Skip to main content
SpringerLink
Log in

Inhibition of testosterone biosynthesis by medrogestone

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Résumé

In vitro, la medrogestone bloque la synthèse des hormones dans les gonades par inhibition de la 3β-hydroxystéroide Δ4,5-isomérase. In vivo, la medrogestone réduit le niveau de testostérone dans le testicules de rat.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. R. Deghenghi, C. Revesz andR. Gaudry, J. med. Chem.6, 301 (1963).

    Article  CAS  PubMed  Google Scholar 

  2. C. Revesz andC. I. Chappel, J. Reprod. Fertil.12, 473 (1966).

    Article  CAS  PubMed  Google Scholar 

  3. Reported in part at The Canadian Federation of Biological Societies, 13th Annual Meeting, June 9–12, 1970 Montreal, Canada.

  4. M. L. Givner, G. Schilling andD. Dvornik, Endocrinology83, 984 (1968).

    Article  CAS  PubMed  Google Scholar 

  5. H. Larsson andM. Stensson, Acta endocr. Copenh.55, 673 (1967).

    CAS  Google Scholar 

  6. T. Nishina, Y. Sakai andM. Kimura, Steroids4, 255 (1964).

    Article  CAS  Google Scholar 

  7. H. Gerdes andW. Staib, Steroids6, 793 (1965).

    Article  CAS  PubMed  Google Scholar 

  8. R. A. Moore, Surgery16, 152 (1944).

    Google Scholar 

  9. C. Huggins andR. A. Stevens, J. Urol.43, 705 (1940).

    Article  Google Scholar 

  10. J. Geller, B. Fruchtman, C. Meyer andH. Newman, J. clin. Endocr. Metab.27, 556 (1967).

    Article  CAS  PubMed  Google Scholar 

  11. J. Geller, J. Am. Geriat. Soc.17, 861 (1969).

    Article  CAS  PubMed  Google Scholar 

  12. R. E. Rango, P. J. McLeod, J. Ruedy andR. I. Ogilvie, Clin. Pharmac. Ther.12, 658 (1971).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, Ayerst Reseach Laboratories, P. O. Box 6115, Montreal, Québéc, Canada

    M. L. Givner & D. Dvornik

Authors
  1. M. L. Givner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Dvornik
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

We wish to thank Mrs.S. gosselin, Miss N. Jagarinec andMrs. F. Fitzsimons for their technical assistance andDr. G. Schilling for analyses by gas-liquid chromatography.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Givner, M.L., Dvornik, D. Inhibition of testosterone biosynthesis by medrogestone. Experientia 28, 1105–1106 (1972). https://doi.org/10.1007/BF01918702

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01918702

Keywords

Search

Navigation