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19 pages, 2936 KiB  
Article
Combination of Chromatographic Analysis and Chemometric Methods with Bioactivity Evaluation of the Antibacterial Properties of Helichrysum italicum Essential Oil
by Tijana Zeremski, Olja Šovljanski, Vladimir Vukić, Biljana Lončar, Milica Rat, Nataša Perković Vukčević, Milica Aćimović and Lato Pezo
Antibiotics 2024, 13(6), 499; https://doi.org/10.3390/antibiotics13060499 (registering DOI) - 28 May 2024
Abstract
Helichrysum italicum (immortelle) essential oil is one of the most popular essential oils worldwide and it has many beneficial properties, including antimicrobial. However, in this plant, the chemical diversity of the essential oil is very pronounced. The aim of this work was to [...] Read more.
Helichrysum italicum (immortelle) essential oil is one of the most popular essential oils worldwide and it has many beneficial properties, including antimicrobial. However, in this plant, the chemical diversity of the essential oil is very pronounced. The aim of this work was to process the GC-MS results of four samples of H. italicum essential oil of Serbian origin by chemometric tools, and evaluate the antimicrobial activity in vitro and in silico. Overall, 47 compounds were identified, the most abundant were γ-curcumene, α-pinene, and ar-curcumene, followed by α-ylangene, neryl acetate, trans-caryophyllene, italicene, α-selinene, limonene, and italidiones. Although the four samples of H. italicum essential oil used in this study were obtained from different producers in Serbia, they belong to the type of essential oil rich in sesquiterpenes (γ-curcumene and ar-curcumene chemotype). In vitro antimicrobial potential showed that five were sensitive among ten strains of tested microorganisms: Staphylococcus aureus, Listeria monocytogenes, Bacillus cereus, Saccharomyces cerevisiae, and Candida albicans. Therefore, these microorganism models were used further for in silico molecular docking through the mechanism of ATP-ase inhibitory activity. Results showed that among all compounds from H. italicum essential oil, neryl acetate has the highest predicted binding energy. Artificial neural network modeling (ANN) showed that two major compounds γ-curcumene and α-pinene, as well as minor compounds such as trans-β-ocimene, terpinolene, terpinene-4-ol, isoitalicene, italicene, cis-α-bergamotene, trans-α-bergamotene, italidiones, trans-β-farnesene, γ-selinene, β-selinene, α-selinene, and guaiol are responsible for the antimicrobial activity of H. italicum essential oil. The results of this study indicate that H. italicum essential oil samples rich in γ-curcumene, α-pinene, and ar-curcumene cultivated in Serbia (Balkan) have antimicrobial potential both in vitro and in silico. In addition, according to ANN modeling, the proportion of neryl acetate and other compounds detected in these samples has the potential to exhibit antimicrobial activity. Full article
20 pages, 1348 KiB  
Article
Korean Paradox of Public Support for the Research and Development Investment in the Sustainable Performance of the Regional Economy
by Yongrok Choi, Siyu Li and Hyoungsuk Lee
Land 2024, 13(6), 759; https://doi.org/10.3390/land13060759 (registering DOI) - 28 May 2024
Abstract
The Swedish Paradox is a well-known phenomenon related to high research and development (R&D) investment with supposedly low aggregate economic performance owing to economic saturation. The Korean economy has not yet become an advanced economy; however, its R&D performance is negligible. Recently, also [...] Read more.
The Swedish Paradox is a well-known phenomenon related to high research and development (R&D) investment with supposedly low aggregate economic performance owing to economic saturation. The Korean economy has not yet become an advanced economy; however, its R&D performance is negligible. Recently, also the R&D share of the GNP has become much higher, and its contribution to the economic growth rate is rapidly decreasing, implying a negative relationship between R&D activities and economic performance. This study uses slacks-based data envelopment analysis to investigate investment performance at the local government level in Korea. Our findings reveal that the average score for R&D investment performance in Korea is 64%, indicating huge potential for an efficiency enhancement of 36%. Notably, among the 16 local governments examined, Seoul and its surrounding metropolitan areas showed the lowest R&D efficiency, while Gangwon and Gwangju exhibited superior performance. Since these two regions have promoted specific missions, such as the medical hub in Gangwon and the optical fiber strategic platform in Gwangju, precise and accurate differentiation appears necessary to avoid a lack of governance. To determine the workable mechanism of R&D support policies, we further divided R&D productivity into three categories by incorporating the Malmquist Index (MI). The paper productivity of R&D shows an increasing trend over the experimental period from 2016 to 2021. However, overall, the MI shows slightly deteriorating productivity with 0.978, owing to the aggravating effect of patents and commercialization of R&D. The success in the paper comes from the harmonized partnership between the strong push factor of the government and voluntary pull factor of the R&D support receiving universities. Thus, we suggest that the Korean government should not depend on the superficial effectiveness of R&D in the term but on public–private partnerships with stronger performance-oriented responsibility. Full article
(This article belongs to the Section Land Socio-Economic and Political Issues)
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27 pages, 6320 KiB  
Article
Different Drug Mobilities in Hydrophobic Cavities of Host–Guest Complexes between β-Cyclodextrin and 5-Fluorouracil at Different Stoichiometries: A Molecular Dynamics Study in Water
by Giuseppina Raffaini, Stefano Elli, Michelina Catauro and Antonio D’Angelo
Int. J. Mol. Sci. 2024, 25(11), 5888; https://doi.org/10.3390/ijms25115888 (registering DOI) - 28 May 2024
Abstract
Cyclodextrins (CDs) are cyclic oligosaccharides able to form noncovalent water-soluble complexes useful in many different applications for the solubilization, delivery, and greater bioavailability of hydrophobic drugs. The complexation of 5-fluorouracil (5-FU) with natural or synthetic cyclodextrins permits the solubilization of this poorly soluble [...] Read more.
