Multiple Sclerosis (MS) is a demyelinating and chronic disease with variable neurological symptoms. There are different scales that score the level of disability, but only few papers have taken into consideration the 5-times sit-to-stand (5STS) test and the 30 s chair stand test (30CST), which are valid and easily obtainable indicators of other neurological diseases. The aim of our research is to verify the validity, reproducibility, and responsiveness of these tests. Patients afflicted with MS were enrolled in the AISM outpatient facility. The inclusion criterion was an EDSS score less than 6.5. We performed the 5STS, 30CST, and timed 25-foot walk (T25-FW) tests and recorded EDSS scores in the first evaluation. Then, we recorded the performance after 5 days (conducted by a second blind operator to ensure test–retest reproducibility), and the last evaluation was made after 12 sessions of physiotherapy. We recruited 38 patients diagnosed with MS. The results show significant data regarding validity, reproducibility, and responsiveness for both scales. The data argue in favor of adding these tests to the relevant clinical assessments. These two tests are simple, reliable, and easy to administer, and the data confirm that they can be included in the evaluation of patients with MS. Full article

Sorghum grain contains high levels and a diverse profile of polyphenols (PPs), which are antioxidants known to reduce oxidative stress when consumed in the diet. Oxidative stress leading to amyloid-β (Aβ) aggregation, neurotoxicity, and mitochondrial dysfunction is implicated in the pathogenesis of Alzheimer’s disease (AD). Thus, PPs have gained attention as possible therapeutic agents for combating AD. This study aimed to (a) quantify the phenolic compounds (PP) and antioxidant capacities in extracts from six different varieties of sorghum grain and (b) investigate whether these PP extracts exhibit any protective effects on human neuroblastoma (BE(2)-M17) cells against Aβ- and tau-induced toxicity, Aβ aggregation, mitochondrial dysfunction, and reactive oxygen species (ROS) induced by Aβ and tert-butyl hydroperoxide (TBHP). PP and antioxidant capacity were quantified using chemical assays. Aβ- and tau-induced toxicity was determined using the 3-(4,5-dimenthylthiazol-2-yl)-2,5-dimethyltetrazolium bromide (MTS) assay. The thioflavin T (Th-T) assay assessed anti-Aβ aggregation. The dichlorodihydrofluorescein diacetate (DCFDA) assay determined the levels of general ROS and the MitoSOX assay determined the levels of mitochondrial superoxide. Sorghum varieties Shawaya short black-1 and IS1311C possessed the highest levels of total phenolics, total flavonoids, and antioxidant capacity, and sorghum varieties differed significantly in their profile of individual PPs. All extracts significantly increased cell viability compared to the control (minus extract). Variety QL33 (at 2000 µg sorghum flour equivalents/mL) showed the strongest protective effect with a 28% reduction in Aβ-toxicity cell death. The extracts of all sorghum varieties significantly reduced Aβ aggregation. All extracts except that from variety B923296 demonstrated a significant (p ≤ 0.05) downregulation of Aβ-induced and TBHP-induced ROS and mitochondrial superoxide relative to the control (minus extract) in a dose- and variety-dependent manner. We have demonstrated for the first time that sorghum polyphenolic extracts show promising neuroprotective effects against AD, which indicates the potential of sorghum foods to exert a similar beneficial property in the human diet. However, further analysis in other cellular models and in vivo is needed to confirm these effects. Full article

Urban parks serve as vital spaces for leisure, social interaction, and nature engagement. At the same time, climate change disproportionately impacts densely populated megacities. While extensive research exists on climate change’s effects on mortality, agriculture, and economic activities, less is known about its impact on urban park usage. Understanding their temporal usage and how temperature changes affect park visitation is crucial for maximizing park benefits and building resiliency. This study analyzes long-term, hourly park visitation data on Dallas, Texas, using digital trace data from SafeGraph (San Francisco, CA, USA), which covers mobile records from approximately 10% of U.S. devices. We focus on five established parks in Dallas and examine their historical temperature data from 2018 to 2022. Descriptive statistics and scatter graphs are utilized to analyze temperature- and demographic-specific visitation patterns. The results of the study highlight the impact of climate change on park visitation and reveal how extreme temperatures influence visitation patterns across parks in Dallas. Additionally, this study explores the differences in visitation based on weekdays versus weekends and highlights demographic disparities. Notably, we examine the implications of nighttime park usage during extreme heat conditions. Our work is informative for urban planners seeking to improve park facilities and comfort amid climate change, ultimately enhancing the resilience and well-being of urban communities. Full article

