Coriolopsis spp. are wood-decaying fungi that inhabit forests. They are mainly distributed in tropical and subtropical areas. Strain Epi910 was isolated from the asymbiotically germinated protocorm of Epidendrum sp. and identified as Coriolopsis strumosa. Symbiotic germination and high-throughput sequencing of the endophytic fungal communities of different parts were performed to characterize the function and spatial distribution of the Epi910 isolate. Under symbiotic germination, Epi910 promoted seed germination and seedling formation as an endophytic native fungus of Epidendrum sp. Endophytic fungal communities from seven different parts of Epidendrum sp. were characterized. In total, 645 OTUs were identified; 30 OTUs were shared among all seven parts. The internal transcribed spacer sequence of Epi910 was identical to that of a dominant shared OTU (OTU6). The relative abundance of OTU6 in the seven parts was identified as follows: capsule pericarp > seed > root > asymbiotically germinated protocorm > epiphytic root > ovary > rachis. Our results suggest that the isolate belonging to Coriolopsis strumosa could promote the germination of Epidendrum sp. There may, therefore, be endophytic fungi other than common orchid mycorrhizal fungi with the ability to enhance germination in orchids. Full article

The change in extreme precipitation events in the conterminous United States (CONUS) has been of interest to the research communities in recent years for its intensification under environmental and climate change. Previous studies have not yet used sub-hourly precipitation observations to examine convective precipitation change over the CONUS. This study aims to fill the gap by examining convective precipitation, identified by radar reflectivity, in the CONUS using the state-of-the-art Multi-radar Multi-sensor data, operated at the NOAA/National Severe Storms Laboratory, with an unprecedentedly high spatial (1 km) and temporal (2 min) resolutions. These high-resolution data are expected to better capture the precipitation peak and the precipitation pattern. The results showed that in CONUS, precipitation reflectivity increased both in magnitude and the number of convective days from 2015 to 2021. For example, in 2019, 60% of areas showed an increase in the magnitude of precipitation, and the average number of convective days over CONUS has increased by 19%. Changes in precipitation also vary by season and region. This study highlights the need for continued monitoring and understanding of the evolving pattern of extreme precipitation in the CONUS, especially at sub-hourly frequency, as it exposes significant impacts on various sectors, including agriculture, infrastructure, and human health. Full article

Youth work is not unitary, has a diverse history, and draws upon differing traditions; however, the focus of all major youth work traditions has been anthropocentric. This approach is now challenged by young people themselves through the climate justice movement, and institutionally through the United Nations Agenda 2030 resolution, which has developed integrated Sustainable Development Goals, which aim to “balance” social, environmental, and economic imperatives. This article examines what insights can be gained from ecopedagogy that would enable youth work to fully integrate an ecological perspective alongside traditional anthropological concerns. The discussion focuses on the nexus and tensions between ecopedagogy and youth work from a theoretical perspective to draw out insights into how changes need to be made to the aims and purposes of youth work, how this might be achieved, and barriers in the current environment. Full article

HSG (high-sulfur gas) reservoirs are prevalent globally, yet their exploitation is hindered by elevated levels of hydrogen sulfide. A decrease in temperature and pressure may result in the formation of sulfur deposits, thereby exerting a notable influence on gas production. Test instruments are susceptible to significant corrosion due to the presence of hydrogen sulfide, resulting in challenges in obtaining bottom hole temperature and pressure test data. Consequently, a WTD (wellbore temperature distribution) model incorporating sulfur precipitation was developed based on PPP (physical property parameter), heat transfer, and GSTP (gas–solid two-phase) flow models. The comparison of a 2.53% temperature error and a 4.80% pressure error with actual field test data indicates that the established model exhibits high accuracy. An analysis is conducted on the impact of various factors, such as production, sulfur layer thickness, reservoir temperature, and reservoir pressure, on the distribution of the wellbore temperature field and pressure field. Increased gas production leads to higher wellhead temperatures. The presence of sulfur deposits reduces the flow area and wellhead pressure. A 40% concentration of hydrogen sulfide results in a 2 MPa pressure drop compared to a 20% concentration. Decreased reservoir pressure and temperature facilitate the formation of sulfur deposits at the wellhead. Full article