Cyclodextrins (CDs) are cyclic oligosaccharides able to form noncovalent water-soluble complexes useful in many different applications for the solubilization, delivery, and greater bioavailability of hydrophobic drugs. The complexation of 5-fluorouracil (5-FU) with natural or synthetic cyclodextrins permits the solubilization of this poorly soluble anticancer drug. In this theoretical work, the complexes between β-CD and 5-FU are investigated using molecular mechanics (MM) and molecular dynamics (MD) simulations in water. The inclusion complexes are formed thanks to the favorable intermolecular interactions between β-CD and 5-FU. Both 1:1 and 1:2 β-CD/5-FU stoichiometries are investigated, providing insight into their interaction geometries and stability over time in water. In the 1:2 β-CD/5-FU complexes, the intermolecular interactions affect the drug’s mobility, suggesting a two-step release mechanism: a fast release for the more exposed and hydrated drug molecule, with greater freedom of movement near the β-CD rims, and a slow one for the less-hydrated and well-encapsulated and confined drug. MD simulations study the intermolecular interactions between drugs and specific carriers at the atomistic level, suggesting a possible release mechanism and highlighting the role of the impact of the drug concentration on the kinetics process in water. A comparison with experimental data in the literature provides further insights. Full article
27 pages, 10089 KiB  
Article
Novel Hierarchical Energy Management System for Enhanced Black Start Capabilities at Distribution and Transmission Networks
by Ayse Colak, Mohamed Abouyehia and Khaled Ahmed
Energies 2024, 17(11), 2605; https://doi.org/10.3390/en17112605 (registering DOI) - 28 May 2024
Abstract
A novel energy management system featuring a unique framework involving multiple hierarchical controllers at the distribution and transmission network levels is proposed. The unique objective function of this energy management system is designed to enhance system inertia during black start and optimise load [...] Read more.
A novel energy management system featuring a unique framework involving multiple hierarchical controllers at the distribution and transmission network levels is proposed. The unique objective function of this energy management system is designed to enhance system inertia during black start and optimise load shedding. The objective function further aims to increase reliance on renewable energy sources, prioritising solar power along with battery and fuel cell technologies. This work delves deeply into the dynamics of multi-area power networks, where some areas possess black start capabilities (BSAs) while others do not (NBSAs). The proposed energy management system specifically explores the complex interplay between these black start capabilities and the hierarchical load restoration order. During grid blackouts, the systems located in BSA areas are tasked with first restoring essential loads in their own regions before extending aid to the adjacent NBSA areas, taking into account factors such as their available reserved power and geographical proximity. This work is extended to analyse complex multi-area power network architectures. This extended analysis provides invaluable insights for enhancing power restoration processes and facilitating the large-scale integration of sustainable energy solutions in complex systems. The proposed energy management system is validated using the IEEE 39-Bus network, which consists of ten distinct areas, each differing in their black start capabilities. The results demonstrate the superiority of the proposed system. Full article
(This article belongs to the Special Issue Energy, Electrical and Power Engineering 2024)
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20 pages, 1152 KiB  
Article
Research on an Index System for the Earthquake Disaster Resistance Capability of Highway Tunnels
by Fei Wan, Nian Zhang, Zheng Lu, Yu Zhang, Xuehui Yan and Jiang Yu
Appl. Sci. 2024, 14(11), 4641; https://doi.org/10.3390/app14114641 (registering DOI) - 28 May 2024
Abstract
To evaluate the earthquake disaster resistance capability of highway tunnels, it is necessary to study an index system for the earthquake disaster resistance capability of highway tunnels. This paper uses a literature research method. The damage of highway tunnels in 12 earthquake disasters [...] Read more.
To evaluate the earthquake disaster resistance capability of highway tunnels, it is necessary to study an index system for the earthquake disaster resistance capability of highway tunnels. This paper uses a literature research method. The damage of highway tunnels in 12 earthquake disasters recorded in detail in China and abroad was investigated. According to the types of hazard-beating bodies and damage forms, 17 seismic damage scenes of highway tunnels are classified. According to different damage scenes, the fault tree analysis model is used to identify the damage-causing factors. Combined with the industry standards, norms and research results related to the earthquake resistance of highway tunnels, the evaluation indices are analyzed from three perspectives: engineering geological factors, tunnel structural factors and operation management factors. According to the principle of index system construction, a four-level index system is constructed, which takes the earthquake disaster resistance capability of highway tunnels as the target layer; engineering geological factors, tunnel structural factors and operation management factors as the criterion layer indices; 12 indicators as the index layer and 35 specific indicators. The established index system for the earthquake disaster resistance capability of highway tunnels has strong scientific, rational and application value and can provide a reference for the evaluation of the earthquake disaster resistance capability of highway tunnels and can also provide important support for the safe operation and sustainable development of highway tunnels. Full article
(This article belongs to the Special Issue Advances in Tunnel and Underground Construction)
18 pages, 944 KiB  
Article
The Simulation and Parameter Optimization of the Hole-Forming Process of a Duckbilled Hole-Forming Device
by Binqiang Zhao, Xiangdong Ni, Wenqing Cai and Kezhi Li
Agriculture 2024, 14(6), 843; https://doi.org/10.3390/agriculture14060843 (registering DOI) - 28 May 2024
Abstract
This paper addresses the hole-forming process of a duckbilled hole-forming device. Based on a coupled simulation using the multi-body dynamics software RecurDyn and the discrete element software EDEM, the hole-forming mechanism of a duckbilled hole-forming device and the influence of control parameters on [...] Read more.
