Based on a waste generated survey by companies in the area of the city of Bahia Blanca (Argentina), the possibility of incorporating part of them in a Portland cement matrix was examined. Among the waste is toner (TW), which is obtained from cartridges used in photocopiers, laser printers, and faxes. This paper aims to analyze the physical and mechanical properties of cement pastes and mortars using toner as a Portland cement replacement compared to a reference sample without toner. The mixes were made with 2.5, 5, 10, and 15 wt.% replacement of cement by toner, and it was measured the flow, normal consistency, setting time, calorimetry, and Frattini test in pastes and mechanical strengths in mortars employing standardized tests. Also, an analysis of the leachate in the curing water was carried out after 56 days to look for contaminating materials. The replacement of up to 5% cement with toner did not produce substantial alterations in the final setting time or mechanical properties. No heavy metals were found in the leachate, so TW can be immobilized in a cementitious matrix as it does not cause leaching above the established limits. Therefore, TW from a local industry can be used in construction materials and could contribute to a reduction of up to 14% of CO₂ emissions with a cement replacement of 15% in cement-based materials. Full article

The greenery of floodplain meadows in arid regions, such as Mongolia, is influenced by climate, hydrology, and land use. In this study, we analyzed the NDVI (Normalized Difference Vegetation Index) of two floodplain meadows located along the South Tamir and Tamir Rivers using LANDSAT images. Our goal was to observe NDVI spatial changes, variations, and mean values in mid-August every six years from 1991 to 2015 and to identify the factors driving these differences. To achieve this, we conducted variance analysis to identify changes in NDVI and implemented Principal Component Analysis to determine the influence of hydro-meteorological factors and grazing intensity. Our findings indicate a significant decrease in greenness, as measured by pixel-scale NDVI, during the late summer period. This decrease was consistently observed, except for a series of harsh winters that followed relatively dry summers, resulting in a disastrous event called dzud, which led to the death of livestock. The decrease in NDVI was amplified by lower precipitation in June, higher temperatures and wind speed in July, and increased precipitation in August, along with a higher frequency of days with convective rain. Our findings have important implications for managing grazing in Mongolia’s grasslands, promoting sustainable land use, and mitigating sandstorms. The variance and average values of NDVI at the pixel level can serve as reliable markers of sustainable pasture management in areas where other vegetation measures are limited. Full article

Plants play a key role in achieving the UN Sustainable Development Goals, which call for a plant-aware and plant-knowledgeable public. This study investigated whether a non-digital educational game supplementary to a lecture on plant diversity can foster plant species literacy in student teachers of biology and environmental science students (n = 78). The 100 species of the lecture were displayed on playing cards together with their scientific names, plant families and symbols for further information. Two players alternately had to find out which plant their opponent had in hand by asking yes/no questions about possible characteristics of the species. Participation in the game was voluntary and took place in students’ free time. Before the game, interest in plants was moderately high and perceived competence to recognize plants was low. Students enjoyed playing the game and increased their interest in plants, their perceived competence to identify plants by species-specific morphological characteristics, and their actual plant species knowledge, as shown by an identification test on campus. A combination of a lecture and an accompanying game can thus be recommended to promote plant species literacy in higher education. Full article

This paper presents a research program called CP2DIMG conducted at the Federation of Environment and Society Research at the University of Corsica. The goal of CP2DIMG is to better understand the influence of emotions on operational personnel’s decision-making, aiming to test training systems dedicated to individuals facing high stress during their professional activities. This type of training system is intended to enhance emotional and mental resilience, thereby improving decision-making ability in uncertain situations under the influence of emotions related to the event. For implementation, the method will be tailored to the specificities of two categories of operational personnel: firefighters and municipal police officers. The expected results will address significant demands from operational professionals in the Mediterranean region for firefighting safety but also for large-scale or highly complex interventions. This study fully integrates into the challenges of the Mediterranean region: forest management, risk prevention plans, and preparedness of local actors responsible for crisis management. Furthermore, individuals responsible for crisis management, including local government officials and risk management and security personnel, will be able to use the obtained results for effective decision-making. Full article