Several years of research into the small circular DNA molecules called SPHINX and BMMF (SPHINX/BMMF) have provided information on several areas of research, medicine, microbiology and nutritional science. But there are still open questions that have not yet been addressed. Due to the unclear classification, evolution and sources of SPHINX/BMMF, a risk assessment is currently not possible. However, risk assessment is necessary as SPHINX/BMMF are suspected to be involved in the development of cancer and neurodegenerative diseases. In order to obtain an overview of the current state of research and to identify research gaps, a review of all the publications on this topic to date was carried out. The focus was primarily on the SPHINX/BMMF group 1 and 2 members, which is the topic of most of the research. It was discovered that the SPHINX/BMMF molecules could be integral components of mammalian cells, and are also inherited. However, their involvement in neurodegenerative and carcinogenic diseases is still unclear. Furthermore, they are probably ubiquitous in food and they resemble bacterial plasmids in parts of their DNA and protein (Rep) sequence. In addition, a connection with bacterial viruses is also suspected. Ultimately, it is still unclear whether SPHINX/BMMF have an infectious capacity and what their host or target is. Full article

Understanding the motivations and decisions behind COVID-19 vaccine acceptance is crucial for designing targeted public health interventions to address vaccine hesitancy. We conducted a qualitative analysis to explore COVID-19 vaccine acceptance among diverse ethnic subgroups of Black Americans in the United States. This study investigates the 2021–2022 responses of 79 African American, Afro-Caribbean, and African respondents over the age of 18 in Washington State and Texas. Respondents were asked “Do you plan to get the COVID-19 vaccination?” Qualitative responses were analyzed by content category and ethnic subgroup. Of the 79 responses, 60 expressed favorable perceptions, 16 expressed unfavorable perceptions, and 3 expressed neutral perceptions. Dominant categories among participants in favor of the vaccine included personal health (26), concern for health of family/or community members (13), and desire to protect others (11). Among the 42 vaccinated African American respondents, the primary motivation was personal health (20). The 12 unvaccinated African American respondents cited fear of side effects as their dominate motivation. Caribbean respondents cited family or elders as motivation for their decision. African respondents were nearly unanimous in taking the vaccine (13/16), citing trust in health care, protecting friends and family, and personal health as reasons. Community and personal relationships were critical decision-making factors in accepting the COVID-19 vaccine, with African Americans having the strongest hesitancy. Full article

In this study, we aimed to identify suitable herbicides for quinoa fields in Anhui Province and explore the value of their potential application in order to achieve the sustainable weed management of the crop and tackle the global issue of unregistered herbicides in quinoa fields. Employing a pre-emergence seed soaking method, we evaluated the effects of different herbicides, such as anilofos, prometryn, pendimethalin, and atrazine on the germination inhibition rate of quinoa seeds, as well as their impacts on the growth indicators of quinoa seedlings. Our findings show that, while these herbicides initially suppressed quinoa seed germination, this effect decreased over time, allowing for the successful germination of all seeds, suggesting the existence of a recovery mechanism in quinoa. An increase in herbicide concentration was correlated with significant decreases in the germination vigor and index of quinoa seeds, along with a decrease in plant height, root length, and fresh weight. Notably, anilofos, prometryn, pendimethalin, and atrazine demonstrated significant inhibitory effects on quinoa seedlings, thus providing critical insights into the sensitivity of quinoa to these chemicals. Greenhouse pot experiments showed that pre-emergence herbicides, such as napropamide, pretilachlor, s-metolachlor, and anilofos, and post-emergence herbicides, including fluroxypyr, penoxsulam, clethodim, quizalofop-P-ethyl, oxaziclomefone, metamifop, benzobicyclon, nicosulfuron, and pinoxaden, are safe for quinoa and suitable for further field trials, broadening the options for integrated weed management strategies. The results of the mixture experiments indicated that penoxsulam and metamifop are safe for quinoa at a ratio of 1:4.6, and their combined activities against dominant weeds in quinoa fields in Anhui Province, such as Digitaria sanguinalis, Cyperus iria, and Amaranthus viridis, were higher than those of single-agent doses, with fresh weight inhibition rates ranging from 66.98% to 92.16% and selectivity indexes ranging from 176.88 to 3282.17. Therefore, this mixture offers a promising approach to enhanced weed control in a sustainable manner. Full article