The scarcity of water resources, climate change, and water-wasting behavior have contributed to a worsening water crisis in many countries. This has raised concerns among farmers and increased pressure on governments. Digital technologies provide effective solutions to reduce resource waste; therefore, exploring farmers’ willingness to implement water-smart farming technologies to reduce waste, especially in developing countries, requires further analysis. To address this gap, this paper aims to investigate the factors that influence farmers’ intention to minimize water waste in Algeria. The theory of planned behavior was extended with the constructs of perceived usefulness of water-smart farming and knowledge of water waste reduction. Primary data were collected from 202 farmers to test the model. The empirical evidence suggests that attitudes, knowledge about water waste reduction, perceived usefulness, and perceived behavioral control significantly predict farmers’ intention to reduce waste. These factors explained 54.6% of the variation in intention. However, social influence was not found to be a significant antecedent of intentions. This paper’s findings can provide useful insights for various stakeholders on how to encourage farmers to reduce water waste and offer guidance on strategies for achieving sustainability in agriculture. Full article

Cavitary corpora lutea are commonly observed during the estrous cycle in bovines. Since the quality of the corpus luteum (CL) is extremely important during embryo transfer when embryos are implanted into the recipient, the ultrasonographic examination of the CL is becoming more and more important in terms of the outcome of the procedure. In the present study, a total of 2477 ultrasonographic transrectal diagnoses were performed, and data were collected between the years of 2018 and 2020 in a large-scale Holstein Friesian dairy farm in Hungary. In 91.1% (n = 2257) and in 8.9% (n = 220) of the cases, compact CLs and cavitary CLs, respectively, were diagnosed at pregnancy diagnosis. The presence of a cavitary CL on the ovary at pregnancy diagnosis increased the odds of remaining open after pregnancy by 21 times compared to the presence of a compact CL (OR = 21.0, p < 0.001) in the cows. The presence of cavitary CL was not influenced either by month or season. Ovarian cysts were detected in 196 cases (8.0%) in the examined animals. The presence of a cavitary CL decreased by 9 times when an ovarian cyst was also diagnosed (OR = 9.0, 1.6% vs. 9.5%, p < 0.001). The presence of an ovarian cyst decreased the odds of established pregnancy by 81 times (OR = 81.1, p < 0.001). Based on our results, the presence of a cavitary CL between days 31 and 42 after artificial insemination is associated with a smaller chance of conception in Holstein Friesian cows. The presence of an ovarian cyst decreases the occurrence of cavitary CL and the chance of conception. Full article

Infections with gastrointestinal nematodes (GINs) reduce the economic efficiency of sheep operations and compromise animal welfare. Understanding the host’s response to GIN infection can help producers identify animals that are naturally resistant to infection. The objective of this study was to characterize the hepatic transcriptome of sheep that had been naturally exposed to GIN parasites. The hepatic transcriptome was studied using RNA-Sequencing technology in animals characterized as high (n = 5) or medium (n = 6) based on their innate immune acute-phase (AP) response phenotype compared with uninfected controls (n = 4), and with biased antibody-mediated (AbMR, n = 5) or cell-mediated (CMR, n = 5) adaptive immune responsiveness compared to uninfected controls (n = 3). Following the assessment of sheep selected for innate responses, 0, 136, and 167 genes were differentially expressed (DE) between high- and medium-responding animals, high-responding and uninfected control animals, and medium-responding and uninfected control animals, respectively (false discovery rate (FDR) < 0.05, and fold change |FC| > 2). When adaptive immune responses were assessed, 0, 53, and 57 genes were DE between antibody- and cell-biased animals, antibody-biased and uninfected control animals, and cell-biased and uninfected control animals, respectively (FDR < 0.05, |FC| > 2). Functional analyses identified enriched gene ontology (GO) terms and metabolic pathways related to the innate immune response and energy metabolism. Six functional candidate genes were identified for further functional and validation studies to better understand the underlying biological mechanisms of host responses to GINs. These, in turn, can potentially help improve decision making and management practices to increase the overall host immune response to GIN infection. Full article