This paper addresses the hole-forming process of a duckbilled hole-forming device. Based on a coupled simulation using the multi-body dynamics software RecurDyn and the discrete element software EDEM, the hole-forming mechanism of a duckbilled hole-forming device and the influence of control parameters on the hole-forming performance of the hole-forming device were studied. In this paper, we analyze the direction and speed of soil particles transported under soil disturbance by a hole-forming device through the simulation and study of the hole-forming mechanism of the hole-forming device. By controlling parameters such as the traction angle, forward speed, and mass of the hole-forming device, the influence of the control parameters on the hole-forming trajectory of the duckbilled hole-forming device was investigated. Orthogonal tests determined the optimal combination of control parameters. The results show that the hole-forming process of the hole-forming device mainly comprises squeezing and shearing the soil to form holes, and the hole-forming performance of the hole-forming device was optimal when the traction angle was 17.3°, the forward speed was 1.11 m/s, and the mass of the hole-forming device was 17.9 kg. Full article
(This article belongs to the Section Agricultural Technology)
16 pages, 1638 KiB  
Article
The German Multicenter Registry for ME/CFS (MECFS-R)
by Hannah Hieber, Rafael Pricoco, Katrin Gerrer, Cornelia Heindrich, Katharina Wiehler, Lorenz L. Mihatsch, Matthias Haegele, Daniela Schindler, Quirin Donath, Catharina Christa, Annika Grabbe, Alissa Kircher, Ariane Leone, Yvonne Mueller, Hannah Zietemann, Helma Freitag, Franziska Sotzny, Cordula Warlitz, Silvia Stojanov, Daniel B. R. Hattesohl, Anna Hausruckinger, Kirstin Mittelstrass, Carmen Scheibenbogen and Uta Behrendsadd Show full author list remove Hide full author list
J. Clin. Med. 2024, 13(11), 3168; https://doi.org/10.3390/jcm13113168 (registering DOI) - 28 May 2024
Abstract
Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystemic disease characterized by a complex, incompletely understood etiology. Methods: To facilitate future clinical and translational research, a multicenter German ME/CFS registry (MECFS-R) was established to collect comprehensive, longitudinal, clinical, epidemiological, and laboratory data [...] Read more.
Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystemic disease characterized by a complex, incompletely understood etiology. Methods: To facilitate future clinical and translational research, a multicenter German ME/CFS registry (MECFS-R) was established to collect comprehensive, longitudinal, clinical, epidemiological, and laboratory data from adults, adolescents, and children in a web-based multilayer-secured database. Results: Here, we present the research protocol and first results of a pilot cohort of 174 ME/CFS patients diagnosed at two specialized tertiary fatigue centers, including 130 (74.7%) adults (mean age 38.4; SD 12.6) and 43 (25.3%) pediatric patients (mean age 15.5; SD 4.2). A viral trigger was identified in 160/174 (92.0%) cases, with SARS-CoV-2 in almost half of them. Patients exhibited severe functional and social impairment, as reflected by a median Bell Score of 30.0 (IQR 30.0 to 40.0) and a poor health-related quality of life assessed with the Short Form-36 health survey, resulting in a mean score of 40.4 (SD 20.6) for physical function and 59.1 (SD 18.8) for mental health. Conclusions: The MECFS-R provides important clinical information on ME/CFS to research and healthcare institutions. Paired with a multicenter biobank, it facilitates research on pathogenesis, diagnostic markers, and treatment options. Trial registration: ClinicalTrials.gov NCT05778006. Full article
(This article belongs to the Special Issue Clinical Aspects of Infectious Diseases)
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16 pages, 1031 KiB  
Article
Investigation of Hydrophysical Properties and Corrosion Resistance of Modified Self-Compacting Concretes
by Adlet M. Zhagifarov, Daniyar A. Akhmetov, Dossym K. Suleyev, Zhanar O. Zhumadilova, Meiram M. Begentayev and Yuryi V. Pukharenko
Materials 2024, 17(11), 2605; https://doi.org/10.3390/ma17112605 (registering DOI) - 28 May 2024
Abstract
Improvement of hydrophysical properties and corrosion resistance of self-compacting concrete to the effects of alternate freezing–thawing and aggressive soils of Southern and Central Kazakhstan is of interest to a wide range of researchers from the side of practical application of the obtained results [...] Read more.
Improvement of hydrophysical properties and corrosion resistance of self-compacting concrete to the effects of alternate freezing–thawing and aggressive soils of Southern and Central Kazakhstan is of interest to a wide range of researchers from the side of practical application of the obtained results in construction practice. It is proposed to form a spatially reinforced fine crystalline structure of a cement matrix with the maximum dense packing by using a complex modifier (hyperplasticizer + polymer + microsilica + fibro fibers) in the composition of self-compacting concretes (SCCs). The introduction of the calculated amount of the above additives increases the operational reliability of the current SCC compositions, increasing the water resistance to W16, frost resistance to F = 500, increasing the compressive strength by 20%, and reducing the mass loss of samples during corrosion leaching to 50%. It has been experimentally established that the proposed addition of the complex modifier (hyperplasticizer + polymer + microsilica + fibro fibers) to the SCC composition allows obtaining self-compacting concrete of high quality with improved performance characteristics (compressive strength, water resistance, frost resistance, and corrosion resistance). Studies have shown that the complex modifier-modified SCC compositions have a high degree of resistance in aggressive environments and leaching corrosion. Based on the results of the conducted tests, it is possible to recommend the obtained SCC compositions for the production of building products working in the zone of alternating freezing–thawing and aggressive soils. Full article
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21 pages, 1768 KiB  
Article
Thermal Decomposition Mechanism of P(DAC-AM) with Serial Cationicity and Intrinsic Viscosity
by Tingting Chen, Yongji Wang and Yuejun Zhang
Polymers 2024, 16(11), 1522; https://doi.org/10.3390/polym16111522 (registering DOI) - 28 May 2024
Abstract
The thermal decomposition of the thermodynamic, kinetic and mechanisms of copolymer P(DAC-AM) samples with serial cationicity and intrinsic viscosity ([η]), and the control samples of homopolymer PAM and PDAC, were studied and analyzed using TG, DSC, FTIR. The results of the [...] Read more.
