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The aim of this study is to examine whether good asset allocation by a CEO leads to superior stock returns and, if so, how one might be able to identify CEOs that are good asset allocators. Employing US data from May 2001 to
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The aim of this study is to examine whether good asset allocation by a CEO leads to superior stock returns and, if so, how one might be able to identify CEOs that are good asset allocators. Employing US data from May 2001 to April 2019, we find that CEOs that invest the company’s cash flows according to a value-investing style seem to outperform companies that do not. We find that high goodwill to assets and high operating margin (good asset allocator) companies outperform companies with high or low goodwill to assets and low operating margin (poor asset allocator) companies. The findings are corroborated with out-of-sample (May 2019–April 2023) robustness tests. When buying other businesses, value investor CEOs ensure that their consolidated operating margins remain high, as opposed to other firms managed by poor asset allocator CEOs who buy businesses that bring down operating margins, either because they overpay or due to an inability to materialize expected synergies. Using both summary statistics and regression analysis, the findings of this study help us identify companies that allocate assets like value investors and enable us to anticipate future stock performance. For example, if a company, on average, has a goodwill/assets ratio of 41.03%, and an operating margin of 21.38%, it is likely this firm would be at the top quartile in terms of stock return performance over at least the next three years. At the same time, if a firm has a low average goodwill/assets ratio (i.e., 1.95%), its operating margins, on average, should be 24.46%, if it wants to achieve a similar performance as that of firms with high goodwill/assets. Moreover, the future stock return predictability of high (low) goodwill/assets and high (low) operating margin firms, found in this study, can help an investor develop trading strategies that can lead to superior stock price performance by effectively taking long positions in (shorting) firms that are (not) managed by value investor CEOs. Finally, the paper’s findings can also help investors in another way. For example, investors tend to be skeptical about companies with high goodwill/assets. The rule of thumb is to beware of companies carrying goodwill on their balance sheets that is more than 25% of assets. Based on our findings, this should not be a problem as long as the company’s operating margin has remained high and is rising.
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Although the pencilfish is a globally popular economic fish in the aquarium market, its taxonomic classification could be further refined. In order to understand the taxonomy of species of the genus Nannostomus (Characiformes, Lebiasinidae) and their phylogenetic position within the order Characiformes, in
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Although the pencilfish is a globally popular economic fish in the aquarium market, its taxonomic classification could be further refined. In order to understand the taxonomy of species of the genus Nannostomus (Characiformes, Lebiasinidae) and their phylogenetic position within the order Characiformes, in this study, we characterized mitochondrial genomes (mitogenomes) from four Nannostomus species for the first time. The four mitogenomes exhibited the typical circular structure, with overall sizes varying from 16,661 bp to 16,690 bp. They contained 13 protein-coding genes (PCGs), 2 ribosomal RNA genes (rRNAs), 22 transfer RNA genes (tRNAs), and 1 control region (CR). Nucleotide composition analysis suggested that the mitochondrial sequences were biased toward A and T. Bayesian inference and maximum likelihood analyses based on PCGs support the family Lebiasinidae classification, described using four Nannostomus species, clustering together with Lebiasina multimaculata from the same family. The results of this study support the current taxonomic classification of the family Lebiasinidae. Phylogenetic analysis also suggested that gene rearrangement would not significantly impact the phylogenetic relationships within the order Characiformes. These results might provide new data regarding the phylogeny and classification of the order Characiformes, thus providing a theoretical basis for the economic development of aquarium fish markets.
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The use of benzodiazepines is strongly associated with an increased risk of traffic accidents due to their side effects of sedation and drowsiness, which can significantly impair driving performance. The main aim of our study was to investigate the trend of benzodiazepine use
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The use of benzodiazepines is strongly associated with an increased risk of traffic accidents due to their side effects of sedation and drowsiness, which can significantly impair driving performance. The main aim of our study was to investigate the trend of benzodiazepine use over nine years (2015–2023) in a population of 15,988 subjects who had their license suspended for driving under the influence (DUI) of alcohol or drugs. Among the 15,988 users accessed to our laboratory, 924 tested positive for at least one benzodiazepine. An increase in the number of positive-testing users was observed in the period 2015–2018, followed by a slight decrease in 2019. Overall, the trend of benzodiazepine use was stable over the next four years (2020–2023), with the highest incidence in 2022. The most common benzodiazepines, and/or metabolites, found in urine samples were α-OH-alprazolam (28.66%; n = 366) and oxazepam (27.25%; n = 348). Several cases of mixed positivity were observed in the study population. The main substances taken with benzodiazepines were cocaine and Δ9-tetrahydrocannabinol. Our findings suggest that people taking benzodiazepines should be monitored, as these have a relevant impact on driving ability in addition to significant interindividual differences in the behavioral effects of benzodiazepines on driving performance.