In Nuclear Power Plants (NPPs), online condition monitoring and the fault detection of structures, systems and components (SSCs) can aid in guaranteeing safe operation. The use of data-driven methods for these tasks is limited by the requirement of physically consistent outcomes, particularly in safety-critical systems. Considering the importance of regulating valves (e.g., safety relief valves and main steam isolation valves), this work proposes a multistage Physics-Informed Neural Network (PINN) for fault detection in such components. Two stages of the PINN are built by developing the process model of the regulating valve, which integrates the basic valve sizing equation into the loss function to jointly train the two stages of the PINN. In the 1st stage, a shallow Neural Network (NN) with only one hidden layer is developed to estimate the equivalent flow coefficient (a key performance indicator of regulating valves) using the displacement of the valve as input. In the 2nd stage, a Deep Neural Network (DNN) is developed to estimate the flow rate expected in normal conditions using inputs such as the estimated flow coefficient from the 1st stage, the differential pressure, and the fluid temperature. Then, the residual, i.e., the difference between the estimated and measured flow rates, is fed into a Deep Support Vector Data Description (DeepSVDD) to detect the occurrence of faults. Moreover, the deviation between the estimated flow coefficients of normal and faulty conditions is used to interpret the consistency of the detection result with physics. The proposed method is, first, applied to a simulation case implemented to emulate the operating characteristics of regulating the valves of NPPs and then validated on a real-world case study based on the DAMADICS benchmark. Compared to state-of-the-art fault detection methods, the obtained results from the proposed method show effective fault detection performance and reasonable flow coefficient estimation, thus guaranteeing the physical consistency of the detection results. Full article

The use of artificial lighting during the incubation phase is a tool that has been studied with the aim of increasing the production rates and hatchability. Using this, this study aims to investigate the effects of the luminous incidence of white and red monochromatic light on the production and metabolism of broiler chicks subjected to low temperatures. A total of 315 eggs of Ross 708 heavy breeders were used. The eggs were distributed randomly, with 35 eggs per tray, totaling 105 eggs per incubator. The treatments were the following: incubation without the use of light; the use of white monochromatic light; and the use of red monochromatic light. The lamps used were of the LED type. The samples were distributed in the factorial completely randomized experimental design with position effect on the tray. Candling, egg weighing, calculating the probability of survival and egg weight loss were performed. Temperatures were recorded using a thermographic camera. At birth, three chicks per tray were euthanized for evaluation: weight with and without yolk residue, gastrointestinal tract biometry, and blood and liver biochemistry. Analyses were performed using the R computational program. It was observed that there was a significant effect of the treatments on the levels of calcium, phosphorus, cholesterol, amylase, glucose, urea and glutamate pyruvate transaminase on the biochemical profile of the blood and on the thermographic temperatures of the eggs; the experiment was kept at low temperatures resulting in thermal stress, with an average temperature of 34.5 °C. Therefore, the use of red and white monochromatic light in the artificial incubation process for brown-colored eggs is not recommended, because in the post-hatching phase, it promoted the metabolism dysregulation on the blood biochemical profile to control the differentiation in the wavelength of traditional incubation. Full article

