The 2023 MDPI Annual Report has
been released!
 
22 pages, 2325 KiB  
Review
Understanding Aβ Peptide Binding to Lipid Membranes: A Biophysical Perspective
by Hasna Ahyayauch, Massimo E. Masserini, Alicia Alonso and Félix M. Goñi
Int. J. Mol. Sci. 2024, 25(12), 6401; https://doi.org/10.3390/ijms25126401 (registering DOI) - 10 Jun 2024
Abstract
Aβ peptides are known to bind neural plasma membranes in a process leading to the deposit of Aβ-enriched plaques. These extracellular structures are characteristic of Alzheimer’s disease, the major cause of late-age dementia. The mechanisms of Aβ plaque formation and deposition are far [...] Read more.
Aβ peptides are known to bind neural plasma membranes in a process leading to the deposit of Aβ-enriched plaques. These extracellular structures are characteristic of Alzheimer’s disease, the major cause of late-age dementia. The mechanisms of Aβ plaque formation and deposition are far from being understood. A vast number of studies in the literature describe the efforts to analyze those mechanisms using a variety of tools. The present review focuses on biophysical studies mostly carried out with model membranes or with computational tools. This review starts by describing basic physical aspects of lipid phases and commonly used model membranes (monolayers and bilayers). This is followed by a discussion of the biophysical techniques applied to these systems, mainly but not exclusively Langmuir monolayers, isothermal calorimetry, density-gradient ultracentrifugation, and molecular dynamics. The Methodological Section is followed by the core of the review, which includes a summary of important results obtained with each technique. The last section is devoted to an overall reflection and an effort to understand Aβ-bilayer binding. Concepts such as Aβ peptide membrane binding, adsorption, and insertion are defined and differentiated. The roles of membrane lipid order, nanodomain formation, and electrostatic forces in Aβ–membrane interaction are separately identified and discussed. Full article
(This article belongs to the Special Issue Structure and Formation Mechanism of Amyloid Fibrils)
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19 pages, 10451 KiB  
Article
Lossy Compression of Single-channel Noisy Images by Modern Coders
by Sergii Kryvenko, Vladimir Lukin and Benoit Vozel
Remote Sens. 2024, 16(12), 2093; https://doi.org/10.3390/rs16122093 (registering DOI) - 10 Jun 2024
Abstract
Lossy compression of remote-sensing images is a typical stage in their processing chain. In design or selection of methods for lossy compression, it is commonly assumed that images are noise-free. Meanwhile, there are many practical situations where an image or a set of [...] Read more.
Lossy compression of remote-sensing images is a typical stage in their processing chain. In design or selection of methods for lossy compression, it is commonly assumed that images are noise-free. Meanwhile, there are many practical situations where an image or a set of its components are noisy. This fact needs to be taken into account since noise presence leads to specific effects in lossy compressed data. The main effect is the possible existence of the optimal operation point (OOP) shown for JPEG, JPEG2000, some coders based on the discrete cosine transform (DCT), and the better portable graphics (BPG) encoder. However, the performance of such modern coders as AVIF and HEIF with application to noisy images has not been studied yet. In this paper, analysis is carried out for the case of additive white Gaussian noise. We demonstrate that OOP can exist for AVIF and HEIF and the performance characteristics in it are quite similar to those for the BPG encoder. OOP exists with a higher probability for images of simpler structure and/or high-intensity noise, and this takes place according to different metrics including visual quality ones. The problems of providing lossy compression by AVIF or HEIF are shown and an initial solution is proposed. Examples for test and real-life remote-sensing images are presented. Full article
(This article belongs to the Special Issue Recent Progress in Hyperspectral Remote Sensing Data Processing)
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13 pages, 16968 KiB  
Article
Elastic Self-Recovering Hybrid Nanogenerator for Water Wave Energy Harvesting and Marine Environmental Monitoring
by Qiuxiang Wang, Gao Yu, Ying Lou, Mengfan Li, Jiaxi Hu, Jiaodi Li, Weiqi Cui, Aifang Yu and Junyi Zhai
Sensors 2024, 24(12), 3770; https://doi.org/10.3390/s24123770 (registering DOI) - 10 Jun 2024
Abstract
To achieve large-scale development of triboelectric nanogenerators (TENGs) for water wave energy harvesting and powering the colossal sensors widely distributed in the ocean, facile and scalable TENGs with high output are urgently required. Here, an elastic self-recovering hybrid nanogenerator (ES-HNG) is proposed for [...] Read more.
To achieve large-scale development of triboelectric nanogenerators (TENGs) for water wave energy harvesting and powering the colossal sensors widely distributed in the ocean, facile and scalable TENGs with high output are urgently required. Here, an elastic self-recovering hybrid nanogenerator (ES-HNG) is proposed for water wave energy harvesting and marine environmental monitoring. The elastic skeletal support of the ES-HNG is manufactured using three-dimensional (3D) printing technology, which is more conducive to the large-scale integration of the ES-HNG. Moreover, the combination of a TENG and an electromagnetic generator (EMG) optimizes the utilization of device space, leading to enhanced energy harvesting efficiency. Experimental results demonstrate that the TENG achieves a peak power output of 42.68 mW, and the EMG reaches a peak power output of 4.40 mW. Furthermore, various marine environment monitoring sensors, such as a self-powered wireless meteorological monitoring system, a wireless alarm system, and a water quality monitoring pen, have been successfully powered by the sophisticated ES-HNG. This work introduces an ES-HNG for water wave energy harvesting, which demonstrates potential in marine environment monitoring and offers a new solution for the sustainable development of the marine internet of things. Full article
(This article belongs to the Section Environmental Sensing)
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20 pages, 2961 KiB  
Article
Mathematical Evaluation of Direct and Inverse Problem Applied in Breakthrough Models of Metal Adsorption
by Wilhamis Fonseca Soeiro, Carlos Henrique Rodrigues Moura, Camila Santana Dias, Emerson Cardoso Rodrigues, Deibson Silva Da Costa, Bruno Marques Viegas and Diego Cardoso Estumano
Appl. Sci. 2024, 14(12), 5035; https://doi.org/10.3390/app14125035 (registering DOI) - 10 Jun 2024
Abstract
The treatment of industrial effluents has great environmental and human health importance. The purification of water from polluting components, such as metals and organic compounds, can be considered one of the main applications in this field, with adsorption being one of the main [...] Read more.