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In this study, we systematically explore the impact of C/Si ratio, pre-carbonization time, H2 etching time, and growth pressure on the buffer layer and subsequent epitaxial layer of 6-inch 4H-SiC wafers. Our findings indicate that the buffer layer’s C/Si ratio and growth
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In this study, we systematically explore the impact of C/Si ratio, pre-carbonization time, H2 etching time, and growth pressure on the buffer layer and subsequent epitaxial layer of 6-inch 4H-SiC wafers. Our findings indicate that the buffer layer’s C/Si ratio and growth pressure significantly influence the overall quality of the epitaxial wafer. Specifically, an optimal C/Si ratio of 0.5 and a growth pressure of 70 Torr yield higher-quality epitaxial layers. Additionally, the pre-carbonization time and H2 etching time primarily affect the uniformity and surface quality of the epitaxial wafer, with a pre-carbonization time of 3 s and an H2 etching time of 3 min found to enhance the surface quality of the epitaxial layer.
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Léa Louise Volmer, Dominik Dannehl, Sabine Matovina, Florin-Andrei Taran, Christina Barbara Walter, Markus Wallwiener, Sara Yvonne Brucker, Andreas Daniel Hartkopf and Tobias Engler
Int. J. Mol. Sci.2024, 25(11), 5910; https://doi.org/10.3390/ijms25115910 (registering DOI) - 29 May 2024
Breast cancer remains a leading cause of cancer mortality in women globally. Despite advancements in systemic therapy, the risk of distant recurrence persists even after such treatment and may be linked to disseminated tumor cells (DTCs). Variability in molecular characteristics between primary tumors
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Breast cancer remains a leading cause of cancer mortality in women globally. Despite advancements in systemic therapy, the risk of distant recurrence persists even after such treatment and may be linked to disseminated tumor cells (DTCs). Variability in molecular characteristics between primary tumors (PTs) and distant metastases underscores the need to comprehensively understand metastatic pathways. This retrospective study investigated discrepancies between HER2 expression in PTs and DTCs and their implications for survival outcomes in 201 early breast cancer (EBC) patients. We found a significant association between HER2 expression in PTs and DTCs when classifying tumors as HER2-high/low/negative. Patients whose HER2 status was discordant between PTs and DTCs exhibited worse distant disease-free survival than those with concordant status. Multivariate analysis confirmed the HER2 status of DTCs as an independent prognostic factor for distant DFS. These findings emphasize the importance of assessing HER2 expression in DTCs and its potential implications for tailored therapy strategies in EBC. Furthermore, prospective trials are needed to validate these findings and explore targeted therapies based on the molecular characteristics of DTCs.
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In this study, we aimed to determine the related role of anxiety and parental resilience on the aggressive tendencies of preschool children during the COVID-19 pandemic. The study sample comprised a total of 293 parents with children aged 4–6 years. Relationships between Preschool
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In this study, we aimed to determine the related role of anxiety and parental resilience on the aggressive tendencies of preschool children during the COVID-19 pandemic. The study sample comprised a total of 293 parents with children aged 4–6 years. Relationships between Preschool Anxiety Scale, Aggression Orientation Scale, and Brief Resilience Scale total and subscale scores were evaluated using Pearson and Spearman correlation analysis. The results of this study show that there is a positive relationship between children’s aggression tendencies and anxiety levels. We observed weak to moderate correlations between parents’ resilience scores and the children’s aggression and anxiety scores. Although linear regression analysis indicated no significant effect of parental resilience on children’s aggressive tendencies, anxiety levels may be related. In addition, study results showed that the physical aggression tendencies of children differed according to their age and the number of children in the family, albeit at a low level. Further studies are needed to identify factors associated with aggression in preschool children.
