 460 youths (246 with normal weight and 214 obese subjects). All participants underwent assessments for anthropometry, blood pressure, circulating fasting levels of glucose, lipids, insulin, and anti-HAdV-36 antibodies; additionally, the homeostatic model assessment of insulin resistance (HOMA-IR) was calculated. In all, 57.17% of the subjects were HAdV-36 seropositive. Moreover, HAdV-36 seroprevalence was higher in obese subjects compared to their normal weight counterparts (59% vs. 55%). BMI (33.1 vs. 32.3 kg/m2, p = 0.03), and waist circumference (107 vs. 104 cm, p = 0.02), insulin levels (21 vs. 16.3 µU/mL, p = 0.003), and HOMA-IR (4.6 vs. 3.9, p = 0.02) were higher in HAdV-36-positive subjects with obesity compared to seronegative subjects. In the obese group, HAdV-36 seropositivity was associated with a reducing effect in blood glucose levels in a model adjusted for total cholesterol, triglyceride levels, age and sex (β = −10.44, p = 0.014). Furthermore, a statistically significant positive relationship was observed between HAdV-36 seropositivity and insulin levels in the obesity group. These findings suggest that natural HAdV-36 infection improves glycemic control but does not ameliorate hyperinsulinemia in obese subjects. Full article
(This article belongs to the Special Issue Research and Clinical Application of Adenovirus (AdV), Volume II)
15 pages, 1161 KiB  
Article
Sodium–Glucose Cotransporter 2 Inhibitor Combined with Conventional Diuretics Ameliorate Body Fluid Retention without Excessive Plasma Volume Reduction
by Maki Asakura-Kinoshita, Takahiro Masuda, Kentaro Oka, Ken Ohara, Marina Miura, Masato Morinari, Kyohei Misawa, Yasuharu Miyazawa, Tetsu Akimoto, Kazuyuki Shimada and Daisuke Nagata
Diagnostics 2024, 14(11), 1194; https://doi.org/10.3390/diagnostics14111194 (registering DOI) - 5 Jun 2024
Abstract
We previously reported that sodium–glucose cotransporter 2 (SGLT2) inhibitors exert sustained fluid homeostatic actions through compensatory increases in osmotic diuresis-induced vasopressin secretion and fluid intake. However, SGLT2 inhibitors alone do not produce durable amelioration of fluid retention. In this study, we examined the [...] Read more.
We previously reported that sodium–glucose cotransporter 2 (SGLT2) inhibitors exert sustained fluid homeostatic actions through compensatory increases in osmotic diuresis-induced vasopressin secretion and fluid intake. However, SGLT2 inhibitors alone do not produce durable amelioration of fluid retention. In this study, we examined the comparative effects of the SGLT2 inhibitor dapagliflozin (SGLT2i group, n = 53) and the combined use of dapagliflozin and conventional diuretics, including loop diuretics and/or thiazides (SGLT2i + diuretic group, n = 23), on serum copeptin, a stable, sensitive, and simple surrogate marker of vasopressin release and body fluid status. After six months of treatment, the change in copeptin was significantly lower in the SGLT2i + diuretic group than in the SGLT2i group (−1.4 ± 31.5% vs. 31.5 ± 56.3%, p = 0.0153). The change in the estimated plasma volume calculated using the Strauss formula was not significantly different between the two groups. Contrastingly, changes in interstitial fluid, extracellular water, intracellular water, and total body water were significantly lower in the SGLT2i + diuretic group than in the SGLT2i group. Changes in renin, aldosterone, and absolute epinephrine levels were not significantly different between the two groups. In conclusion, the combined use of the SGLT2 inhibitor dapagliflozin and conventional diuretics inhibited the increase in copeptin levels and remarkably ameliorated fluid retention without excessively reducing plasma volume and activating the renin–angiotensin–aldosterone and sympathetic nervous systems. Full article
(This article belongs to the Special Issue Kidney Disease: Biomarkers, Diagnosis, and Prognosis: 3rd Edition)
30 pages, 4181 KiB  
Review
The Complement System as a Therapeutic Target in Retinal Disease
by Joshua Ong, Arman Zarnegar, Amrish Selvam, Matthew Driban and Jay Chhablani
Medicina 2024, 60(6), 945; https://doi.org/10.3390/medicina60060945 (registering DOI) - 5 Jun 2024
Abstract
The complement cascade is a vital system in the human body’s defense against pathogens. During the natural aging process, it has been observed that this system is imperative for ensuring the integrity and homeostasis of the retina. While this system is critical for [...] Read more.