Community inclusion is a human right for all people, including people with mental illness. It is also an important part of individualized support to enable people experiencing mental illness to live in their preferred communities and to recover. In Taiwan, no study has investigated the social experiences of healthcare professionals. To fill this knowledge gap and inform ongoing mental health system strengthening, this study examined the not-in-my-backyard (NIMBY) phenomenon observed while establishing community mental health clubhouses in Taiwan and corresponding experiences of community inclusion. Data were collected through semi-structured interviews of 16 purposively sampled frontline healthcare professionals from Taiwanese mental health clubhouses. Data were analyzed using qualitative content analysis. Two themes were identified: “NIMBY phenomenon: Community residents’ resistance to clubhouses” and “Measures adopted by the clubhouse for community inclusion”. Two categories with eleven subcategories emerged. The findings demonstrate the following conclusions. First, the NIMBY phenomenon is related to the stigmatization and discrimination faced by individuals with mental disorders in society. Second, in Asian societies, mental disorders are associated with a particular social and cultural context. Third, the fear and rejection of individuals with mental disorders deepen their social exclusion. Forth, community mental health clubhouse models employ seven strategic approaches to community inclusion, listed as follows: capacity building for individuals, direct interaction with the public through community activities, provision of community services, life skills training, repairing and managing neighborhood relationships, assisting individuals in obtaining community employment, and conducting social education for community residents. Clearly, we need to combat social exclusion of people with mental illness and promote inclusive and accessible services and systems across sectors. Full article

Objectives: The goal of our study was to determine the incidence of cerebellar atrophy, assess the imaging findings in the posterior fossa and determine the incidence of hippocampal sclerosis in a cohort of pediatric patients with confirmed tuberous sclerosis complex (TSC). Material and methods: MRI studies of 98 TSC pediatric patients (mean age 7.67 years) were evaluated for cerebellar atrophy, cerebral/cerebellar tubers, white matter lesions, subependymal nodules, subependymal giant cell astrocytomas, ventriculomegaly, and hippocampal sclerosis. Clinical charts were revisited for clinical symptoms suggesting cerebellar involvement, for seizures and treatment for seizures, behavioral disorders and autism. Results: Cerebral tubers were present in 97/98 cases. In total, 97/98 had subependymal nodules, 15/98 had SEGA, 8/98 had ventriculomegaly and 4/98 had hippocampal sclerosis. Cerebellar tubers were found in 8/98 patients (8.2%), whereas cerebellar atrophy was described in 38/98 cases (38.8%). In 37/38 patients, cerebellar volume loss was mild and diffuse, and only one case presented with left hemi-atrophy. Briefly, 32/38 presented with seizures and were treated with anti-seizure drugs. In total, 8/38 (21%) presented with behavioral disorders, 10/38 had autism and 2/38 presented with seizures and behavioral disorders and autism. Conclusions: Several studies have demonstrated cerebellar involvement in patients with TSC. Cerebellar tubers differ in shape compared with cerebral tubers and are associated with cerebellar volume loss. Cerebellar atrophy may be focal and diffuse and one of the primary cerebellar manifestations of TSC, especially if a TSC2 mutation is present. Cerebellar degeneration may, however, also be secondary/acquired due to cellular damage resulting from seizure activity, the effects of anti-seizure drugs and anoxic–ischemic injury from severe seizure activity/status epilepticus. Further, prospective studies are required to identify and establish the pathogenic mechanism of cerebellar atrophy in patients with TSC. Full article

