The 2023 MDPI Annual Report has
been released!
 
13 pages, 4656 KiB  
Article
Artificial Intelligence in Postoperative Care: Assessing Large Language Models for Patient Recommendations in Plastic Surgery
by Cesar A. Gomez-Cabello, Sahar Borna, Sophia M. Pressman, Syed Ali Haider, Ajai Sehgal, Bradley C. Leibovich and Antonio J. Forte
Healthcare 2024, 12(11), 1083; https://doi.org/10.3390/healthcare12111083 (registering DOI) - 24 May 2024
Abstract
Since their release, the medical community has been actively exploring large language models’ (LLMs) capabilities, which show promise in providing accurate medical knowledge. One potential application is as a patient resource. This study analyzes and compares the ability of the currently available LLMs, [...] Read more.
Since their release, the medical community has been actively exploring large language models’ (LLMs) capabilities, which show promise in providing accurate medical knowledge. One potential application is as a patient resource. This study analyzes and compares the ability of the currently available LLMs, ChatGPT-3.5, GPT-4, and Gemini, to provide postoperative care recommendations to plastic surgery patients. We presented each model with 32 questions addressing common patient concerns after surgical cosmetic procedures and evaluated the medical accuracy, readability, understandability, and actionability of the models’ responses. The three LLMs provided equally accurate information, with GPT-3.5 averaging the highest on the Likert scale (LS) (4.18 ± 0.93) (p = 0.849), while Gemini provided significantly more readable (p = 0.001) and understandable responses (p = 0.014; p = 0.001). There was no difference in the actionability of the models’ responses (p = 0.830). Although LLMs have shown their potential as adjunctive tools in postoperative patient care, further refinement and research are imperative to enable their evolution into comprehensive standalone resources. Full article
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17 pages, 994 KiB  
Review
Enhancing Biogas Production Amidst Microplastic Contamination in Wastewater Treatment Systems: A Strategic Review
by Job Oliver Otieno, Agnieszka Cydzik-Kwiatkowska and Piotr Jachimowicz
Energies 2024, 17(11), 2555; https://doi.org/10.3390/en17112555 (registering DOI) - 24 May 2024
Abstract
This review highlights the significant interaction between microplastic (MP) pollution and its impact on wastewater treatment systems, focusing on optimizing biogas production. We explore various sources of MPs, including tire-derived MPs, and their introduction into wastewater environments. This review delves into the mechanical [...] Read more.
This review highlights the significant interaction between microplastic (MP) pollution and its impact on wastewater treatment systems, focusing on optimizing biogas production. We explore various sources of MPs, including tire-derived MPs, and their introduction into wastewater environments. This review delves into the mechanical and physicochemical challenges MPs pose in treatment processes, emphasizing the need for comprehensive mitigation strategies. The biological effects of MPs on microbial consortia essential for biogas production are analyzed, particularly how these pollutants interfere with each stage of anaerobic digestion—hydrolysis, acidogenesis, acetogenesis, and methanogenesis—and, consequently, biogas generation. We examine MPs’ quantitative and qualitative impacts on biogas output and production rates, uncovering how MPs disrupt microbial activity in these stages. This review also discusses novel mitigation strategies combining different sludge pretreatment methods with MPs. Our goal is to enhance the sustainability of wastewater management by promoting efficient biogas production and environmental protection in the presence of persistent MP contamination. Full article
(This article belongs to the Section B: Energy and Environment)
25 pages, 10420 KiB  
Article
A Deep Learning Method to Mitigate the Impact of Subjective Factors in Risk Estimation for Machinery Safety
by Xiaopeng Zhu, Aiguo Wang, Ke Zhang and Xueming Hua
Appl. Sci. 2024, 14(11), 4519; https://doi.org/10.3390/app14114519 (registering DOI) - 24 May 2024
Abstract
Risk estimation holds significant importance in the selection of risk reduction measures and ensuring machinery safety. However, subjective influences of assessors lead to an inconsistent understanding of risk among relevant stakeholders, hindering the achievement of safety. As similarities exists in product updates or [...] Read more.
Risk estimation holds significant importance in the selection of risk reduction measures and ensuring machinery safety. However, subjective influences of assessors lead to an inconsistent understanding of risk among relevant stakeholders, hindering the achievement of safety. As similarities exists in product updates or applications in engineering practice, the historical risk information of similar products or applications has essential application value. A novel deep learning approach was established to estimate risks based on historical risk information. To address the issue of overfitting caused by a limited dataset, a data augmentation technique was employed. Our experiment was conducted on the raw, 2×, and 6× hazard event dataset of an industrial robot, demonstrating a substantial improvement in both accuracy and stability. On the validation dataset, there was an increase in median accuracy from 55.56% to 96.92%, with a decrease in standard deviation from 0.118 to 0.015. On the new dataset, the trained network also showed near-perfect performance on similar hazard events and trustworthiness on completely different ones. In cases of risk deviations, approximately 80% of them were small deviations (|RIdeviation| ≤ 2) without a noticeable bias (RIdis is close to 1). The LSTM-based deep learning network makes risk estimation “black-boxed” and “digitized”. Assessors just need to focus on hazard identification with risk being determined by the trained network, mitigating the impact of individual factors. Moreover, the historical risk estimation information can be transformed into a trained network, facilitating the development of a standardized benchmark within project teams, enterprises, and relevant stakeholders to promote coordinated safety measures. Full article
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25 pages, 2680 KiB  
Article
Deep Learning-Based Causal Inference Architecture and Algorithm between Stock Closing Price and Relevant Factors
by Wanqi Xing, Chi Chen and Lei Xue
Electronics 2024, 13(11), 2056; https://doi.org/10.3390/electronics13112056 (registering DOI) - 24 May 2024
Abstract
Numerous studies are based on the correlation among stock factors, which affects the measurement value and interpretability of such studies. Research on the causality among stock factors primarily relies on statistical models and machine learning algorithms, thereby failing to fully exploit the formidable [...] Read more.