The treatment of industrial effluents has great environmental and human health importance. The purification of water from polluting components, such as metals and organic compounds, can be considered one of the main applications in this field, with adsorption being one of the main treatment methods. Therefore, with the objective of describing the dynamics of the process in an adsorption column and estimating the parameters involved, in this work, an algorithm for the Method of Lines (MOL) was used in order to numerically solve the model formed by the mass balance in liquid phase, the linear driving force equation (LDF), and the Langmuir isotherm for equilibrium. In addition, a sensitivity analysis of the phenomenon was carried out in relation to the parameters and a subsequent estimation of these was made through the Monte Carlo technique via the Markov chain (MCMC). The validation algorithm was created using data from actual breakthrough curves found in the literature. The experimental data were obtained from the literature for the adsorption of Cadmium (Cd), Copper (Cu), Nickel (Ni), Zinc (Zn), and Chrome (Cr) ions. Among all the estimates, the one that had the lowest adjustment to the data was that related to zinc metal, which had an R2 equal to 0.8984. For the other metals, the correlation coefficient had a value closer to unity. This demonstrates that, in general, the estimates were good enough to represent the dynamics of adsorption. Full article
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10 pages, 2216 KiB  
Communication
Design and Fabrication of a Biomimetic Smart Material for Electrochemical Detection of Carbendazim Pesticides in Real Samples with Enhanced Selectivity
by Francisco Franciné Maia Júnior, Rui Sales Junior, Geovani Ferreira Barbosa, Sajjad Hussain, Eduardo Jara-Cornejo and Sabir Khan
Biosensors 2024, 14(6), 304; https://doi.org/10.3390/bios14060304 (registering DOI) - 10 Jun 2024
Abstract
Agricultural products are vitally important for sustaining life on earth and their production has notably grown over the years worldwide in general and in Brazil particularly. Elevating agricultural practices consequently leads to a proportionate increase in the usage of pesticides that are crucially [...] Read more.
Agricultural products are vitally important for sustaining life on earth and their production has notably grown over the years worldwide in general and in Brazil particularly. Elevating agricultural practices consequently leads to a proportionate increase in the usage of pesticides that are crucially important for enhanced crop yield and protection. These compounds have been employed excessively in alarming concentrations, causing the contamination of soil, water, and air. Additionally, they pose serious threats to human health. The current study introduces an innovative tool for producing appropriate materials coupled with an electrochemical sensor designed to measure carbendazim levels. The sensor is developed using a molecularly imprinted polymer (MIP) mounted on a glassy carbon electrode. This electrode is equipped with multi-walled carbon nanotubes (MWCNTs) for improved performance. The combined system demonstrates promising potential for accurately quantifying carbendazim. The morphological characteristics of the synthesized materials were investigated using field emission scanning electron microscopy (FESEM) and the Fourier-transform infrared (FTIR) technique. The analytical curve was drawn using the electrochemical method in the range of 2 to 20 ppm while for HPLC 2–12 ppm; the results are presented as the maximum adsorption capacity of the MIP (82.4%) when compared with NIP (41%) using the HPLC method. The analysis conducted using differential pulse voltammetry (DPV) yielded a limit of detection (LOD) of 1.0 ppm and a repeatability of 5.08% (n = 10). The results obtained from the analysis of selectivity demonstrated that the proposed electrochemical sensor is remarkably efficient for the quantitative assessment of carbendazim, even in the presence of another interferent. The sensor was successfully tested for river water samples for carbendazim detection, and recovery rates ranging from 94 to 101% were obtained for HPLC and 94 to 104% for the electrochemical method. The results obtained show that the proposed electrochemical technique is viable for the application and quantitative determination of carbendazim in any medium. Full article
(This article belongs to the Special Issue Molecularly Imprinted Polymers for Chemical Sensing)
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18 pages, 1364 KiB  
Article
Science Identity in Undergraduates: A Comparison of First-Year Biology Majors, Senior Biology Majors, and Non-STEM Majors
by Krista L. Lucas and Thomas L. Vandergon
Educ. Sci. 2024, 14(6), 624; https://doi.org/10.3390/educsci14060624 (registering DOI) - 10 Jun 2024
Abstract
We argue it is important for everyone to possess basic scientific literacy for multiple reasons. Viewing oneself as a science person or not can impact one’s confidence and willingness to engage with science content thereby improving science literacy. Identifying as a science person [...] Read more.