This research delves into the territorial nuances of political populism, examining Portugal’s CHEGA party as a case study. Through a comprehensive analysis of survey data and correlational studies, this study reveals that discontent, manifesting in the rise of populist movements, is intricately linked to the economic decline and neglect of specific regions. The unexpected success of CHEGA is not merely a socio-economic phenomenon but a product of deeply rooted territorial dynamics. The findings underscore the importance of adopting place-sensitive development policies that address the unique challenges of overlooked territories, steering clear of traditional compensatory measures. The urgency to counteract long-term economic decline, industrial decay, and brain drain demands innovative strategies that tap into latent economic potential and provide tangible opportunities. As we confront the rise of anti-establishment voting threatening European unity, this research advocates for a paradigm shift towards place-sensitive policies to navigate the crossroads of discontent and foster a more resilient, inclusive future. Full article

Between 20 and 30% of the feedstock delivered cost is the highway hauling. In order to achieve maximum truck productivity, and thus minimize hauling cost, the hauling technology needs to provide for rapid loading and unloading. Three prototype technologies have been proposed to address the hauling issue. The first was developed by Stinger to secure a load of large rectangular bales, and it is identified as the Advanced Load Securing System (ALSS). For this study, the ALSS technology is applied on two trailers hooked in tandem (ALSS-2) loaded with 20 bales each. The second technology (Cable), is a cable system for securing a load of bales (round or rectangular) on a standard flatbed trailer. With the third technology (Rack), bales are loaded into a 20-bale rack at an SSL, and this rack is unloaded as a unit at the biorefinery. Bales remain in the rack until processed, thus avoiding single-bale handling at the receiving facility. A cost comparison, which begins with bales in single-layer ambient storage in SSLs and ends with bales in single file on a conveyor into the biorefinery, was done for the three hauling technologies paired with three load-out technologies. Cost for the nine options ranged from 48.56 USD/Mg (11 load-outs, Cable hauling) to 34.90 USD/Mg (8 loads-outs, ALSS-2 hauling). The most significant cost issue was the reduction in truck cost; 25.54 USD/Mg (20 trucks, Cable) and 15.15 USD/Mg (10 trucks, Rack). Full article

The efficient separation of solid and liquid phases of soil under reductive conditions is of the utmost importance to study soil chemistry and to predict the mobility and bioavailability of nutrients and toxic contaminants in waterlogged reduced soils (WRSs). However, there is no established method for efficiently separating the solid and liquid phases of WRS within a short time while maintaining its reductive conditions. This study aimed to verify the applicability of a simple centrifugal filtration method (CFM) for the efficient separation of solid and liquid phases of a WRS and examine the CFM-extracted soil solution to confirm that the reductive condition was maintained during the solid–liquid separation process. Incubation experiments were performed under reductive conditions with or without ethanol/molasses used as additional organic material (OM), while the soil solution was collected by both a suction method and CFM at different centrifugation speeds (700, 2760, and 11,000 rpm) and times (1–7 min). The results showed that the soil pH increased with time while the Eh decreased, indicating that its reducing state was enhanced during the incubation experiments. The addition of OM promoted the reductive conditions in the first days of the experiments. Centrifugation speed, rather than time, was found to be the key to extract the maximum amount of soil solution, while a higher centrifugation speed (11,000 rpm), which represents the permanent wilting point, was found to be most effective for extracting the maximum amount of soil solution. The results exhibited no significant difference in solute (As, Fe(II), and Mn) concentrations when varying amounts of CFM-extracted soil solution were measured. The statistical analysis also indicated no significant (p > 0.05) difference between the solute concentrations in the CFM-extracted soil solution and the solute concentrations in the soil solution extracted by the suction method, confirming that the reductive condition was maintained during solid–liquid separation by CFM. This study suggests that CFM operating at a higher centrifugation speed could potentially be employed as a simple and highly effective technique to efficiently separate the solid and liquid phases of WRS (sandy clay loam) within a short time while maintaining its reductive conditions. Full article