Numerous studies are based on the correlation among stock factors, which affects the measurement value and interpretability of such studies. Research on the causality among stock factors primarily relies on statistical models and machine learning algorithms, thereby failing to fully exploit the formidable computational capabilities of deep learning models. Moreover, the inference of causal relationships largely depends on the Granger causality test, which is not suitable for non-stationary and non-linear stock factors. Also, most existing studies do not consider the impact of confounding variables or further validation of causal relationships. In response to the current research deficiencies, this paper introduces a deep learning-based algorithm aimed at inferring causal relationships between stock closing prices and relevant factors. To achieve this, causal diagrams from the structural causal model (SCM) were integrated into the analysis of stock data. Subsequently, a sliding window strategy combined with Gated Recurrent Units (GRUs) was employed to predict the potential values of closing prices, and a grouped architecture was constructed inspired by the Potential Outcomes Framework (POF) for controlling confounding variables. The architecture was employed to infer causal relationships between closing price and relevant factors through the non-linear Granger causality test. Finally, comparative experimental results demonstrate a marked enhancement in the accuracy and performance of closing price predictions when causal factors were incorporated into the prediction model. This finding not only validates the correctness of the causal inference, but also strengthens the reliability and validity of the proposed methodology. Consequently, this study has significant practical implications for the analysis of causality in financial time series data and the prediction of stock prices. Full article
20 pages, 2282 KiB  
Review
Progress in Spin Logic Devices Based on Domain-Wall Motion
by Bob Bert Vermeulen, Bart Sorée, Sebastien Couet, Kristiaan Temst and Van Dai Nguyen
Micromachines 2024, 15(6), 696; https://doi.org/10.3390/mi15060696 (registering DOI) - 24 May 2024
Abstract
Spintronics, utilizing both the charge and spin of electrons, benefits from the nonvolatility, low switching energy, and collective behavior of magnetization. These properties allow the development of magnetoresistive random access memories, with magnetic tunnel junctions (MTJs) playing a central role. Various spin logic [...] Read more.
Spintronics, utilizing both the charge and spin of electrons, benefits from the nonvolatility, low switching energy, and collective behavior of magnetization. These properties allow the development of magnetoresistive random access memories, with magnetic tunnel junctions (MTJs) playing a central role. Various spin logic concepts are also extensively explored. Among these, spin logic devices based on the motion of magnetic domain walls (DWs) enable the implementation of compact and energy-efficient logic circuits. In these devices, DW motion within a magnetic track enables spin information processing, while MTJs at the input and output serve as electrical writing and reading elements. DW logic holds promise for simplifying logic circuit complexity by performing multiple functions within a single device. Nevertheless, the demonstration of DW logic circuits with electrical writing and reading at the nanoscale is still needed to unveil their practical application potential. In this review, we discuss material advancements for high-speed DW motion, progress in DW logic devices, groundbreaking demonstrations of current-driven DW logic, and its potential for practical applications. Additionally, we discuss alternative approaches for current-free information propagation, along with challenges and prospects for the development of DW logic. Full article
(This article belongs to the Special Issue Magnetic and Spin Devices, 3rd Edition)
17 pages, 10612 KiB  
Article
A New Approach to Interior Design: Generating Creative Interior Design Videos of Various Design Styles from Indoor Texture-Free 3D Models
by Zichun Shao, Junming Chen, Hui Zeng, Wenjie Hu, Qiuyi Xu and Yu Zhang
Buildings 2024, 14(6), 1528; https://doi.org/10.3390/buildings14061528 (registering DOI) - 24 May 2024
Abstract
Interior design requires designer creativity and significant workforce investments. Meanwhile, Artificial Intelligence (AI) is crucial for enhancing the creativity and efficiency of interior design. Therefore, this study proposes an innovative method to generate multistyle interior design and videos with AI. First, this study [...] Read more.
Interior design requires designer creativity and significant workforce investments. Meanwhile, Artificial Intelligence (AI) is crucial for enhancing the creativity and efficiency of interior design. Therefore, this study proposes an innovative method to generate multistyle interior design and videos with AI. First, this study created a new indoor dataset to train an AI that can generate a specified design style. Subsequently, video generation and super-resolution modules are integrated to establish an end-to-end workflow that generates interior design videos from texture-free 3D models. The proposed method utilizes AI to produce diverse interior design videos directly, thus replacing the tedious tasks of texture selection, lighting arrangement, and video rendering in traditional design processes. The research results indicate that the proposed method can effectively provide diverse interior design videos, thereby enriching design presentation and improving design efficiency. Additionally, the proposed workflow is versatile and scalable, thus holding significant reference value for transforming traditional design toward intelligence. Full article
(This article belongs to the Special Issue Advanced Technologies for Urban and Architectural Design)
10 pages, 690 KiB  
Article
Epidemiological Surveillance of Respiratory Diseases in Urban Stray Cats in Shanghai
by Dequan Yang, Houbin Ju, Xin Li, Haixiao Shen, Feifei Ge, Xianchao Yang, Hongjing Zhao, Xiujuan Wu, Xiaoying Zhu, Xiaoxu Wang, Jian Wang and Shixin Huang
Animals 2024, 14(11), 1562; https://doi.org/10.3390/ani14111562 (registering DOI) - 24 May 2024
Abstract
Urban stray cats are cats without owners that survive in the wild for extended periods of time. They are one of the most common stray animals in cities, and as such, monitoring the pathogens carried by urban stray cats is an important component [...] Read more.
