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Kinetic studies on the absorption and excretion of 4-allyloxy-3-chlorphenylacetic-acid (alclofenac) in man

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Summary

The excretion kinetics and blood levels of alclofenac (14C-carbonyl) have been investigated in 9 patients treated orally (400, 800 or 1200 mg single dose) or rectally (400 mg single dose). The results obtained have shown that: 1) the absorption and excretion of oral alclofenac are highly effective and rapid at the dose levels tested; 2) the blood levels are directly dose-related but cannot be correlated quantiatively with the urinary excretion; 3) binding of the drug to erythrocytes is only detectable at high blood levels; 4) rectal and oral administration are equally effective; 5) the analgesic activity of alclofenac is related to its blood concentrations.

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References

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Authors and Affiliations

  1. Continental Pharma Research Laboratories, Machelen

    R. Roncucci, M. J. Simon, G. Lambelin, M. Saquet, C. Gillet, H. van Cauwenberge, P. Lefèbvre, J. C. Daubresse & N. P. Buu-Hoi

  2. Institut de Médecine, Département de Clinique et de Pathologie Médicales, Université de Liège, Liège, Belgium

    R. Roncucci, M. J. Simon, G. Lambelin, M. Saquet, C. Gillet, H. van Cauwenberge, P. Lefèbvre, J. C. Daubresse & N. P. Buu-Hoi

  3. Institut du Radium, Paris, France

    R. Roncucci, M. J. Simon, G. Lambelin, M. Saquet, C. Gillet, H. van Cauwenberge, P. Lefèbvre, J. C. Daubresse & N. P. Buu-Hoi

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  1. R. Roncucci
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  2. M. J. Simon
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  3. G. Lambelin
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  4. M. Saquet
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  5. C. Gillet
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  6. H. van Cauwenberge
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  7. P. Lefèbvre
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  8. J. C. Daubresse
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  9. N. P. Buu-Hoi
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Roncucci, R., Simon, M.J., Lambelin, G. et al. Kinetic studies on the absorption and excretion of 4-allyloxy-3-chlorphenylacetic-acid (alclofenac) in man. Eur J Clin Pharmacol 3, 176–181 (1971). https://doi.org/10.1007/BF00572460

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  • DOI: https://doi.org/10.1007/BF00572460

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