The complement cascade is a vital system in the human body’s defense against pathogens. During the natural aging process, it has been observed that this system is imperative for ensuring the integrity and homeostasis of the retina. While this system is critical for proper host defense and retinal integrity, it has also been found that dysregulation of this system may lead to certain retinal pathologies, including geographic atrophy and diabetic retinopathy. Targeting components of the complement system for retinal diseases has been an area of interest, and in vivo, ex vivo, and clinical trials have been conducted in this area. Following clinical trials, medications targeting the complement system for retinal disease have also become available. In this manuscript, we discuss the pathophysiology of complement dysfunction in the retina and specific pathologies. We then describe the results of cellular, animal, and clinical studies targeting the complement system for retinal diseases. We then provide an overview of complement inhibitors that have been approved by the Food and Drug Administration (FDA) for geographic atrophy. The complement system in retinal diseases continues to serve as an emerging therapeutic target, and further research in this field will provide additional insights into the mechanisms and considerations for treatment of retinal pathologies. Full article
(This article belongs to the Special Issue Retinal Diseases: Clinical Presentation and Novel Treatments)
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23 pages, 16642 KiB  
Article
Cutting Performance of a Longitudinal and Torsional Ultrasonic Vibration Tool in Milling of Inconel 718
by Hang Zhang, Guosheng Su, Yan Xia, Peirong Zhang, Binxun Li, Yujing Sun, Jin Du and Bin Fang
Coatings 2024, 14(6), 719; https://doi.org/10.3390/coatings14060719 (registering DOI) - 5 Jun 2024
Abstract
Inconel 718 has excellent thermal and chemical properties and is widely used in the manufacture of aerospace parts; however, there are some problems in the machining of Inconel 718, such as a large milling force, serious tool wear, and poor surface quality. In [...] Read more.
Inconel 718 has excellent thermal and chemical properties and is widely used in the manufacture of aerospace parts; however, there are some problems in the machining of Inconel 718, such as a large milling force, serious tool wear, and poor surface quality. In this research, a type of longitudinal–torsional ultrasonic milling (LTUM) tool is designed based on theoretical computations and FEM simulation analysis. To verify the design rationality of the developed LTUM tool, milling experiments are performed. It is verified that the LTUM tool can realize an elliptical vibration path at the tool tip. The resonance frequency of the tool is 21.32 kHz, the longitudinal amplitude is 6.8 µm, and the torsional amplitude is 1.4 µm. In the milling of Inconel 718, the experimental data of LTUM are compared with those of conventional milling (CM). The comparative experiments show that the LTUM tool can effectively lessen the milling force and tool wear in the milling of Inconel 718, improve the surface quality, inhibit the generation of burrs, and improve the chip breaking ability. The application potential of the LTUM tool in high-performance milling of Inconel 718 parts is proven. Full article
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16 pages, 1875 KiB  
Article
Synovial Membrane Is a Major Producer of Extracellular Inorganic Pyrophosphate in Response to Hypoxia
by Émilie Velot, Sylvie Sébillaud and Arnaud Bianchi
Pharmaceuticals 2024, 17(6), 738; https://doi.org/10.3390/ph17060738 (registering DOI) - 5 Jun 2024
Abstract
Calcium pyrophosphate dehydrate (CPPD) crystals are found in the synovial fluid of patients with articular chondrocalcinosis or sometimes with osteoarthritis. In inflammatory conditions, the synovial membrane (SM) is subjected to transient hypoxia, especially during movement. CPPD formation is supported by an increase in [...] Read more.