In engineering, the stress state of expanded tubes is crucial for ensuring structural integrity and preventing stress corrosion cracking. The analysis of stresses and strains in tubes subjected to mechanical expansion using an ogive bullet is essential, yet existing theoretical methods for estimating the stress distributions, especially with spherical and ogive shapes, are sparse. This study explores the expansion of 3/8 inch copper and stainless-steel tubes using an expanding bullet, where tangential and longitudinal strains are measured. A novel analytical approach is introduced to evaluate the stresses and strains, segmenting the tube into three zones, each analyzed with a distinct theory. Validation is achieved through an axisymmetric finite element model that employs a multi-linear kinematic hardening material behavior. The analytical model also estimates the expanding mandrel’s push force, which is then compared with the results from numerical simulations and experimental data, showing good agreement across methods. Full article

The initial Swedish discourse of transnational adoption as a win-win situation has changed over its more than 60-year-long history. This article aims to trace and present some themes in this history, with a particular focus on the public debate and the different narratives that representatives of the adoption triangle—the adoptees, the adoptive parents, and the biological parents—tell when dealing with transnational and transracial adoption as a personal and political phenomenon. The article draws from an ongoing study of discourses and narratives of transnational adoption based, above all, on journalism, memoirs, governmental documents, and previous research. It attempts to present the contradictory perspectives on transnational adoption to create a diffractive pattern. The diffractive analysis makes it possible to show how the investigated narratives and discourses on transnational adoption change in encounters with experiences made, and even more so, made visible and knowledgeable, in social practices. Full article

Sea level rise due to global warming is a continuing and, disappointingly, accelerating process which has already affected and will further impact coastal lowlands and the social and economic activities in these areas. Delos Island, situated in the middle of the Cyclades in the Aegean Sea, was considered the most sacred of all islands in ancient Greek culture and was a trading hub for the entire eastern Mediterranean. Uninhabited since the 7th century AD, and consistently the focus of research and touristic attention, the island is designated as an archaeological site and inscribed on the UNESCO World Heritage List. Previous studies on the relative sea level (rsl) changes suggest a steadily rising rsl during the last 6300 years, starting from a sea level of −4.80 ± 0.20 m in the Late Neolithic. The seafront of the ancient city of Delos is subject to the effects of rsl rise, which have caused significant coastline retreat and exposure to the northerly winds and waves, whereas parts of the coastal lowland, where the remains of the ancient city lie, are inundated, forming extended wetlands. The future impacts of rsl rise on the seafront of ancient Delos are illustrated on very-high-resolution digital surface models, evaluating both the flooding risk under different climatic projections, as provided by the IPCC AR6 report, and the ongoing land subsidence, as recorded by GNSS data. An rsl rise ranging from 87 cm (SSP1-2.6 scenario) to 148 cm (SSP5-8.5 scenario) is anticipated by 2150, requiring both resilience strategies and adaptation solutions as well as mitigation policies to cope with the effects of climate change. Full article