We argue it is important for everyone to possess basic scientific literacy for multiple reasons. Viewing oneself as a science person or not can impact one’s confidence and willingness to engage with science content thereby improving science literacy. Identifying as a science person may develop early but is not fixed and may shift through science identity work. We investigated science identity views between STEM (science, technology, engineering, and mathematics) and non-STEM majors and assessed whether these views may be influenced by science identity work. Our questions were as follows: (1) How does science identity perception differ between non-STEM and STEM majors? (2) How do non-STEM and STEM students’ perceptions of their science identity change over time? (3) How do non-STEM majors describe a science person compared to STEM majors? We surveyed first-year biology majors, senior biology majors, and non-STEM majors to address our research questions. We found significant shifts in science identity in non-STEM majors taking a general education lab science class pre-course and post-course, differences in agreement regarding science identity between groups, and differences in how a science person is defined among the groups. Our data suggest that instructors can scaffold and support students’ science identity work to increase confidence, STEM retention, and ultimately can improve overall scientific literacy. Full article
(This article belongs to the Special Issue STEM Education for All: Breaking Barriers and Building Bridges)
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12 pages, 1296 KiB  
Article
The Usefulness of Intravascular Ultrasound and Optical Coherence Tomography in Patients Treated with Rotational Atherectomy: An Analysis Based on a Large National Registry
by Wojciech Siłka, Michał Kuzemczak, Krzysztof Piotr Malinowski, Łukasz Kołtowski, Kinga Glądys, Mariola Kłak, Ewa Kowacka, Damian Grzegorek, Piotr Waciński, Michał Chyrchel, Miłosz Dziarmaga, Sylwia Iwańczyk, Miłosz Jaguszewski, Wojciech Wańha, Wojciech Wojakowski, Fabrizio D’Ascenzo, Zbigniew Siudak and Rafał Januszek
J. Cardiovasc. Dev. Dis. 2024, 11(6), 177; https://doi.org/10.3390/jcdd11060177 (registering DOI) - 10 Jun 2024
Abstract
Background: Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) have been shown to improve the clinical outcomes of percutaneous coronary interventions (PCIs) in selected subsets of patients. Aim: The aim was to investigate whether the use of OCT or IVUS during a PCI [...] Read more.
Background: Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) have been shown to improve the clinical outcomes of percutaneous coronary interventions (PCIs) in selected subsets of patients. Aim: The aim was to investigate whether the use of OCT or IVUS during a PCI with rotational atherectomy (RA-PCI) will increase the odds for successful revascularization, defined as thrombolysis in myocardial infarction (TIMI) 3 flow. Methods: Data were obtained from the national registry of PCIs (ORPKI) maintained by the Association of Cardiovascular Interventions (AISN) of the Polish Cardiac Society. The dataset includes PCIs spanning from January 2014 to December 2021. Results: A total of 6522 RA-PCIs were analyzed, out of which 708 (10.9%) were guided by IVUS and 86 (1.3%) by OCT. The postprocedural TIMI 3 flow was achieved significantly more often in RA-PCIs guided by intravascular imaging (98.7% vs. 96.6%, p < 0.0001). Multivariable analysis revealed that using IVUS and OCT was independently associated with an increased chance of achieving postprocedural TIMI 3 flow by 67% (odds ratio (OR), 1.67; 95% confidence interval (CI): 1.40–1.99; p < 0.0001) and 66% (OR, 1.66; 95% CI: 1.09–2.54; p = 0.02), respectively. Other factors associated with successful revascularization were as follows: previous PCI (OR, 1.72; p < 0.0001) and coronary artery bypass grafting (OR, 1.09; p = 0.002), hypertension (OR, 1.14; p < 0.0001), fractional flow reserve assessment during angiogram (OR, 1.47; p < 0.0001), bifurcation PCI (OR, 3.06; p < 0.0001), and stent implantation (OR, 19.6, p < 0.0001). Conclusions: PCIs with rotational atherectomy guided by intravascular imaging modalities (IVUS or OCT) are associated with a higher procedural success rate compared to angio-guided procedures. Full article
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13 pages, 465 KiB  
Article
An Assessment of Existing Sport-Related Concussion Guidelines in Ireland: The Need for a United Approach
by Ayrton Walshe, Ed Daly and Lisa Ryan
J. Funct. Morphol. Kinesiol. 2024, 9(2), 101; https://doi.org/10.3390/jfmk9020101 (registering DOI) - 10 Jun 2024
Abstract
In 2014, an Irish parliament white paper called for greater addressing of sport-related concussions (SRCs) in Ireland, requesting the adoption of the Concussion in Sport Group’s (CISGs) guidelines and greater consistency in SRC return to play (RTP) management. Ten years later, it is [...] Read more.