The thermal decomposition of the thermodynamic, kinetic and mechanisms of copolymer P(DAC-AM) samples with serial cationicity and intrinsic viscosity ([η]), and the control samples of homopolymer PAM and PDAC, were studied and analyzed using TG, DSC, FTIR. The results of the thermal decomposition thermodynamics confirmed that the thermal decomposition processes of the serial P(DAC-AM) samples and the two control samples could be divided into two stages. It was found that the processes of the copolymer P(DAC-AM) samples were not a simple superposition of those of homopolymers, whose monomers had composed the unit structures of the copolymer, but there were interactions between the two suspension groups. The results of thermal decomposition kinetics showed that the apparent activation energy (E) of the thermal decomposition process of all polymer samples had different varying trends in the terms of weight-loss rate (α). The reaction order (n) of the thermal decomposition of P(DAC-AM) in Stage I and II was close to 1, but in the former and the latter it tended to be 2 and 0.5, respectively. Finally, the thermal decomposition mechanism of copolymer P(DAC-AM) samples was discussed. The above research could not only fill in the knowledge vacancy of the thermal decomposition of the thermodynamic, kinetic and mechanisms of P(DAC-AM), but could also lay a foundation for the study of thermal decomposition mechanisms of the other types of polymers, including cationic polymers. Full article
(This article belongs to the Special Issue Thermal Properties Analysis of Polymers)
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17 pages, 7047 KiB  
Article
Genetic Diversity and Population Structure of Bursaphelenchus xylophilus in Guangdong, Guangxi, and Jiangsu Provinces in China
by Yuan Feng, Wenjing Jian, Xiaolei Ding and Jianren Ye
Forests 2024, 15(6), 934; https://doi.org/10.3390/f15060934 (registering DOI) - 28 May 2024
Abstract
This study aimed to investigate the genetic structures of pine wood nematodes (PWNs, Bursaphelenchus xylophilus (Steiner & Buhrer) Nickle)), in Guangdong (GD), Guangxi (GX), and Jiangsu (JS) Provinces (the major PWN dispersal centers). Furthermore, we also explored potential migration routes among the [...] Read more.
This study aimed to investigate the genetic structures of pine wood nematodes (PWNs, Bursaphelenchus xylophilus (Steiner & Buhrer) Nickle)), in Guangdong (GD), Guangxi (GX), and Jiangsu (JS) Provinces (the major PWN dispersal centers). Furthermore, we also explored potential migration routes among the different provinces in order to provide insights into the epidemic source of PWNs in the three provinces in China. We re-sequenced a total of 241 PWNs collected from the above provinces using next-generation sequencing to obtain raw genomic data. Bioinformatics analysis was used to identify the SNPs, genetic structures, and selective sweeps of the PWNs. The results indicate that the PWNs from these three provinces can be classified into five groups (A, B, C, D, and E), among which the genetic variations are significant. All PWN strains from JS were exclusively found in Group A. The PWNs in Groups B and C were composed of strains from GD and GX, while Groups D and E comprised only GD strains. Introgression analysis identified two possible pathways: (1) from Group A to Group B-GX and (2) from Group E to Group D. Selective sweep analysis showed that in Groups B and C, the candidate genes of Group B were mainly related to pectin lyase activity. Full article
(This article belongs to the Section Genetics and Molecular Biology)
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29 pages, 5195 KiB  
Article
Elevated Temperature Effects on Protein Turnover Dynamics in Arabidopsis thaliana Seedlings Revealed by 15N-Stable Isotope Labeling and ProteinTurnover Algorithm
by Kai-Ting Fan, Yuan Xu and Adrian D. Hegeman
Int. J. Mol. Sci. 2024, 25(11), 5882; https://doi.org/10.3390/ijms25115882 (registering DOI) - 28 May 2024
Abstract
Global warming poses a threat to plant survival, impacting growth and agricultural yield. Protein turnover, a critical regulatory mechanism balancing protein synthesis and degradation, is crucial for the cellular response to environmental changes. We investigated the effects of elevated temperature on proteome dynamics [...] Read more.
