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DNA-dependent-DNA-polymerase: Possible limiting influence on cell reproduction during viral leukemogenesis

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Summary

Evidence is presented that during viral leukemogenesis spleen cell nuclei show an increase in labelling index and mean grain count, that is not accompanied by any changes in the nuclear level of DNA-polymerase-α. It is suggested that polymerase production remains under the control of the normal cell mechanisms and the virus may affect cell proliferation by altering the primer-template levels.

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Authors and Affiliations

  1. Cancer Research Unit, Clinical Radiation Therapy Research Center, Allegheny General Hospital, 320 East North Avenue, 15212, Pittsburgh, PA, USA

    J. P. OKunewick & P. G. Braunschweiger

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  1. J. P. OKunewick
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  2. P. G. Braunschweiger
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Additional information

Acknowledgment. This work was supported in part by NIH-NCI grant No. 1-PO2-CA-10438 and by USERDA contract No. E (11-1) 3097, P.G.B. was also supported by contract NCI-CB-43899.

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OKunewick, J.P., Braunschweiger, P.G. DNA-dependent-DNA-polymerase: Possible limiting influence on cell reproduction during viral leukemogenesis. Experientia 34, 108–109 (1978). https://doi.org/10.1007/BF01921932

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