Abstract
Intracaudate injections of kainic acid destroy striatal neurons containing acetylcholine and gamma-aminobutyric acid but leave dopaminergic nerve terminals in this brain region intact. Rats injected with the drug are aphagic and adipsic, and have other behavioral abnormalities strikingly similar to those seen in animals with lesions in the dopaminergic nigrostriatal bundle.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Behavior, Animal / drug effects
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Caudate Nucleus / drug effects*
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Caudate Nucleus / physiology
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Choline O-Acetyltransferase / metabolism
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Dopamine / metabolism
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Dose-Response Relationship, Drug
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Drinking Behavior / drug effects*
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Feeding Behavior / drug effects*
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Glutamate Decarboxylase / metabolism
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Kainic Acid / pharmacology*
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Male
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Posture
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Pyrrolidines / pharmacology*
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Rats
Substances
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Pyrrolidines
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Choline O-Acetyltransferase
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Glutamate Decarboxylase
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Kainic Acid
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Dopamine