ANTIBIOTIC MSD-819. PREPARATION AND PROPERTIES OF BIOLOGICALLY ACTIVE DERIVATIVES

THOMAS W. MILLER; A. KATHRINE MILLER; FRANK J. WOLF; EDWARD O. STAPLEY; DAVID HENDLIN

doi:10.7164/antibiotics.22.293

THOMAS W. MILLER, A. KATHRINE MILLER, FRANK J. WOLF, EDWARD O. STAPLEY, DAVID HENDLIN

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JOURNAL FREE ACCESS

1969 Volume 22 Issue 7 Pages 293-296

DOI https://doi.org/10.7164/antibiotics.22.293

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Abstract

Seven derivatives of 6-chloro-2-quinoxalinecarboxylic acid 1, 4-dioxide were prepared. These include esters, amides and the acid hydrazide. The derivatives were tested against fifteen bacteria by agar diffusion assay and against two bacterial infections in vivo. Increased effectiveness on oral administration was observed with the carboxamide.

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