Urban stray cats are cats without owners that survive in the wild for extended periods of time. They are one of the most common stray animals in cities, and as such, monitoring the pathogens carried by urban stray cats is an important component of urban epidemiological surveillance. In order to understand the prevalence of respiratory diseases in urban stray cats in Shanghai and provide scientific evidence for the development of targeted prevention and control strategies for respiratory diseases in stray cats, we collected 374 ocular, nasal, and oropharyngeal swabs from urban stray cats in Shanghai from January 2022 to December 2022. After RNA extraction, we used real-time PCR to detect six respiratory pathogens, including influenza A virus, feline calicivirus, feline herpesvirus type 1, Mycoplasma, Chlamydia, and Bordetella bronchiseptica. The results showed that among the 374 samples, 146 tested positive, with a positivity rate of 39.04%. The highest positivity rate was observed for Mycoplasma felis at 18.72% (70/374), followed by Chlamydia felis at 11.76% (44/374), feline calicivirus at 3.74% (14/374), feline herpesvirus 1 at 3.48% (13/374), Bordetella bronchiseptica at 1.34% (5/374), and influenza A virus was not detected. The highest positivity rate for Mycoplasma felis was in Minhang District at 31.94% (23/72), while Chlamydia felis and Bordetella bronchiseptica had the highest positivity rates in Jiading District at 23.53% (8/34) and 5.88% (2/34), respectively. The highest positivity rates for feline calicivirus and feline herpesvirus 1 were both observed in Qingpu District, at 14.46% (12/83) and 9.64% (8/83), respectively. A total of 36 samples showed mixed infections with two or more pathogens, with Mycoplasma felis being involved in 32 of these mixed infections, with the highest number of mixed infections being with Chlamydia felis at 25 samples. Respiratory pathogen positivity was detected throughout the year, with peak detection rates in summer and winter. The positivity rates of cat respiratory pathogens in different seasons showed statistical differences (χ2 = 27.73, p < 0.01). There was no statistical difference in the positivity rates of respiratory pathogens between cats of different genders (χ2 = 0.92, p > 0.05). The positivity rates of respiratory pathogens in cats of different age groups showed statistical differences (χ2 = 44.41, p < 0.01). Mycoplasma felis and Chlamydia felis were the main pathogens causing respiratory infections in stray cats, with Mycoplasma felis showing a much higher positivity rate than other respiratory pathogens and often co-infecting with Chlamydia felis and feline calicivirus. The positivity rate of Mycoplasma felis was high in summer, autumn, and winter, with no statistical difference between seasons. These results indicate a serious overall prevalence of respiratory pathogens in urban stray cats in the Shanghai area, showing seasonal trends and mixed infections with other pathogens. These findings suggest the need for comprehensive prevention and control measures to address respiratory pathogen infections in urban stray cats in the Shanghai area. Full article
(This article belongs to the Section Companion Animals)
13 pages, 450 KiB  
Review
The Impact of Artificial Intelligence (AI) on Midwifery Education: A Scoping Review
by Angela Kranz and Harald Abele
Healthcare 2024, 12(11), 1082; https://doi.org/10.3390/healthcare12111082 (registering DOI) - 24 May 2024
Abstract
As in other healthcare professions, artificial intelligence will influence midwifery education. To prepare midwifes for a future where AI plays a significant role in healthcare, educational requirements need to be adapted. This scoping review aims to outline the current state of research regarding [...] Read more.
As in other healthcare professions, artificial intelligence will influence midwifery education. To prepare midwifes for a future where AI plays a significant role in healthcare, educational requirements need to be adapted. This scoping review aims to outline the current state of research regarding the impact of AI on midwifery education. The review follows the framework of Arksey and O’Malley and the PRISMA-ScR. Two databases (Academic Search Premier and PubMed) were searched for different search strings, following defined inclusion criteria, and six articles were included. The results indicate that midwifery practice and education is faced with several challenges as well as opportunities when integrating AI. All articles see the urgent need to implement AI technologies into midwifery education for midwives to actively participate in AI initiatives and research. Midwifery educators need to be trained and supported to use and teach AI technologies in midwifery. In conclusion, the integration of AI in midwifery education is still at an early stage. There is a need for multidisciplinary research. The analysed literature indicates that midwifery curricula should integrate AI at different levels for graduates to be prepared for their future in healthcare. Full article
(This article belongs to the Special Issue Midwifery-Led Care and Practice: Promoting Maternal and Child Health)
14 pages, 513 KiB  
Review
From Marrow to Bone and Fat: Exploring the Multifaceted Roles of Leptin Receptor Positive Bone Marrow Mesenchymal Stromal Cells
by Parash Prasad and Jose A. Cancelas
Cells 2024, 13(11), 910; https://doi.org/10.3390/cells13110910 (registering DOI) - 24 May 2024
Abstract
The bone marrow (BM) stromal cell microenvironment contains non-hematopoietic stromal cells called mesenchymal stromal cells (MSCs). MSCs are plastic adherent, form CFU-Fs, and give rise to osteogenic, adipogenic, chondrogenic progenitors, and most importantly provide HSC niche factor chemokine C-X-C motif ligand 12 (CXCL12) [...] Read more.