Discontinuity is a key element used by geoscientists and civil engineers to characterize rock masses. The traditional approach to detecting and measuring rock discontinuity relies on fieldwork, which poses dangers to human life. Photogrammetric pattern recognition and 3D measurement techniques offer new possibilities without direct contact with rock masses. This study proposes a new approach to detect discontinuities using close-range photogrammetric techniques and convolutional neural networks (CNNs) trained on a small amount of data. Investigations were conducted on basalts in Bala, Ankara, Türkiye. A total of 34 multi-view images were collected with a remotely piloted aircraft system (RPAS), and discontinuity lines were manually delineated on a point cloud generated from these images. The lines were back-projected onto the raw images to increase the amount of data, a process we call multi-view (3D) augmentation. We further evaluated radiometric and geometric augmentation methods, the contribution of multi-view augmentation to the proposed model, and the transfer learning performance of six different CNN architectures. The highest performance was achieved with U-Net + SE-ResNeXt-50 with an F1-score of 90.6%. The CNN model trained from scratch with local features also yielded a similar F1-score (91.7%), which is the highest performance reported in the literature. Full article

Alzheimer’s disease (AD) presents a significant challenge due to its multifaceted nature, characterized by cognitive decline, memory loss, and neuroinflammation. Though AD is an extensively researched topic, effective pharmacological interventions remain elusive, prompting explorations into non-pharmacological approaches. Microcurrent (MC) therapy, which utilizes imperceptible currents, has emerged as a potent clinical protocol. While previous studies have focused on its therapeutic effects, this study investigates the impact of MC on neuronal damage and neuroinflammation in an AD mouse model, specifically addressing potential side effects. Utilizing 5xFAD transgenic mice, we examined the effects of MC therapy on neuronal integrity and inflammation. Our findings suggest that MC therapy attenuates memory impairment and reduces neurodegeneration, as evidenced by improved performance in memory tests and the preservation of the neuronal structure. Additionally, MC therapy significantly decreases amyloid-beta (Aβ) plaque deposition and inhibits apoptosis, indicating its potential to mitigate AD pathology. This study determined that glial activation is effectively reduced by using MC therapy to suppress the TLR4-MyD88-NFκB pathway, which consequently causes the levels of inflammatory factors TNF-α, IL-1β, and IL-6 to decrease, thus implicating TLR4 in neurodegenerative disease-related neuroinflammation. Furthermore, while our study did not observe significant adverse effects, a further clinical trial into potential side effects and neuroinflammatory responses associated with MC therapy is warranted. Full article

Although not completely understood, the role of the Hedgehog-GLI (HH-GLI) signaling pathway in melanoma and epithelial skin tumors has been reported before. In this study, we confirmed in various melanoma cell line models that keratin 16 (KRT16) and S100 Calcium-Binding Protein A7 (S100A7) are transcriptional targets of GLI Family Zinc Finger (GLI) proteins. Besides their important role in protecting and maintaining the epidermal barrier, keratins are somehow tightly connected with the S100 family of proteins. We found that stronger expression of KRT16 indeed corresponds to stronger expression of S100A7 in our clinical melanoma samples. We also report a trend regarding staining of GLI1, which corresponds to stronger staining of GLI3, KRT16, and S100A7 proteins. The most interesting of our findings is that all the proteins are detected specifically in the epidermis overlying the tumor, but rarely in the tumor itself. The examined proteins were also not detected in the healthy epidermis at the edges of the sample, suggesting that the staining is specific to the epidermis overlaying the tumor mass. Of all proteins, only S100A7 demonstrated a statistically significant trend regarding tumor staging and staining intensity. Results from our clinical samples prove that immune infiltration is an important feature of melanoma. Pigmentophages and tumor-infiltrating lymphocytes (TIL) demonstrate a significant association with tumor stage, while mononuclear cells are equally present in all stages. For S100A7, we found an association between the number of TILs and staining intensity. Considering these new findings presented in our study, we suggest a more detailed examination of the possible role of the S100A7 protein as a biomarker in melanoma. Full article