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Influenza A viruses (IAVs) pose a significant global threat to human health. A tightly controlled host immune response is critical to avoid any detrimental effects of IAV infection. It is critical to investigate the association between the response of Toll-like receptors (TLRs) and
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Influenza A viruses (IAVs) pose a significant global threat to human health. A tightly controlled host immune response is critical to avoid any detrimental effects of IAV infection. It is critical to investigate the association between the response of Toll-like receptors (TLRs) and influenza virus. Because TLRs may act as a double-edged sword, a balanced TLR response is critical for the overall benefit of the host. Consequently, a thorough understanding of the TLR response is essential for targeting TLRs as a novel therapeutic and prophylactic intervention. To date, a limited number of studies have assessed TLR and IAV interactions. Therefore, further research on TLR interactions in IAV infection should be conducted to determine their role in host–virus interactions in disease causation or clearance of the virus. Although influenza virus vaccines are available, they have limited efficacy, which should be enhanced to improve their efficacy. In this study, we discuss the current status of our understanding of the TLR response in IAV infection and the strategies adopted by IAVs to avoid TLR-mediated immune surveillance, which may help in devising new therapeutic or preventive strategies. Furthermore, recent advances in the use of TLR agonists as vaccine adjuvants to enhance influenza vaccine efficacy are discussed.
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Jacksaint Saintila, Sandra P. Carranza-Cubas, Antonio Serpa-Barrientos, Renzo Felipe Carranza Esteban, Denis Frank Cunza-Aranzábal and Yaquelin E. Calizaya-Milla
Nutrients2024, 16(11), 1663; https://doi.org/10.3390/nu16111663 (registering DOI) - 29 May 2024
Background: Vegetarianism is commonly associated with various health benefits. However, the association between this dietary regimen and aspects of mental health remains ambiguous. This study compared the symptoms of depression and anxiety, emotional eating (EmE), and body mass index (BMI) in Peruvian
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Background: Vegetarianism is commonly associated with various health benefits. However, the association between this dietary regimen and aspects of mental health remains ambiguous. This study compared the symptoms of depression and anxiety, emotional eating (EmE), and body mass index (BMI) in Peruvian vegetarian and non-vegetarian adults. Methods: A cross-sectional study was conducted on 768 Peruvian adults, of whom 284 (37%) were vegetarians and 484 (63%) were non-vegetarians. The Depression Patient Health Questionnaire-2 (PHQ-2), Generalized Anxiety Disorder Scale-2 (GAD-2), and an EmE questionnaire were applied; additionally, the BMI was calculated. Simple and multiple linear regression and Poisson regression models with robust variance were used to evaluate the association between depression, anxiety, EmE, and BMI with dietary patterns. Results: The vegetarians (Adjusted Prevalence Ratio [PR] = 0.24, 95% CI 0.16–0.31; p < 0.001) reported more depressive symptoms than the non-vegetarians. This trend persisted for anxiety, with an adjusted PR of 0.17 (95% CI: 0.01–0.29; p = 0.012). However, the vegetarians (adjusted PR = −0.38, 95% CI: −0.61–−0.14; p < 0.001) reported lower EmE scores compared to the non-vegetarians. Likewise, the vegetarians had a lower mean BMI than the non-vegetarians (B = −0.16, 95% CI: −0.21–−0.08; p < 0.001). Conclusions: Vegetarian diets are associated with increased symptoms of depression and anxiety, as well as lower EmE and BMI scores. Further longitudinal studies are needed to elucidate these associations and determine causality and the underlying mechanisms involved.
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The early Triassic (~250 Ma) hornblende gabbro from the Tengxian area of Yunkai Massif, South China, contains a mineral assemblage of clinopyroxene, hornblende, biotite, plagioclase, K-feldspar and quartz and accessory apatite, and zircon and ilmenite. Based on mineral association and crystallization sequence, two
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The early Triassic (~250 Ma) hornblende gabbro from the Tengxian area of Yunkai Massif, South China, contains a mineral assemblage of clinopyroxene, hornblende, biotite, plagioclase, K-feldspar and quartz and accessory apatite, and zircon and ilmenite. Based on mineral association and crystallization sequence, two generations of the mineral assemblage have been identified: clinopyroxene + plagioclase + apatite (zircon) in Generation I and ilmenite + hornblende + biotite + K-feldspar + quartz in Generation II. The high crystallization temperature (T = 999–1069 °C) of clinopyroxene and its coexistence with labradorite (An = 52–58) indicate that Generation I crystallized in a basaltic magma, while the hornblende’s relatively low crystallization temperature (T = 780–820 °C) and coexistence with K-feldspar and quartz suggest that Generation II formed in an evolved alkaline melt. The mineralogical records are likely attributed to pulsed intrusion of the late-stage evolved magma into a crystal mush, like in Generation I. The bulk-rock geochemical data include a sub-alkaline affinity, arc-type trace element features, and highly enriched Sr-Nd-Pb-Hf isotopic compositions, consistent with the isotopic records from the accessory minerals, e.g., the very high δ18O values in both zircon and apatite and significantly negative εHf(t) in zircon. The combined mineral and bulk-rock geochemical data suggest that the primary magma for the Tengxian hornblende gabbro was derived from a mantle wedge that had been metasomatized by voluminous subducted terrigenous sediment-derived melts in response to subduction of the Paleo-Tethys Ocean.
