Chrysospermins v New Peptaibol Antibiotics from Apiocrea chrysosperma Ap101

KLAUSJÜRGEN DORNBERGER; WOLFGANG IHN; MICHAEL RITZAU; UDO GRÄFE; BRIGITTE SCHLEGEL; WERNER F. FLECK; JÖRG W. METZGER

doi:10.7164/antibiotics.48.977

Chrysospermins v New Peptaibol Antibiotics from Apiocrea chrysosperma Ap101

KLAUSJÜRGEN DORNBERGER, WOLFGANG IHN, MICHAEL RITZAU, UDO GRÄFE, BRIGITTE SCHLEGEL, WERNER F. FLECK, JÖRG W. METZGER

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JOURNAL FREE ACCESS

1995 Volume 48 Issue 9 Pages 977-989

DOI https://doi.org/10.7164/antibiotics.48.977

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Abstract

Four new members of peptaibol antibiotics, designated as chrysospermins A, B, C, and D, were isolated from the mycelium of Apiocrea chrysosperma AplOl by solvent extraction, silica gel chromatography and preparative recycling HPLC. Their structures as new nonadecapeptides were settled by detailed spectroscopic analysis and chemical degradation experiments. The chrysospermins display antibacterial and antifungal activity, and induce pigment formation by the fungus Phoma destructiva.

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