The bone marrow (BM) stromal cell microenvironment contains non-hematopoietic stromal cells called mesenchymal stromal cells (MSCs). MSCs are plastic adherent, form CFU-Fs, and give rise to osteogenic, adipogenic, chondrogenic progenitors, and most importantly provide HSC niche factor chemokine C-X-C motif ligand 12 (CXCL12) and stem cell factor (SCF). Different authors have defined different markers for mouse MSC identification like PDGFR+Sca-1+ subsets, Nestin+, or LepR+ cells. Of these, the LepR+ cells are the major source of SCF and CXCL12 in the BM microenvironment and play a major role in HSC maintenance and hematopoiesis. LepR+ cells give rise to most of the bones and BM adipocytes, further regulating the microenvironment. In adult BM, LepR+ cells are quiescent but after fracture or irradiation, they proliferate and differentiate into mesenchymal lineage osteogenic, adipogenic and/or chondrogenic cells. They also play a crucial role in the steady-state hematopoiesis process, as well as hematopoietic regeneration and the homing of hematopoietic stem cells (HSCs) after myeloablative injury and/or HSC transplantation. They line the sinusoidal cavities, maintain the trabeculae formation, and provide the space for HSC homing and retention. However, the LepR+ cell subset is heterogeneous; some subsets have higher adipogenic potential, while others express osteollineage-biased genes. Different transcription factors like Early B cell factor 3 (EBF3) or RunX2 help maintain this balance between the self-renewing and committed states, whether osteogenic or adipogenic. The study of LepR+ MSCs holds immense promise for advancing our understanding of HSC biology, tissue regeneration, metabolic disorders, and immune responses. In this review, we will discuss the origin of the BM resident LepR+ cells, different subtypes, and the role of LepR+ cells in maintaining hematopoiesis, osteogenesis, and BM adipogenesis following their multifaceted impact. Full article
9 pages, 210 KiB  
Opinion
CAR-T and Bispecific Antibodies: The New Standard for Relapsed and Refractory Multiple Myeloma, or Reserved for Late-Line Salvage Therapy?
by Paula Rodriguez-Otero and Thomas Martin
Hemato 2024, 5(2), 171-179; https://doi.org/10.3390/hemato5020014 (registering DOI) - 24 May 2024
Abstract
The treatment of relapsed and refractory multiple myeloma has improved substantially in the last 5–10 years based on the development and use of several novel classes of drugs and drug combinations. These advances have led to improvements in progression-free and overall survival as [...] Read more.
The treatment of relapsed and refractory multiple myeloma has improved substantially in the last 5–10 years based on the development and use of several novel classes of drugs and drug combinations. These advances have led to improvements in progression-free and overall survival as well as quality of life. The general tendency has been to advance drugs/combinations that have performed well in advanced disease to the earlier line settings (frontline, first/early relapse). There are several triplet drug combinations that, when used as part of first or early relapse, can provide remission durations of 3 years or longer. More recently, impressive responses have been seen with the use of targeted immunotherapeutics (chimeric antigen receptor T-cells and bispecific antibodies) in heavily pretreated patients with MM. These treatments, however, have been associated with some new and occasionally severe toxicities, including cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome, and severe infections, including opportunistic infections and profound cytopenias. These potential toxicities bring into question whether these immune-targeting drugs should remain as late-line therapeutics or whether the high single-agent overall response rates mandate that these agents be used in earlier line settings. Herein, the authors provide a point and counterpoint about the future use of these agents. Full article
18 pages, 300 KiB  
Article
Sustainable Purchasing Behaviors in Generation Z: The Role of Social Identity and Behavioral Intentions in the Saudi Context
by Islam Elgammal, Marwa Ghanem and Obaid Al-Modaf
Sustainability 2024, 16(11), 4478; https://doi.org/10.3390/su16114478 (registering DOI) - 24 May 2024
Abstract
This study investigates the sustainable purchasing behaviors of Generation Z in Saudi Arabia, providing an insightful exploration by integrating the theory of planned behavior and social identity approach. Through qualitative research, the study uncovers nuanced insights into the motivational factors and social dynamics [...] Read more.
This study investigates the sustainable purchasing behaviors of Generation Z in Saudi Arabia, providing an insightful exploration by integrating the theory of planned behavior and social identity approach. Through qualitative research, the study uncovers nuanced insights into the motivational factors and social dynamics influencing eco-friendly consumer choices among young adults. It highlights the importance of environmental consciousness, peer influence, and identity-based motivations in shaping sustainable purchasing patterns. The findings reveal that Generation Z’s decisions are significantly influenced by a combination of personal attitudes, perceived social norms, and identity-related aspirations towards sustainability. This research broadens the current understanding of green consumption in a culturally specific context, suggesting that young consumers’ sustainable behaviors are deeply intertwined with their social identities and environmental awareness. The implications of these findings are significant for policymakers, marketers, and manufacturers aiming to encourage eco-friendly practices among younger generations, highlighting the need for tailored strategies that resonate with their values and social identities. Full article
15 pages, 467 KiB  
Article
Adipose Dysfunction Indices as a Key to Cardiometabolic Risk Assessment—A Population-Based Study of Post-Myocardial Infarction Patients
by Elżbieta Szczepańska, Małgorzata Słoma-Krześlak, Agnieszka Białek-Dratwa, Izabela Dudzik and Oskar Kowalski
Metabolites 2024, 14(6), 299; https://doi.org/10.3390/metabo14060299 (registering DOI) - 24 May 2024
Abstract
Anthropometric indices, such as the BMI (body mass index), WC (waist circumference), and WHR (waist–hip ratio) are commonly used for cardiometabolic risk assessment. Consequently, in the context of evaluating cardiometabolic risk in the post-MI population, it is worthwhile to consider indices such as [...] Read more.
