Skip to main content
SpringerLink
Log in

Substances synaptolytiques, curarisantes et nicotinolytiques

  • Kurze Mitteilungen
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Diethylaminoethyl ester of phenyl-cyclopentane carboxylic acid (Parpanit) and diaminoethylphenothiazine (2987 R. P., Diparcol), substances paralysing the autonomic synapses, the postsynaptic cholinergic innervation and the motor centers, protect very actively against nicotinic and cholinergic intoxication. Parpanit has no anticholinesterase action, while Diparcol inactivates selectively pseudo-cholinesterasein vitro andin vivo.

Curarizing and synaptolytic agents as tubocurarine, methyltubocurarine, diiodoethylate of bis (quinoleyl-8′-1, 5-pentane) (3381 R. P.) and lauryl-dimethyl-aminoethanol (764 L.), protect against nicotinic intoxication, but do not suppress the muscarinic actions of cholinergic agents.

Triiodate of tri(tri-ethylammonium-methoxy)-1,2,3-benzene (2559 F.), curarizing, but not synaptolytic substance, protects only against nicotinic convulsions and muscular fasciculations.

Tetra-ethyl-ammonium, synaptolytic substance, protects only against synaptic stimulations induced by nicotinic agents.

Atropine protects against nicotinic and muscarinic actions of nicotinic substances, but not against nicotinic convulsions and muscular fasciculations.

The curarizing and synaptolytic substances as well as atropine do not inhibit cholinesterases. Thus no correlation exists between anticholinesterase, synaptolytic and nicotinolytic properties.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. C. Heymans, R. Pannier etR. Verbeke, Arch. int. Pharmacodyn.72, 405 (1946).

    PubMed  CAS  Google Scholar 

  2. C. Heymans etJ. Jacob ib.74, 233 (1947).

    PubMed  CAS  Google Scholar 

  3. R. Verbeke, ib.75, 415 (1948); ib.79, 1 (1949).

    PubMed  CAS  Google Scholar 

  4. R. Verbeke etZ. Votava, ib., sous presse (1949).

  5. G. H. Acheson etG. K. Moe, J. Pharmacol.84, 189 (1945);87, 220, 273 (1946).

    CAS  Google Scholar 

  6. R. E. Boelaert, Arch. int. Pharmacodyn.75, 417 (1948).

    PubMed  CAS  Google Scholar 

  7. R. Domenjoz, Schweiz. med. Wschr.50, 1282 (1946).

    Google Scholar 

  8. C. Heymans etG. R. de Vleeschhouwer, Arch. int. Pharmacodyn.75, 413, 307 (1948).

    PubMed  CAS  Google Scholar 

  9. H. Gilman etD. A. Shirley, J. Amer. Chem. Soc.66, 888 (1944).

    Article  CAS  Google Scholar 

  10. D. Bovet, J. Fournel etP. Charpentier, Thérapie2, 115 (1947).

    CAS  Google Scholar 

  11. C. Heymans, J. J. Estable etS. Castillo de Bonneveaux, C. R. Soc. biol. Montevideo (25 nov. 1948); Science109, 122 (1949) Arch. int. Pharmacodyn, sous presse (1949).

    CAS  Google Scholar 

  12. C. Heymans, H. Mazzella etE. Migliaro, C. R. Soc. Biol. Montevideo (25 nov. 1948); Arch. int. Pharmacodyn., sous presse.

  13. D. Dovet, S. Courvoisier, R. Ducrot etR. Horclois, C. R. Acad. Sci.1, 597;2, 1733 (1947).

    Google Scholar 

  14. A. van den Oostende, Arch. int. Pharmacodyn.75, 419 (1948).

    PubMed  Google Scholar 

  15. L. Bihan et coll., ib., sous presse (1949).

  16. M. J. Dallemagne etE. Philippot, ib., sous presse (1949).

  17. G. van den Heuvel, ib., sous presse (1949).

  18. C. Heymans, J. J. Estable etS. Castillo de Bonneveaux, C. R. Soc. biol. Montevideo (25 nov. 1948); Science109, 122 (1949); Arch. int. Pharmacodyn., sous presse (1949).

    Article  PubMed  CAS  Google Scholar 

  19. D. Bovet, F. Depierre etY. de Lestrange, C. R. Acad. Sci.2, 74 (1947).

    Google Scholar 

  20. A. van den Oostende, Arch. int. Pharmacodyn.75, 419 (1948).

    PubMed  Google Scholar 

  21. C. Heymans, J. J. Estable etS. Castillo de Bonneveaux, C. R. Soc. biol. Montevideo (25 nov. 1948); Science109, 122 (1949); Arch. int. Pharmacodyn., sous presse (1949).

    Article  PubMed  CAS  Google Scholar 

  22. J. J. Gordon, Nature162, 146 (1948).

    Article  PubMed  CAS  Google Scholar 

  23. C. Heymans etG. R. de Vleeschhouver, Arch. int. Pharmacodyn.75, 413, 307 (1948).

    PubMed  CAS  Google Scholar 

  24. C. Heymans, J. J. Estable etS. Castillo de Bonneveaux, C. R. Soc. biol. Montevideo (25 nov. 1948); Science109, 122 (1949); Arch. int. Pharmacodyn., sous presse (1949).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut de pharmacologie de l'Université de Gand, Belgique

    C. Heymans & G. van den Heuvel

Authors
  1. C. Heymans
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. van den Heuvel
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Heymans, C., van den Heuvel, G. Substances synaptolytiques, curarisantes et nicotinolytiques. Experientia 5, 213–214 (1949). https://doi.org/10.1007/BF02172502

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02172502

Search

Navigation