The Italian national territory is characterised by the widespread presence of cavities dating back to different periods, especially in urban areas. The lack of knowledge of the position of the entrances, planimetric developments and state of preservation contributes to accentuating the unknowns related to sinkhole risk, which are directly related to potential cavity collapses with the opening of surface chasms. To deepen knowledge with a view to risk mitigation, a method has been developed to employ surveys obtained from Unmanned Aerial Vehicles (UAVs) to locate entrances even in hard-to-access urban areas. These surveys, properly supported with GNSS stations, were then integrated with cavity surveys obtained from low-cost lidar mounted on iPhones. Comparisons were made with traditional surveying techniques to better understand the reliability of the surveys made with low-cost lidar. The 3D models obtained, combined with geomechanical surveys of the rock masses hosting the cavities, allowed the application of simplified and empirical methods for an initial stability assessment. This method was tested on a portion of the municipality of Grotte di Castro (Province of Viterbo—Italy). Full article

With the increasing popularity of clean energy, the use of micro turbines to recover surplus energy in the water supply pipelines of high-rise buildings has attracted more attention. This study adopts a predictor model based on Radial Basis Function Neural Network (RBFNN) to optimize the draft tube shape for micro-Francis turbines. The predictor model is formed on a dataset provided by numerical simulations, which are validated by lab tests. Specifically, numerical investigations are carried out in the shape of a draft tube to determine an optimal model. Additionally, the superiority of the RBFNN model in nonlinear optimization is verified by comparing it with other models under the same date sets. After that, the design parameters are optimized using RBFNN and sequential quadratic programming algorithm (SQPA). Finally, the turbine prototype is fabricated and tested on a lab test rig. The experimental results indicate that the numerical method adopted in this research is accurate enough for such a micro-Francis turbine performance prediction. Under the design conditions, the proposed micro-Francis turbine produces a power of 147 W with an efficiency of over 29%, which shows a considerable improvement compared to the initial prototype. Full article

Objectives: Mitral valve repair is the current standard approach for mitral valve regurgitation. However, patients suffering from functional mitral regurgitation have a significant risk of recurrent regurgitation. Adjustable mitral rings may provide a solution for this adverse event. Methods: A single-center, first-in-man clinical study was performed on patients suffering from mitral valve regurgitation. Patients were implanted with the study ring and followed for six months. A balloon catheter can be inserted into the study ring frame at any time after implantation and inflated independently in the areas P1, P2, or P3, which reduces the anterior-posterior diameter. Results: Five patients (75.4 ± 6.1 years; EuroSCORE II 2.1 ± 0.9%; three female) were successfully implanted. Mechanisms of mitral regurgitation were prolapse of the P2-segment in three patients and annular dilation in two patients. Surgical implantation according to the protocol was feasible and is described herein. Median cardiopulmonary bypass time and cross clamp time were 105 (118; 195) and 94 (90; 151) min, respectively. The median intensive care unit stay was 2 (2; 3) days. No perioperative, 30-day, or 6-month mortality was observed, and the repair was stable without residual or recurrent regurgitation ≥ grade 2. All patients reached the primary endpoint without device-related morbidity. Conclusions: Successful implantation was completed in five patients without device-related adverse events. Ring implantation was safe and feasible for all patients. The opportunity of post-implant adjustment to improve leaflet coaptation is a promising new therapeutic strategy that is assessed in a phase II study. Full article

The research focuses on ultra-lightweight foam concrete with a dry density below 200 kg/m³, primarily used as insulation material. Factors that may affect material properties are categorized into mixing techniques and material composition, and experimental investigations were conducted on the impact of these factors on the rheological properties of cement slurry, density at different time intervals, compressive strength, and thermal conductivity of foam concrete samples. The experimental results indicate the influence of mixing speed and mixing duration on the instrument during the cement slurry production and mixing process with foam. Additionally, variations in foam concrete sample properties are observed due to the water-to-cement ratio, foam content, and foam density in the selected material compositions. By analyzing the material density at different time intervals, the relationship between the ambient air trapped during the mixing process and the viscosity of the material can be indirectly observed. This analysis can also reveal the correlation between the unplanned air content and the properties of the material. Full article