Anthropometric indices, such as the BMI (body mass index), WC (waist circumference), and WHR (waist–hip ratio) are commonly used for cardiometabolic risk assessment. Consequently, in the context of evaluating cardiometabolic risk in the post-MI population, it is worthwhile to consider indices such as the Visceral Adiposity Index (VAI) and Body Adiposity Index (BAI), which have emerged as valuable risk assessment tools in clinical trials. The aim of this study was to provide a more comprehensive understanding of the importance of anthropometric indices and body composition analysis in evaluating the cardiometabolic risk among post-myocardial infarction patients. In the pursuit of this objective, this study involved assessing the BMI, WC, WHR, WHtR, VAI, BAI, and body composition in a population of patients. This study enrolled a total of 120 patients hospitalised at the Silesian Centre for Heart Diseases (SCCS) due to MI, and body composition analysis evaluated various parameters including the percentage of adipose tissue (FatP) [%], total adipose tissue (FatM) [kg], fat-free mass (FFM) [kg], muscle mass (PMM) [kg], total body water (TBW) [kg], and visceral adipose tissue (VFAT). The mean BMI for the entire group was 27.76 ± 4.08, with women exhibiting a significantly lower value compared with men (26.66 ± 3.33 vs. 28.16 ± 4.27). The mean values obtained for the WHR, WHtR, BAI, and VAI were 0.97 ± 0.08, 0.59 ± 0.07, 28.37 ± 5.03, and 3.08 ± 3.50, respectively. Based on the visceral adiposity index (VAI), in 47.5% patients, there was no adipose tissue dysfunction, with a higher proportion among women (71.88%) compared with men (38.64%). What raises concern is that 32.50% of patients had acute ATD, with a significantly higher prevalence among men (38.64%) compared with women (15.63%). Conclusion: The study results suggest that the BMI, WC, and WHR have their limitations, whereas the WHtR, VAI, and BAI provide a more comprehensive view of cardiometabolic risk, especially in the context of adipose tissue distribution and its metabolic consequences. Incorporating the WHtR, VAI, and BAI into routine clinical practice may enhance the management of cardiometabolic risk, especially among post-MI patients. Full article
(This article belongs to the Special Issue Epidemiology, Nutrition and Metabolism)
15 pages, 3301 KiB  
Article
High-Resolution Estimation of Soil Saturated Hydraulic Conductivity via Upscaling and Karhunen–Loève Expansion within DREAM( ZS )
by Yang Xia and Na Li
Appl. Sci. 2024, 14(11), 4521; https://doi.org/10.3390/app14114521 (registering DOI) - 24 May 2024
Abstract
Quantification of the soil hydraulic conductivity is key to the study of water flow and solute transport in unsaturated soils. Rapid advances in measurement technology have provided a large number of observations at different scales, offering unprecedented opportunities and challenges for the estimation [...] Read more.
Quantification of the soil hydraulic conductivity is key to the study of water flow and solute transport in unsaturated soils. Rapid advances in measurement technology have provided a large number of observations at different scales, offering unprecedented opportunities and challenges for the estimation of hydraulic parameters. This paper proposes an inverse estimation method for downscaling of observations on coarse scales to estimate hydraulic parameters on high-resolution scales. Due to the significant spatial heterogeneity, the inversion faces the problems of dynamics-based integration of data at different scales, model uncertainty due to hundreds and thousands of parameters, and computational consumption due to the large number of forward simulations. To overcome these problems, this paper uses an efficient Bayesian optimization DREAM(ZS) as an inverse framework, and incorporates an analytical upscaling method and Karhunen–Loève (KL) expansion to infer finer-scale saturated hydraulic conductivity distribution conditioned on coarse-scale measurements. The efficient upscaling method is used to link measurements and hydraulic parameters at different scales, and Karhunen–Loève (KL) expansion is incorporated to greatly reduce the dimension of the parameter to be estimated. To further improve the efficiency of the inversion, a locally one-dimensional (LOD) algorithm is used to solve the multidimensional water flow model at coarse scales. The proposed inverse model is applied in a series of numerical experiments to demonstrate its applicability and effectiveness under different flow boundary conditions, different levels of ratio between coarse- and fine-scale grids, different densities of observation points, and different degrees of statistic heterogeneity of soil mediums. Full article
15 pages, 507 KiB  
Article
Partial Replacement of Fishmeal with Seafood Discards for Juvenile Penaeus japonicus: Effects on Growth, Flesh Quality, Chemical and Fatty Acid Composition
by Marco Ragni, Maria Antonietta Colonna, Laura Di Turi, Claudia Carbonara, Francesco Giannico, Michela Cariglia, Giuseppe Palma and Simona Tarricone
Fishes 2024, 9(6), 195; https://doi.org/10.3390/fishes9060195 (registering DOI) - 24 May 2024
Abstract
The present study was designed to assess the influence of fishmeal replacement with increasing percentages of fresh seafood discards (0, 25, 50 and 75%) in diets for Penaeus japonicus on growth performance, physical characteristics and the chemical and fatty acid composition of shrimp [...] Read more.