The Kaiyang phosphate mining area in Guizhou, which is located in the central–southern part of the Yangtze Block, hosts one of China’s more significant phosphate-enriched strata within the Doushantuo Formation. This formation is essential for phosphate mining and also preserves multiple magmatic events, which are closely linked to the assembly and breakup of the Rodinia supercontinent. Our comprehensive studies in petrology, geochemistry, zircon U-Pb geochronology, and fission-track dating reveal that the primary ore mineral in phosphorite is collophane, which is accompanied by dolomite, quartz, pyrite, and zircon. The majority of detrital zircons in the phosphorite, as well as the overlying dolostone and underlying sandstone, are of magmatic origin, with a record of multiple stages of magmatic ages. Among these, the older age groups of ~2500 Ma and ~2000–1800 Ma represent the ancient crystalline basement of the Yangtze Block from the Paleoproterozoic era. The three main age peaks at ~880 Ma, ~820 Ma, and ~780 Ma indicate that the magmatic event at ~880 Ma was related to the assembly of the Rodinia supercontinent during the Grenvillian period. The most prominent age peak at ~820 Ma marks a critical time point for the transition from assembly to the breakup of the Rodinia supercontinent, with the Yangtze Block’s response to the supercontinent breakup events lasting at least until ~780 Ma. The youngest group of zircon ages from the phosphorite (~594 Ma), and the underlying sandstone (~529 Ma) establishes the minimum age for the phosphorite formation, indicating that the Doushantuo phosphorite layer in the Kaiyang area was formed after 594 Ma, i.e., even later than 529 Ma. The zircon fission-track ages in the three rock types of the phosphorite-bearing rocks can be divided into three groups: 501–489 Ma, ~366 Ma, and 53–39 Ma. All of these groups are presumed to be associated with the tectonic uplift events that follow mineralization. The first two age groups correspond to the two major tectonic uplift events during the Caledonian period, which resulted in the formation of the Qianzhong Uplift. The ages of 53–39 Ma are related to the late uplift of the Himalayan orogeny, and they represent its response in the Kaiyang area of Guizhou. Full article

Speckle reduction is a key preprocessing approach for the applications of Synthetic Aperture Radar (SAR) data. For many interpretation tasks, high-quality SAR images with a rich texture and structure information are useful. Therefore, a satisfactory SAR image filter should retain this information well after processing. Some quantitative assessment indicators have been presented to evaluate the edge-preservation capability of single-polarization SAR filters, among which the non-clean-reference-based (i.e., blind) ones are attractive. However, most of these indicators are derived based only on the basic fact that the speckle is a kind of multiplicative noise, and they do not take into account the detailed statistical distribution traits of SAR data, making the assessment not robust enough. Moreover, to our knowledge, there are no specific blind assessment indicators for fully Polarimetric SAR (PolSAR) filters up to now. In this paper, a blind assessment indicator based on an SAR Ratio Gradient Operator (RGO) and Confidence Interval Estimation (CIE) is proposed. The RGO is employed to quantify the edge gradient between two neighboring image patches in both the speckled and filtered data. A decision is then made as to whether the ratio gradient value in the filtered image is close to that in the unobserved clean image by considering the statistical traits of speckle and a CIE method. The proposed indicator is also extended to assess the PolSAR filters by transforming the polarimetric scattering matrix into a scalar which follows a Gamma distribution. Experiments on the simulated SAR dataset and three real-world SAR images acquired by ALOS-PALSAR, AirSAR, and TerraSAR-X validate the robustness and reliability of the proposed indicator. Full article

Secret key exchange relies on the creation of correlated signals, serving as the raw resource for secure communication. Thermal states exhibit Hanbury Brown and Twiss correlations, which offer a promising avenue for generating such signals. In this paper, we present an experimental implementation of a central broadcast thermal-state quantum key distribution (QKD) protocol in the microwave region. Our objective is to showcase a straightforward method of QKD utilizing readily available broadcasting equipment. Unlike conventional approaches to thermal-state QKD, we leverage displaced thermal states. These states enable us to share the output of a thermal source among Alice, Bob, and Eve via both waveguide channels and free space. Through measurement and conversion into bit strings, our protocol produces key-ready bit strings without the need for specialized equipment. By harnessing the inherent noise in thermal broadcasts, our setup facilitates the recovery of distinct bit strings by all parties involved. Full article

