Abstract
Interruption of the ascending noradrenergic neurons of the locus coeruleus in the rat forebrain with 6-hydroxydopamine produced a progressive accumulation, proximal to the lesion, of tritiated dihydroalprenolol binding activity over 2 days. This accumulation could be blocked by interrupting the neurons closer to their cell bodies. Competitive binding studies with the beta 2 agonist Zinterol suggested that the accumulated beta-receptors were primarily of the beta 1 subtype. These results suggest that, in the rat brain, some beta 1-adrenoreceptors are located in presynaptic, noradrenergic locus coeruleus neurons and are transported in their axons.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adrenergic Fibers / metabolism*
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Animals
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Autonomic Nerve Block
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Axonal Transport*
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Axons / metabolism*
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Brain / metabolism*
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Dihydroalprenolol / metabolism
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Ethanolamines / metabolism
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Hydroxydopamines / pharmacology
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Hypothalamus, Anterior / metabolism
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Locus Coeruleus / metabolism
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Male
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Oxidopamine
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Rats
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Receptors, Adrenergic / metabolism*
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Receptors, Adrenergic, beta / metabolism*
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Receptors, Neurotransmitter / metabolism*
Substances
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Ethanolamines
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Hydroxydopamines
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Receptors, Adrenergic
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Receptors, Adrenergic, beta
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Receptors, Neurotransmitter
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Dihydroalprenolol
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zinterol
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Oxidopamine