We previously reported that sodium–glucose cotransporter 2 (SGLT2) inhibitors exert sustained fluid homeostatic actions through compensatory increases in osmotic diuresis-induced vasopressin secretion and fluid intake. However, SGLT2 inhibitors alone do not produce durable amelioration of fluid retention. In this study, we examined the comparative effects of the SGLT2 inhibitor dapagliflozin (SGLT2i group, n = 53) and the combined use of dapagliflozin and conventional diuretics, including loop diuretics and/or thiazides (SGLT2i + diuretic group, n = 23), on serum copeptin, a stable, sensitive, and simple surrogate marker of vasopressin release and body fluid status. After six months of treatment, the change in copeptin was significantly lower in the SGLT2i + diuretic group than in the SGLT2i group (−1.4 ± 31.5% vs. 31.5 ± 56.3%, p = 0.0153). The change in the estimated plasma volume calculated using the Strauss formula was not significantly different between the two groups. Contrastingly, changes in interstitial fluid, extracellular water, intracellular water, and total body water were significantly lower in the SGLT2i + diuretic group than in the SGLT2i group. Changes in renin, aldosterone, and absolute epinephrine levels were not significantly different between the two groups. In conclusion, the combined use of the SGLT2 inhibitor dapagliflozin and conventional diuretics inhibited the increase in copeptin levels and remarkably ameliorated fluid retention without excessively reducing plasma volume and activating the renin–angiotensin–aldosterone and sympathetic nervous systems. Full article

The complement cascade is a vital system in the human body’s defense against pathogens. During the natural aging process, it has been observed that this system is imperative for ensuring the integrity and homeostasis of the retina. While this system is critical for proper host defense and retinal integrity, it has also been found that dysregulation of this system may lead to certain retinal pathologies, including geographic atrophy and diabetic retinopathy. Targeting components of the complement system for retinal diseases has been an area of interest, and in vivo, ex vivo, and clinical trials have been conducted in this area. Following clinical trials, medications targeting the complement system for retinal disease have also become available. In this manuscript, we discuss the pathophysiology of complement dysfunction in the retina and specific pathologies. We then describe the results of cellular, animal, and clinical studies targeting the complement system for retinal diseases. We then provide an overview of complement inhibitors that have been approved by the Food and Drug Administration (FDA) for geographic atrophy. The complement system in retinal diseases continues to serve as an emerging therapeutic target, and further research in this field will provide additional insights into the mechanisms and considerations for treatment of retinal pathologies. Full article

Inconel 718 has excellent thermal and chemical properties and is widely used in the manufacture of aerospace parts; however, there are some problems in the machining of Inconel 718, such as a large milling force, serious tool wear, and poor surface quality. In this research, a type of longitudinal–torsional ultrasonic milling (LTUM) tool is designed based on theoretical computations and FEM simulation analysis. To verify the design rationality of the developed LTUM tool, milling experiments are performed. It is verified that the LTUM tool can realize an elliptical vibration path at the tool tip. The resonance frequency of the tool is 21.32 kHz, the longitudinal amplitude is 6.8 µm, and the torsional amplitude is 1.4 µm. In the milling of Inconel 718, the experimental data of LTUM are compared with those of conventional milling (CM). The comparative experiments show that the LTUM tool can effectively lessen the milling force and tool wear in the milling of Inconel 718, improve the surface quality, inhibit the generation of burrs, and improve the chip breaking ability. The application potential of the LTUM tool in high-performance milling of Inconel 718 parts is proven. Full article