Calcium pyrophosphate dehydrate (CPPD) crystals are found in the synovial fluid of patients with articular chondrocalcinosis or sometimes with osteoarthritis. In inflammatory conditions, the synovial membrane (SM) is subjected to transient hypoxia, especially during movement. CPPD formation is supported by an increase in extracellular inorganic pyrophosphate (ePPi) levels, which are mainly controlled by the transporter Ank and ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1). We demonstrated previously that transforming growth factor (TGF)-β1 increased ePPi production by inducing Ank and Enpp1 expression in chondrocytes. As the TGF-β1 level raises in synovial fluid under hypoxic conditions, we investigated whether hypoxia may transform SM as a major source of ePPi production. Synovial fibroblasts and SM explants were exposed to 10 ng/mL of TGF-β1 in normoxic or hypoxic (5% O2) culture conditions. Ank and Enpp1 expression were assessed by quantitative PCR, Western blot and immunohistochemistry. ePPi was quantified in culture supernatants. RNA silencing was used to define the respective roles of Ank and Enpp1 in TGF-β1-induced ePPi generation. The molecular mechanisms involved in hypoxia were investigated using an Ank promoter reporter plasmid for transactivation studies, as well as gene overexpression and RNA silencing, the respective role of hypoxia-induced factor (HIF)-1 and HIF-2. Our results showed that TGF-β1 increased Ank, Enpp1, and therefore ePPi production in synovial fibroblasts and SM explants. Ank was the major contributor in ePPi production compared to ENPP1. Hypoxia increased ePPi levels on its own and enhanced the stimulating effect of TGF-β1. Hypoxic conditions enhanced Ank promoter transactivation in an HIF-1-dependent/HIF-2-independent fashion. We demonstrated that under hypoxia, SM is an important contributor to ePPi production in the joint through the induction of Enpp1 and Ank. These findings are of interest as a rationale for the beneficial effect of anti-inflammatory drugs on SM in crystal depositions. Full article
(This article belongs to the Section Pharmacology)
24 pages, 734 KiB  
Article
Decarbonization Drivers and Their Impact on Business Models in the Energy-Intensive Manufacturing Industry (EIMI)
by Franziska Mais and Thomas Bauernhansl
Sustainability 2024, 16(11), 4836; https://doi.org/10.3390/su16114836 (registering DOI) - 5 Jun 2024
Abstract
EIMIs face the challenge of adapting to the Paris Agreement and the European Green Deal to achieve carbon neutrality. Driven by consumer interest in low-carbon products, regulatory requirements, and investor priorities, companies are pressured to integrate sustainability beyond short-term financial gains. The growing [...] Read more.
EIMIs face the challenge of adapting to the Paris Agreement and the European Green Deal to achieve carbon neutrality. Driven by consumer interest in low-carbon products, regulatory requirements, and investor priorities, companies are pressured to integrate sustainability beyond short-term financial gains. The growing awareness of the environmental impact of business models (BM) has fueled the development of Sustainable Business Models (SBMs). Although the importance of decarbonization of EIMIs has increased, there is a lack of industry-specific research examining the combination of decarbonization and business models, as well as their interrelationships and correlations. This study addresses the discussion on the role of SBMs in decarbonization, improving the understanding of how these drivers can be integrated to enable new BMs for EIMIs. Based on a structured literature review and semi-structured interviews within the EIMIs, the study identifies BM components influenced by these drivers requiring sustainable business model innovation (SBMI). Results show that decarbonization drivers significantly impact all BM components. Experts emphasize the importance of collaborative approaches and cooperation throughout the value chain. This research highlights the need for systematic analysis to understand how companies can manage decarbonization drivers effectively and suggests exploring potential SBM design options. Full article
(This article belongs to the Section Economic and Business Aspects of Sustainability)
12 pages, 256 KiB  
Article
Spheno-Orbital Meningiomas: The Rationale behind the Decision-Making Process of Treatment Strategy
by Giuseppe Mariniello, Sergio Corvino, Giuseppe Corazzelli, Oreste de Divitiis, Giancarlo Fusco, Adriana Iuliano, Diego Strianese, Francesco Briganti and Andrea Elefante
Cancers 2024, 16(11), 2148; https://doi.org/10.3390/cancers16112148 (registering DOI) - 5 Jun 2024
Abstract
Surgery stands as the primary treatment for spheno-orbital meningiomas, following a symptoms-oriented approach. We discussed the decision-making process behind surgical strategies through a review of medical records from 80 patients who underwent surgical resection at the University of Naples Federico II. Different surgical [...] Read more.
