Abstract
Coronary arteries from hearts of cardiac patients contain significantly higher concentrations of histamine than do those from noncardiac patients. The coronary vessels of cardiac patients are also hyperresponsive to histamine and serotonin. These differences between groups of patients suggest an explanation for coronary artery spasm in heart disease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Animals
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Arteriosclerosis / physiopathology
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Catecholamines / analysis
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Cattle
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Coronary Vasospasm / physiopathology*
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Coronary Vessels / analysis
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Coronary Vessels / drug effects
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Coronary Vessels / physiopathology*
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Female
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Histamine / analysis*
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Histamine / pharmacology
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Humans
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Male
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Middle Aged
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Norepinephrine / pharmacology
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Serotonin / analysis
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Serotonin / pharmacology
Substances
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Catecholamines
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Serotonin
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Histamine
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Norepinephrine