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“Rejoice, Texandria, for Oda!” Thus begins the series of chants and readings commemorating the virgin St Oda, patron of the village that took her name—Sint-Oedenrode—in the late medieval liturgy of the town of ’s-Hertogenbosch. Overt praise for the surrounding region, Texandria, extending across
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“Rejoice, Texandria, for Oda!” Thus begins the series of chants and readings commemorating the virgin St Oda, patron of the village that took her name—Sint-Oedenrode—in the late medieval liturgy of the town of ’s-Hertogenbosch. Overt praise for the surrounding region, Texandria, extending across the northern limits of the duchy of Brabant and diocese of Liège, is a recurring theme in the liturgy inspired by the saint’s legend. Yet how did Oda, of Scottish origin, become so closely associated with this remote region? And what was the significance of her liturgical veneration in ’s-Hertogenbosch, to which Sint-Oedenrode was enfranchised? Exemplifying interactions between central and secondary places within a specific region, this study argues for the relevance of the historical approach to urban–rural dynamics in medieval hagiography and its related liturgy. Recognition that smaller towns and villages played important roles in regional networks prompts more focused attention to regional priorities in the legends and liturgies of local saints. That Oda’s cult is attested by a diversity of extant documentary evidence—historical, hagiographic, and liturgical, including newly discovered liturgical readings—facilitates interpretation of her veneration in ’s-Hertogenbosch and of the intertextual connections between her legend and those of other saints, notably Lambert, associated with the duchy and diocese. As suggested by this example, regionalism merits greater scrutiny as an integral component of civic religion.
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Ildikó Császár, Tibor Kalmár, Zoltán Maróti, János Ávéd, Edit Szederkényi, János Zombori, Gabriella Pankotai-Bodó, Sándor Turkevi-Nagy and Béla Iványi
Int. J. Mol. Sci.2024, 25(11), 5907; https://doi.org/10.3390/ijms25115907 (registering DOI) - 29 May 2024
Pathogenic variants in the FAN1 gene lead to a systemic disease with karyomegalic interstitial nephritis (KIN) at the forefront clinically. The phenotypic–genotypic features of a FAN1 mutation-related disease involving five members of a Hungarian Caucasian family are presented. Each had adult-onset chronic kidney
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Pathogenic variants in the FAN1 gene lead to a systemic disease with karyomegalic interstitial nephritis (KIN) at the forefront clinically. The phenotypic–genotypic features of a FAN1 mutation-related disease involving five members of a Hungarian Caucasian family are presented. Each had adult-onset chronic kidney disease of unknown cause treated with renal replacement therapy and elevated liver enzymes. Short stature, emaciation, latte-colored skin, freckles, and a hawk-like nose in four patients, a limited intellect in two patients, and chronic restrictive lung disease in one patient completed the phenotype. Severe infections occurred in four patients. All five patients had ceased. Four patients underwent autopsy. KIN and extrarenal karyomegaly were observed histologically; the livers showed no specific abnormality. The genotyping using formalin-fixed tissue samples detected a hitherto undescribed homozygous FAN1 mutation (c.1673_1674insT/p.Met558lfs*4; exon 5) in three of these patients and a heterozygous FAN1 mutation in one patient. The reason for the heterozygosity is discussed. In addition, 56 family members consented to the screening for FAN1 mutation from which 17 individuals proved to be heterozygous carriers; a blood chemistry evaluation of their kidney and liver function did not find any abnormality. The clinical presentation of FAN1-related disease was multifaceted, and not yet described manifestations were observed besides kidney and liver disease. Mutation in this gene should be suspected in adults with small kidneys of unknown cause, elevated liver enzymes, and recurrent infections, even without a family history.
