Tumor location detected with radioactively labeled monoclonal antibody and external scintigraphy

Science. 1979 Nov 16;206(4420):844-7. doi: 10.1126/science.493985.

Abstract

Murine teratocarcinomas were located in mice by external gamma-ray scintigraphy with an iodine-125-labeled monoclonal antibody specific to the tumors. The specificity of the method was increased by subtracting the radiation produced by an iodine-125-labeled indifferent monoclonal antibody of the same immunoglobulin class as the tumor-specific antibody.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Neoplasm
  • Clone Cells / immunology
  • Mice
  • Neoplasms, Experimental / diagnosis
  • Neoplasms, Experimental / immunology
  • Radionuclide Imaging / methods*
  • Teratoma / diagnosis*
  • Teratoma / immunology

Substances

  • Antibodies, Neoplasm