The present study was designed to assess the influence of fishmeal replacement with increasing percentages of fresh seafood discards (0, 25, 50 and 75%) in diets for Penaeus japonicus on growth performance, physical characteristics and the chemical and fatty acid composition of shrimp flesh. Each diet was administered for 108 days, and the trial was assayed in triplicate. The final body weight and the specific growth rate were significantly higher (p < 0.05) in shrimps fed with 75% fishmeal replacement as compared to 25%, while the abdomen weight and the total length were the highest (p < 0.01). Moreover, 75% replacement showed a significantly (p < 0.05) lower value of hardness and a greater crude protein and lipid content as compared to the 0% replacement. The shrimps fed with high levels of seafood discards (50 and 75%) showed a lower saturated fatty acid concentration and, in turn, a greater amount of polyunsaturated fatty acids in shrimp meat significantly (p < 0.05) affected the lower atherogenic and thrombogenic indices. In conclusion, replacing 75% of fishmeal with seafood discards provided satisfactory results. An economic analysis based on ESG indicators and PESTLE methodology is provided in order to show the socio-economic and governance impacts affecting the replacement of shrimps’ diet with fish discard. Full article
(This article belongs to the Section Nutrition and Feeding)
53 pages, 2611 KiB  
Review
Recent Advances in Graphene-Based Single-Atom Photocatalysts for CO2 Reduction and H2 Production
by Muhammad Yasir Akram, Tuba Ashraf, Muhammad Saqaf Jagirani, Ahsan Nazir, Muhammad Saqib and Muhammad Imran
Catalysts 2024, 14(6), 343; https://doi.org/10.3390/catal14060343 (registering DOI) - 24 May 2024
Abstract
The extensive use of single-atom catalysts (SACs) has appeared as a significant area of investigation in contemporary study. The single-atom catalyst, characterized by its maximum atomic proficiency and great discernment of the transition-metal center, has a unique combination of benefits from both heterogeneous [...] Read more.
The extensive use of single-atom catalysts (SACs) has appeared as a significant area of investigation in contemporary study. The single-atom catalyst, characterized by its maximum atomic proficiency and great discernment of the transition-metal center, has a unique combination of benefits from both heterogeneous and homogeneous catalysts. Consequently, it effectively bridges the gap between these two types of catalysts, leveraging their distinctive features. The utilization of SACs immobilized on graphene substrates has garnered considerable interest, primarily because of their capacity to facilitate selective and efficient photocatalytic processes. This review aims to comprehensively summarize the progress and potential uses of SACs made from graphene in photocatalytic carbon dioxide (CO2) reduction and hydrogen (H2) generation. The focus is on their contribution to converting solar energy into chemical energy. The present study represents the various preparation methods and characterization approaches of graphene-based single-atom photocatalyst This review investigates the detailed mechanisms underlying these photocatalytic processes and discusses recent studies that have demonstrated remarkable H2 production rates through various graphene-based single-atom photocatalysts. Additionally, the pivotal roleof theoretical simulations, likedensity functional theory (DFT), to understand the structural functional relationships of these SACs are discussed. The potential of graphene-based SACs to revolutionize solar-to-chemical energy conversion through photocatalytic CO2 reduction and H2 production is underscored, along with addressing challenges and outlining future directions for this developing area of study. By shedding light on the progress and potential of these catalysts, this review contributes to the collective pursuit of sustainable and efficient energy conversion strategies to mitigate the global climate crisis. Full article
(This article belongs to the Special Issue Recent Advances in Photo/Electrocatalytic Water Splitting)
10 pages, 284 KiB  
Communication
Imidazolinone Resistance in Oilseed Rape (Brassica napus L.): Current Status, Breeding, Molecular Markers and Prospects for Application in Hybrid Seed Purity Improvement
by Elena Victorovna Kozar and Elena Alekseevna Domblides
Horticulturae 2024, 10(6), 553; https://doi.org/10.3390/horticulturae10060553 (registering DOI) - 24 May 2024
Abstract
Resistance of agricultural crops to herbicides is an important topic that concerns many researchers. One of the most popular groups of herbicides is the imidazolinone group. Resistant forms of crops such as wheat (Triticum aestivum L.), sunflower (Helianthus annuus L.), corn [...] Read more.
Resistance of agricultural crops to herbicides is an important topic that concerns many researchers. One of the most popular groups of herbicides is the imidazolinone group. Resistant forms of crops such as wheat (Triticum aestivum L.), sunflower (Helianthus annuus L.), corn (Zea mays L.), rice (Oryza sativa L.) and oilseed rape (Brassica napus L.) have been developed to this group of herbicides. All crops resistant to this group of herbicides have the commercial name Clearfield®. In this review, the information concerning oilseed rape resistance to the imidazolinone group of herbicides is collected and summarized; it will be useful for breeders and researchers engaged in this direction. This review touches upon the topic of mechanisms of oilseed rape resistance to imidazolinones. Mutation variants known to date, which provide resistance to this group of herbicides, are described, and known molecular markers of them are presented. Approaches to the selection of oilseed rape for resistance to the imidazolinone group of herbicides are mentioned. Various methods of utilizing imidazolinone resistance to improve the purity of hybrid seeds are also considered. Full article
(This article belongs to the Special Issue Advances in Brassica Crops Genomics and Breeding, Volume II)
11 pages, 4001 KiB  
Article
Predicting Grape Yield with Vine Canopy Morphology Analysis from 3D Point Clouds Generated by UAV Imagery
by Adam Šupčík, Gabor Milics and Igor Matečný
Drones 2024, 8(6), 216; https://doi.org/10.3390/drones8060216 (registering DOI) - 24 May 2024
Abstract
With its ability to estimate yield, winemakers may better manage their vineyards and obtain important insights into the possible crop. The proper estimation of grape output is contingent upon an accurate evaluation of the morphology of the vine canopy, as this has a [...] Read more.
