SYNTHESIS OF HISTARGIN AND RELATED COMPOUNDS AND THEIR INHIBITION OF ENZYMES

KOTO MORIGUCHI; YOSHIHISA UMEDA; KEIKO MIYAZAKI; TERUYA NAKAMURA; KEIJI OGAWA; FUKIKO KOJIMA; HIRONOBU IINUMA; TAKAAKI AOYAGI

doi:10.7164/antibiotics.41.1823

KOTO MORIGUCHI, YOSHIHISA UMEDA, KEIKO MIYAZAKI, TERUYA NAKAMURA, KEIJI OGAWA, FUKIKO KOJIMA, HIRONOBU IINUMA, TAKAAKI AOYAGI

Author information

JOURNAL FREE ACCESS

1988 Volume 41 Issue 12 Pages 1823-1827

DOI https://doi.org/10.7164/antibiotics.41.1823

Details

Abstract

A novel method for the synthesis of histargin and its analogs is described. It includes two kinds of N-alkylation reactions that prevent the formation of side products. The inhibition of enzymes by these compounds was also measured. Some of the compounds strongly inhibited carboxypeptidase B, carboxypeptidase A, carboxypeptidase N (kiniase I), and angiotensin converting enzyme.

Corresponding author

Register with J-STAGE for free!