In 2014, an Irish parliament white paper called for greater addressing of sport-related concussions (SRCs) in Ireland, requesting the adoption of the Concussion in Sport Group’s (CISGs) guidelines and greater consistency in SRC return to play (RTP) management. Ten years later, it is unclear how these requests have been addressed. Recently, the United Kingdom’s government centralised guidelines to one SRC document for all grassroots sports. This study aimed to investigate all publicly available SRC guidance in Irish sports and national governing bodies (NGBs) to determine if centralised guidelines are warranted. Sport Ireland and the Irish Federation of Sports were searched for all recognised NGBs and sports in Ireland. Websites were searched for any information pertaining to SRCs and data were extracted and collated in Microsoft Excel. In total, 15 of 83 sports and/or NGBs included SRC guidance, nine of which provided RTP protocols. Various iterations of the CISGs guidance and tools were implemented. Several sports with a documented SRC risk had no guidelines present. The findings indicate disjointed and outdated guidance across Irish sport. Additionally, there are sports with a documented concussion risk that have no SRC guidance available. This study provides support for centralised guidelines to be adopted in Irish grassroots sports. Full article
(This article belongs to the Section Sports Medicine and Nutrition)
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23 pages, 19273 KiB  
Article
Soft-Tissue Management Dental Implants with Digitally Customized Healing Abutments: A Pilot Study
by Maurizio De Francesco, Elisabetta Ferrara, Francesco Inchingolo, Grazieli Dalmaschio, Alberto Pispero, Angelo Michele Inchingolo, Gianna Dipalma, Tiziano Testori, Gianluca Martino Tartaglia and Biagio Rapone
Prosthesis 2024, 6(3), 596-618; https://doi.org/10.3390/prosthesis6030042 (registering DOI) - 10 Jun 2024
Abstract
Background: This pilot study aimed to evaluate the effectiveness of digitally crafted customized healing abutments in stabilizing peri-implant soft tissues following tooth extraction and assess the preservation of peri-implant soft tissue architecture over 5 years. Material and Methods: Forty patients (age ≥ 25 [...] Read more.
Background: This pilot study aimed to evaluate the effectiveness of digitally crafted customized healing abutments in stabilizing peri-implant soft tissues following tooth extraction and assess the preservation of peri-implant soft tissue architecture over 5 years. Material and Methods: Forty patients (age ≥ 25 years) were divided into test (n = 20) and control (n = 20) groups. The test group received dental implants with immediate loading after tooth extraction, along with customized healing abutments fabricated using CAD/CAM technology. The control group received dental implants with immediate loading without customized healing abutments. The primary outcome was the change in distance between the peri-implant soft tissue margin and implant fixture surface from baseline to 5 years post implantation. Results: In the test group, there was a significant decrease in the distance between the peri-implant soft tissue margin and fixture surface from baseline to 5 years (p < 0.001), with pairwise comparisons showing significant differences between multiple time points (p < 0.05). The control group showed less pronounced changes over time. Conclusions: Within the limitations of this pilot study, digitally fabricated customized healing abutments appear effective in stabilizing peri-implant soft tissues and preserving soft tissue architecture around dental implants over 5 years following immediate implant placement. Randomized controlled trials are needed to confirm these findings. Full article
(This article belongs to the Collection Oral Implantology: Current Aspects and Future Perspectives)
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12 pages, 967 KiB  
Article
Impairment in Right Ventricular-Pulmonary Arterial Coupling in Overweight and Obesity
by Athina Goliopoulou, Evangelos Oikonomou, Panagiotis Theofilis, Vasiliki Tsigkou, George Makavos, Islam Kourampi, Maria Katsioupa, Vaios-Dionysios Antoniou, Ignatios Ikonomidis, Vaia Lambadiari, Aikaterini Tsatsaragkou, Savvas Sarantos, George E. Zakynthinos, Manolis Vavuranakis and Gerasimos Siasos
J. Clin. Med. 2024, 13(12), 3389; https://doi.org/10.3390/jcm13123389 (registering DOI) - 10 Jun 2024
Abstract
Background: The association of obesity with right ventricular function and the interplay between right heart and pulmonary circulation is incompletely understood. We evaluate the role of obesity as a determinant of right ventricular-pulmonary artery coupling (RVAC). Methods: We retrospectively studied consecutive subjects without [...] Read more.
Background: The association of obesity with right ventricular function and the interplay between right heart and pulmonary circulation is incompletely understood. We evaluate the role of obesity as a determinant of right ventricular-pulmonary artery coupling (RVAC). Methods: We retrospectively studied consecutive subjects without overt cardiovascular or pulmonary disease. Subjects were stratified according to body mass index (BMI) as normal weight, overweight, or obese. A transthoracic echocardiographic study was used to assess left and right heart functional and structural parameters. RVAC was assessed using the ratio of peak systolic velocity of the tricuspid annulus to pulmonary artery systolic pressure (PASP). Results: A total of 145 subjects were enrolled with diabetes mellitus incidence higher in obese. There was no difference in left ventricular global longitudinal strain and in PASP or markers of right ventricular systolic function based on BMI. RVAC was significantly lower in the presence of obesity (normal weight: 0.52 (0.19) cm·(sec·mmHg)−1 vs. overweight: 0.47 (0.16) cm·(sec·mmHg)−1 vs. obese: 0.43 (0.14) cm·(sec·mmHg)−1, p = 0.03), even after adjustment for confounders (β: −0.085, 95% confidence interval: −0.163, −0.009, p = 0.029). Conclusions: Our findings highlight the relationship between metabolic impairment and RVAC, suggesting additional mechanisms for heart failure development observed in obese subjects. Full article
(This article belongs to the Section Cardiovascular Medicine)
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16 pages, 501 KiB  
Article
Improving the Giant-Armadillo Optimization Method
by Glykeria Kyrou, Vasileios Charilogis and Ioannis G. Tsoulos
Analytics 2024, 3(2), 225-240; https://doi.org/10.3390/analytics3020013 (registering DOI) - 10 Jun 2024
Abstract
Global optimization is widely adopted presently in a variety of practical and scientific problems. In this context, a group of widely used techniques are evolutionary techniques. A relatively new evolutionary technique in this direction is that of Giant-Armadillo Optimization, which is based on [...] Read more.