With its ability to estimate yield, winemakers may better manage their vineyards and obtain important insights into the possible crop. The proper estimation of grape output is contingent upon an accurate evaluation of the morphology of the vine canopy, as this has a substantial impact on the final product. This study’s main goals were to gather canopy morphology data using a sophisticated 3D model and assess how well different morphology characteristics predicted yield results. An unmanned aerial vehicle (UAV) with an RGB camera was used in the vineyards of Topoľčianky, Slovakia, to obtain precise orthophotos of individual vine rows. Following the creation of an extensive three-dimensional (3D) model of the assigned region, a thorough examination was carried out to determine many canopy characteristics, including thickness, side section dimensions, volume, and surface area. According to the study, the best combination for predicting grape production was the side section and thickness. Using more than one morphological parameter is advised for a more precise yield estimate as opposed to depending on only one. Full article
(This article belongs to the Special Issue Advances of UAV in Precision Agriculture)
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20 pages, 474 KiB  
Review
An Emerging Concentric Spatial Turn for Sustainable Systems: Beyond the Diametric Spatial Frame in Bacon’s View of Humans as Apart from and above the Natural World towards Being-Alongside Nature
by Paul Downes
Sustainability 2024, 16(11), 4479; https://doi.org/10.3390/su16114479 (registering DOI) - 24 May 2024
Abstract
A spatial turn is increasingly being recognised across education, the humanities, and social sciences to critique Western Cartesian assumptions treating space as either empty or a diametric opposition bringing dualistic splits between reason/emotion and mind/body. Bacon’s vision of human subjugation of nature as [...] Read more.
A spatial turn is increasingly being recognised across education, the humanities, and social sciences to critique Western Cartesian assumptions treating space as either empty or a diametric opposition bringing dualistic splits between reason/emotion and mind/body. Bacon’s vision of human subjugation of nature as a tool for human progress is examined as a diametric spatial projection, where humans are above and apart from nature, in a mirror-image inverted symmetry of above/below hierarchy and side-by-side assumed separation as diametric space. Building on an interdisciplinary synthesis between an aspect of the structural anthropology of Lévi-Strauss, De Beauvoir’s othering, and Bronfenbrenner’s social-ecological systems in psychology, allied with a Heideggerian critique of being as needing a mode of ‘being alongside the world’, a shift in experiential and conceptual space is proposed in this conceptual review article for education. This shift is towards a framework of concentric spatial systems of sustainability. Concentric relational spaces of assumed connection and relative openness and away from diametric spaces of splitting and closure have been developed recently for sustainability concerns regarding inclusion in education. This article goes further to interrogate systems of concentric relational space for belonging with and encountering the natural world for environmental sustainability. Full article
23 pages, 3375 KiB  
Article
Seismic Design Procedure for Low-Rise Cold-Formed Steel–Special Bolted Moment Frames
by Atsushi Sato and Honoka Kitagawa
Appl. Sci. 2024, 14(11), 4520; https://doi.org/10.3390/app14114520 (registering DOI) - 24 May 2024
Abstract
In 2007, the American Iron and Steel Institute (AISI) established a standard for cold-formed steel–special bolted moment frames (CFS-SBMFs). This structural system is designed to resist seismic forces. The CFS-SBMF system employs double-channel beams and square hollow structural section (HSS) columns that are [...] Read more.
In 2007, the American Iron and Steel Institute (AISI) established a standard for cold-formed steel–special bolted moment frames (CFS-SBMFs). This structural system is designed to resist seismic forces. The CFS-SBMF system employs double-channel beams and square hollow structural section (HSS) columns that are bolted together to create a sturdy and robust structural frame. However, the CFS-SBMF system is only suitable for constructing one-storey buildings, and ASCE 7 prohibits its use in buildings with a height of over one storey. This study was conducted to expand the use of CFS-SBMFs to the construction of multi-storey low-rise buildings. Firstly, a new moment connection detail is proposed, and a design procedure is proposed to ensure that bolted connections, instead of beams or columns, have the ductility to withstand seismic forces. Secondly, the proposed design procedure for bolted connections was verified through full-scale cyclic testing. Finally, a comprehensive evaluation was undertaken to evaluate the proposed structural system’s performance under seismic excitation. The evaluation included nonlinear dynamic analysis and incremental dynamic analysis (IDA) according to FEMA P695, which provided a detailed understanding of the seismic design factors (SDFs) in multi-storey low-rise CFS-SBMF buildings. Full article
(This article belongs to the Special Issue Performance-Based Seismic Design)
11 pages, 408 KiB  
Article
The Impact of Newly Diagnosed Early Breast Cancer on Psychological Resilience, Distress Levels, and the Perception of Health
by Anuska Budisavljevic, Natalija Dedic Plavetic, Kristina Klaric, Renata Kelemenic-Drazin and Marina Letica-Crepulja
Int. J. Environ. Res. Public Health 2024, 21(6), 677; https://doi.org/10.3390/ijerph21060677 (registering DOI) - 24 May 2024
Abstract
Confronting a breast cancer diagnosis, along with complex and challenging treatment procedures, is an extremely stressful experience. Psychological resilience is the ability to maintain or restore normal functioning while facing adversity. We aimed to explore the impact of an early breast cancer diagnosis [...] Read more.
Confronting a breast cancer diagnosis, along with complex and challenging treatment procedures, is an extremely stressful experience. Psychological resilience is the ability to maintain or restore normal functioning while facing adversity. We aimed to explore the impact of an early breast cancer diagnosis on psychological resilience, distress, and perception of health. A cross-sectional study was conducted, including 50 patients newly diagnosed with early breast cancer and 67 healthy women with screening mammograms graded 1 or 2 using a Breast Imaging Reporting and Data System. The levels of distress, perception of health, and psychological resilience were assessed using the depression, anxiety, and stress scale, the SF 36-Item Health Survey 1.0, and the Connor–Davidson RISC-25 scale. Differences between variables were examined using the t-test and chi-square test for interval and categorial variables. The surveys were conducted within four weeks of a breast cancer diagnosis. Patients with breast cancer reported a deterioration of their health relative to the previous year and significantly higher levels of psychological resilience, while there was no significant difference between the groups in levels of stress, anxiety, or depression. The process of diagnosis with early breast cancer may activate psychological dynamic processes which are involved in the effective adaptation to acute stress, leading to higher resilience levels in breast cancer patients compared to healthy controls. Full article
(This article belongs to the Special Issue The Impact of Anxiety, Depression, and Stress on Mental Health)
13 pages, 494 KiB  
Article
Digital Cytology in Veterinary Education: A Comprehensive Survey of Its Application and Perception among Undergraduate and Postgraduate Students
by Marta Giacomazzo, Francesco Cian, Massimo Castagnaro, Maria Elena Gelain and Federico Bonsembiante
Animals 2024, 14(11), 1561; https://doi.org/10.3390/ani14111561 (registering DOI) - 24 May 2024
Abstract
The COVID-19 pandemic accelerated technological changes in veterinary education, particularly in clinical pathology and anatomic pathology courses transitioning from traditional methods to digital pathology (DP). This study evaluates the personal effectiveness and satisfaction, as well as the advantages and disadvantages, of DP, in [...] Read more.
