The purpose of this study is to explore the sustainability of island tourism by investigating the increasingly dangerous climate conditions that tourists encounter under climate change. The exploratory case of Hawaii, United States is offered to explore how thermal stress risks have (1) changed as a process of climate change and (2) are associated with airport arrivals of domestic tourists from states other than Hawaii (dependent variable). Hawaii is a destination-based island in the lower-latitudes of the Pacific Ocean that attracts more tourists than many stand-alone countries. Thermal stress—our independent variable—is a climate measure for heat exposure and has medically prescribed levels (°C) for heat-related risks to recreationalists and workers. The findings indicate that (1) thermal stress is increasing as a process of climate change over the past four decades (1984–2023), (2) moderate thermal stress risks are positively related to tourists’ demand (2015–2023), and (3) moderate thermal stress risks are more strongly related to tourists’ demand than lower risk levels. The results suggest that despite increased thermal stress, the demand for tourists’ arrivals remains sustainable for Hawaii. Though not significant, we also observed a decline in tourists’ arrivals with moderately high thermal stress risks. Implications are broken down for each of the sustainable tourism stakeholders: visitors, communities, industry, and the natural environment. Full article

Land-use change (LUC) is a significant contributor to the increase in atmospheric CO₂ concentrations, with previous studies demonstrating its profound impact on soil organic carbon (SOC). The conversion of primary forests to farmland has been recognized as the most significant type of LUC inducing CO₂ release from the soil. Therefore, it is critical to understand the impacts of forest LUC on SOC storage, with a particular focus on primary forest to farmland conversion. In this study, we conducted a meta-analysis of 411 observations from 41 published works and found that SOC storage decreased significantly following the conversion of primary forests to farmland. Factors such as soil depth and climate zone influenced the degree of SOC storage loss, with SOC loss being less severe in deeper soil following a conversion from primary forests to farmland. Moreover, the loss of SOC storage was more severe in temperate regions compared to tropical regions. The input and output of surface SOC, changes in soil structure, and increases in atmospheric CO₂ concentrations were significant reasons for the loss of SOC following primary forest to farmland LUC. However, improving tillage methods and implementing sustainable agricultural management strategies can help reduce SOC loss. These findings highlight the importance of sustainable land-use practices in mitigating the negative impacts of forest LUC on SOC storage and the global carbon cycle. Full article

As the fields of engineering, energy, and geology become increasingly complex, decision makers face escalating challenges that require skilled solutions to meet practical production needs. Evolutionary algorithms, inspired by biological evolution, have emerged as powerful methods for tackling intricate optimization problems without relying on gradient data. Among these, the tree-seed algorithm (TSA) distinguishes itself due to its unique mechanism and efficient searching capabilities. However, an imbalance between its exploitation and exploration phases can lead it to be stuck in local optima, impeding the discovery of globally optimal solutions. This study introduces an improved TSA that incorporates water-cycling and quantum rotation-gate mechanisms. These enhancements assist the algorithm in escaping local peaks and achieving a more harmonious balance between its exploitation and exploration phases. Comparative experimental evaluations, using the CEC 2017 benchmarks and a well-known metaheuristic algorithm, demonstrate the upgraded algorithm’s faster convergence rate and enhanced ability to locate global optima. Additionally, its application in optimizing reservoir production models underscores its superior performance compared to competing methods, further validating its real-world optimization capabilities. Full article

The production of fricatives involves the complex interaction of articulatory constraints resulting from the formation of the appropriate oral constriction, the control of airflow through the constriction so as to achieve frication and, in the case of voiced fricatives, the maintenance of glottal oscillation by attending to transglottal pressure. To better understand this mechanism in a relatively understudied language, we explore the articulatory characteristics of five pairs of plain and palatalized Romanian fricatives produced by 10 native speakers using ultrasound imaging. Our analysis includes an assessment of the robustness of the plain-palatalized contrast at different places of articulation, a comparison of secondary palatalization with other relevant word-final [Ci] structures, and the identification of individual variation patterns. Since our study is the first to document the articulatory properties of secondary palatalization in Romanian, our findings are of descriptive interest. Full article