The expression and function of podoplanin (PDPN) in the normal human placenta has been debated in placental evaluation. This study emphasizes the importance of a multimodal approach of PDPN expression in normal human placentas. A complete examination is performed using immunohistochemistry, RNAscope and automated Digital Image examination (DIA) interpretation. QuPath DIA-based analysis automatically generated the stromal and histological scores of PDPN expression for immunohistochemistry and RNAscope stains. The umbilical cord’s isolated fibroblasts and luminal structures expressed PDPN protein and PDPN_mRNA. RNAscope detected PDPN_mRNA upregulation in syncytial placental knots trophoblastic cells, but immunohistochemistry did not certify this at the protein level. The study found a significant correlation between the IHC and RNAscope H-Score (p = 0.033) and Allred Score (p = 0.05). A successful multimodal strategy for PDPN assessment in human placentas confirmed PDPN expression heterogeneity in the full-term human normal placenta and umbilical cord at the protein and mRNA level. In placental syncytial knots trophoblastic cells, PDPN showed mRNA overexpression, suggesting a potential role in placenta maturation. Full article

One of the several differences between Modern European Portuguese (EP) and Modern Brazilian Portuguese (BP) is the prepositional expression of complements licensed by the preposition a. While in EP the preposition a occurs in several contexts, this element has been substituted by other strategies in BP, as is extensively discussed in the literature. The aim of this paper is to investigate the historical behavior of a-marked prepositional accusatives (PP-ACC) in Portuguese. In order to do so, a search was conducted for PP-ACCs in the Historical Portuguese Corpus Tycho Brahe. The results showed an increase of PP-ACCs in the 17th century, followed by a decrease in the 18th century. Thereafter, unmarked accusatives (NP-ACC) were analyzed in the corpus, which resulted in 7756 sentences, contrasting with 624 PP-ACCs in the same contexts. This result shows that the a-marked accusative is far less common than bare accusatives in Historical Portuguese. Psych verbs, however, behaved differently, showing a constant increase in PP-ACCs. In EP, the preposition a still introduces Experiencer arguments in structures with some psych verbs (O vinho agradou ao João—lit. ‘The wine pleased ‘to’ John’). In BP, the preposition a has disappeared in psych predicates (O vinho agradou Ø o João—‘The wine pleased John’). In both Modern EP and BP, most PP-ACCs have become typical unmarked direct objects. In the context of psych verbs, however, structural accusative assignment has shifted to structural dative Case in Modern EP, so as to ascertain the interpretation of the Experiencer in the internal argument via the preposition a. While in Modern BP, the argument is not overtly marked since it receives inherent accusative case in the derivation. Full article

The frequency of freshwater cyanobacterial blooms is increasing globally due to climate change and eutrophication, particularly in reservoirs. Reservoir ecosystems exhibit unique characteristics, and there is a complex relationship between factors such as light, temperature, nutrient salts, hydrology, and algal growth. The impact of the other factors on algal growth varies significantly among different reservoirs. Thus, it is crucial to assess the effectiveness of various algal control measures implemented in different reservoirs. This study conducted a comprehensive assessment by establishing a eutrophication model for the Shanzi Reservoir in Fuzhou City. The model incorporated meteorology, hydrology, carbon dynamics, nutrient cycling, and biological communities. The effectiveness of diverse management measures was systematically evaluated. The findings demonstrate that increasing the water level, reducing nutrient salts in sediments, and implementing ecological fish stocking effectively suppressed algal growth to varying degrees and improved nitrogen and phosphorus levels. Lower water levels and ecological fish stocking had a significant impact on algal reproduction, while sediment reduction had a minimal effect. Conversely, lower water levels and ecological fish stocking did not significantly improve nitrogen and phosphorus concentrations in the reservoir, whereas sediment reduction had a noticeable effect. Consequently, the management strategies for the Shanzi Reservoir should prioritize external control measures and the implementation of ecological fish stocking. Full article