Calcium pyrophosphate dehydrate (CPPD) crystals are found in the synovial fluid of patients with articular chondrocalcinosis or sometimes with osteoarthritis. In inflammatory conditions, the synovial membrane (SM) is subjected to transient hypoxia, especially during movement. CPPD formation is supported by an increase in extracellular inorganic pyrophosphate (ePPi) levels, which are mainly controlled by the transporter Ank and ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1). We demonstrated previously that transforming growth factor (TGF)-β1 increased ePPi production by inducing Ank and Enpp1 expression in chondrocytes. As the TGF-β1 level raises in synovial fluid under hypoxic conditions, we investigated whether hypoxia may transform SM as a major source of ePPi production. Synovial fibroblasts and SM explants were exposed to 10 ng/mL of TGF-β1 in normoxic or hypoxic (5% O₂) culture conditions. Ank and Enpp1 expression were assessed by quantitative PCR, Western blot and immunohistochemistry. ePPi was quantified in culture supernatants. RNA silencing was used to define the respective roles of Ank and Enpp1 in TGF-β1-induced ePPi generation. The molecular mechanisms involved in hypoxia were investigated using an Ank promoter reporter plasmid for transactivation studies, as well as gene overexpression and RNA silencing, the respective role of hypoxia-induced factor (HIF)-1 and HIF-2. Our results showed that TGF-β1 increased Ank, Enpp1, and therefore ePPi production in synovial fibroblasts and SM explants. Ank was the major contributor in ePPi production compared to ENPP1. Hypoxia increased ePPi levels on its own and enhanced the stimulating effect of TGF-β1. Hypoxic conditions enhanced Ank promoter transactivation in an HIF-1-dependent/HIF-2-independent fashion. We demonstrated that under hypoxia, SM is an important contributor to ePPi production in the joint through the induction of Enpp1 and Ank. These findings are of interest as a rationale for the beneficial effect of anti-inflammatory drugs on SM in crystal depositions. Full article

EIMIs face the challenge of adapting to the Paris Agreement and the European Green Deal to achieve carbon neutrality. Driven by consumer interest in low-carbon products, regulatory requirements, and investor priorities, companies are pressured to integrate sustainability beyond short-term financial gains. The growing awareness of the environmental impact of business models (BM) has fueled the development of Sustainable Business Models (SBMs). Although the importance of decarbonization of EIMIs has increased, there is a lack of industry-specific research examining the combination of decarbonization and business models, as well as their interrelationships and correlations. This study addresses the discussion on the role of SBMs in decarbonization, improving the understanding of how these drivers can be integrated to enable new BMs for EIMIs. Based on a structured literature review and semi-structured interviews within the EIMIs, the study identifies BM components influenced by these drivers requiring sustainable business model innovation (SBMI). Results show that decarbonization drivers significantly impact all BM components. Experts emphasize the importance of collaborative approaches and cooperation throughout the value chain. This research highlights the need for systematic analysis to understand how companies can manage decarbonization drivers effectively and suggests exploring potential SBM design options. Full article

Surgery stands as the primary treatment for spheno-orbital meningiomas, following a symptoms-oriented approach. We discussed the decision-making process behind surgical strategies through a review of medical records from 80 patients who underwent surgical resection at the University of Naples Federico II. Different surgical approaches were employed based on the tumor’s location relative to the optic nerve’s long axis, categorized into lateral (type I), medial (type II), and diffuse (type III). We examined clinical, neuroradiological, surgical, pathological, and outcome factors. Proptosis emerged as the most frequent symptom (97%), followed by visual impairment (59%) and ocular motility issues (35%). Type I represented 20%, type II 43%, and type III 17%. Growth primarily affected the optic canal (74%), superior orbital fissure (65%), anterior clinoid (60%), and orbital apex (59%). The resection outcomes varied, with Simpson grades I and II achieved in all type I cases, 67.5% of type II, and 18% of type III. Recurrence rates were highest in type II (41.8%) and type III (59%). Improvement was notable in proptosis (68%) and visual function (51%, predominantly type I). Surgery for spheno-orbital meningiomas should be tailored to each patient, considering individual characteristics and tumor features to improve quality of life by addressing primary symptoms like proptosis and visual deficits. Full article

Hymenoptera is the fourth-most diverse insect order today, including wasps, bees, bumblebees, and ants. They show a wide panoply of modes of life, such as herbivory, predation, parasitoidism, pollination, and eusociality. This group also includes a great number of extinct species from both amber and compression outcrops. Hymenopterans probably originated in the Paleozoic, although their oldest record is from the Middle or Late Triassic, and their diversity expanded since the Cretaceous. Here, we present a review of the Hymenoptera in Lower Cretaceous ambers from Lebanon (Barremian) and Spain (Albian), which is pivotal for the study of hymenopteran evolution. Hymenoptera in Lebanese ambers are represented by 32 species in 22 genera within 15 families, while in Spanish ambers, they correspond to 49 species in 40 genera within 18 families. Most of these species belong to the ‘Parasitica’, and only a few species have been assigned to the Aculeata. The group ‘Symphyta’ is represented by one species in Spanish amber. The paleobiogeography and possible paleobiologies of the species in these ambers are reviewed. Furthermore, checklists for all Hymenoptera species in Lebanese and Spanish ambers are provided. Full article