Pancreatic stone protein (PSP) is an acute-phase reactant mainly produced in response to stress. Its diagnostic and prognostic accuracy for several types of infection has been studied in several clinical settings. The aim of the current review was to assess all studies examining a possible connection of pancreatic stone protein levels with the severity and possible complications of patients diagnosed with infection. We performed a systematic search in PubMed, Scopus, the Cochrane Library and Clinicaltrials.gov to identify original clinical studies assessing the role of pancreatic stone protein in the diagnosis and prognosis of infectious diseases. We identified 22 eligible studies. Ten of them provided diagnostic aspects, ten studies provided prognostic aspects, and another two studies provided both diagnostic and prognostic information. The majority of the studies were performed in an intensive care unit (ICU) setting, five studies were on patients who visited the emergency department (ED), and three studies were on burn-injury patients. According to the literature, pancreatic stone protein has been utilized in patients with different sites of infection, including pneumonia, soft tissue infections, intra-abdominal infections, urinary tract infections, and sepsis. In conclusion, PSP appears to be a useful point-of-care biomarker for the ED and ICU due to its ability to recognize bacterial infections and sepsis early. Further studies are required to examine PSP’s kinetics and utility in specific populations and conditions. Full article

Thiourea and its derivatives have become a significant focal point within the organic synthesis field, garnering attention for their diverse biological applications, including antibacterial, antioxidant, anticancer, anti-inflammatory, anti-Alzheimer, antituberculosis and antimalarial properties. My objective is to present a comprehensive and easily understandable analysis of recent advancements in the organic synthesis of thiourea derivatives. My focus is on the structure and activity of these derivatives over the past five years, highlighting the significant progress made in the field of organic synthesis. Additionally, I evaluate the current state of research in this area and provide an overview of the latest trends and future prospects. This review will prove to be beneficial for researchers, academics and industry professionals involved in drug development and organic synthesis. Full article

There is a myriad of diseases that plague the world ranging from infectious, cancer and other chronic diseases with varying interventions. However, the dynamism of causative agents of infectious diseases and incessant mutations accompanying other forms of chronic diseases like cancer, have worsened the treatment outcomes. These factors often lead to treatment failure via different drug resistance mechanisms. More so, the cost of developing newer drugs is huge. This underscores the need for a paradigm shift in the drug delivery approach in order to achieve desired treatment outcomes. There is intensified research in nanomedicine, which has shown promises in improving the therapeutic outcome of drugs at preclinical stages with increased efficacy and reduced toxicity. Regardless of the huge benefits of nanotechnology in drug delivery, challenges such as regulatory approval, scalability, cost implication and potential toxicity must be addressed via streamlining of regulatory hurdles and increased research funding. In conclusion, the idea of nanotechnology in drug delivery holds immense promise for optimizing therapeutic outcomes. This work presents opportunities to revolutionize treatment strategies, providing expert opinions on translating the huge amount of research in nanomedicine into clinical benefits for patients with resistant infections and cancer. Full article

Chronic obstructive pulmonary disease (COPD) is a heterogeneous lung condition characterized by persistent respiratory symptoms and airflow limitation. While there are some available treatment options, the effectiveness of treatment varies depending on individual differences and the phenotypes of the disease. Therefore, exploring or identifying potential therapeutic targets for COPD is urgently needed. In recent years, there has been growing evidence showing that lysophospholipids, namely lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), can play a significant role in the pathogenesis of COPD. Exploring the metabolism of lysophospholipids holds promise for understanding the underlying mechanism of COPD development and developing novel strategies for COPD treatment. This review primarily concentrates on the involvement and signaling pathways of LPC and LPA in the development and progression of COPD. Furthermore, we reviewed their associations with clinical manifestations, phenotypes, and prognosis within the COPD context and discussed the potential of the pivotal signaling molecules as viable therapeutic targets for COPD treatment. Full article