Global warming poses a threat to plant survival, impacting growth and agricultural yield. Protein turnover, a critical regulatory mechanism balancing protein synthesis and degradation, is crucial for the cellular response to environmental changes. We investigated the effects of elevated temperature on proteome dynamics in Arabidopsis thaliana seedlings using 15N-stable isotope labeling and ultra-performance liquid chromatography-high resolution mass spectrometry, coupled with the ProteinTurnover algorithm. Analyzing different cellular fractions from plants grown under 22 °C and 30 °C growth conditions, we found significant changes in the turnover rates of 571 proteins, with a median 1.4-fold increase, indicating accelerated protein dynamics under thermal stress. Notably, soluble root fraction proteins exhibited smaller turnover changes, suggesting tissue-specific adaptations. Significant turnover alterations occurred with redox signaling, stress response, protein folding, secondary metabolism, and photorespiration, indicating complex responses enhancing plant thermal resilience. Conversely, proteins involved in carbohydrate metabolism and mitochondrial ATP synthesis showed minimal changes, highlighting their stability. This analysis highlights the intricate balance between proteome stability and adaptability, advancing our understanding of plant responses to heat stress and supporting the development of improved thermotolerant crops. Full article
(This article belongs to the Special Issue Plant Omics: Sensing, Signaling, Regulation and Homeostasis)
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16 pages, 9108 KiB  
Article
High-Oleic Sunflower Oil as a Potential Substitute for Palm Oil in Sugar Coatings—A Comparative Quality Determination Using Multispectral Imaging and an Electronic Nose
by Nicole Ollinger, Bernhard Blank-Landeshammer, Lisa Schütz-Kapl, Angeline Rochard, Iris Pfeifenberger, Jens Michael Carstensen, Manfred Müller and Julian Weghuber
Foods 2024, 13(11), 1693; https://doi.org/10.3390/foods13111693 (registering DOI) - 28 May 2024
Abstract
Palm oil has a bad reputation due to the exploitation of farmers and the destruction of endangered animal habitats. Therefore, many consumers wish to avoid the use of palm oil. Decorative sugar contains a small amount of palm oil to prevent the sugar [...] Read more.
Palm oil has a bad reputation due to the exploitation of farmers and the destruction of endangered animal habitats. Therefore, many consumers wish to avoid the use of palm oil. Decorative sugar contains a small amount of palm oil to prevent the sugar from melting on hot bakery products. High-oleic sunflower oil used as a substitute for palm oil was analyzed in this study via multispectral imaging and an electronic nose, two methods suitable for potential large-batch analysis of sugar/oil coatings. Multispectral imaging is a nondestructive method for comparing the wavelength reflections of the surface of a sample. Reference samples enabled the estimation of the quality of unknown samples, which were confirmed via acid value measurements. Additionally, for quality determination, volatile compounds from decorative sugars were measured with an electronic nose. Both applications provide comparable data that provide information about the quality of decorative sugars. Full article
(This article belongs to the Section Food Analytical Methods)
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14 pages, 1181 KiB  
Review
Arrhythmias in Cardiac Sarcoidosis: Management and Prognostic Implications
by Suganya Arunachalam Karikalan, Ali Yusuf and Hicham El Masry
J. Clin. Med. 2024, 13(11), 3165; https://doi.org/10.3390/jcm13113165 (registering DOI) - 28 May 2024
Abstract
Cardiac sarcoidosis (CS) is characterized by various arrhythmic manifestations ranging from catastrophic sudden cardiac death secondary to ventricular arrhythmia, severe conduction disease, sinus node dysfunction, and atrial fibrillation. The management of CS is complex and includes not only addressing the arrhythmia but also [...] Read more.
Cardiac sarcoidosis (CS) is characterized by various arrhythmic manifestations ranging from catastrophic sudden cardiac death secondary to ventricular arrhythmia, severe conduction disease, sinus node dysfunction, and atrial fibrillation. The management of CS is complex and includes not only addressing the arrhythmia but also controlling the myocardial inflammation resultant from the autoimmune reaction. Arrhythmic manifestations of CS carry significant prognostic implications and invariably affect long-term survival in these patients. In this review, we focus on management of arrhythmic manifestation of cardiac sarcoidosis as well as risk stratification for sudden cardiac death in these patients. Full article
(This article belongs to the Special Issue Recent Advances in the Diagnosis and Treatment of Cardiomyopathy)
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34 pages, 4847 KiB  
Article
Perspectives on Artificial Intelligence Adoption for European Union Elderly in the Context of Digital Skills Development
by Ioana Andreea Bogoslov, Sorina Corman and Anca Elena Lungu
Sustainability 2024, 16(11), 4579; https://doi.org/10.3390/su16114579 (registering DOI) - 28 May 2024
Abstract
In today’s digitalized era, embracing new and emerging technologies is a requirement to remain competitive. The present research investigates the adoption of artificial intelligence (AI) by the elderly in the European landscape, emphasizing the importance of individuals’ digital skills. As has already been [...] Read more.
In today’s digitalized era, embracing new and emerging technologies is a requirement to remain competitive. The present research investigates the adoption of artificial intelligence (AI) by the elderly in the European landscape, emphasizing the importance of individuals’ digital skills. As has already been globally recognized, the most imminent demographic challenge is no longer represented by the rapid growth of the population but by its aging. Thus, the paper initially analyzed European perspectives on AI adoption, also discussing the importance of focusing on seniors. A bibliometric analysis was required afterward, and the review of the resulting relevant scientific publications uncovered gaps in understanding the relationship between older individuals and AI, particularly in terms of digital competence. Further exploration considered the EU population’s digital literacy and cultural influences using Hofstede’s model, while also identifying potential ways to improve the elderly’s digital skills and promote the adoption of AI. Results indicate a growing interest in AI adoption among the elderly, underscoring the urgent need for digital skills development. The imperative of personalized approach implementations, such as specialized courses, personalized training sessions, or mentoring programs, was underscored. Moreover, the importance of targeted strategies and collaborative efforts to ensure equitable participation in the digital age was identified as a prerequisite for AI adoption by seniors. In terms of potential implications, the research can serve as a starting point for various stakeholders in promoting an effective and sustainable adoption of AI among older citizens in the EU. Full article
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23 pages, 9319 KiB  
Article
Drought Monitoring and Prediction in Agriculture: Employing Earth Observation Data, Climate Scenarios and Data Driven Methods; a Case Study: Mango Orchard in Tamale, Ghana
by Marius Hobart, Michael Schirrmann, Abdul-Halim Abubakari, Godwin Badu-Marfo, Simone Kraatz and Mohammad Zare
Remote Sens. 2024, 16(11), 1942; https://doi.org/10.3390/rs16111942 (registering DOI) - 28 May 2024
Abstract
The study focused on the prediction of the Temperature Vegetation Dryness Index (TVDI), an agricultural drought index, for a Mango orchard in Tamale, Ghana. It investigated the temporal relationship between the meteorological drought index, Standardized Precipitation Index (SPI), and TVDI. The SPI was [...] Read more.
