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Insulin secretion and (pro)insulin biosynthesis of cultured mice islets after glibenclamide loading in vitro

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Summary

Isolated islets from C57B1/6J mice exposed to 10 mmoles/1 glucose supplemented with 5 μg/ml glibenclamide for 48 h released significantly less insulin in the subsequent short-time incubation thanuntreated controls (without glibenclamide), whereas insulin biosynthesis was not suppressed by glibenclamide treatment.

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Authors and Affiliations

  1. Central Institute for Diabetes “Gerhardt Katsch”, DDR-2201, Karlsburg, German Democratic Republic

    Brigitte Ziegler, Barbara Wilke, M. Ziegler, S. Schmidt & H. Zühlke

Authors
  1. Brigitte Ziegler
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  2. Barbara Wilke
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  3. M. Ziegler
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  4. S. Schmidt
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  5. H. Zühlke
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Additional information

Investigations were carried out as a part of the “ForschungsprojektDiabetes mellitus und Fettstoffwechselstörungen”, supported by the Ministry of Health of the GDR.

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Ziegler, B., Wilke, B., Ziegler, M. et al. Insulin secretion and (pro)insulin biosynthesis of cultured mice islets after glibenclamide loading in vitro. Experientia 36, 467–468 (1980). https://doi.org/10.1007/BF01975151

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  • DOI: https://doi.org/10.1007/BF01975151

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