The COVID-19 pandemic accelerated technological changes in veterinary education, particularly in clinical pathology and anatomic pathology courses transitioning from traditional methods to digital pathology (DP). This study evaluates the personal effectiveness and satisfaction, as well as the advantages and disadvantages, of DP, in particular digital cytology (DC), as a teaching method among European veterinary students, both at the undergraduate and postgraduate level, who attended digital pathology courses during and before the pandemic. A further aim is to discuss the differences between the two student groups. A Google Form survey consisting of 11 multiple-choice questions was emailed to pathology teachers and distributed to their students. Results indicated that undergraduate students showed greater digital pathology training, favouring DC as the most effective learning modality. In contrast, postgraduate students reported less digital slide training, and their preference for learning cytology was split between DC alone and DC integrated with traditional microscopy. All students experienced whole slide imaging for learning cytology slides prevalently, and they stated that DC enhanced their learning experience. While DC demonstrates personal effectiveness and satisfaction as a teaching method, it is important to not replace pathology training with light microscopy completely, as almost a third of the students indicated. Full article
15 pages, 3687 KiB  
Systematic Review
A Systematic Literature Review on Inflammatory Markers in the Saliva of Patients with Multiple Sclerosis: A Cause or a Consequence of Periodontal Diseases
by Vasile Calin Arcas, Ioan Andrei Tig, Doru Florian Cornel Moga, Alexandra Lavinia Vlad, Corina Roman-Filip and Anca Maria Fratila
Medicina 2024, 60(6), 859; https://doi.org/10.3390/medicina60060859 (registering DOI) - 24 May 2024
Abstract
Background and Objectives: Multiple sclerosis (MS) is a chronic neurodegenerative disease often linked with systemic conditions such as periodontal diseases (PDs). This systematic review aims to explore the association between inflammatory markers in saliva and PDs in MS patients, assessing the use [...] Read more.
Background and Objectives: Multiple sclerosis (MS) is a chronic neurodegenerative disease often linked with systemic conditions such as periodontal diseases (PDs). This systematic review aims to explore the association between inflammatory markers in saliva and PDs in MS patients, assessing the use of saliva as a non-invasive tool to monitor disease progression. Materials and Methods: 82 publications were examined after a thorough search of scholarly databases to determine whether inflammatory markers were present in MS patients and whether they were associated with periodontal disease (PD). Quality and bias were assessed using the Newcastle–Ottawa Scale, resulting in eight articles that were thoroughly analyzed. Results: The results point to a strong correlation between MS and periodontal disorders, which may point to the same pathophysiological mechanism. It does, however, underscore the necessity of additional study to determine a definitive causal association. Conclusions: The findings indicate a strong association between MS and PDs, likely mediated by systemic inflammatory responses detectable in saliva. The review highlights the importance of oral health in managing MS and supports the utility of saliva as a practical, non-invasive medium for monitoring systemic inflammation. Further research is necessary to confirm the causal relationships and to consider integrating salivary diagnostics into routine clinical management for MS patients. Full article
(This article belongs to the Special Issue Boundaries between Oral and General Health)
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12 pages, 650 KiB  
Article
Development and Properties of Recycled Biomass Fly Ashes Modified Mortars
by Julien Hubert, Sophie Grigoletto, Frédéric Michel, Zengfeng Zhao and Luc Courard
Recycling 2024, 9(3), 46; https://doi.org/10.3390/recycling9030046 (registering DOI) - 24 May 2024
Abstract
The production of biomass fly ash has been increasing every year in Europe, reaching 5.5 million tons in 2020. Fly ash produced by burning biomass is not yet accepted in the standards as a substitute material for cement in mortar and concrete. In [...] Read more.
The production of biomass fly ash has been increasing every year in Europe, reaching 5.5 million tons in 2020. Fly ash produced by burning biomass is not yet accepted in the standards as a substitute material for cement in mortar and concrete. In a first approach, the substitution limit of biomass ash is determined by comparing the mechanical strengths (among others, compressive strength), fresh state properties and hardened properties of mortars produced with fly ash with those of mortars produced with coal fly ash (EN 450-1 and ASTM C618). Masonry and rendering mortars have been designed with different substitution rates of fly ashes from wood combustion in thermal power plants. Although there is an overall decrease in performance, mortars made with biomass ash retain properties that make them suitable for use in masonry (loss of 13% compressive strength for masonry mortars with 10% substitution rate after 90 days) or rendering (loss of 20% compressive strength for rendering mortars with 10% substitution rate after 90 days). Water absorption and porosity (24.1 and 23.7% for masonry and rendering mortars, respectively) are, however, not significantly modified, which potentially contributes to good durability properties. Full article
(This article belongs to the Special Issue Resource Recovery from Waste Biomass)

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