Extraintestinal pathogenic Escherichia coli (ExPEC) strains are capable of causing various systemic infections in both humans and animals. In this study, we isolated and characterized 30 E. coli strains from the parenchymatic organs and brains of young (<3 months of age) camel calves which died in septicemia. Six of the strains showed hypermucoviscous phenotype. Based on minimum inhibitory concentration (MIC) values, seven of the strains were potentially multidrug resistant, with two additional showing colistin resistance. Four strains showed mixed pathotypes, as they carried characteristic virulence genes for intestinal pathotypes of E. coli: three strains carried cnf1, encoding cytotoxic necrotizing factor type 1, the key virulence gene of necrotoxigenic E. coli (NTEC), and one carried eae encoding intimin, the key virulence gene of enteropathogenic E. coli (EPEC). An investigation of the integration sites of pathogenicity islands (PAIs) and the presence of prophage-related sequences showed that the strains carry diverse arrays of mobile genetic elements, which may contribute to their antimicrobial resistance and virulence patterns. Our work is the first to describe ExPEC strains from camels, and points to their veterinary pathogenic as well as zoonotic potential in this important domestic animal. Full article

This work aims to investigate the effect of liquid physical properties on the behavior of binary droplets impact on the heated smooth aluminum alloy plate with a high-speed imaging system. Two groups of mixed solutions with similar boiling point differences are selected as the working liquid, in which the low-boiling-point components are both ethanol and the high-boiling point components are propanol and water, respectively. Compared to the ethanol/propanol binary droplets, the experimental results show that the ethanol/water binary droplets have diverse impact phenomena and significantly broad transition boiling regimes, as well as the reduced droplet residence time and increased Leidenfrost temperature point. With the decreasing ethanol content in ethanol/water binary droplets, these effects become more prominent. For secondary atomization, the ethanol/water binary droplet undergoes parent droplet breakup into fragment droplets with larger diameters (D_s > 0.3 mm). Both binary droplets produce satellite droplets with small diameters (D_s < 0.3 mm) by puffing and ejection. In terms of the ethanol/propanol binary droplet impact, the probability of puffing is higher and the satellite droplet diameters are small. In the ethanol/water binary droplet impact, the probability of ejection is higher and the satellite droplet diameter distribution is wider. When an ethanol/water binary droplet of 25 vol.% ethanol content impacts the heated wall at T_s = 120 °C, a novel large bubble shrinkage phenomenon occurs at the late stage of droplet evaporation. This phenomenon is proposed to be relevant to the increasing surface tension and saturation temperature with decreasing ethanol content, as well as the decreasing ambient temperature above the top surface of the bubble. Full article

It has been discovered that the peel of a pumpkin (Cucurbita maxima), regarded as a waste product of pumpkin processing, has significant amounts of carotenoids and other antioxidants. This study aims to identify the most effective extraction parameters for an ultrasonic-assisted extraction method to extract the total carotenoids (TCs) and assess the antioxidant activity (AA) of pumpkin peel. To determine the effects of the extraction time, temperature, and material-to-solvent ratio on the recovery of TCs and AA, a response surface methodology utilizing the central composite design (CCD) was used. The extraction temperature (6.25–98.75 °C), extraction duration (13.98–128.98 min), and solvent ratio (0.23–50.23 mL) were the variables studied in the coded form of the experimental plan. The carotenoid concentration varied from 0.53 to 1.06 mg/g DW, while the AA varied from 0.34 to 7.28 µM TE/g DW. The findings indicated that the optimal extraction parameters were an 80 °C temperature, a 10 mL solvent ratio, and a 100 min extraction time. The study confirmed that the optimum extraction conditions resulted in an experimental TC yield of 0.97 mg/g DW and an AA of 7.25 µM TE/g DW. Overall, it should be emphasized that the extraction process can be enhanced by setting the operating factors to maximize the model responses. Full article

