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Synthesis and primary biological evaluation of 188ReN-NEMPTDD

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Abstract

A new nitrido-188Re complex, 188ReN-NEMPTDD, was synthesized through a modified method in high yield. This complex was stable in vitro. The biodistribution in normal mice showed that this ReN complex accumulated in the liver and was eliminated quickly from almost all organs. VX2 carcinoma was grown in the livers of rabbits. Transcatheter arterial embolization (TAE) was performed using 188ReN-NEMPTDD/lipiodol solution. The SPECT images showed that the lipiodol solution could be concentrated in the tumor for about 12 hours. These results indicated that 188ReN-NEMPTDD/lipiodol could be a potential radiopharmaceutical for liver cancer.

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Authors and Affiliations

  1. Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education), Sichuan University, Chengdu, 610064, P.R. China

    Guan-Quan Wang, Ji Zhang, Na Wang & Xiao-Qi Yu

  2. Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics (CAEP), Mianyang, 621900, P.R. China

    Guan-Quan Wang, Shun-Zhong Luo, Hong-Yuan Wei, Wen-Jin Wang, Yu-Qing Yang & Guo-Ping Liu

  3. State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, P.R. China

    Xiao-Qi Yu

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  1. Guan-Quan Wang
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  2. Ji Zhang
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  3. Shun-Zhong Luo
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  4. Na Wang
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  5. Hong-Yuan Wei
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  6. Wen-Jin Wang
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  7. Yu-Qing Yang
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  8. Guo-Ping Liu
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  9. Xiao-Qi Yu
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Correspondence to Xiao-Qi Yu.

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Wang, GQ., Zhang, J., Luo, SZ. et al. Synthesis and primary biological evaluation of 188ReN-NEMPTDD. J Radioanal Nucl Chem 277, 365–369 (2008). https://doi.org/10.1007/s10967-007-7033-2

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  • DOI: https://doi.org/10.1007/s10967-007-7033-2

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