Abstract
During the last 20 years it became much more interesting to test new chemicals as fast as possible for their carcinogenic potency. Therefore new test models were developed. Mutagenicity seems to be one sign for carcinogenicity. Therefore test systems using microorganisms were studied which are influenced by mutagenic substances. These systems are described, first of all the Ames-Test, using revertants ofSalmonella typhimurium, secondly theEscherichia coli system deficient of DNA-polymerase A (DNA-Pol A−). The yeastSaccharomyces cerevisiae was introduced some years ago and finally theNeurospora crassa system serves as an additional test to define exactly the localisation of mutations. The tests and their problems are discussed.
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Gericke, D. Mikrobielle Kurzzeitteste zur Bestimmung der mutagenen Potenz chemischer Substanzen. Naturwissenschaften 70, 173–179 (1983). https://doi.org/10.1007/BF01047554
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DOI: https://doi.org/10.1007/BF01047554