The study focused on the prediction of the Temperature Vegetation Dryness Index (TVDI), an agricultural drought index, for a Mango orchard in Tamale, Ghana. It investigated the temporal relationship between the meteorological drought index, Standardized Precipitation Index (SPI), and TVDI. The SPI was calculated based on utilizing precipitation data from the World Meteorological Organization (WMO) database (2010–2022) and CMIP6 projected precipitation data (2023–2050) from 35 climate models representing various Shared Socioeconomic Pathway (SSP) climate change scenarios. Concurrently, TVDI was derived from Landsat 8/9 satellite imagery, validated using thermal data obtained from unmanned aerial vehicle (UAV) surveys. A comprehensive cross-correlation analysis between TVDI and SPI was conducted to identify lag times between these indices. Building on this temporal relationship, the TVDI was modeled as a function of SPI, with varying lag times as inputs to the Wavelet-Adaptive Neuro-Fuzzy Inference System (Wavelet-ANFIS). This innovative approach facilitated robust predictions of TVDI as an agricultural drought index, specifically relying on SPI as a predictor of meteorological drought occurrences for the years 2023–2050. The research outcome provides practical insights into the dynamic nature of drought conditions in the Tamale mango orchard region. The results indicate significant water stress projected for different time frames: 186 months for SSP126, 183 months for SSP245, and 179 months for both SSP370 and SSP585. This corresponds to a range of 55–57% of the projected months. These insights are crucial for formulating proactive and sustainable strategies for agricultural practices. For instance, implementing supplemental irrigation systems or crop adaptations can be effective measures. The anticipated outcomes contribute to a nuanced understanding of drought impacts, facilitating informed decision-making for agricultural planning and resource allocation. Full article
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11 pages, 5394 KiB  
Article
An Algorithm for Jaw Pain among Divers
by Angelo Vivacqua, Kathleen Fan, Alexander Gürtler, Florian M. Thieringer and Britt-Isabelle Berg
J. Clin. Med. 2024, 13(11), 3167; https://doi.org/10.3390/jcm13113167 (registering DOI) - 28 May 2024
Abstract
Background: Temporomandibular disease (TMD) is commonly seen, and divers also experience pain in the temporomandibular joint (TMJ) or masticatory muscles. This article aims to provide a tool for diving physicians or medical professionals involved in diving medicine since jaw pain among divers is [...] Read more.
Background: Temporomandibular disease (TMD) is commonly seen, and divers also experience pain in the temporomandibular joint (TMJ) or masticatory muscles. This article aims to provide a tool for diving physicians or medical professionals involved in diving medicine since jaw pain among divers is a pertinent subject and can be challenging to evaluate without some background in dentistry or maxillofacial surgery. Method: A basic algorithm was developed to provide a tool to differentiate jaw pains experienced by divers. Three brief case studies were developed, and five diving physicians were tasked with diagnosing the cases using the algorithm. Additionally, simple exercises and massage techniques that can benefit patients with TMD, particularly immediately after diving, are outlined. Results: All five diving physicians successfully diagnosed the cases using the algorithm. However, three of them were unable to diagnose the first case (disc luxation) without consulting the algorithm. Nevertheless, all physicians acknowledged the utility of the algorithm. Conclusions: Jaw pain in divers can stem from diverse causes, but effective treatment options exist. Our study findings provide valuable insights to assist diving physicians in making accurate diagnoses and guiding appropriate patient management, which may include referrals to specialists such as dentists, maxillofacial surgeons, or orthodontists. Full article
(This article belongs to the Special Issue Clinical Advances in Oral Maxillofacial Surgery)
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27 pages, 18429 KiB  
Article
Enhancing Tribological Performance of Self-Lubricating Composite via Hybrid 3D Printing and In Situ Spraying
by Alessandro M. Ralls, Zachary Monette, Ashish K. Kasar and Pradeep L. Menezes
Materials 2024, 17(11), 2601; https://doi.org/10.3390/ma17112601 (registering DOI) - 28 May 2024
Abstract
In this work, a self-lubricating composite was manufactured using a novel hybrid 3D printing/in situ spraying process that involved the printing of an acrylonitrile butadiene styrene (ABS) matrix using fused deposition modeling (FDM), along with the in situ spraying of alumina (Al2 [...] Read more.
In this work, a self-lubricating composite was manufactured using a novel hybrid 3D printing/in situ spraying process that involved the printing of an acrylonitrile butadiene styrene (ABS) matrix using fused deposition modeling (FDM), along with the in situ spraying of alumina (Al2O3) and hexagonal boron nitride (hBN) reinforcements during 3D printing. The results revealed that the addition of the reinforcement induced an extensive formation of micropores throughout the ABS structure. Under tensile-loading conditions, the mechanical strength and cohesive interlayer bonding of the composites were diminished due to the presence of these micropores. However, under tribological conditions, the presence of the Al2O3 and hBN reinforcement improved the frictional resistance of ABS in extreme loading conditions. This improvement in frictional resistance was attributed to the ability of the Al2O3 reinforcement to support the external tribo-load and the shearing-like ability of hBN reinforcement during sliding. Collectively, this work provides novel insights into the possibility of designing tribologically robust ABS components through the addition of in situ-sprayed ceramic and solid-lubricant reinforcements. Full article
(This article belongs to the Special Issue Advanced Materials: Process, Properties, and Applications)
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18 pages, 3308 KiB  
Review
Multi-Vehicle Collaborative Planning Technology under Automatic Driving
by Songsong Rong, Ruifeng Meng, Junhong Guo, Pengfei Cui and Zhi Qiao
Sustainability 2024, 16(11), 4578; https://doi.org/10.3390/su16114578 (registering DOI) - 28 May 2024
Abstract
Autonomous vehicles hold the potential to significantly improve traffic efficiency and advance the development of intelligent transportation systems. With the progression of autonomous driving technology, collaborative planning among multiple vehicles in autonomous driving scenarios has emerged as a pivotal challenge in realizing intelligent [...] Read more.
