Background: The aim of this study was to determine if the rise in new surgical procedures for glaucoma is changing the baseline features of patients. Methods: In this retrospective study, we reviewed the baseline features of patients undergoing their first glaucoma surgery in 2011 and 2021, collecting data regarding intraocular pressure (IOP), visual field (VF) parameters, stage of disease, and the type of surgery. Results: In the study, 455 patients were included in the analysis. From these, 230 eyes had glaucoma surgery performed in 2011 (Group A) and 225 eyes in 2021 (Group B). When considering the baseline features, Group A was older than Group B (72.7 ± 10.7 and 70 ± 12.4 years; p = 0.02, respectively), and showed a significantly more advanced VF mean defect (−16.4 ± 8.8 and −13.8 ± 8.7 dB; p < 0.01, respectively) and a higher IOP (25.9 ± 6.6 and 24.9 ± 7.8 mmHg; p = 0.02, respectively). Overall, severe VF damage at the time of surgery was more frequent in Group A (74.3%) than in Group B (60.8%) (p < 0.01). The overall number of traditional glaucoma surgeries was 211 in 2011, reducing to 94 ten years later, with similar severe pre-operative VF defects. In 2021, minimally invasive bleb surgery (MIBS) represented 58% of all surgeries. Conclusions: In the last ten years, patients receiving glaucoma surgery for the first time were younger, had less severe disease, and a more contained IOP. The baseline feature modifications were probably related to the diffusion of new procedures, especially MIBS, which allowed for treating patients at an earlier stage, reserving traditional procedures for advanced cases. Full article

The application of chemical operations in food processing, in which pure chemical compounds are used to modify food ingredients, often raises social concerns. One of the most frequently modified dietary substances is starch, e.g., E1401–E1404, E1412–E1414, E1420, E1422, E1440, E1442, and E1450–E1452. An alternative solution to chemical treatments seems to be the use of raw materials naturally containing substrates applied for starch modification. Heating starch with a lemon juice concentrate can be considered a novel and effective method for producing starch citrate, which is part of the so-called “green chemistry”. The modified preparations obtained as a result of potato starch esterification with natural lemon juice had a comparable degree of esterification to that of the esters produced with pure citric acid. In addition, the use of the juice doubled their resistance to amylolytic enzymes compared to the preparations made with pure acid. Replacing citric acid with lemon juice can facilitate the esterification process, and the analyzed properties of both types of modified preparations indicate that starch esters produced with pure citric acid can be successfully replaced by those produced using natural lemon juice, which may increase the social acceptance of these modified preparations. Full article

Consider a collection of entities moving continuously with bounded speed, but otherwise unpredictably, in some low-dimensional space. Two such entities encroach upon one another at a fixed time if their separation is less than some specified threshold. Encroachment, of concern in many settings such as collision avoidance, may be unavoidable. However, the associated difficulties are compounded if there is uncertainty about the precise location of entities, giving rise to potential encroachment and, more generally, potential congestion within the full collection. We adopt a model in which entities can be queried for their current location (at some cost) and the uncertainty region associated with an entity grows in proportion to the time since that entity was last queried. The goal is to maintain low potential congestion, measured in terms of the (dynamic) intersection graph of uncertainty regions, at specified (possibly all) times, using the lowest possible query cost. Previous work in the same uncertainty model addressed the problem of minimizing the congestion potential of point entities using location queries of some bounded frequency. It was shown that it is possible to design query schemes that are $O\left(1\right)$-competitive, in terms of worst-case congestion potential, with other, even clairvoyant query schemes (that exploit knowledge of the trajectories of all entities), subject to the same bound on query frequency. In this paper, we initiate the treatment of a more general problem with the complementary optimization objective: minimizing the query frequency, measured as the reciprocal of the minimum time between queries (granularity), while guaranteeing a fixed bound on congestion potential of entities with positive extent at one specified target time. This complementary objective necessitates quite different schemes and analyses. Nevertheless, our results parallel those of the earlier papers, specifically tight competitive bounds on required query frequency. Full article

Although glaucoma is a leading cause of irreversible blindness worldwide, its pathogenesis is incompletely understood, and intraocular pressure (IOP) is the only modifiable risk factor to target the disease. Several associations between the gut microbiome and glaucoma, including the IOP, have been suggested. There is growing evidence that interactions between microbes on the ocular surface, termed the ocular surface microbiome (OSM), and tear proteins, collectively called the tear proteome, may also play a role in ocular diseases such as glaucoma. This study aimed to find characteristic features of the OSM and tear proteins in patients with glaucoma. The whole-metagenome shotgun sequencing of 32 conjunctival swabs identified Actinobacteria, Firmicutes, and Proteobacteria as the dominant phyla in the cohort. The species Corynebacterium mastitidis was only found in healthy controls, and their conjunctival microbiomes may be enriched in genes of the phospholipase pathway compared to glaucoma patients. Despite these minor differences in the OSM, patients showed an enrichment of many tear proteins associated with the immune system compared to controls. In contrast to the OSM, this emphasizes the role of the proteome, with a potential involvement of immunological processes in glaucoma. These findings may contribute to the design of new therapeutic approaches targeting glaucoma and other associated diseases. Full article