Global optimization is widely adopted presently in a variety of practical and scientific problems. In this context, a group of widely used techniques are evolutionary techniques. A relatively new evolutionary technique in this direction is that of Giant-Armadillo Optimization, which is based on the hunting strategy of giant armadillos. In this paper, modifications to this technique are proposed, such as the periodic application of a local minimization method as well as the use of modern termination techniques based on statistical observations. The proposed modifications have been tested on a wide series of test functions available from the relevant literature and compared against other evolutionary methods. Full article
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19 pages, 1194 KiB  
Review
Emerging Prognostic Markers in Patients Undergoing Liver Resection for Hepatocellular Carcinoma: A Narrative Review
by Elena Panettieri, Andrea Campisi, Agostino M. De Rose, Caterina Mele, Felice Giuliante, Jean-Nicolas Vauthey and Francesco Ardito
Cancers 2024, 16(12), 2183; https://doi.org/10.3390/cancers16122183 (registering DOI) - 10 Jun 2024
Abstract
In patients with hepatocellular carcinoma (HCC), liver resection is potentially curative. Nevertheless, post-operative recurrence is common, occurring in up to 70% of patients. Factors traditionally recognized to predict recurrence and survival after liver resection for HCC include pathologic factors (i.e., microvascular and capsular [...] Read more.
In patients with hepatocellular carcinoma (HCC), liver resection is potentially curative. Nevertheless, post-operative recurrence is common, occurring in up to 70% of patients. Factors traditionally recognized to predict recurrence and survival after liver resection for HCC include pathologic factors (i.e., microvascular and capsular invasion) and an increase in alpha-fetoprotein level. During the past decade, many new markers have been reported to correlate with prognosis after resection of HCC: liquid biopsy markers, gene signatures, inflammation markers, and other biomarkers, including PIVKA-II, immune checkpoint molecules, and proteins in urinary exosomes. However, not all of these new markers are readily available in clinical practice, and their reproducibility is unclear. Liquid biopsy is a powerful and established tool for predicting long-term outcomes after resection of HCC; the main limitation of liquid biopsy is represented by the cost related to its technical implementation. Numerous patterns of genetic expression capable of predicting survival after curative-intent hepatectomy for HCC have been identified, but published findings regarding these markers are heterogenous. Inflammation markers in the form of prognostic nutritional index and different blood cell ratios seem more easily reproducible and more affordable on a large scale than other emerging markers. To select the most effective treatment for patients with HCC, it is crucial that the scientific community validate new predictive markers for recurrence and survival after resection that are reliable and widely reproducible. More reports from Western countries are necessary to corroborate the evidence. Full article
(This article belongs to the Special Issue Advanced Strategies in the Care of Hepatocellular Carcinoma Patients)
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14 pages, 605 KiB  
Article
IGF-1 and IGFBP-1 as Possible Predictors of Response to Lifestyle Intervention—Results from Randomized Controlled Trials
by Nina M. T. Meyer, Stefan Kabisch, Ulrike Dambeck, Caroline Honsek, Margrit Kemper, Christiana Gerbracht, Ayman M. Arafat, Andreas L. Birkenfeld, Peter E. H. Schwarz, Jürgen Machann, Martin A. Osterhoff, Martin O. Weickert and Andreas F. H. Pfeiffer
Int. J. Mol. Sci. 2024, 25(12), 6400; https://doi.org/10.3390/ijms25126400 (registering DOI) - 10 Jun 2024
Abstract
Lifestyle interventions can prevent type 2 diabetes (T2DM). However, some individuals do not experience anticipated improvements despite weight loss. Biomarkers to identify such individuals at early stages are lacking. Insulin-like growth factor 1 (IGF- 1) and Insulin-like growth factor binding protein 1(IGFBP-1) were [...] Read more.
Lifestyle interventions can prevent type 2 diabetes (T2DM). However, some individuals do not experience anticipated improvements despite weight loss. Biomarkers to identify such individuals at early stages are lacking. Insulin-like growth factor 1 (IGF- 1) and Insulin-like growth factor binding protein 1(IGFBP-1) were shown to predict T2DM onset in prediabetes. We assessed whether these markers also predict the success of lifestyle interventions, thereby possibly guiding personalized strategies. We analyzed the fasting serum levels of IGF-1, IGFBP-1, and Insulin-like growth factor binding protein 2 (IGFBP-2) in relation to changes in metabolic and anthropometric parameters, including intrahepatic lipids (IHLs) and visceral adipose tissue (VAT) volume, measured by magnetic resonance imaging (MRI), in 345 participants with a high risk for prediabetes (54% female; aged 36–80 years). Participants were enrolled in three randomized dietary intervention trials and assessed both at baseline and one year post-intervention. Statistical analyses were performed using IBM SPSS Statistics (version 28), and significance was set at p < 0.05. Within the 1-year intervention, overall significant improvements were observed. Stratifying individuals by baseline IGF-1 and IGFBP-1 percentiles revealed significant differences: higher IGF-1 levels were associated with more favorable changes compared to lower levels, especially in VAT and IHL. Lower baseline IGFBP-1 levels were associated with greater improvements, especially in IHL and 2 h glucose. Higher bioactive IGF-1 levels might predict better metabolic outcomes following lifestyle interventions in prediabetes, potentially serving as biomarkers for personalized interventions. Full article
(This article belongs to the Special Issue The Role of the IGF Axis in Disease 3.0)
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21 pages, 2445 KiB  
Systematic Review
Cooling Benefits of Urban Tree Canopy: A Systematic Review
by Yihan Yin, Song Li, Xiaoyi Xing, Xinyi Zhou, Yujie Kang, Qi Hu and Yanjing Li
Sustainability 2024, 16(12), 4955; https://doi.org/10.3390/su16124955 (registering DOI) - 10 Jun 2024
Abstract
As an important part of urban ecosystems, trees can effectively alleviate the urban heat island effect. Tree canopies cool and humidify through shading and evapotranspiration, regulating the urban thermal environment. So far, many studies have analyzed the heat mitigation effect of urban green [...] Read more.