Text matching, as a core technology of natural language processing, plays a key role in tasks such as question-and-answer systems and information retrieval. In recent years, the development of neural networks, attention mechanisms, and large-scale language models has significantly contributed to the advancement of text-matching technology. However, the rapid development of the field also poses challenges in fully understanding the overall impact of these technological improvements. This paper aims to provide a concise, yet in-depth, overview of the field of text matching, sorting out the main ideas, problems, and solutions for text-matching methods based on statistical methods and neural networks, as well as delving into matching methods based on large-scale language models, and discussing the related configurations, API applications, datasets, and evaluation methods. In addition, this paper outlines the applications and classifications of text matching in specific domains and discusses the current open problems that are being faced and future research directions, to provide useful references for further developments in the field. Full article

Although learning analytics (LA) often processes massive data, not all courses in higher education institutions are on a large scale, such as courses for employed adult learners (EALs) or master’s students. This places LA in a new situation with small datasets. This paper explores the contemporary situation of how LA has been used for small datasets, whereby we examine how the observed LA provisions can be validated in practice, which opens up possible LA solutions for small datasets and takes a further step from previous studies to enhance this topic. By examining the field of LA, a systematic literature review on state-of-the-art LA and small datasets was conducted. Thirty relevant articles were selected for the final review. The results of the review were validated through a small-scale course for EALs at a Swedish university. The findings revealed that the methods of multiple analytical perspectives and data sources with the support of contexts and learning theories are useful for strengthening the reliability of results from small datasets. More empirical evidence is required to validate possible LA methods for small datasets. The LA cycle should be closed to be able to further assess the goodness of the models generated from small datasets. Full article

The compaction of asphalt pavement is a crucial step to ensure its service life. Although intelligent compaction technology can monitor compaction quality in real time, its application to individual asphalt surface courses still faces limitations. Therefore, it is necessary to study the compaction mechanism of asphalt pavements from the particle level to optimize intelligent compaction technology. This study constructed an asphalt pavement compaction model using the Discrete Element Method (DEM). First, the changes in pavement smoothness during the compaction process were analyzed. Second, the changes in the angular velocity of the mixture and the triaxial angular velocity (TAV) of the mortar, aggregates, and mixture during vibratory compaction were examined. Finally, the correlations between the TAV amplitude and the coordination number (CN) amplitude with the compaction degree of the mixture were investigated. This study found that vibratory compaction can significantly reduce asymmetric wave deformation, improving pavement smoothness. The mixture primarily rotates in the vertical plane during the first six passes of vibratory compaction and within the horizontal plane during the seventh pass. Additionally, TAV reveals the three-dimensional dynamic rotation characteristics of the particles, and the linear relationship between its amplitude and the pavement compaction degree aids in controlling the compaction quality of asphalt pavements. Finally, the linear relationship between CN amplitude and pavement compaction degree can predict the stability of the aggregate structure. This study significantly enhances quality control in pavement compaction and advances intelligent compaction technology development. Full article

Fluidic actuation systems are optimizable as to energy consumption by reducing the friction in the hydraulic cylinders. Polymeric materials with special antifriction properties and good resistance to hydraulic fluids can be deployed to enhance the performance of hydraulic cylinders. Small friction forces can also be ensured by facilitating the hydrodynamic separation of the elements of the friction tribosystem, namely the seal and sealed-off surface, respectively. The study presented in this paper analyzed the hydrodynamic separation phenomenon in hydraulic cylinders with coaxial sealing systems of the pistons. The process underlying the forming of the fluid film between the seal and its contact surface was considered and the formula for calculating film thickness was deduced. This paper presents graphs that describe the variation of the fluid film thickness versus the dimensional and material characteristics of the sealing systems. The study yielded recommendations as to the most adequate polymeric material to be used and the optimum dimensional characteristics of the seal. Full article