Three different iridium(III) complexes, labelled as Ir1–Ir3, each bearing a unique anchoring moiety (diethyl [2,2′-bipyridine]-4,4′-dicarboxylate, tetraethyl [2,2′-bipyridine]-4,4′-diylbis(phosphonate), or [2,2′-biquinoline]-4,4′-dicarboxylic acid), were synthesized to serve as photosensitizers. Their electrochemical and photophysical characteristics were systematically investigated. ERP measurements were employed to elucidate the impact of the anchoring groups on the photocatalytic hydrogen generation performance of the complexes. The novel iridium(III) complexes were integrated with platinized TiO₂ (Pt–TiO₂) nanoparticles and tested for their ability to catalyze hydrogen production under visible light. A H₂ turnover number (TON) of up to 3670 was obtained upon irradiation for 120 h. The complexes with tetraethyl [2,2′-bipyridine]-4,4′-diylbis(phosphonate) anchoring groups were found to outperform those bearing other moieties, which may be one of the important steps in the development of high-efficiency iridium(III) photosensitizers for hydrogen generation by water splitting. Additionally, toxicological analyses found no significant difference in the toxicity to luminescent bacteria of any of the present iridium(III) complexes compared with that of TiO₂, which implies that the complexes investigated in this study do not pose a high risk to the aquatic environment compared to TiO₂. Full article

Aiming at the problem that there is a big contradiction between accuracy and calculation and cost based on the RSSI positioning algorithm, an accurate and effective cooperative positioning algorithm is proposed in combination with error correction and refinement measures in each stage of positioning. At the ranging stage, the RSSI measurement value is converted to distance by wireless channel modeling and the dynamic acquisition of the power attenuation factor. Then, the ranging correction is carried out by using the known anchor node ranging error information. The Taylor series expansion least-square iterative refinement algorithm is implemented in the position optimization stage, and satisfactory positioning accuracy is obtained. The idea of cooperative positioning is introduced to upgrade the nodes that meet the requirements and are upgraded to anchor nodes and participate in the positioning of other nodes to improve the positioning coverage and positioning accuracy. The experimental results show that the localization effect of this algorithm is close to that of the Taylor series expansion algorithm based on coordinates but far higher than that of the basic least-squares localization algorithm. The positioning accuracy can be improved rapidly with the decrease in the distance measurement error. Full article

The United States is suffering from an epidemic associated with high-risk strains of the Human Papillomavirus (HPV) predominantly responsible for the development of head and neck squamous cell carcinoma (HNSCC). Treatment with immune checkpoint inhibitors targeting programmed death 1 (PD-1) or its ligand PD-L1 has shown poor efficacy in HNSCC patients, observing only a 20–30% response. Therefore, biological marker identification associated with PD-1 blockade response is important to improve prognosis and define novel therapeutics for HNSCC patients. Therapy response was associated with increased frequencies of activated CD27⁺T cells, activated CD79a⁺ B cells, antigen-presenting CD74⁺ dendritic and B cells, and PD-L1⁺ and PD-L2⁺ myeloid-derived suppressor cells (MDSCs). The oral microbiota composition differed significantly in mice bearing tongue tumors and treated with anti-PD-1. A higher abundance of Allobaculum, Blautia, Faecalibacterium, Dorea, or Roseburia was associated with response to the therapy. However, an increase in Enterococcus was attributed to tongue tumor-bearing non-responding mice. Our findings indicate that differences in immune phenotypes, protein expression, and bacterial abundance occur as mice develop tongue tumors and are treated with anti-PD-1. These results may have a clinical impact as specific bacteria and immune phenotype could serve as biomarkers for treatment response in HNSCC. Full article