As an important part of urban ecosystems, trees can effectively alleviate the urban heat island effect. Tree canopies cool and humidify through shading and evapotranspiration, regulating the urban thermal environment. So far, many studies have analyzed the heat mitigation effect of urban green spaces; however, there are relatively few studies on the cooling effect of tree canopies. Specifically, relevant research focusing on different spatial scales has not been explored. Therefore, this review systematically summarizes the research on the benefits of tree canopy cooling carried out in recent years, analyzes the research content, and evaluates the indicators and key influencing factors of the benefits of tree canopy cooling from four different spatial scales: urban, block, community, and individual. It was found that canopy factors, other vegetation factors, and environmental factors jointly affect the benefits of canopy cooling. This research focuses on the benefits of canopy cooling at different spatial scales. The smaller the research scale, the more discussion and attention will be paid to vegetation factors. This paper puts forward major directions for future research and development, providing optimization strategies for urban planning or plant design at different scales in the context of climate change. Full article
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16 pages, 2454 KiB  
Article
Occurrence and Mechanisms Conferring Multiple Resistance to ALS-Inhibiting and Auxins Mimics Herbicides in Papaver rhoeas from Tunisia
by Myriem Chtourou, Maria Dolores Osuna, Germán Mora Marín, Zeineb Hada, Joel Torra and Thouraya Souissi
Agronomy 2024, 14(6), 1249; https://doi.org/10.3390/agronomy14061249 (registering DOI) - 10 Jun 2024
Abstract
Herbicide-resistant corn poppy (Papaver rhoeas L.) is one of the most important broadleaved weeds and the number of resistant cases is still growing. The aims of this study were to confirm the resistance of P. rhoeas from Tunisia to ALS inhibitors and [...] Read more.
Herbicide-resistant corn poppy (Papaver rhoeas L.) is one of the most important broadleaved weeds and the number of resistant cases is still growing. The aims of this study were to confirm the resistance of P. rhoeas from Tunisia to ALS inhibitors and auxin mimics and investigate the mechanisms of Target-Site Resistance (TSR) and Non-Target Site Resistance (NTSR) involved. Dose–response trials to determine cross-resistance patterns for ALS inhibitors and auxin mimics were conducted in a greenhouse. In this study, multiple resistance to tribenuron-methyl and dicamba but not to 2,4-D was found in P. rhoeas populations. Cross-resistance to imazamox was confirmed as well. Sequence analysis of the ALS gene detected target-site mutations in codon 197 of the ALS gene, namely, Pro197His, Pro197Thr, Pro197Leu, and Pro197Asn. In this study, the metabolism experiments with malathion (a cytochrome P450 inhibitor) showed that malathion reduced resistance to imazamox, indicating that P450 is involved in the resistance. TSR and NTSR mechanisms to ALS inhibitors likely coexist. The findings of this study revealed a significant synergistic interaction between malathion and dicamba in particular populations, suggesting that the resistance to auxin mimics can be conferred by enhanced metabolism. Full article
(This article belongs to the Special Issue Herbicides and Chemical Control of Weeds)
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16 pages, 639 KiB  
Article
Can Non-farm Employment Improve Dietary Diversity of Left-Behind Family Members in Rural China?
by Yonghu Zhang, Yifeng Zhang and Tingjin Wang
Foods 2024, 13(12), 1818; https://doi.org/10.3390/foods13121818 (registering DOI) - 10 Jun 2024
Abstract
Rural residents in China are still at risk of malnutrition, and increasing dietary diversity is crucial to improving their health. This study empirically analyzed the impact of non-farm employment on the dietary diversity of rural left-behind family members based on the China Land [...] Read more.
Rural residents in China are still at risk of malnutrition, and increasing dietary diversity is crucial to improving their health. This study empirically analyzed the impact of non-farm employment on the dietary diversity of rural left-behind family members based on the China Land Economy Survey (CLES) 2020–2021 panel data at the farm and village levels. Dietary diversity was measured using the dietary diversity score (DDS) and the Chinese Food Guide Pagoda Score (CFGPS). The empirical results show that non-farm employment significantly enhances the dietary diversity of rural left-behind household members, including animal food diversity and plant food diversity. This result verifies the altruism phenomenon of non-farm employment in family diet. Mechanism analysis shows that non-farm employment enhances the dietary diversity of rural left-behind family members by increasing the level of family income, Internet accessibility, and family education. Heterogeneity analysis shows that non-farm employment does not enhance the dietary diversity of rural empty nesters and even has a negative impact. This reminds us that the nutritional health of rural empty nesters needs attention in the context of rapid urbanization and aging. Full article
(This article belongs to the Section Food Systems)
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18 pages, 586 KiB  
Article
Curriculum Middle Leader Practices and Teachers Perceptions of Their Effectiveness: A Study in New Zealand Secondary Schools
by Camilla Highfield, Pauline Thompson and Rachel Woods
Educ. Sci. 2024, 14(6), 623; https://doi.org/10.3390/educsci14060623 (registering DOI) - 10 Jun 2024
Abstract
This study reports the quantitative results of middle leaders’ self-reported practices and compares their responses to the perceptions of the teachers who report to them (n = 158). Likert scale questionnaires were used to measure the extent to which middle leaders focused on [...] Read more.