Human activities and climate change have profound impacts on the ecological environment of oases in Xinjiang, and it is of great significance to explore the spatial and temporal evolution patterns of ecological environment quality in this region for the sustainable development of Xinjiang. The remote sensing ecological index (RSEI) was extracted from the Google Earth Engine (GEE) platform from 2000 to 2020, and the coefficient of variation and Hurst index were used to reveal the spatial and temporal characteristics and stability of the ecological environment quality of the artificial oasis and natural oasis in Xinjiang. The key factors affecting the ecological environment quality are explored through correlation analysis and geoprobes. The results show that the distribution of the ecological environment in Xinjiang oases is high in the north and low in the south, and the overall quality shows a fluctuating downward trend from 0.210 to 0.189. Artificial oases have higher RSEI values, stability, and sustainability than natural oases. The RSEI in the study area was mainly influenced by humidity, followed by greenness and heat, and dryness had the least influence on the RSEI model. Based on the geodetector, the top three highest contributors were found to be precipitation (PRE) (0.83) > relative humidity (RHU) (0.82) > evapotranspiration (ET) (0.57). Climate is the main factor affecting the ecological quality of oases, and the RSEI can be improved by increasing the proportion of artificial oases. The study aims to provide a scientific basis for the sustainable development of oases in arid zones. Full article

Conservation Translocation (CT), which includes reintroduction, reinforcement and introduction, is gaining momentum, responding to serious population decline in many orchids. Orchid conservation underpinned by a greater emphasis on understanding biotic and abiotic factors of habitats is critical for successful recovery and restoration programmes. Anacamptis morio, commonly known as green-winged orchid (GWO), is a terrestrial orchid found throughout Europe, but populations in England rapidly declined in its native range in the last several decades. The current study explored the relationship between soil abiotic characteristics and the community composition of key fungal groups. Wild sites in Essex and Cumbria in England, where successful colonies are currently present, were compared to potential sites for CT in Cumbria. The Cumbrian sites managed by cattle grazing include the wild site and three potential CT sites, with two of them hosting no GWO plants. The Essex site, fOxley Meadow, where no cattle is used for grassland management, hosts the largest population of GWO in England. The aim of this study was to understand whether the community composition of fungi and soil characteristics of the potential CT sites in Cumbria are nearly compatible with that of Oxley Meadow. Oxley Meadow, with around 65,000 plants, stands out as a unique habitat compared to all Cumbria sites, as it showed low organic content. Nitrate and phosphate content were smaller for Oxley Meadow compared to other Cumbrian sites. The proportion of Basidiomycota fungi was greater in Oxley Meadow compared to all Cumbrian sites where Ascomycota dominated. The abundant fungal group found in Oxley Meadow was Agaricales. From Agariclaes, Hygrophoraceae or waxcaps fungi are considered an indicator group of fungi and were the most abundant group in Oxley Meadow. They have a negative correlation with targeted key fungal groups and abiotic parameters. More in-depth assessments using additional primers are essential to better understand the fungal diversity and how this diversity translates to the resilience of orchid habitats. This preliminary study points to future studies to assess whether sites are near-compatible to the wild site where large colonies are present using additional primers collected over different time scales. Full article

Recent research on attitudes to Australian English (AusE) shows that there is a general increase in its acceptance, legitimacy, and endonormativity. However, a certain “cultural cringe” exists, particularly when “broad” AusE is seen as representative of the variety. A significant gap in the literature is how the perceptions and usage of AusE may change as the population becomes more diverse. This paper presents findings of an online survey of language attitudes towards AusE with 661 respondents across Australia, over a third of whom were born overseas. Overall, there is minimal evidence of a standard language ideology, with 80% of respondents reporting having an accent to some degree. Almost half of respondents report occasionally or frequently changing their accents due to context, interlocutor, or making themselves understood. When asked to rate AusE along six traits on a seven-point scale, the traits of educatedness, professionalism, and attractiveness were consistently centered on neutral. For friendliness and likeability, the majority skewed towards neutral and positive. For the trait of clarity, there was a greater range of responses, but overall, 50% of respondents found AusE to be somewhat, moderately, or really clear. These findings further our understanding of attitudes and ideologies in Australia’s increasingly diverse language ecology. Full article

Ultra-high-performance concrete (UHPC) is considered to be a promising material for the strengthening of damaged reinforced concrete (RC) members due to its high mechanical strength and low permeability. However, its high material cost, limited code provisions, and scattered material properties limit its wide application. There is a great need to review existing articles and create a database to assist different technical committees for future code provisions on UHPC. This study presents a comprehensive overview focusing on the effect of the UHPC layer on the flexural and shear strengthening of RC beams. From this review, it was evident that (1) different retrofitting configurations have a remarkable effect on the cracking moment compared to the maximum moment in the case of flexural strengthening; (2) the ratios of the shear span and UHPC layer thickness have a notable effect on shear strengthening and the failure mode; and (3) different bonding techniques have insignificant effects on shear strengthening but a positive impact on flexural strengthening. Overall, it can be concluded that three-side strengthening has a higher increment range for flexural (maximum, 81%–120%; cracking, 300%–500%) and shear (maximum, 51%–80%; cracking, 121%–180%) strengthening. From this literature review, an experimental database was established, and different failure modes were identified. Finally, this research highlights current issues with UHPC and recommends some future works. Full article