Plants, being sessile, are continuously exposed to varietal environmental stressors, which consequently induce various bio-physiological changes in plants that hinder their growth and development. Oxidative stress is one of the undesirable consequences in plants triggered due to imbalance in their antioxidant defense system. Biochemical studies suggest that nanoparticles are known to affect the antioxidant system, photosynthesis, and DNA expression in plants. In addition, they are known to boost the capacity of antioxidant systems, thereby contributing to the tolerance of plants to oxidative stress. This review study attempts to present the overview of the role of nanoparticles in plant growth and development, especially emphasizing their role as antioxidants. Furthermore, the review delves into the intricate connections between nanoparticles and plant signaling pathways, highlighting their influence on gene expression and stress-responsive mechanisms. Finally, the implications of nanoparticle-assisted antioxidant strategies in sustainable agriculture, considering their potential to enhance crop yield, stress tolerance, and overall plant resilience, are discussed. Full article

Secukinumab and Dead Sea treatment result in clear skin for many psoriasis patients, through distinct mechanisms. However, recurrence in the same areas after treatments suggests the existence of a molecular scar. We aimed to compare the molecular and genetic differences in psoriasis patients who achieved complete response from secukinumab and Dead Sea climatotherapy treatments. We performed quantitative immunohistochemical and transcriptomic analysis, in addition to digital spatial profiling of skin punch biopsies. Histologically, both treatments resulted in a normalization of the lesional skin to a level resembling nonlesional skin. Interestingly, the transcriptome was not normalized by either treatments. We revealed 479 differentially expressed genes between secukinumab and Dead Sea climatotherapy at the end of treatment, with a psoriasis panel identifying SERPINB4, SERPINB13, IL36G, IL36RN, and AKR1B10 as upregulated in Dead Sea climatotherapy compared with secukinumab. Using digital spatial profiling, pan-RAS was observed to be differentially expressed in the microenvironment surrounding CD103⁺ cells, and IDO1 was differentially expressed in the dermis when comparing the two treatments. The differences observed between secukinumab and Dead Sea climatotherapy suggest the presence of a molecular scar, which may stem from mechanistically different pathways and potentially contribute to disease recurrence. This may be important for determining treatment response duration and disease memory. Full article

Aging is a progressive physiological degeneration associated with a decline in chemosensory processes and cognitive abilities and a reduction in synaptic plasticity. The biological bases of ageing are still not completely understood, and many theories have been proposed. This study aimed to evaluate the occurrence of age-related changes affecting the chemosensory function (gustatory and olfactory) and general cognitive abilities and their potential associations in women. To this aim, 319 women (the age ranging from 18 to 92 years) were recruited and divided into four different age groups: 18–34 years, 35–49 years, 50–64 years, and ≥65 years. Our results confirmed that in women, gustatory, olfactory, and cognitive functions decline, though in a different manner during aging. Olfactory and cognitive function showed a slight decline along the first three age classes, with a dramatic decrease after age 65 years, while gustatory function decreased more gradually. Olfactory and gustatory deficits may have a high degree of predictivity for general cognitive function as well as for specific cognitive subdomains such as visuospatial/executive abilities, language, memory, and attention. Our study highlighted the importance of using chemosensory assessments for the early diagnosis of cognitive decline and for the development of appropriate personalized risk prevention strategies. Full article

Unmanned underwater vehicle-dual-manipulator systems (UVDMSs) have attracted much research due to their humanoid operation capabilities, which have the advantage of cooperative manipulations and transporting underwater objects. Meanwhile, collision avoidance of UVDMSs is more challenging than that of unmanned underwater vehicle-dual manipulator systems (UVMSs). In this work, a model predictive control (MPC) approach is proposed for collision avoidance in objects transporting tasks of UVDMSs. The minimum distances of mutual manipulators and frame obstacles are handled as velocity constraints in the optimization of the UVDMS’s object tracking control. The command velocity generated by the model predictive kinematic controller is tracked by a dynamic inversion control scheme while model uncertainties are compensated by a neural network. Moreover, the tracking errors of the proposed dynamic controller are proved to be convergent by the Lyapunov method. At last, a three-dimensional (3D) UVDMS simulation platform is developed to verify the effectiveness of the proposed control strategy in the tasks of collision avoidance and object transport. Full article