This study reports the quantitative results of middle leaders’ self-reported practices and compares their responses to the perceptions of the teachers who report to them (n = 158). Likert scale questionnaires were used to measure the extent to which middle leaders focused on goal orientation, professional collaboration, effective instructional practices, and supporting teacher development within their department. The analysis provides insight into this phenomenon within six different state-funded secondary schools, with results showing middle leaders almost always rate their practices more effectively than the teachers who report to them. Common areas identified as requiring increased effectiveness were middle leaders’ use of resources to support learning, use of data to support the instructional programme, and identification of effective professional learning opportunities for teachers. Reported levels of effectiveness compared with student academic achievement in the senior secondary school setting align with agreement ratings and the socio-economic status of students who attend the school. This paper highlights the need for the ongoing support of middle leaders to be provided with deliberate support and development for leading teachers. Full article
(This article belongs to the Special Issue Critical Issues for Senior, Middle and Other Levels of Leadership)
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11 pages, 238 KiB  
Article
Semi-Symmetric Metric Connections and Homology of CR-Warped Product Submanifolds in a Complex Space Form Admitting a Concurrent Vector Field
by Meraj Ali Khan, Ibrahim Al-Dayel and Sudhakar Kumar Chaubey
Symmetry 2024, 16(6), 719; https://doi.org/10.3390/sym16060719 (registering DOI) - 10 Jun 2024
Abstract
In this paper, we conduct a thorough study of CR-warped product submanifolds in a Kaehler manifold, utilizing a semi-symmetric metric connection within the framework of warped product geometry. Our analysis yields fundamental and noteworthy results that illuminate the characteristics of these submanifolds. Additionally, [...] Read more.
In this paper, we conduct a thorough study of CR-warped product submanifolds in a Kaehler manifold, utilizing a semi-symmetric metric connection within the framework of warped product geometry. Our analysis yields fundamental and noteworthy results that illuminate the characteristics of these submanifolds. Additionally, we investigate the implications of our findings on the homology of these submanifolds, offering insights into their topological properties. Notably, we present a compelling proof demonstrating that, under a specific condition, stable currents cannot exist for these warped product submanifolds. Our research outcomes contribute significant knowledge concerning the stability and behavior of CR-warped product submanifolds equipped with a semi-symmetric metric connection. Furthermore, this work establishes a robust groundwork for future explorations and advancements in this particular field of study. Full article
13 pages, 5246 KiB  
Article
Dynamic Purkinje Meter as a Tool for Intraocular Lens Position Measurement
by Eliska Palkovicova, Jiri Cendelin and Petr Kudrna
Inventions 2024, 9(3), 66; https://doi.org/10.3390/inventions9030066 (registering DOI) - 10 Jun 2024
Abstract
Due to the increasing demands of today’s society on visual quality and patient comfort, and due to the growing interest in the implantation of new and more complex intraocular lens (IOL) designs, determining the IOL position occupies an important position in current ophthalmological [...] Read more.
Due to the increasing demands of today’s society on visual quality and patient comfort, and due to the growing interest in the implantation of new and more complex intraocular lens (IOL) designs, determining the IOL position occupies an important position in current ophthalmological practice. The dynamic Purkinje meter combines the construction of static Purkinje meters, presented in recent years, with dynamic examination of the IOL position according to the optical axis of the IOL. Full article
(This article belongs to the Special Issue Inventions and Innovations in Optical Sensing Materials and Devices)
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13 pages, 455 KiB  
Review
Do Atopic Dermatitis and Psoriasis Have an Impact on Cognitive Decline—Latest Research Review
by Marcin Kuryłło and Ewa Mojs
Healthcare 2024, 12(12), 1170; https://doi.org/10.3390/healthcare12121170 (registering DOI) - 10 Jun 2024
Abstract
Background: Atopic dermatitis and psoriasis are chronic skin diseases that affect the mental health of patients. The relationship between AD and psoriasis and cognitive processes in patients remains unclear. The aim of the review was to answer the question of whether AD and [...] Read more.
Background: Atopic dermatitis and psoriasis are chronic skin diseases that affect the mental health of patients. The relationship between AD and psoriasis and cognitive processes in patients remains unclear. The aim of the review was to answer the question of whether AD and psoriasis have an impact on cognitive decline in patients. Method: A systematic literature search was conducted on PubMed and EBSCO to identify case–control, cross-sectional, or cohort studies that evaluated the association between atopic dermatitis and psoriasis and cognitive impairment. Results: Most of the studies included in the review confirmed cognitive decline in patients with atopic dermatitis and psoriasis. Conclusions: It seems that atopic dermatitis and psoriasis may negatively affect cognitive processes such as working memory, concentration, attention, and speed of motor reactions. Psychological interventions targeting distorted cognitive processing could improve the quality of life of patients with atopic dermatitis and psoriasis. Full article
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17 pages, 5924 KiB  
Article
Abundance and Species Richness of Lianas in a Karst Seasonal Rainforest: The Influence of Abiotic and Biotic Factors
by Jianxing Li, Fang Lu, Dongxing Li, Bin Wang, Yili Guo, Shujun Wen, Fuzhao Huang, Wanglan Tao, Nianwu Tang, Xiankun Li and Wusheng Xiang
Forests 2024, 15(6), 1011; https://doi.org/10.3390/f15061011 (registering DOI) - 10 Jun 2024
Abstract
Lianas are a crucial component of karst seasonal rainforests, yet research on them has predominantly focused on non-karst regions. Consequently, their abundance and species richness remain relatively understudied within karst ecosystems. We aimed to document the abundance and species richness of lianas and [...] Read more.