Surgery stands as the primary treatment for spheno-orbital meningiomas, following a symptoms-oriented approach. We discussed the decision-making process behind surgical strategies through a review of medical records from 80 patients who underwent surgical resection at the University of Naples Federico II. Different surgical approaches were employed based on the tumor’s location relative to the optic nerve’s long axis, categorized into lateral (type I), medial (type II), and diffuse (type III). We examined clinical, neuroradiological, surgical, pathological, and outcome factors. Proptosis emerged as the most frequent symptom (97%), followed by visual impairment (59%) and ocular motility issues (35%). Type I represented 20%, type II 43%, and type III 17%. Growth primarily affected the optic canal (74%), superior orbital fissure (65%), anterior clinoid (60%), and orbital apex (59%). The resection outcomes varied, with Simpson grades I and II achieved in all type I cases, 67.5% of type II, and 18% of type III. Recurrence rates were highest in type II (41.8%) and type III (59%). Improvement was notable in proptosis (68%) and visual function (51%, predominantly type I). Surgery for spheno-orbital meningiomas should be tailored to each patient, considering individual characteristics and tumor features to improve quality of life by addressing primary symptoms like proptosis and visual deficits. Full article
(This article belongs to the Section Molecular Cancer Biology)
13 pages, 1676 KiB  
Review
The Wasps (Hymenoptera) from Lower Cretaceous Lebanese and Spanish Ambers
by Sergio Álvarez-Parra and Dany Azar
Foss. Stud. 2024, 2(2), 110-122; https://doi.org/10.3390/fossils2020005 (registering DOI) - 5 Jun 2024
Abstract
Hymenoptera is the fourth-most diverse insect order today, including wasps, bees, bumblebees, and ants. They show a wide panoply of modes of life, such as herbivory, predation, parasitoidism, pollination, and eusociality. This group also includes a great number of extinct species from both [...] Read more.
Hymenoptera is the fourth-most diverse insect order today, including wasps, bees, bumblebees, and ants. They show a wide panoply of modes of life, such as herbivory, predation, parasitoidism, pollination, and eusociality. This group also includes a great number of extinct species from both amber and compression outcrops. Hymenopterans probably originated in the Paleozoic, although their oldest record is from the Middle or Late Triassic, and their diversity expanded since the Cretaceous. Here, we present a review of the Hymenoptera in Lower Cretaceous ambers from Lebanon (Barremian) and Spain (Albian), which is pivotal for the study of hymenopteran evolution. Hymenoptera in Lebanese ambers are represented by 32 species in 22 genera within 15 families, while in Spanish ambers, they correspond to 49 species in 40 genera within 18 families. Most of these species belong to the ‘Parasitica’, and only a few species have been assigned to the Aculeata. The group ‘Symphyta’ is represented by one species in Spanish amber. The paleobiogeography and possible paleobiologies of the species in these ambers are reviewed. Furthermore, checklists for all Hymenoptera species in Lebanese and Spanish ambers are provided. Full article
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53 pages, 6188 KiB  
Review
A Survey of Text-Matching Techniques
by Peng Jiang and Xiaodong Cai
Information 2024, 15(6), 332; https://doi.org/10.3390/info15060332 (registering DOI) - 5 Jun 2024
Abstract
Text matching, as a core technology of natural language processing, plays a key role in tasks such as question-and-answer systems and information retrieval. In recent years, the development of neural networks, attention mechanisms, and large-scale language models has significantly contributed to the advancement [...] Read more.
Text matching, as a core technology of natural language processing, plays a key role in tasks such as question-and-answer systems and information retrieval. In recent years, the development of neural networks, attention mechanisms, and large-scale language models has significantly contributed to the advancement of text-matching technology. However, the rapid development of the field also poses challenges in fully understanding the overall impact of these technological improvements. This paper aims to provide a concise, yet in-depth, overview of the field of text matching, sorting out the main ideas, problems, and solutions for text-matching methods based on statistical methods and neural networks, as well as delving into matching methods based on large-scale language models, and discussing the related configurations, API applications, datasets, and evaluation methods. In addition, this paper outlines the applications and classifications of text matching in specific domains and discusses the current open problems that are being faced and future research directions, to provide useful references for further developments in the field. Full article
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