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A comparison of the pharmacological activity ofgD9-Tetrahydrocannabinol and its monohydroxylated metabolites in man

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Se hizo un estudio comparativo de la capacidad del Δ9-tetrahidro-cannabinol y de sus metabolitos monohidroxilados en producir effectos similares a los de la marihuana cuando son inyectados intravenosamente a humanos. Se encontro que la hidroxilacion en la posición 11 no cambio la potencia, en la posición 8β la redujo, y en la posición 8α la abolio por completo.

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References

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Authors and Affiliations

  1. Department of Psychiatry, University of North Carolina School of Medicine, 27514, Chapel Hill, N. Carolina, USA

    M. Rerez-Reyes, Martha C. Timmons, M. A. Lipton, H. D. Christensen, K. H. Davis & M. E. Wall

  2. Research Triangle Institute, 27709, Research Triangle Park, N. Carolina, USA

    M. Rerez-Reyes, Martha C. Timmons, M. A. Lipton, H. D. Christensen, K. H. Davis & M. E. Wall

Authors
  1. M. Rerez-Reyes
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  2. Martha C. Timmons
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  3. M. A. Lipton
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  4. H. D. Christensen
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  5. K. H. Davis
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  6. M. E. Wall
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Additional information

These studies were conducted under Contract No. HSM-42-71-95 between the Center for Studies of Narcotic and Drug Abuse of the Division of Narcotic Addition and Drug Abuse, NIMH, and the Research Triangle Institute. In addition, this investigation was supported by Public Health service Research Grant No. RR-46 from the General Clinical Research Centers Branch of the Division of Research Resources. We thank Drs.Monique Braude and st.Szara, Center for Studies of Narcotic and Drug Abuse, NIMH, for their interest and encouragement of this program. We also thankCarolyn Bishop andDaynise Skeen for their technical assistance.

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Rerez-Reyes, M., Timmons, M.C., Lipton, M.A. et al. A comparison of the pharmacological activity ofgD9-Tetrahydrocannabinol and its monohydroxylated metabolites in man. Experientia 29, 1009–1010 (1973). https://doi.org/10.1007/BF01930433

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  • DOI: https://doi.org/10.1007/BF01930433

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