Autonomous vehicles hold the potential to significantly improve traffic efficiency and advance the development of intelligent transportation systems. With the progression of autonomous driving technology, collaborative planning among multiple vehicles in autonomous driving scenarios has emerged as a pivotal challenge in realizing intelligent transportation systems. Serving as the cornerstone of unmanned mission decision-making, collaborative motion planning algorithms have garnered increasing attention in both theoretical exploration and practical application. These methods often follow a similar paradigm: the system initially discerns the driving intentions of each vehicle, subsequently assesses the surrounding environment, engages in path-planning, and formulates specific behavioral decisions. The paper discusses trajectory prediction, game theory, following behavior, and lane merging issues within the paradigm mentioned above. After briefly introducing the background of multi-vehicle autonomous driving, it provides a detailed description of the technological prerequisites for implementing these techniques. It reviews the main algorithms in motion planning, their functionalities, and applications in road environments, as well as current and future challenges and unresolved issues. Full article
(This article belongs to the Section Sustainable Transportation)
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14 pages, 1816 KiB  
Article
The Role of Adsorption Phenomena in ac Conductivity Measurements of Dielectric Nanoparticle Suspensions
by Ioulia Chikina and Andrey Varlamov
Colloids Interfaces 2024, 8(3), 34; https://doi.org/10.3390/colloids8030034 (registering DOI) - 28 May 2024
Abstract
The authors of numerous measurements of conductivity for suspensions of nanoparticles of various types carried out in the last decade came to the general conclusion that the well-known Maxwell’s theory is not applicable to quantitative explanation of the properties of such systems. In [...] Read more.
The authors of numerous measurements of conductivity for suspensions of nanoparticles of various types carried out in the last decade came to the general conclusion that the well-known Maxwell’s theory is not applicable to quantitative explanation of the properties of such systems. In the present work, we demonstrate that the Maxwell’s theory can be still applicable even for such systems, but the specifics of the standard ac measurements have to be correctly taken into account. Namely, the dependence of the capacitance of “metal–electrolyte” cuvette boundaries on nanoparticle adsorption, which in its turn dramatically depends on nanoparticle concentration, has to be taken into account. The latter circumstance strongly (via the RC characteristic of the circuit) affects the results of conductivity measurements. We propose the new algorithm of the impedance measurement data analysis for the particles’ concentration dependence of conductivity σ(ϕ) (where ϕ is the volume fraction of nanoparticles in suspension) for the suspensions of the diamante nanoparticles in alcohol which demonstrates the adequate correspondence of the Maxwell’s theory to the available experimental findings. Full article
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22 pages, 1492 KiB  
Systematic Review
Dexmedetomidine as an Adjuvant to Nerve Block for Cancer Surgery: A Systematic Review and Meta-Analysis
by Christrijogo Soemartono Waloejo, Dian Anggraini Permatasari Musalim, David Setyo Budi, Nando Reza Pratama, Soni Sunarso Sulistiawan and Citrawati Dyah Kencono Wungu
J. Clin. Med. 2024, 13(11), 3166; https://doi.org/10.3390/jcm13113166 (registering DOI) - 28 May 2024
Abstract
Background/Objectives: Our understanding of dexmedetomidine, as an adjuvant to nerve blocks in cancer surgery, is characterized by a current lack of compelling evidence, and it remains unknown whether the potential benefits of use outweigh the risks. The aim of the study was [...] Read more.
Background/Objectives: Our understanding of dexmedetomidine, as an adjuvant to nerve blocks in cancer surgery, is characterized by a current lack of compelling evidence, and it remains unknown whether the potential benefits of use outweigh the risks. The aim of the study was to evaluate the benefit and safety profiles of dexmedetomidine as an adjuvant to nerve blocks in cancer surgery. Methods: Systematic searches were conducted in MEDLINE, ScienceDirect, Cochrane Library, Springer, medRxiv, and Scopus up to 17 May 2024. Risk ratios (RR) for binary outcomes and standardized mean differences (SMDs) for continuous outcomes were quantified. Results: Twenty studies were identified. In breast cancer surgery, the use of dexmedetomidine reduced 24 h total morphine consumption (SMD = −1.99 [95% CI −3.01 to −0.98], p = 0.0001, I2 = 91%, random effects) and prolonged the requirement for morphine rescue analgesia (SMD = 2.98 [95% CI 0.01 to 5.95], p = 0.05, I2 = 98%, random effects). In abdominal cancer surgery, the dexmedetomidine group had lower total sufentanil consumption (SMD = −1.34 [95% CI −2.29 to −0.40], p = 0.005, I2 = 84%, random effects). Dexmedetomidine reduced the VAS score and decreased postoperative nausea and vomiting (PONV). No studies using dexmedetomidine reported serious adverse events. Conclusions: Using dexmedetomidine as an adjuvant to nerve blocks in cancer surgery could lower the VAS pain score and prolong the regional anesthesia duration, which would lead to a decrease in total opioid consumption and possibly contribute to fewer PONV events. Furthermore, the reports of no serious adverse events indicate its good safety profile. Full article
(This article belongs to the Section Anesthesiology)
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23 pages, 2156 KiB  
Article
Machine Learning Identification of Nutrient Intake Variations across Age Groups in Metabolic Syndrome and Healthy Populations
by Chenglin Cai, Hongyu Li, Lijia Zhang, Junqi Li, Songqi Duan, Zhengfeng Fang, Cheng Li, Hong Chen, Metab Alharbi, Lin Ye, Yuntao Liu and Zhen Zeng
Nutrients 2024, 16(11), 1659; https://doi.org/10.3390/nu16111659 (registering DOI) - 28 May 2024
Abstract
This study undertakes a comprehensive examination of the intricate link between diet nutrition, age, and metabolic syndrome (MetS), utilizing advanced artificial intelligence methodologies. Data from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2018 were meticulously analyzed using machine [...] Read more.