What is truth? We have entered another period fraught with Gospel confusion—beyond postmodernism to what can be called “post-Christianity”. This is not unusual—so we should not be overwhelmed. This happens periodically, as early as Gal 1:9: “If anybody is preaching to you a gospel other than what you accepted, let him be eternally condemned”. It is all a question of the Gospel, or put another way, evangelism (the communication or announcing “the good news of God”). Evangelism is proclaiming and living a distinct message of Jesus Christ. Jesus is Himself the embodiment of the “good news”. The Gospel has been challenged, eroded and corrupted over the centuries—yet rediscovered by those who practice exegesis of the Biblical record of the New Testament. This article moves on to look at how secular philosophy—rather than Christian philosophy—and other “forms of the truth” have influenced the current situation we find ourselves in. Full article

The prefabricated recyclable supporting structure (PRSS) is an innovative support system that integrates a steel skeleton with polymer waterproof technology. Earth berms are extensively adopted to support the PRSS, but there is limited understanding on the factors influencing their behavior in circular excavations. In this paper, a numerical model is first validated with a case history in Henan, China. Afterwards, the geometric parameters of the earth berms, including the height (H), the top width (B₁), and the bottom width (B₂), on the behavior of the PRSS, are investigated. It is shown that, by increasing the height, top width and bottom width of earth berms, the lateral deflections, and bending moments of supporting piles, as well as the ground surface settlements, tend to decrease. However, the reduction effect of these parameters diminishes as well. Moreover, the raised effective formation level considering the effect of the earth berms on stability and deformation analyses is discussed. The factor of the safety of the excavation is almost doubled when axisymmetric conditions are considered compared to plane strain conditions. In deformation analysis, the raised effective formation level increases with the height of the earth berms until a steady value is reached. Full article

Freixo de Numão (FNG) and Capinha (CG) granites are prominent intrusions in the Douro Group (northern Central Iberian Zone, CIZ) and Beiras Supergroup (southern CIZ) metasediments, respectively. U-Pb dating revealed crystallization ages of 306 ± 2 Ma for FNG and 301 ± 3 Ma for CG, whereas Lu–Hf systematics has shown ɛHf_t values ranging from −4.5 to +0.6 and from −5.5 to +0.3 in FNG and CG autocrysts, respectively, suggesting that they originate from heterogeneous crustal anatectic melts, but a direct mantle-derived material contribution can also be considered. The isotopic data of inherited zircon cores of both granites, with ɛHf_t values ranging from −16.8 to +8.4 in FNG, and from −19.4 to +10.1 in CG, are compatible with a derivation from heterogeneous Neoproterozoic metasedimentary sources, consisting of juvenile and recycled crustal materials, comparable to those of the wall rocks. However, the less evolved initial ¹⁷⁶Hf/¹⁷⁷Hf signature of magmatic zircons of both granites requires more immature metasediments/juvenile materials as main sources for the parental magmas. In fact, for FNG, the high Sr and Ba whole-rock content, and the upper Cambrian inheritance highlight the involvement of a metaigneous protolith in its genesis. Full article

Climate change severely affects urban water systems (UWSs). Infrastructure historically designed for milder conditions cannot manage growing water demands and extreme events. To obtain a resilient water sector, adaptation and mitigation strategies must address rising water challenges while striving for net-zero emissions. Researchers have noted that extreme decentralization is positively associated with closing cycles while reducing transport costs. However, part of the scientific community defends centralized schemes due to economies of scale. The objective of this systematic review is to understand the trade-offs associated with the adoption of different scales at UWSs design and how this impacts system resilience. This process includes identifying different scale trade-offs and unique environmental aspects that influence the optimal scale suitability. A clear distinction was made in terms of scale concept and classification, considering different design levels. That is, considering the UWS at the city level and water management units (WMUs) at the local level. Similarly, a classification of different scales for each level, covering all water streams—supply, wastewater, and stormwater—was introduced. We defined the key environmental aspects that influence the optimal scale and location suitability: ten at the city-catchment level and eleven at the site-neighbourhood level. Scale impacts three major UWSs functionalities that have repercussions on urban resilience: net energy, net water, and ecosystem services (ES). Full article