We report the case of a 55-year-old man with multi-symptomatic transverse myelitis after vaccination against coronavirus disease 2019 (COVID-19). The patient was diagnosed based on the course of the disease and the results of imaging and laboratory tests. We excluded other most probable causes of the disease. The quick start of diagnosis allowed for early treatment with intravenous steroids and then plasmapheresis and the implementation of modern rehabilitation methods using biofeedback platforms, among others, and an exoskeleton. The patient returned to work, but the rehabilitation process continues to this day due to persistent symptoms that impair the patient’s quality of life. Full article

The increasing range of faults encountered by mechanical systems has brought great challenges for conducting intelligent fault diagnosis based on insufficient samples, in recent years. To tackle the issue of unbalanced samples, an improved methodology based on a generative adversarial network that uses sample generation and classification is proposed. First, 1D vibration signals are transformed into 2D images considering the features of the vibrating signals. Next, the optimized generation adversarial network is constructed for adversarial training to synthesize diverse fake 2D images according to actual sample characteristics with the generative model as a generator and the discriminative model as a discriminator. Our model uses an attenuated learning rate with a cross-iteration batch normalization layer to enhance the validity of the generator. Last, the discriminative model as a classifier is used to identify the fault states. The experimental results demonstrate that the proposed strategy efficiently improves fault identification accuracy in the two cases of sample imbalance. Full article

The utilization of bismuth as a sensing material for the detection of heavy metal ions has gained significant attention due to its exceptional interfacial activity and selective absorption properties. However, it also poses challenges in terms of agglomeration and its inferior electrical conductivity during the synthesis process. This paper employed a facile in situ synthesis and electrodeposition approach to uniformly grow a bismuth film on a conductive carbon cloth, designated as Bi/Ag@CC. The Bi/Ag@CC electrode material exhibited benign electrochemical properties, enabling its application for detecting Pb²⁺ in tap water and lake water samples. Furthermore, this work investigated the impact of electrochemical parameters, including electrolyte pH, deposition potential and pre-enrichment time, on the detection performance. The results demonstrated the sensor’s wide linear range (from 20 to 400 ppb) and detection limits (0.15 ppb) for heavy metal ion detection, along with excellent anti-interference capabilities and satisfactory repeatability, with an RSD of less than 2.31% (n = 6). This paper offers a novel strategy for positioning the bismuth-based composite as a promising candidate for practical electrochemical sensing applications. Full article

Crosslinked polyethylene (XLPE) is an important polyethylene modification material which is widely used in high-voltage direct current (HVDC) transmission systems. Low-density polyethylene (LDPE) was used as a matrix to improve the thermal and electrical properties of XLPE composites through the synergistic effect of a crosslinking agent and nanopore structure molecular sieve, TS-1. It was found that the electrical and thermal properties of the matrices were different due to the crosslinking degree and crosslinking efficiency, and the introduction of TS-1 enhanced the dielectric constants of the two matrices to 2.53 and 2.54, and the direct current (DC) resistivities were increased to 3 × 10¹² and 4 × 10¹² Ω·m, with the enhancement of the thermal conductivity at different temperatures. As the applied voltage increases, the DC breakdown field strength is enhanced from 318 to 363 kV/mm and 330 to 356 kV/mm. The unique nanopore structure of TS-1 itself can inhibit the injection and accumulation in the internal space of crosslinked polyethylene composites, and the pore size effect of the filler can limit the development of electron impact ionization, inhibit the electron avalanche breakdown, and improve the strength of the external applied electric field (breakdown field) that TS-1/XLPE nanocomposites can withstand. This provides a new method for the preparation of nanocomposite insulating dielectric materials for HVDC transmission systems with better performance. Full article

Approximately 15–50% of patients with Crohn’s disease (CD) will require surgery within ten years following the diagnosis. The management of modifiable risk factors before surgery is essential to reduce postoperative complications and to promote a better postoperative recovery. Preoperative malnutrition reduced functional capacity, sarcopenia, immunosuppressive medications, anemia, and psychological distress are frequently present in CD patients. Multimodal prehabilitation consists of nutritional, functional, medical, and psychological interventions implemented before surgery, aiming at optimizing preoperative status and improve postoperative recovery. Currently, studies evaluating the effect of multimodal prehabilitation on postoperative outcomes specifically in CD are lacking. Some studies have investigated the effect of a single prehabilitation intervention, of which nutritional optimization is the most investigated. The aim of this narrative review is to present the physiologic rationale supporting multimodal surgical prehabilitation in CD patients waiting for surgery, and to describe its main components to facilitate their adoption in the preoperative standard of care. Full article