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Fermented prebiotic and probiotic products with kefir are very important to slow down and prevent the growth of tumors and to treat cancer by stimulating the immune response against tumor cells. Cyclophosphamide (CPx) is widely preferred in cancer treatment but its effectiveness in
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Fermented prebiotic and probiotic products with kefir are very important to slow down and prevent the growth of tumors and to treat cancer by stimulating the immune response against tumor cells. Cyclophosphamide (CPx) is widely preferred in cancer treatment but its effectiveness in high doses is restricted because of its side effects. The aim of this study was to investigate the protective effects of kefir against CPx-induced heart and liver toxicity. In an experiment, 42 Wistar albino rats were divided into six treatment groups: the control (Group 1), the group receiving 150 mg/kg CPx (Group 2), the groups receiving 5 and 10 mg/kg kefir (Groups 3 and 4) and the groups receiving 5 and 10 mg/kg kefir + CPx (Group 5 and 6). Fermented kefirs obtained on different days by traditional methods were mixed and given by gavage for 12 days, while a single dose of CPx was administered intraperitoneally (i.p.) on the 12th day of the experiment. It was observed that alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatinine kinase-MB (CK-MB), ischemia modified albumin (IMA) and Troponin I values, which indicate oxidative stress, increased in the CPx-administered group, and this level approached that of the control in the CPx + kefir groups. Likewise, as a result of the kefir, the rats’ CPx-induced histopathological symptoms were reduced, and their heart and liver tissue were significantly improved. In conclusion, it was observed that kefir had a cytoprotective effect against CPx-induced oxidative stress, hepatotoxicity and cardiotoxicity, bringing their biochemical parameters closer to those of the control by suppressing oxidative stress and reducing tissue damage.
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As a project construction organization model, whole-process engineering consulting (WPEC) is currently being promoted in China’s engineering consulting industry. However, various factors create numerous obstacles that hinder this model’s effective promotion and application. One essential task is to deeply analyze the transmission mechanism
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As a project construction organization model, whole-process engineering consulting (WPEC) is currently being promoted in China’s engineering consulting industry. However, various factors create numerous obstacles that hinder this model’s effective promotion and application. One essential task is to deeply analyze the transmission mechanism of the influencing factors in the promotion and application of WPEC, and explore effective pathways for promoting and applying this model. This paper systematically organizes and summarizes 10 primary influencing factors and 38 secondary influencing factors for promoting WPEC. Using the complex network analysis method, a network of influencing factors for promoting WPEC, a network structure, and motif analyses are conducted. The results show that the influencing factors have a complex transmission mechanism, and complex network analysis can reveal the laws of their construction and their causes. This paper provides a systematic basis and theoretical support for the effective formulation of policies related to the promotion and application of WPEC.
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Clarice Mariano Fernandes, Greyce Luci Bernardo, Ana Carolina Fernandes, Ana Paula Gines Geraldo, Daniela Barbieri Hauschild, Débora Kurrle Rieger Venske, Fharlley Lohann Medeiros, Rossana Pacheco da Costa Proença and Paula Lazzarin Uggioni
Objective: To investigate the impact of the Nutrition and Culinary in the Kitchen (NCK) Program on the cooking skills of Brazilian individuals with type 2 diabetes mellitus (T2DM). Methods: A randomized controlled intervention study was performed, with intervention and control groups. The intervention
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Objective: To investigate the impact of the Nutrition and Culinary in the Kitchen (NCK) Program on the cooking skills of Brazilian individuals with type 2 diabetes mellitus (T2DM). Methods: A randomized controlled intervention study was performed, with intervention and control groups. The intervention group participated in weekly sessions of the NCK Program for six weeks (including two in-person practical cooking and three online cooking workshops). The cooking recipes were adapted by replacing high glycemic index ingredients with low and medium glycemic index alternatives. Of note, the recipes did not contain added sugars or sweeteners, were based on the use of fresh or minimally processed foods, herbs, and spices, and were sensorially tested by individuals with T2DM before use in the intervention. The study outcomes were participant score changes on the seven scales. A validated online instrument was administered to the control and intervention groups at baseline (T1) and post-intervention (T2). Parametric and non-parametric tests were used to assess the differences between the T1 and T2 parameters. Results: Of the 60 individuals enrolled, 44 answered the questionnaire at both times. The findings revealed a 45.37% ± 93.57% increase in Knowledge of Cooking Terms in the intervention group, whereas the control group showed a 3.82% ± 16.17% reduction (p = 0.008). There was an increase in all the other cooking skills and healthy eating scales from T1 to T2 in the intervention group, but the differences were not significant. Conclusions: The development of cooking skills can contribute to increasing culinary knowledge and the availability of time to cook at home. The results contribute to the planning of health actions aimed at individuals with DM2 through culinary interventions and public food and nutrition policies.