Background and aims: This paper aims to study an alternative solution to hormonal replacement therapy in specific groups of patients who underwent thyroidectomy during childhood or adulthood. After cryopreservation, thyroid autotransplantation could be an alternative solution which would allow us to use the ability of the thyroid tissue of producing hormones according to the physiological needs of the body. Materials and methods: A feasibility study about the effects of the most modern cryopreservation techniques on the structural and functional integrity of the follicular cells of the thyroid tissue has been carried out. Patients who could benefit from the treatment have been found for both autotransplant techniques. Additionally, a literature review has been conducted. Results: The histological analysis has shown that cryopreservation does not alter the original architecture, and the culture examination that cell viability is successfully preserved. Moreover, both thyroid autotransplantation studies on animals and those on humans that were found in the literature have shown good results regarding the viability and functionality of the transplant. Conclusions: The viability of cryopreserved thyroid tissue found in this study is encouraging. Further studies to evaluate the levels of FT3, FT4 and thyroglobulin in thyroid tissue after cryopreservation are needed to verify that the secretory properties of the thyrocytes have been maintained intact. Furthermore, autotransplanted cases found in the literature do not have a long-term follow-up. Full article

Heterologous vaccines, which induce immunity against several related pathogens, can be a very useful and rapid way to deal with new pandemics. In this study, the potential impact of licensed COVID-19 vaccines on cytotoxic and helper cell immune responses against Khosta-2, a novel sarbecovirus that productively infects human cells, was analyzed for the 567 and 41 most common HLA class I and II alleles, respectively. Computational predictions indicated that most of these 608 alleles, covering more than 90% of the human population, contain sufficient fully conserved T-cell epitopes between the Khosta-2 and SARS-CoV-2 spike-in proteins. Ninety percent of these fully conserved peptides for class I and 93% for class II HLA molecules were verified as epitopes recognized by CD8⁺ or CD4⁺ T lymphocytes, respectively. These results show a very high correlation between bioinformatic prediction and experimental assays, which strongly validates this study. This immunoinformatics analysis allowed a broader assessment of the alleles that recognize these peptides, a global approach at the population level that is not possible with experimental assays. In summary, these findings suggest that both cytotoxic and helper cell immune protection elicited by currently licensed COVID-19 vaccines should be effective against Khosta-2 virus infection. Finally, by being rapidly adaptable to future coronavirus pandemics, this study has potential public health implications. Full article

Tinea incognito is a dermatophyte infection with atypical features, due to the use of topical or systemic steroids or other immunosuppressive medications. Delayed diagnosis, spread of the infection to critical body surfaces, resistance to antifungal drugs, and increased costs due to prolonged hospitalization and multiple treatment regimens often complicate tinea incognito. It can affect individuals of all ages and genders, but it is more common in children. Atypical clinical appearance often necessitates differentiation from other diseases such as eczema, seborrheic dermatitis, lupus erythematosus, psoriasis, or other non-fungal skin conditions. The treatment of tinea incognito usually involves discontinuation of topical steroids or other immunosuppressive medications. Preventive measures and management of the underlying fungal infection are necessary and can be achieved with antifungal drugs. Patients should wear loose cotton clothes, use boiling water for laundry, and iron their clothing before wearing them. Additionally, they should avoid sharing bed linens, towels, clothes, and shoes. This review aims to raise awareness of tinea incognito among health practitioners, provide tips for detecting the disorder, include it in the differentials, and evaluate the available diagnostic procedures. Full article