The tumor suppressor gene F-box and WD repeat domain-containing (FBXW) 7 reduces cancer stemness properties by promoting the protein degradation of pluripotent stem cell markers. We recently demonstrated the transcriptional repression of FBXW7 by the three-dimensional (3D) spheroid formation of several cancer cells. In the present study, we found that the transcriptional activity of FBXW7 was promoted by the inhibition of the Ca²⁺-activated K⁺ channel, K_Ca1.1, in a 3D spheroid model of human prostate cancer LNCaP cells through the Akt-Nrf2 signaling pathway. The transcriptional activity of FBXW7 was reduced by the siRNA-mediated inhibition of the CCAAT-enhancer-binding protein C/EBP δ (CEBPD) after the transfection of miR223 mimics in the LNCaP spheroid model, suggesting the transcriptional regulation of FBXW7 through the Akt-Nrf2-CEBPD-miR223 transcriptional axis in the LNCaP spheroid model. Furthermore, the K_Ca1.1 inhibition-induced activation of FBXW7 reduced (1) K_Ca1.1 activity and protein levels in the plasma membrane and (2) the protein level of the cancer stem cell (CSC) markers, c-Myc, which is a molecule degraded by FBXW7, in the LNCaP spheroid model, indicating that K_Ca1.1 inhibition-induced FBXW7 activation suppressed CSC conversion in K_Ca1.1-positive cancer cells. Full article

In this paper, an approach is proposed for assessing the performance of experts in the group from two perspectives: (1) individual consistencies and (2) deviations from the group decision. The quality of performance of the experts is based on combining the standard and rough analytic hierarchy process (AHP) with the technique for order of preference by similarity to the ideal solution (TOPSIS). The statistical method CRITIC is used to derive weights for the TOPSIS method before the experts are assessed based on demonstrated consistency and deviations from the group. Common performance indicators, such as consistency ratio, Euclidean distance, compatibility, and Spearman’s correlation coefficient, are proposed for re-grouping experts before making the final decisions. A genetic algorithm enables the efficient solving of this complex clustering problem. Implementing the described approach and method can be useful in comparable assessment frameworks. A critical aspect is conducting a thorough pre-assessment of the competence of potential decision makers, often referred to as experts who may not consistently exhibit apparent expertise. The competence of decision makers (which does not have to be associated with compatibility) is evidenced by selected consistency parameters, and in a way, a pre-assessment of their competence follows Plato’s ‘government of the wise’ principle. In the presented study, the compatibility of individuals in the group with the collective position (group decision) is measured by parameters related to their compatibility with the group solution and statistical deviation while ranking decision elements. The proposed multi-model-based approach stands out for its resilience in conducting thorough pre-assessment of the quality (competence) of potential decision makers, often regarded as experts who might not consistently display evident expertise. The wetland study area in Serbia is used as an example application, where seven measures for reducing the risk of drought were evaluated by twelve experts coming from different sectors and with different backgrounds and expertise. Full article

Background: Improving local antibiotic delivery is a promising approach to improve infection control and potentially shorten systemic treatment in periprosthetic joint infection (PJI). This study investigates the use of an antibiotic-loaded, mouldable collagen–tricalciumphosphate composite in treatment of hip PJI. Methods: 124 application cases in 79 patients were included from a referral centre; systemic adverse infects, local complications, and infection control were analysed. Results: In most cases, either vancomycin or meropenem were used. Pathogens were previously known in 82 (66%) cases with polymicrobial infection in 20 (25%) patients. There were no cases of hypercalcaemia. Acute kidney injure was present in 14 (11%) cases. Chronic kidney failure persisted in two cases. During a mean follow-up of 12 (SD 9.3; range 3–35) months, implant survival was achieved in 73 (92%) patients; revision due to PJI was performed in 19 cases. Conclusion: Mouldable collagen–tricalciumphosphate composite bone substitute as a local antibiotic carrier in revision hip arthroplasty appears to be a valid option for local antibiotic delivery without systemic complications. Implant survival of 92% supports the hypothesis that local antibiotic therapy is an important component in the treatment of PJI. Full article

