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Analysis of a 1-Mb BAC contig overlapping the mouse Nkrp1 cluster of genes: cloning of three new Nkrp1 members, Nkrp1d, Nkrp1e, and Nkrp1f

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Abstract.

The murine Nkrp1 gene family encodes three previously identified activation and inhibitory receptors expressed on natural killer (NK) cells. This family includes the gene for NKR-P1C (NK1.1), the most specific serologic marker on C57BL/6-derived NK cells and is localized in a gene cluster in the NK gene complex (NKC). To further analyze the Nkrp1 family, we constructed and analyzed a bacterial artificial chromosome contig. A genomic organization of the Nkrp1 family was obtained and three new Nkrp1 genes were isolated from interleukin-2-activated NK cells. Thus, the Nkrp1 family adds to the repertoire of receptors expressed by NK cells.

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Authors and Affiliations

  1. Howard Hughes Medical Institute, Division of Rheumatology, Washington University, Box 8045, 660 S. Euclid Avenue, Saint Louis, MO 63110, USA

    Béatrice Plougastel, Keiko Matsumoto, Chad Dubbelde & Wayne M. Yokoyama

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  1. Béatrice Plougastel
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  2. Keiko Matsumoto
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  3. Chad Dubbelde
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  4. Wayne M. Yokoyama
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Correspondence to Béatrice Plougastel.

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Plougastel, B., Matsumoto, K., Dubbelde, C. et al. Analysis of a 1-Mb BAC contig overlapping the mouse Nkrp1 cluster of genes: cloning of three new Nkrp1 members, Nkrp1d, Nkrp1e, and Nkrp1f . Immunogenetics 53, 592–598 (2001). https://doi.org/10.1007/s002510100367

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  • DOI: https://doi.org/10.1007/s002510100367

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