In steel tied arch bridges where the hangers are made of rigid bars, the replacement of damaged hangers is rather complex. In fact, while generally the cable hangers are already prepared with anchors at the ends and their replacement traces the initial stages of construction with their prestressing, on the contrary, the rigid bars are welded to the arch and the deck, so their replacement must include the design of a new suspension system that allows the insertion of a pretension where this had never been considered. To check the reliability of this new system, a prototype of tensioner was studied for the case of a steel arch bridge in which the high level of corrosion made it necessary to replace all the original hangers with new ones. This entailed the need to test the tensioner performance with the aim of ensuring the axial force transmission between the two hanger segments without slippage in the threads, as well as to test the correct tension setting before construction and putting into service the hangers to be replaced. For this reason, a predictive experimental campaign was carried out on a prototype by means of tests for the mechanical characterization of the materials used, tensile tests of the system, and tensioning tests under load, measuring the displacements and strains of the system elements. The results of the tests, with slippage in the threads limited to the 2% of total elongation, and the turnaround-stressing curves were useful for the definition of the pieces to be assembled during on-site work and for addressing the operating procedures of the tensioning phases on-site during hanger replacement. Validation with the on-site monitoring of stressing operation was conducted at the end; the monitoring of tension through dynamic tests confirmed the agreement of on-site results with the predictive loading tests of the experimental campaign on the tensioner prototype. Full article

Indigenous goats are important in the livelihoods of rural households in East African countries. This is due to their ability to produce and reproduce in different environments and climatic conditions. Even though these indigenous goats are important, there is little available information on the genetic characterization of these breeds in Africa and at the international level. This paper reviews the status of indigenous goats, highlighting their production systems, phenotypic and genetic characteristics, and genetic diversity, and proposes potential ways for sustainable improvement and conservation in East African countries. Most households use traditional production systems with various uncharacterized goat breeds and ecotypes, which are hence named after the tribe or locality in which they are found. Most of these goats are classified as small East African breeds, with significant variability in morphological features. Some of the challenges to goat production in this region are indiscriminate crossbreeding, lack of pedigree records, parasites and disease incidences, low-quality pastures, and low levels of management. There is a need for a collaborative approach amongst the actors in goat breeding value chains as well as integrating modern genomic tools into breeding programs to enhance selection. This will ensure the resilience and sustainability of these unique indigenous goat populations in East Africa Full article

Magnesium-based biomaterials hold remarkable promise for various clinical applications, offering advantages such as reduced stress-shielding and enhanced bone strengthening and vascular remodeling compared to traditional materials. However, ensuring the quality of preclinical research is crucial for the development of these implants. To achieve implant success, an understanding of the cellular responses post-implantation, proper model selection, and good study design are crucial. There are several challenges to reaching a safe and effective translation of laboratory findings into clinical practice. The utilization of Mg-based biomedical devices eliminates the need for biomaterial removal surgery post-healing and mitigates adverse effects associated with permanent biomaterial implantation. However, the high corrosion rate of Mg-based implants poses challenges such as unexpected degradation, structural failure, hydrogen evolution, alkalization, and cytotoxicity. The biocompatibility and degradability of materials based on magnesium have been studied by many researchers in vitro; however, evaluations addressing the impact of the material in vivo still need to be improved. Several animal models, including rats, rabbits, dogs, and pigs, have been explored to assess the potential of magnesium-based materials. Moreover, strategies such as alloying and coating have been identified to enhance the degradation rate of magnesium-based materials in vivo to transform these challenges into opportunities. This review aims to explore the utilization of Mg implants across various biomedical applications within cellular (in vitro) and animal (in vivo) models. Full article

The widespread use of traditional packaging materials poses significant environmental challenges. Adopting green packaging is essential for reducing pollution and conserving natural resources. This paper aims to examine the effectiveness of government incentives and penalties in promoting the adoption of green packaging by logistics companies. We developed an evolutionary game theory model that involves governments and logistics companies, comparing the impacts of static and dynamic reward and penalty policies. The results indicate that (1) static policies often lead to oscillatory adoption rates of green packaging without achieving a stable equilibrium, while dynamic policies generally promote steadier adoption of sustainable practices. (2) Different combinations of dynamic policies have varying influences on logistics companies’ propensity to adopt green packaging solutions. Specifically, dynamic rewards and static penalties are particularly effective at encouraging logistics companies to adopt green packaging. (3) A combination of dynamic rewards and penalties tends to facilitate more rapid and consistent adoption of green packaging by logistics companies. (4) An increase in government supervision costs is associated with reduced regulatory actions and a lower prevalence of green packaging. These insights are critical for policymakers aiming to craft regulations that successfully encourage sustainability within logistics operations. Full article