Growing concerns over gambling problems across age groups have sparked research in public health and psychology. During emerging adulthood, individuals are more susceptible to mental health problems and more likely to develop gambling problems than in other age groups. This study explored the potential differences between emerging adults and adults aged 30+ in terms of problem gambling severity (PGS), gambling-related harm (GRH), depression and anxiety, and the mediating role of depression and anxiety in the association between age, PGS, and GRH. A representative online sample of 3244 Israelis aged 18 and over was divided into two groups: 740 emerging adults aged 18–29 and 2504 adults aged 30+. Gambling behaviors, the Problem Gambling Severity Index, the Short Gambling Harm Screen, and the Patient Health Questionnaire-4 assessing depression and anxiety were administered. Emerging adults had significantly higher levels of GRH, PGS, and depression-anxiety than their older counterparts, above and beyond gender and education. Depression-anxiety fully mediated the associations between age and gambling-related outcomes. These findings underscore the importance of considering psychological well-being in efforts to address problem gambling and gambling-related harms, especially in emerging adults. Full article

The centrality of amyloid-beta (Aβ) is an indisputable tenet of Alzheimer’s disease (AD). It was initially indicated by the detection (1991) of a mutation within Aβ protein precursor (AβPP) segregating with the disease, which served as a basis for the long-standing Amyloid Cascade Hypothesis (ACH) theory of AD. In the intervening three decades, this notion was affirmed and substantiated by the discovery of numerous AD-causing and AD-protective mutations with all, without an exception, affecting the structure, production, and intraneuronal degradation of Aβ. The ACH postulated that the disease is caused and driven by extracellular Aβ. When it became clear that this is not the case, and the ACH was largely discredited, a new theory of AD, dubbed ACH2.0 to re-emphasize the centrality of Aβ, was formulated. In the ACH2.0, AD is caused by physiologically accumulated intraneuronal Aβ (iAβ) derived from AβPP. Upon reaching the critical threshold, it triggers activation of the autonomous AβPP-independent iAβ generation pathway; its output is retained intraneuronally and drives the AD pathology. The bridge between iAβ derived from AβPP and that generated independently of AβPP is the neuronal integrated stress response (ISR) elicited by the former. The ISR severely suppresses cellular protein synthesis; concurrently, it activates the production of a small subset of proteins, which apparently includes components necessary for operation of the AβPP-independent iAβ generation pathway that are absent under regular circumstances. The above sequence of events defines “conventional” AD, which is both caused and driven by differentially derived iAβ. Since the ISR can be elicited by a multitude of stressors, the logic of the ACH2.0 mandates that another class of AD, referred to as “unconventional”, has to occur. Unconventional AD is defined as a disease where a stressor distinct from AβPP-derived iAβ elicits the neuronal ISR. Thus, the essence of both, conventional and unconventional, forms of AD is one and the same, namely autonomous, self-sustainable, AβPP-independent production of iAβ. What distinguishes them is the manner of activation of this pathway, i.e., the mode of causation of the disease. In unconventional AD, processes occurring at locations as distant from and seemingly as unrelated to the brain as, say, the knee can potentially trigger the disease. The present study asserts that these processes include traumatic brain injury (TBI), chronic traumatic encephalopathy, viral and bacterial infections, and a wide array of inflammatory conditions. It considers the pathways which are common to all these occurrences and culminate in the elicitation of the neuronal ISR, analyzes the dynamics of conventional versus unconventional AD, shows how the former can morph into the latter, explains how a single TBI can hasten the occurrence of AD and why it takes multiple TBIs to trigger the disease, and proposes the appropriate therapeutic strategies. It posits that yet another class of unconventional AD may occur where the autonomous AβPP-independent iAβ production pathway is initiated by an ISR-unrelated activator, and consolidates the above notions in a theory of AD, designated ACH2.0/E (for expanded ACH2.0), which incorporates the ACH2.0 as its special case and retains the centrality of iAβ produced independently of AβPP as the driving agent of the disease. Full article