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Battlefield surveillance radar is usually 2-D radar, which cannot realize target three-dimensional localization, leading to poor resolution for the air target in the elevation dimension. Previous researchers have used the Traditional Height Finder Radar (HFR) or multiple 2-D radar networking to estimate the
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Battlefield surveillance radar is usually 2-D radar, which cannot realize target three-dimensional localization, leading to poor resolution for the air target in the elevation dimension. Previous researchers have used the Traditional Height Finder Radar (HFR) or multiple 2-D radar networking to estimate the target three-dimensional location. However, all of them face the problems of high cost, poor real-time performance and high requirement of space–time registration. In this paper, Reconfigurable Intelligent Surfaces (RISs) with low cost are introduced into the 2-D radar to realize the target three-dimensional localization. Taking advantage of the wide beam of 2-D radar in the elevation dimension, several Unmanned Aerial Vehicles (UAVs) carrying RISs are set in the receiving beam to form multiple auxiliary measurement channels. In addition, the traditional 2-D radar measurements combined with the auxiliary channel measurements are used to realize the target three-dimensional localization by solving a nonlinear least square problem with a convex optimization method. For the proposed RIS-assisted target three-dimensional localization problem, the Cramer–Rao Lower Bound (CRLB) is derived to measure the target localization accuracy. Simulation results verify the effectiveness of the proposed 3-D localization method, and the influences of the number, the positions and the site errors of the RISs on the localization accuracy are covered.
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In this paper, we present the exploration of indoor positioning technologies for UAVs, as well as navigation techniques for path planning and obstacle avoidance. The objective was to perform warehouse inventory tasks, using a drone to search for barcodes or markers to identify
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In this paper, we present the exploration of indoor positioning technologies for UAVs, as well as navigation techniques for path planning and obstacle avoidance. The objective was to perform warehouse inventory tasks, using a drone to search for barcodes or markers to identify objects. For the indoor positioning techniques, we employed visual-inertial odometry (VIO), ultra-wideband (UWB), AprilTag fiducial markers, and simultaneous localization and mapping (SLAM). These algorithms included global positioning, local positioning, and pre-mapping positioning, comparing the merits and drawbacks of various techniques and trajectories. For UAV navigation, we combined the SLAM-based RTAB-map indoor mapping and navigation path planning of the ROS for indoor environments. This system enabled precise drone positioning indoors and utilized global and local path planners to generate flight paths that avoided dynamic, static, unknown, and known obstacles, demonstrating high practicality and feasibility. To achieve warehouse inventory inspection, a reinforcement learning approach was proposed, recognizing markers by adjusting the UAV’s viewpoint. We addressed several of the main problems in inventory management, including efficiently planning of paths, while ensuring a certain detection rate. Two reinforcement learning techniques, AC (actor–critic) and PPO (proximal policy optimization), were implemented based on AprilTag identification. Testing was performed in both simulated and real-world environments, and the effectiveness of the proposed method was validated.
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Agricultural insects play a crucial role in transmitting plant viruses and host a considerable number of insect-specific viruses (ISVs). Among these insects, the white-backed planthoppers (WBPH; Sogatella furcifera, Hemiptera: Delphacidae) are noteworthy rice pests and are responsible for disseminating the southern rice
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Agricultural insects play a crucial role in transmitting plant viruses and host a considerable number of insect-specific viruses (ISVs). Among these insects, the white-backed planthoppers (WBPH; Sogatella furcifera, Hemiptera: Delphacidae) are noteworthy rice pests and are responsible for disseminating the southern rice black-streaked dwarf virus (SRBSDV), a significant rice virus. In this study, we analyzed WBPH transcriptome data from public sources and identified three novel viruses. These newly discovered viruses belong to the plant-associated viral family Solemoviridae and were tentatively named Sogatella furcifera solemo-like virus 1-3 (SFSolV1-3). Among them, SFSolV1 exhibited a prevalent existence in different laboratory populations, and its complete genome sequence was obtained using rapid amplification of cDNA ends (RACE) approaches. To investigate the antiviral RNA interference (RNAi) response in WBPH, we conducted an analysis of virus-derived small interfering RNAs (vsiRNAs). The vsiRNAs of SFSolV1 and -2 exhibited typical patterns associated with the host’s siRNA-mediated antiviral immunity, with a preference for 21- and 22-nt vsiRNAs derived equally from both the sense and antisense genomic strands. Furthermore, we examined SFSolV1 infection and distribution in WBPH, revealing a significantly higher viral load of SFSolV1 in nymphs’ hemolymph compared to other tissues. Additionally, in adult insects, SFSolV1 exhibited higher abundance in male adults than in female adults.