S-parameters are widely used to detail the scattering parameters of radio frequency (RF) components and microwave circuit modules. The vector network analyzer (VNA) is the most commonly used device for measuring S-parameters. Given the multiple frequency points, complex values, and intricate uncertainty propagation involved, accurately assessing the uncertainty of S-parameter measurements is difficult. In this study, we proposed a new method for assessing S-parameter uncertainty based on the covariance matrices, tracing back to the nominal uncertainty of calibration standards. First, we analyzed the relevant theory of uncertainty assessment using covariance matrices and subsequently deduced the mechanism of Type B uncertainty propagating from calibration standards to error model coefficients and S-parameter measurements to evaluate Type B measurement uncertainty. In this study, a novel measurement system was constructed for measuring grounded coplanar waveguides by using a VNA and calibration standards with 8- and 12-error models. Initially, the model assessed the Type B uncertainty of measuring four S-parameters of a grounded coplanar waveguide. Next, the VNA calibrated with the 12-error model was used to conduct multiple repeated measurements to assess the Type A uncertainty of the grounded coplanar waveguide. Finally, the composite uncertainty was constructed, which demonstrated that the proposed method can be used for assessing the uncertainty of S-parameters. Full article

The present study examines the recent evolution of a cliff coast along the Aegean Sea, considering its geotectonic context, oceanographic factors, sediment dynamics, and human impact. Initially, the formation of this coastal stretch was influenced by neotectonic faults, oriented both semi-parallel and diagonally relative to the present coastline orientation (NE–SW). Subsequently, the delivery of terrestrial sediment from ephemeral rivers and cliff erosion, along with nearshore wave-induced hydrodynamics have played a secondary role in shaping its current configuration, which includes a beach zone along the base of the cliff. This secondary phase of coastal evolution occurred over the past 4–5 thousand years, coinciding with a period of slow sea level rise (approximately 1 mm/year). Evidence such as uplifted notches and beachrock formations extending to around 5 m water depth suggests intervals of relative sea level stability, interrupted by episodic tectonic events. Anthropogenic interventions, related to both changes in coastal sediment budget and coastal engineering projects, have caused beach erosion, particularly in its central and northern sectors. Full article

Aim/Objective: This umbrella review of systematic reviews aims to summarize the available data regarding both success and survival rates of tooth autotransplantation, in addition to analyzing the risk factors that are connected to those rates. Methods: This umbrella review was performed according to the evaluation of various meta-analyses and systematic reviews following AMSTAR2 guidelines. A systematic search of literature on PubMed, Scopus, MEDLINE, EMBASE, and the Cochrane Database. Six systematic reviews were included. Explicit inclusion and exclusion criteria were applied. It is registered in PROSPERO under the registration number (CRD-42023415623). Results: The studies reviewed were written from 2014 to 2018, which extracted the information from various studies spanning from 1968 to 2014. According to the selected studies regarding autotransplanted teeth in humans, they showed the following: A survival rate overall of 87.39% and a success rate overall of 90.29%. These factors were the most common in relation to the success of the autotransplanted teeth: age, gender, and stage of root development. On the other hand, common unfavorable results linked to the transplanted teeth in these studies were failure, ankylosis, and internal root resorption, followed by extraction and hypermobility. Conclusions: The wide body of evidence gathered illustrates that autotransplantation is an operation that dispenses high rates of survival and success. Furthermore, risk factors like root development stage, recipient site, and donor tooth type established a remarkable association with the negative outcomes of the procedure. For successful tooth autotransplantation, patient selection is crucial. Younger patients and those with donor teeth at an optimal stage of root development typically experience better outcomes. Preoperative planning should include comprehensive evaluations and advanced imaging techniques to accurately assess both the donor tooth and the recipient site. Nonetheless, on account of heterogeneity and the quality of the studies included in this investigation, caution should be taken when interpreting the mentioned results. Full article

(1) Background: The spontaneous combustion of coal (SCC) not only consumes huge amounts of coal resources but also causes environmental degradation. Rare earth elements (REE) can be taken as an effective indicator to evaluate the environmental effects of SCC. Coal in the Rujigou Mine has been spontaneously combusting for hundreds of years. (2) Methods: The geochemical properties of REE and major elements in the soil of the Rujigou coal mine are methodically examined to reveal the environmental effects of SCC. (3) Results: Soil REE concentration in the Rujigou mine is 216.09 mg/kg, and there is an enrichment of light rare earth elements (LREE) and a depletion of heavy rare earth elements (HREE), LREE/HREE in Rujigou mine was 5.52. The spontaneous combustion of coal could change the vertical distribution of REE, which is conducive to the enrichment of LREE. According to the Eu anomaly and δCe/δEu, the source of material in this mine may be derived from the terrigenous clastic rock controlled by weak reduction. Aluminum and titanium have similar geochemical behavior to REE, especially LREE. The concentration of sulfur is negatively correlated with REE, especially HREE. Calcium, sodium, and magnesium all had a negative correlation with LREE. (4) Conclusions: The spontaneous combustion of coal can lead to the fractionation of light and heavy rare earth elements, resulting in the enrichment of LREE and depletion of HREE. Full article

