Neuronal cell Thy-1 glycoprotein: homology with immunoglobulin

Science. 1982 May 14;216(4547):696-703. doi: 10.1126/science.6177036.

Abstract

The amino acid sequences of mouse brain Thy-1 glycoproteins are shown to be homologous to those of variable-region immunoglobulin domains. There is also good homology with constant domains and beta 2-microglobulin; overall the results suggest that Thy-1 may be like the primordial immunoglobulin domain. Preliminary evidence for an invertebrate Thy-1 homolog supports this possibility.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, Surface / immunology*
  • Biological Evolution
  • Epitopes
  • Glycoproteins / immunology*
  • Immunoglobulin Constant Regions / immunology
  • Immunoglobulin Variable Region / immunology
  • Immunoglobulins / immunology*
  • Isoantibodies / biosynthesis
  • Protein Conformation
  • Thy-1 Antigens

Substances

  • Antigens, Surface
  • Epitopes
  • Glycoproteins
  • Immunoglobulin Constant Regions
  • Immunoglobulin Variable Region
  • Immunoglobulins
  • Isoantibodies
  • Thy-1 Antigens