Repression of human cytomegalovirus (HCMV) immediate-early (IE) gene expression is a key regulatory step in the establishment and maintenance of latent reservoirs. Viral IE transcription and protein accumulation can be elevated during latency by treatment with histone deacetylase inhibitors such as valproic acid (VPA), rendering infected cells visible to adaptive immune responses. However, the latency-associated viral protein UL138 inhibits the ability of VPA to enhance IE gene expression during infection of incompletely differentiated myeloid cells that support latency. UL138 also limits the accumulation of IFNβ transcripts by inhibiting the cGAS-STING-TBK1 DNA-sensing pathway. Here, we show that, in the absence of UL138, the cGAS-STING-TBK1 pathway promotes both IFNβ accumulation and VPA-responsive IE gene expression in incompletely differentiated myeloid cells. Inactivation of this pathway by either genetic or pharmacological inhibition phenocopied UL138 expression and reduced VPA-responsive IE transcript and protein accumulation. This work reveals a link between cytoplasmic pathogen sensing and epigenetic control of viral lytic phase transcription and suggests that manipulation of pattern recognition receptor signaling pathways could aid in the refinement of MIEP regulatory strategies to target latent viral reservoirs. Full article

The physical model test is an effective method to study the bearing behavior of digging hold foundations due to its low cost and clear boundary conditions. Here, similar materials of rocks were configured and employed to study the bearing capacity and failure model of digging hold foundations in rock ground. Firstly, sixteen groups of material proportion schemes were employed to make similar materials of rocks, and the effects of four mix parameters were analyzed. Then, similar materials of rocks were employed to perform the uplift tests of digging hold foundations. The results show that the mass ratio of fine particles and aggregate has the greatest influence on the density and internal friction angle, while the cement moisture content has the greatest influence on the cohesion and compressive strength of similar materials of rocks. During the pull-out process of the digging hold foundation, the radial cracks radiate outward from the circumferential cracks, which is different from those in the field test because the ground is small and uniform without fissures inside. The foundation drives the surrounding similar materials to be pulled up as a whole with a certain failure angle, which increases from 35.7° to 42.5° as the internal friction angle decreases from 56° to 41°. In addition, the ratio between the equivalent shear strength in Chinese Code and uniaxial compressive strength falls in the range of 0.027–0.05. Full article

It is generally assumed that compatibility with special relativity is guaranteed by the invariance of the fundamental equations of quantum physics under Lorentz transformations and the impossibility of transferring energy or information faster than the speed of light. Despite this, various contradictions persist, which make us suspect the solidity of that compatibility. This paper focuses on collapse theories—although they are not the only way of interpreting quantum theory—in order to examine what seems to be insurmountable difficulties we encounter when trying to construct a space–time picture of such typically quantum processes as state vector reduction or the non-separability of entangled systems. The inescapable nature of such difficulties suggests the need to go further in the search for new formulations that surpass our current conceptions of matter and space–time. Full article

The narrow pH application range and lower utilization of ferrous ions (Fe(II)) restrict the application of Fe(II)/persulfate (PS) technology. In this paper, simulated sunlight and citric acid (Cit) as a chelator were introduced in an Fe(II)/PS system to overcome the drawbacks and enhance the degradation of typical antibiotic sulfamethoxazole (SMX) in secondary wastewater. The degradation kinetics, mechanism, and influence factors of SMX in a sunlight/Fe(II)/Cit/PS system and a sunlight/Fe(II)/Cit system as a comparable system were investigated. The removal efficiency of SMX can reach 71.15% and 85.25% in the sunlight/Fe(II)/Cit system and sunlight/Fe(II)/Cit/PS system with 0.1 mM Fe(II), 0.6 mM Cit, and 1 mM PS. The increase of Fe(II) concentration in both systems proved that sunlight promoted the regeneration of Fe(II) from the ferric ion chelates. However, the Fe(II) concentration decreased after 30 min in the sunlight/Fe(II)/Cit/PS system because of the decomposition of Cit. Radical quencher experiments indicated that SO₄^·−, ·OH, and O₂^·− contributed 2.48%, 88.43%, and 6.91% to the removal of SMX, respectively. Electron paramagnetic resonance spectra also proved the formation of ·OH and O₂^·−. The degradation of SMX was proposed to proceed via isomerization, cleavage of S–N bond, and hydroxylation. Overall, the sunlight/Fe(II)/Cit/PS process can be used as an advanced treatment technology for antibiotics in municipal wastewater. Full article