There are many works associating the presence of nitrate in water and the occurrence of cancer in humans. The most common method for quantifying nitrate in water is based on the use of toxic cadmium as a reductant. In this work, a new approach was developed for the quantification of nitrate in bottled water with indirect spectrophotometry using Zn⁰ as a reductant. Nitrate is reduced to nitrite using Zn⁰ in a buffered medium (acetate/acetic acid) and quantified with visible spectrophotometry using the Griess reaction between sulfanilamide and N-(1-naphthyl)-ethylenediamine. The influence of pH, buffer solution (constitution and concentration), Zn⁰ (mass and granulometry), and agitation time on the efficiency of nitrite generation was evaluated. The optimal conditions were an acetate–acetic acid buffer solution with a concentration and pH of 0.75 mol L⁻¹ and 6.00, respectively, and a Zn⁰ particle size of 20 MESH and Zn⁰ mass of 300 mg. The limits of detection and quantification (LoD and LoQ) were 0.024 and 0.08 mg L⁻¹, respectively. The method’s accuracy and precision were evaluated using the analysis of commercial bottled water. In conclusion, the use of Zn⁰ instead of cadmium provided a green method with excellent LoD/LoQ. Further, the method proved to be simple and easy to apply during outdoor analysis. Full article

Lanthanide elements such as europium exhibit distinctive emissions due to the transitions of inner-shell 4f electrons. Inorganic materials containing lanthanide elements have been widely used as phosphors in conventional displays. The hybridization of lanthanide ions with organic components enables to control of the material’s shapes and properties and broadens the possibility of lanthanide compounds as inorganic–organic materials. Lanthanide ion-containing polyoxometalate anions (Ln-POM) are a promising category as an inorganic component to design and synthesize inorganic–organic hybrids. Several inorganic–organic Ln-POM systems have been reported by hybridizing with cationic surfactants as luminescent materials. However, single-crystalline ordering has not been achieved in most cases. Here, we report syntheses and structures of inorganic–organic hybrid crystals of lanthanide-based POM and bolaamphiphile surfactants with two hydrophilic heads in one molecule. An emissive decatungstoeuropate ([EuW₁₀O₃₆]⁹⁻, EuW₁₀) anion was employed as a lanthanide source. The bolaamphiphile counterparts are 1,8-octamethylenediammonium ([H₃N(CH₂)₈NH₃]²⁺, C₈N₂) and 1,10-decamethylenediammonium ([H₃N(CH₂)₁₀NH₃]²⁺, C₁₀N₂). Both hybrid crystals of C₈N₂-EuW₁₀ and C₁₀N₂-EuW₁₀ were successfully obtained as single crystals, and their crystal structures were unambiguously determined using X-ray diffraction measurements. The photoluminescence properties of C₈N₂-EuW₁₀ and C₁₀N₂-EuW₁₀ were investigated by means of steady-state and time-resolved spectroscopy. The characteristic emission derived from the EuW₁₀ anion was retained after the hybridization process. Full article

Cardiovascular diseases are the most common causes of mortality and disability worldwide. Eicosanoids are a group of bioactive metabolites that are mainly oxidized by arachidonic acid. Eicosanoids play a diverse role in cardiovascular diseases, with some exerting beneficial effects while others have detrimental consequences. However, a causal relationship between eicosanoid levels and cardiovascular disease remains unclear. Six single nucleotide polymorphisms (SNPs) with strong associations with plasma eicosanoid levels were selected. Summary-level data for cardiovascular disease were obtained from publicly available genome-wide association studies. A two-sample MR analysis identified that plasma eicosanoid levels were inversely correlated with unstable angina pectoris (OR 1.06; 95% CI 1–1.12; p = 0.04), myocardial infarction (OR 1.05; 95% CI 1.02–1.09; p = 0.005), ischemia stroke (OR 1.05; 95% CI 1–1.11; p = 0.047), transient ischemic attack (OR 1.03; 95% CI 1–1.07; p = 0.042), heart failure (OR 1.03; 95% CI 1.01–1.05; p = 0.011), and pulmonary embolism (OR 1.08; 95% CI 1.02–1.14; p = 1.69 × 10⁻⁶). In conclusion, our data strongly suggest a genetic causal link between high plasma eicosanoid levels and an increased cardiovascular disease risk. This study provides genetic evidence for treating cardiovascular diseases. Full article