The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
PS-6 AND PS-7, NEW β-LACTAM ANTIBIOTICS ISOLATION, PHYSICOCHEMICAL PROPERTIES AND STRUCTURES
NORIO SHIBAMOTO, AKIHIKO KOKI, MASAYOSHI NISHINO, KOSUMI NAKAMURA, KOHKI KIYOSHIMA, KAZUHIKO OKAMURA, MITSUYASU OKABE, ROKURO OKAMOTO, YASUO FUKAGAWA, YASUTAKA SHIMAUCHI, TOMOYUKI ISHIKURA
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1980 Volume 33 Issue 10 Pages 1128-1137

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Abstract

Antibiotics PS-6 and PS-7 which are shown to be 5R, 6R-3-(2-acetamido)ethylthio-6-isopropyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid and 5R, 6R-3-(E)-(2-acetamido) vinylthio-6-ethyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid respectively, are new β-lactam compounds isolated from fermentation broths of Streptomyces cremeus subsp. auratilis A271, S. fulvoviridis A933, S. olivaceus ATCC 31126 and S. flavogriseus NRRL 8139. Fermentation, isolation, physicochemical properties and structures of antibiotics PS-6 and PS-7 are described.

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© Japan Antibiotics Research Association
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The Journal of Antibiotics, Series A

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