The alkali-activated composites technique is a promising method for the in situ preparation of cavity filling/grouting materials from engineering waste soil. To investigate the feasibility of engineering waste soil utilization by the alkali activation process, the macroscopic and microscopic properties of the fly ash/slag-based alkali-activated composites, after solidification/stabilization (S/S) with sandy clay excavated at Baishitang Station of Shenzhen Metro, were studied. The unconfined compressive strength (UCS) test was conducted to evaluate the S/S effect of alkali-activated composites. The results show that the optimum quality ratio of slag and fly ash correspond to 7:3, the modulus of alkaline activator to 1.3, and the alkalinity of alkaline activator to 10%. The alkali-activated composite’s strength under these parameters can reach 45.25 MPa at 3 days, 49.85 MPa at 7 days, and 62.33 MPa at 28 days. A maximum 3-day UCS of 21.71 MPa, 75% of the 28-day UCS, was achieved by an engineering waste soil and alkali-activated composites mass ratio of 5:5, slaked lime content of 4.5%, and a water-to-solid ratio of 0.26, and it can also meet the required fluidity and setting time for construction well. Fluidity is primarily affected by the soil-to-binder ratio, which decreases as the ratio decreases, while the water-to-solid ratio increases fluidity. Slaked lime has minimal impact on fluidity. The setting time is mainly influenced by the soil-to-binder ratio, followed by slaked lime content and water-to-solid ratio, with setting time shortening as the soil-to-binder ratio and slaked lime content increase, and lengthening as the water-to-solid ratio increases. Through Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and Energy Dispersive Spectroscopy (EDS) tests, microscopic analysis showed that loose granular units are firmly cemented by alkali-activated composites. Based on the results of on-site grouting tests in karst caves, the alkali-activated grout materials reached a strength of 5.2 MPa 28 days after filling, which is 162.5% of the strength of cement grouting material, satisfying most of the requirements for cavity filling in Shenzhen. Full article

Robots are becoming an increasingly important part of our society and have started to be used in tasks that require communicating with humans. Communication can be decoupled in two dimensions: symbolic (information aimed to achieve a particular goal) and spontaneous (displaying the speaker’s emotional and motivational state) communication. Thus, to enhance human–robot interactions, the expressions that are used have to convey both dimensions. This paper presents a method for modelling a robot’s expressiveness as a combination of these two dimensions, where each of them can be generated independently. This is the first contribution of our work. The second contribution is the development of an expressiveness architecture that uses predefined multimodal expressions to convey the symbolic dimension and integrates a series of modulation strategies for conveying the robot’s mood and emotions. In order to validate the performance of the proposed architecture, the last contribution is a series of experiments that aim to study the effect that the addition of the spontaneous dimension of communication and its fusion with the symbolic dimension has on how people perceive a social robot. Our results show that the modulation strategies improve the users’ perception and can convey a recognizable affective state. Full article

This paper is dedicated to developing a risk assessment indicator system applicable to transportation infrastructure investment projects in the public–private partnership (PPP) model. Initially, through practical research, literature reviews, and expert interviews, key risk factors for transportation infrastructure investment projects in the PPP mode were identified. Based on these risk factors, a preliminary risk assessment indicator system was established. Subsequently, the principal component analysis (PCA) was used to reduce the dimensions of the indicators, simplify the structure of the system, and highlight key risk factors. Simultaneously, the CRITIC-EWM method was applied to calculate the weights of the indicators. Furthermore, to validate the effectiveness of the indicator system, a questionnaire survey was conducted, collecting 314 responses. Structural equation modeling was applied to validate the effectiveness of the indicator system and examine its application value in practical risk management processes. The primary contribution of this study lies in proposing a method for constructing a risk assessment indicator system that combines quantitative and qualitative analyses, providing new theoretical and practical guidance for risk management of transportation infrastructure investment projects under the PPP mode. Full article