Summary
As a new type of the nucleic acid analogs, poly-L-lysine derivatives containing adenine, thymine and uracil were prepared. By using the activated ester method, carboxyethyl derivatives of the nucleic acid bases were grafted onto poly-L-lysine. The thymine and uracil derivatives were completely substituted to poly-L-lysine. The content of adenine unit in the polymer, however, was less than that of the thymine analog.
Similar content being viewed by others
References
N.ANAND, N.S.R.K.MURTHY, F.NAIDER and M.GOODMAN: Macromolecules, 4, 564 ( 1971 )
C.G.OVERBERGER and Y.INAKI J.Polym.Sci., Polym.Chem. Ed., ( 1978 ), in press
M.SELA, R.ARNON and I.JACOBSON: Biopolymers, 1, 517 ( 1963 )
K.TAKEMOTO: J.Polym.Sci., Polym.Symp., No.55, 105 ( 1976 )
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ishikawa, T., Inaki, Y. & Takemoto, K. Synthesis of nucleic acid base substituted poly-L-lysine. Polymer Bulletin 1, 85–89 (1978). https://doi.org/10.1007/BF00255719
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00255719