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Sebastian Rask Hamm, Josefine Amalie Loft, Laura Pérez-Alós, Line Dam Heftdal, Cecilie Bo Hansen, Dina Leth Møller, Mia Marie Pries-Heje, Rasmus Bo Hasselbalch, Kamille Fogh, Annemette Hald, Sisse Rye Ostrowski, Ruth Frikke-Schmidt, Erik Sørensen, Linda Hilsted, Henning Bundgaard, Peter Garred, Kasper Iversen, Michael Perch, Søren Schwartz Sørensen, Allan Rasmussen, Caroline A. Sabin and Susanne Dam Nielsenadd
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As solid organ transplant (SOT) recipients remain at risk of severe outcomes after SARS-CoV-2 infections, vaccination continues to be an important preventive measure. In SOT recipients previously vaccinated with at least three doses of BNT162b2, we investigated humoral responses to BNT162b2 booster doses.
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As solid organ transplant (SOT) recipients remain at risk of severe outcomes after SARS-CoV-2 infections, vaccination continues to be an important preventive measure. In SOT recipients previously vaccinated with at least three doses of BNT162b2, we investigated humoral responses to BNT162b2 booster doses. Anti-SARS-CoV-2 receptor binding domain (RBD) immunoglobulin G (IgG) was measured using an in-house ELISA. Linear mixed models were fitted to investigate the change in the geometric mean concentration (GMC) of anti-SARS-CoV-2 RBD IgG after vaccination in participants with intervals of more or less than six months between the last two doses of vaccine. We included 107 SOT recipients vaccinated with a BNT162b2 vaccine. In participants with an interval of more than six months between the last two vaccine doses, we found a 1.34-fold change in GMC per month (95% CI 1.25–1.44), while we found a 1.09-fold change in GMC per month (95% CI 0.89–1.34) in participants with an interval of less than six months between the last two vaccine doses, resulting in a rate ratio of 0.82 (95% CI 0.66 to 1.01, p = 0.063). In conclusion, the administration of identical COVID-19 mRNA vaccine boosters within six months to SOT recipients may result in limited humoral immunogenicity of the last dose.
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This study evaluates a hybrid heating system in a single-family building in northeastern Poland, which has a temperate continental climate. The analysis covers two heating seasons in 2021/2022 and 2022/2023. The hybrid heating system includes an air heat pump HPA–08 CS Plus with
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This study evaluates a hybrid heating system in a single-family building in northeastern Poland, which has a temperate continental climate. The analysis covers two heating seasons in 2021/2022 and 2022/2023. The hybrid heating system includes an air heat pump HPA–08 CS Plus with a heating power of 8.2 kW (AHP), a condensing gas boiler VC146/5–5 with a power of 14 kW (GB–Condens.), and a solid fuel boiler with a power of 11 kW for central heating. Additionally, hot water is heated by a Basic 270 (DHW’s AHP) air–water heat pump with a power of 2 kW, utilizing a tank with a capacity of 270 dm3 equipped with two heating coils. The building’s average electricity consumption is around 5400 kWh/year. A 4.96 kWp photovoltaic installation is installed on the building’s roof at a 40° angle towards the south to supplement the hybrid system. The study aims to assess whether the PV installation can adequately cover the energy needs of the hybrid heat source for heating and hot water. Furthermore, the study calculates the emission of pollutants (CO2, SOx, NOx, CO, and PM10) into the atmosphere. The total annual electricity production from PV installations was 5444.9 kWh in 2021/2022 and 5684.8 kWh in 2022/2023. The excess electricity was stored in the PGE power grid as per the Prosumer settlement rules. The installed PV installation is sufficient to power the following devices annually: AHP, DHW’s AHP, and GB–Condens. However, the daily electricity production from the PV installation is not enough to cover the energy needs of the heat pump for heating during the cold months in Poland (I–III, XI–XII). It can meet the power needs of a PC all year round and can also be stored during the summer months, for example, in energy warehouses or by directly storing it in the PGE power grid. The use of the PV installation resulted in an average reduction in pollutant emissions into the atmosphere: CO2—94.1%, SOx—91.8%, NOx—95.6%, CO—9.7%, and PM10—32.1%.
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In this note, we study skew cyclic and skew constacyclic codes over the mixed alphabet , where p is an odd prime with m odd and
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In this note, we study skew cyclic and skew constacyclic codes over the mixed alphabet , where p is an odd prime with m odd and with , and with Such codes consist of the juxtaposition of three codes of the same size over and , respectively. We investigate the generator polynomial for skew cyclic codes over . Furthermore, we discuss the structural properties of the skew cyclic and skew constacyclic codes over We also study their q-ary images under suitable Gray maps.