Lianas are a crucial component of karst seasonal rainforests, yet research on them has predominantly focused on non-karst regions. Consequently, their abundance and species richness remain relatively understudied within karst ecosystems. We aimed to document the abundance and species richness of lianas and investigate their relationships with abiotic and biotic factors, based on data from a fully mapped 15 ha plot in a karst seasonal rainforest of Nonggang (SW China). Structural equation models (SEMs) were employed to estimate the path coefficients and variation of dependent variables, enabling a comprehensive analysis of the factors affecting the abundance and species richness of liana. Within the 15 ha plot, a total of 23,819 lianas were identified, encompassing 113 species from 34 families. These lianas constituted 24.16% of the total woody plant density and 33.44% of the species present, but only 4.32% of the total woody plant basal area. Lianas are primarily influenced by abiotic factors, especially elevation and phosphorus (P), with less impact from biotic factors. Our findings reveal that lianas, despite constituting a relatively small percentage of the total woody plant basal area, significantly contribute to the density and diversity of the forest. Notably, abiotic factors such as elevation and phosphorus availability predominantly shape the distribution and richness of lianas, highlighting the importance of these environmental variables. The findings offer valuable insights for future liana studies and the preservation of karst forests’ biodiversity. Full article
(This article belongs to the Special Issue Biodiversity in Forests: Management, Monitoring for Conservation)
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16 pages, 3555 KiB  
Article
JNK Signaling Positively Regulates Acute Ethanol Tolerance in C. elegans
by Changhoon Jee and Enkhzul Batsaikhan
Int. J. Mol. Sci. 2024, 25(12), 6398; https://doi.org/10.3390/ijms25126398 (registering DOI) - 10 Jun 2024
Abstract
Alcohol use disorder (AUD) is a chronic neurobehavioral condition characterized by a cycle of tolerance development, increased consumption, and reinstated craving and seeking behaviors during withdrawal. Understanding the intricate mechanisms of AUD necessitates reliable animal models reflecting its key features. Caenorhabditis elegans ( [...] Read more.
Alcohol use disorder (AUD) is a chronic neurobehavioral condition characterized by a cycle of tolerance development, increased consumption, and reinstated craving and seeking behaviors during withdrawal. Understanding the intricate mechanisms of AUD necessitates reliable animal models reflecting its key features. Caenorhabditis elegans (C. elegans), with its conserved nervous system and genetic tractability, has emerged as a valuable model organism to study AUD. Here, we employ an ethanol vapor exposure model in Caenorhabditis elegans, recapitulating AUD features while maintaining high-throughput scalability. We demonstrate that ethanol vapor exposure induces intoxication-like behaviors, acute tolerance, and ethanol preference, akin to mammalian AUD traits. Leveraging this model, we elucidate the conserved role of c-jun N-terminal kinase (JNK) signaling in mediating acute ethanol tolerance. Mutants lacking JNK signaling components exhibit impaired tolerance development, highlighting JNK’s positive regulation. Furthermore, we detect ethanol-induced JNK activation in C. elegans. Our findings underscore the utility of C. elegans with ethanol vapor exposure for studying AUD and offer novel insights into the molecular mechanisms underlying acute ethanol tolerance through JNK signaling. Full article
(This article belongs to the Special Issue C. elegans as a Disease Model: Molecular Perspectives)
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24 pages, 9809 KiB  
Article
Wind-Induced Response Analysis and Fatigue Reliability Study of a Steel–Concrete Composite Wind Turbine Tower
by Meng Zhang, Bing Liu, Chongqi Gao, Md Nayim Hossain and Guifeng Zhao
Buildings 2024, 14(6), 1740; https://doi.org/10.3390/buildings14061740 (registering DOI) - 10 Jun 2024
Abstract
Taking an actual 3MW steel–concrete composite wind turbine tower as an example, a finite element model of the tower structure was established, and static bearing capacity and dynamic time history response analyses were performed to identify the locations where the structure is prone [...] Read more.
Taking an actual 3MW steel–concrete composite wind turbine tower as an example, a finite element model of the tower structure was established, and static bearing capacity and dynamic time history response analyses were performed to identify the locations where the structure is prone to failure. On this basis, the fatigue lives of the turbine tower at the most unfavorable locations were predicted using linear cumulative damage theory, and the fatigue reliability at the corresponding locations of the structure was calculated using the kriging–subset simulation method. The most dangerous locations of the tower that are most prone to failure are as follows: the bottom of the leeward side of the upper steel tube, the flange of the steel tube, the bolt-hole imprinting surface of the flange, the leeward side of the transition tube, and the top of the leeward side of the concrete tube. The failure risk of the flange and bolt-hole imprinting surface of the upper steel tube is relatively high, followed by that of the transition tube. This indicates that special attention should be given to the design and daily maintenance of this part. The fatigue resistance of the tower can be enhanced by improving the strength of the flange plate or increasing the number of bolts and strengthening the transition tube. Full article
(This article belongs to the Special Issue Wind Load Effects on High-Rise and Long-Span Structures)
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