Abstract
The dynamics of multiple Plasmodium infections in asymptomatic children living under intense malaria transmission pressure provide evidence for a density-dependent regulation that transcends species as well as genotype. This regulation, in combination with species- and genotype-specific immune responses, results in nonindependent, sequential episodes of infection with each species.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Animals
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Child
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Child, Preschool
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Female
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Genotype
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Humans
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Malaria / immunology
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Malaria / parasitology*
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Malaria Vaccines
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Male
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Papua New Guinea
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Parasitemia / parasitology*
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Plasmodium / genetics
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Plasmodium / physiology*
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Plasmodium falciparum / physiology
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Plasmodium malariae / physiology
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Plasmodium vivax / physiology
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Species Specificity