This study undertakes a comprehensive examination of the intricate link between diet nutrition, age, and metabolic syndrome (MetS), utilizing advanced artificial intelligence methodologies. Data from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2018 were meticulously analyzed using machine learning (ML) techniques, specifically extreme gradient boosting (XGBoost) and the proportional hazards model (COX). Using these analytic methods, we elucidated a significant correlation between age and MetS incidence and revealed the impact of age-specific dietary patterns on MetS. The study delineated how the consumption of certain dietary components, namely retinol, beta-cryptoxanthin, vitamin C, theobromine, caffeine, lycopene, and alcohol, variably affects MetS across different age demographics. Furthermore, it was revealed that identical nutritional intakes pose diverse pathogenic risks for MetS across varying age brackets, with substances such as cholesterol, caffeine, and theobromine exhibiting differential risks contingent on age. Importantly, this investigation succeeded in developing a predictive model of high accuracy, distinguishing individuals with MetS from healthy controls, thereby highlighting the potential for precision in dietary interventions and MetS management strategies tailored to specific age groups. These findings underscore the importance of age-specific nutritional guidance and lay the foundation for future research in this area. Full article
(This article belongs to the Section Nutrition and Metabolism)
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15 pages, 1093 KiB  
Article
Formation Fit for Purpose: Empowering Religious Educators Working in Catholic Schools
by Antonella Poncini
Religions 2024, 15(6), 665; https://doi.org/10.3390/rel15060665 (registering DOI) - 28 May 2024
Abstract
The purpose of this paper is to provide curriculum support to religious educators working in Catholic schools. The paper provides a practical response to research advocating serious attention be given to religious educators because they are at the “coalface” of Catholic education, increasingly [...] Read more.
The purpose of this paper is to provide curriculum support to religious educators working in Catholic schools. The paper provides a practical response to research advocating serious attention be given to religious educators because they are at the “coalface” of Catholic education, increasingly confronted by content and policy decisions, the diverse values and needs of their students, and other competing cultural and social challenges. Religious educators play a significant role in the evangelising mission of the Catholic Church as interpreters of Scripture and Tradition and can positively or negatively influence the quality of their students’ learning and its application. Entitled RECALL, the support offered to religious educators in this paper is research-led and utilises educational, standards-based principles. It is a community-minded approach that aims to build religious literacy and deepen the religious educators’ awareness and connections to the legacy of the Catholic Faith Tradition. The desired outcome is to inspire evidence-based conversations encompassing faith and reason, the perceived value and reality of the identity and mission of the Catholic Church, and its impact on Catholic culture and education. Intended to enhance rather than replace existing professional formation, the approach has structures, pedagogical processes, and practices that draw from a set of overarching theoretical considerations. Furthermore, the approach employs three guiding questions for categorising and analysing Catholic content. The questions are: (i) “Who are we as Catholics and what is our mission?” (ii) “What do we believe?” and (iii) “How do we practice?” The proposed curriculum support to religious educators may foster a culture of learning in Religious Education that is focused on improving and progressing the quality of educational outcomes for students. The premise is that if religious educators are supported to engage with the great Gospel narrative, their students may do the same. Full article
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12 pages, 1973 KiB  
Article
Goodwill Valuation Enhancement through Capitalization Method and Statistical Impact Analysis
by Shariq Mohammed, Amir Ahmad Dar, Mohammad Shahfaraz Khan, Imran Azad, Gopu Jayaraman and Olayan Albalawi
J. Risk Financial Manag. 2024, 17(6), 226; https://doi.org/10.3390/jrfm17060226 (registering DOI) - 28 May 2024
Abstract
The valuation of Goodwill (GW) has remained one of the several critical issues in financial analysis. This aspect is particularly important for mergers and acquisitions due to the significance of intangible assets. This study delves into the capitalization method of super profit (CMSP), [...] Read more.
The valuation of Goodwill (GW) has remained one of the several critical issues in financial analysis. This aspect is particularly important for mergers and acquisitions due to the significance of intangible assets. This study delves into the capitalization method of super profit (CMSP), a prominent technique for GW valuation, enhanced by the integration of statistical tools. Assessing a company’s excess profits over its average return on tangible assets is part of the CMSP. Finding the variables that have a significant impact on GW valuation, such as average profit, capital employed, and rate of return, is the main goal of this research. These issues are thoroughly investigated through statistical analysis to give stakeholders useful information for well-informed decision-making. Additionally, the study seeks to identify the external elements influencing this process as well as the internal aspects influencing GW valuation. Regression analysis, correlation matrices, response analysis and ANOVA are used to improve GW assessment and comprehension of the complex relationships between different factors. Full article
(This article belongs to the Section Mathematics and Finance)
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