This paper investigates the seismic performance of prefabricated segmental bridge columns (PSBCs) with hybrid post-tensioned tendons and energy dissipation (ED) bars under cyclic loading. PSBCs with unbonded and hybrid bonded prestressed tendons and columns incorporating ED bars are designed to improve the lateral strength, energy dissipation, and limit the residual drift. The PSBCs under cyclic loading were investigated using the three-dimensional finite element (FE) modeling platform ABAQUS. The FE model was calibrated against experimental results, with an overall error of less than 10%. The seismic performance of the proposed PSBCs was evaluated based on critical parameters, including lateral strength, residual plastic displacement, and the energy dissipation capacity. The results show that bonding the tendons in the plastic hinge region as opposed to the overall bonding along the column leads to a better cyclic performance. The lateral strength, and recentering abilities are further improved by bonding tendons up to 2/3 of the length in the plastic hinge region, along with 100–300 mm in the footing. It was also found that selecting a longitudinal length of ED bars crossing multiple precast segmental joints and having a circumferential spread of 70–90% of core concrete results in a higher bearing capacity and energy dissipation compared to ED bars crossing the single joint. Full article

Wind energy is highly volatile, and large-scale wind power grid integration significantly impacts grid stability. Accurate forecasting of wind turbine power can improve wind power consumption and ensure the economy of the power grid. This paper proposes a multistep forecasting method for offshore wind turbine power based on a multi-timescale input and an improved transformer. First, the wind speed sequence is decomposed by the VMD method to extract adequate timing information and remove the noise, after which the decomposition signals are merged with the rest of the timing features, and the dataset is split according to different timescales. A GRU receives the short-timescale inputs, and the Improved Transformer captures the timing relationship of the long-timescale inputs. Finally, a CNN is used to extract the information of each time point at the output of each branch, and the fully connected layer outputs multistep forecasting results. Experiments were conducted on operation data from four wind turbines located within the offshore wind farm but not near the edge. The results show that the proposed method achieved average errors of 0.0522 in MAE, 0.0084 in MSE, and 0.0907 in RMSE on a four-step forecast. This outperformed comparison methods LSTM, CNN-LSTM, LSTM-Attention, and Informer. The proposed method demonstrates superior forecasting performance and accuracy for multistep offshore wind turbine power forecasting. Full article

At present, HTS magnets cannot operate in the real closed-loop persistent current mode due to the existence of joint resistance, flux creep, and AC loss of the HTS tape. Instead of using a current source, HTS flux pumps are capable of injecting flux into closed HTS magnets without electrical contact. This paper presents a practical superconducting DC dynamo for charging a conduction-cooled HTS magnet system based on a flux-pumping technique. To minimize heat losses, the rotor is driven by a servo motor mounted outside the vacuum dewar by utilizing magnetic fluid dynamic sealing. Different parameters, such as air gap and rotating speed, have been tested to investigate the best pumping effect, and finally, it successfully powers a 27.3 mH HTS non-insulated double-pancake coil to the current of 54.2 A within 76 min. As a low-cost and compact substitute for the traditional current source, the realization of a contactless DC power supply can significantly improve the flexibility and mobility of the HTS magnet system and could be of great significance for the technological innovation of future HTS magnets used in offshore wind turbines, biomedical, aerospace, etc. Full article

In the face of increasing demands for tasks such as mountain rescue, geological exploration, and military operations in complex wilderness environments, planning an efficient walking route is crucial. To address the inefficiency of traditional two-dimensional path planning, this paper proposes a two-stage path planning algorithm. First, an improved Probabilistic Roadmap (PRM) algorithm is used to quickly and roughly determine the initial path. Then, the morphological dilation is applied to process the grid points of the initial path, retaining the surrounding area of the initial path for a precise positioning of the search range. Finally, the idea of the A^∗ algorithm is applied to achieve precise path planning in the refined search range. During the process of constructing the topology map, we utilized parallelization acceleration strategies to expedite the graph construction. In order to verify the effectiveness of the algorithm, we used terrain data to construct a wilderness environment model, and tests were conducted on off-road path planning tasks with different terrains and distances. The experimental results show a substantial enhancement in the computational efficiency of the proposed algorithm relative to the conventional A^∗ algorithm by 30 to 60 times. Full article