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Meat characterized by a high marbling value is typically anticipated to display enhanced sensory attributes. This study aimed to predict the marbling scores of rib-eye, steaks sourced from the Longissimus dorsi muscle of different cattle types, namely Boran, Senga, and Sheko, by employing
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Meat characterized by a high marbling value is typically anticipated to display enhanced sensory attributes. This study aimed to predict the marbling scores of rib-eye, steaks sourced from the Longissimus dorsi muscle of different cattle types, namely Boran, Senga, and Sheko, by employing digital image processing and machine-learning algorithms. Marbling was analyzed using digital image processing coupled with an extreme gradient boosting (GBoost) machine learning algorithm. Meat texture was assessed using a universal texture analyzer. Sensory characteristics of beef were evaluated through quantitative descriptive analysis with a trained panel of twenty. Using selected image features from digital image processing, the marbling score was predicted with R2 (prediction) = 0.83. Boran cattle had the highest fat content in sirloin and chuck cuts (12.68% and 12.40%, respectively), followed by Senga (11.59% and 11.56%) and Sheko (11.40% and 11.17%). Tenderness scores for sirloin and chuck cuts differed among the three breeds: Boran (7.06 ± 2.75 and 3.81 ± 2.24, respectively), Senga (5.54 ± 1.90 and 5.25 ± 2.47), and Sheko (5.43 ± 2.76 and 6.33 ± 2.28 Nmm). Sheko and Senga had similar sensory attributes. Marbling scores were higher in Boran (4.28 ± 1.43 and 3.68 ± 1.21) and Senga (2.88 ± 0.69 and 2.83 ± 0.98) compared to Sheko (2.73 ± 1.28 and 2.90 ± 1.52). The study achieved a remarkable milestone in developing a digital tool for predicting marbling scores of Ethiopian beef breeds. Furthermore, the relationship between quality attributes and beef marbling score has been verified. After further validation, the output of this research can be utilized in the meat industry and quality control authorities.
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Evaluating the vulnerability of urban transportation systems to flood disasters can provide scientific support for urban disaster prevention and mitigation. Current methods for assessing the flood vulnerability of urban roads often overlook the internal relationships within the complex spatial composition of road networks
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Evaluating the vulnerability of urban transportation systems to flood disasters can provide scientific support for urban disaster prevention and mitigation. Current methods for assessing the flood vulnerability of urban roads often overlook the internal relationships within the complex spatial composition of road networks and surface structures. In this study, based on the theory of complex networks, a dual-layer network assessment model is established for evaluating the flood vulnerability of urban transportation systems by coupling basic geographic data with road network vector data. Unlike traditional methods, this model considers the complex relationship between road network structures and ground surfaces, uncovering a correlation between road network structure and road flood vulnerability. By utilizing this model, the flood vulnerability of road networks in Shenzhen, as well as the city’s spatial flood vulnerability, are quantitatively assessed. Based on the quantitative results, we create maps illustrating the distribution of road and spatial flood vulnerability in Shenzhen. The study results reflect that roads highly vulnerable to flooding are mainly located in the central urban area of the southwest, with the flood vulnerability spatially concentrated primarily in the northern and western regions. Using data from government reports, news stories, and other sources over the past five years, we compile recorded instances of urban waterlogging. The quantitative results of the model are consistent with the distribution trend in recorded waterlogging points, indicating that the model’s outcomes are authentic and reliable.
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In this study, we critically examine the potential of recycled construction materials, focusing on how these materials can significantly reduce greenhouse gas (GHG) emissions and energy usage in the construction sector. By adopting an integrated approach that combines Life Cycle Assessment (LCA) and
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In this study, we critically examine the potential of recycled construction materials, focusing on how these materials can significantly reduce greenhouse gas (GHG) emissions and energy usage in the construction sector. By adopting an integrated approach that combines Life Cycle Assessment (LCA) and Material Flow Analysis (MFA) within the circular economy framework, we thoroughly examine the lifecycle environmental performance of these materials. Our findings reveal a promising future where incorporating recycled materials in construction can significantly lower GHG emissions and conserve energy. This underscores their crucial role in advancing sustainable construction practices. Moreover, our study emphasizes the need for robust regulatory frameworks and technological innovations to enhance the adoption of environmentally responsible practices. We encourage policymakers, industry stakeholders, and the academic community to collaborate and promote the adoption of a circular economy strategy in the building sector. Our research contributes to the ongoing discussion on sustainable construction, offering evidence-based insights that can inform future policies and initiatives to improve environmental stewardship in the construction industry. This study aligns with the European Union’s objectives of achieving climate-neutral cities by 2030 and the United Nations’ Sustainable Development Goals outlined for completion by 2030. Overall, this paper contributes to the ongoing dialogue on sustainable construction, providing a fact-driven basis for future policy and initiatives to enhance environmental stewardship in the industry.
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