ExLibris header image
SFX Logo
Title: A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase
Source:

Science [0036-8075] Edwards, M J yr:2009


Collapse list of basic services Basic
Sorry, no full text available...
Please use the document delivery service (see below)  
Holding information
Holdings in library search engine ALBERT GO
Document delivery
Request document via Library/Bibliothek GO
Users interested in this article also expressed an interest in the following:
1. Trefzer, A. "Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic." Antimicrobial agents and chemotherapy 46.5 (2002): 1174-1182. Link to Full Text for this item Link to SFX for this item
2. Collin, F. "Exploiting bacterial DNA gyrase as a drug target: current state and perspectives." Applied microbiology and biotechnology 92.3 (2011): 479-497. Link to Full Text for this item Link to SFX for this item
3. Hubbard, Roderick E. "Structure-based drug discovery and protein targets in the CNS." Neuropharmacology 60.1 (2010): 7-23. Link to SFX for this item
4. Nishio, M. "Structural basis for the cooperative interplay between the two causative gene products of combined factor V and factor VIII deficiency." Proceedings of the National Academy of Sciences of the United States of America 107.9 (2010): 4034-4039. Link to Full Text for this item Link to SFX for this item
5. CHIEN, S. "Cytotoxic and novel skeleton compounds from the heartwood of Chamaecyparis obtusa var. formosana." Tetrahedron Letters 48.9 (2007): 1567-1569. Link to SFX for this item
6. Alt, S. "Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics." Journal of antimicrobial chemotherapy 66.9 (2011): 2061-2069. Link to SFX for this item
7. Oppegard, Lisa M. "In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus." Antimicrobial agents and chemotherapy 53.5 (2009): 2110-2119. Link to Full Text for this item Link to SFX for this item
8. "Peperotetraphin inhibits the proliferation of human prostate cancer cells via induction of cell cycle arrest and apoptosis." Medical oncology. 32.2: 1-6. Link to SFX for this item
9. G. Castaman; S. H. Giacomelli; M. E. Mancuso; G. D’Andrea; R. Santacroce; S. Sanna; E. Santagostino; P. M. Mannucci; A. Goodeve; F. Rodeghiero;, G. "Deep intronic variations may cause mild hemophilia a." Journal of thrombosis and haemostasis 9.8 (2011): 1541-1548. Link to Full Text for this item Link to SFX for this item
10. Galm, U. "Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040." Archives of microbiology 178.2 (2002): 102-14. Link to Full Text for this item Link to SFX for this item
11. Duckers, C. "Residual platelet factor V ensures thrombin generation in patients with severe congenital factor V deficiency and mild bleeding symptoms." Blood 115.4 (2010): 879-886. Link to SFX for this item
12. Flatman, R. "Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action." Antimicrobial agents and chemotherapy 49.3 (2005): 1093-1100. Link to Full Text for this item Link to SFX for this item
13. H, H n. "Coumarin formation in novobiocin biosynthesis: beta-hydroxylation of the aminoacyl enzyme tyrosyl-S-NovH by a cytochrome P450 NovI." Chemistry & biology 8.4 (2001): 301-12. Link to SFX for this item
14. Nyfeler, B. "Deletion of 3 residues from the C-terminus of MCFD2 affects binding to ERGIC-53 and causes combined factor V and factor VIII deficiency." Blood 111.3 (2008): 1299-1301. Link to SFX for this item
15. Galm, U. "Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tu 6040." Archives of microbiology 178.2 (2002): 102-. Link to Full Text for this item Link to SFX for this item
16. Brown, Scott P. "Healthy skepticism: assessing realistic model performance." Drug discovery today 14.7 (2009): 420-427. Link to SFX for this item
17. Xu, J. "Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock." Journal of thrombosis and haemostasis 7.5 (2009): 851-6. Link to Full Text for this item Link to SFX for this item
18. Kinugawa, M. "Skeletal protein protection : the mode of action of an anti-osteoporotic marine alkaloid, norzoanthamine." Journal of bone and mineral metabolism 27.3 (2009): 303-314. Link to SFX for this item
19. Gleeson, M Paul P. "Generation of a set of simple, interpretable ADMET rules of thumb." Journal of medicinal chemistry 51.4 (2008): 817-34. Link to Full Text for this item Link to SFX for this item
20. Berlinck, R. "The chemistry and biology of organic guanidine derivatives." Natural product reports 25.5 (2008): 919-954. Link to Full Text for this item Link to SFX for this item
View More...
View Less...
Select All Clear All

Expand list of advanced services Advanced