This study compared the risks for developing second primary cancers and cardiotoxicity following radiotherapy for thymoma. Three different 3D-CRT, IMRT, and VMAT plans were generated with 6 MV photons for 12 females with thymoma. Dose-volume histogram data were employed to estimate the second cancer risks using a mechanistic non-linear model. The radiation doses to the heart and cardiac substructures were combined with linear models to assess the probability of cardiotoxicity. The mean lifetime risk for lung, esophageal, thyroid, left breast, and right breast cancer induction was 4.34–4.49%, 0.30–0.31%, 0.05–0.07%, 2.06–2.30%, and 2.04–2.34%, respectively, depending upon the radiotherapy technique. The relative risk for major cardiac events, including myocardial infarction, coronary revascularization, and death, was 1.43–1.55, whereas that for chronic heart failure was 1.20–1.29. The IMRT and VMAT significantly reduced the risk for cardiotoxicity with respect to 3D-CRT (p ≤ 0.023). Small but significant reductions were observed for most organ-specific cancer risks with IMRT compared to conformal treatment (p ≤ 0.008). Similar decreases were detected only for esophageal and thyroid cancer with VMAT (p ≤ 0.033). No difference was found in the probability for radiation-induced lung cancer with the three techniques (p ≥ 0.06). Healthcare professionals may use these data to select the appropriate radiotherapy technique and restrict the risk of late effects. Full article

Inactivated and live attenuated vaccines are the mainstays of preventing viral poultry diseases. However, the development of recombinant DNA technology in recent years has enabled the generation of recombinant virus vector vaccines, which have the advantages of preventing multiple diseases simultaneously and simplifying the vaccination schedule. More importantly, some can induce a protective immune response in the presence of maternal antibodies and offer long-term immune protection. These advantages compensate for the shortcomings of traditional vaccines. This review describes the construction and characterization of primarily poultry vaccine vectors, including fowl poxvirus (FPV), fowl adenovirus (FAdV), Newcastle disease virus (NDV), Marek’s disease virus (MDV), and herpesvirus of turkey (HVT). In addition, the pathogens targeted and the immunoprotective effect of different poultry recombinant virus vector vaccines are also presented. Finally, this review discusses the challenges in developing vector vaccines and proposes strategies for improving immune efficacy. Full article

Nature-related financial risks have emerged as critical concerns for policymakers and financial actors. Central to this issue are ecosystem services, which play an integral role in various production processes but may be interrupted due to the degradation of nature. This article delves into the vulnerability of European SMEs by combining firm-level exposures to ecosystem service dependencies with regional information on the relative abundance of ecosystem services provisioning and the risk of natural hazards. Focusing on long-term debt positions to gauge financial stability implications, the results reveal moderate nature risks for European SMEs at the current stance but also highlight a possible concentration of risks and a need to further refine the use of available indicators. Full article

Most cyanobacteria that form harmful algal blooms (HABs) in inland waterbodies can overwinter in sediments. This field demonstration within an urban pond was conducted to bolster a database on the novel use of algaecide treatments to proactively target overwintering cyanobacteria located in sediments prior to HAB formation. In March 2023, a peroxide-based algaecide was applied to sediments of a water feature located in urban Kansas City, Kansas, and cyanobacteria responses were measured over subsequent weeks and months. Multiple lines of evidence were used to discern the impacts of proactive treatments on overwintering cells in sediments and HAB severity throughout the growing season. Although results of the measured cyanobacterial responses were mixed, three of five lines of evidence indicated proactive algaecide treatments were effective at decreasing the transfer of cyanobacteria to the water column and HAB severity during months when HABs tended to occur. Microcystin concentrations immediately post-treatment (hours) remained at the analytical detection limit (0.10 µg/L) and were below USEPA risk-based thresholds, highlighting the benefits of application prior to the exponential growth phase of toxin-producing cyanobacteria. These results expand the dataset and methodology for field-scale proactive algaecide applications targeting overwintering cyanobacterial cells in sediment to mitigate and delay HAB development. Full article

Introduction: Kidney transplantation is the preferred modality of kidney replacement therapy for eligible patients with end-stage kidney disease (ESKD), given that it has been found to reduce mortality rates, improve quality of life, and is cost-effective compared to dialysis. Recent advancements in human leukocyte antigen (HLA) typing and donor-specific antibody (DSA) detection have helped to reduce the risk of rejection, but antibody-mediated rejection (AMR) can still occur without DSA. Previous studies suggest that rejection can be attributed to antibodies against Non-Human Leucocyte Antigens (non-HLAs). We aimed to acquire further understanding of the prevalence and distribution of non-HLA antibodies in our local population and attempt to correlate these findings with graft outcomes, as well as assess whether non-HLA antibodies can be utilized to determine graft impairment and dysfunction. Methods: We conducted a retrospective study involving kidney transplant recipients between January 2010 and December 2020. All included individuals were aged over 18 and underwent kidney-alone transplants; were ABO- and HLA-compatible; and were matched at A, B, and DR loci (mismatch 0:0:0). HLA testing was negative at the time of transplantation. The samples from both cases of early graft rejection and the control group were tested for non-HLA antibodies using One Lambda LABScreen^TM, Autoantibody kit groups 1, 2, and 3, as well as the Immucor LIFECODES non-HLA autoantibody assay. Results: A total of 850 kidney transplant recipients were included, in which 12 patients experienced early graft rejection within the first month post transplant and 18 patients who did not experience graft rejection were selected as study controls. Our study reported no correlation between the total burden of non-HLA antibodies and early rejection, most likely as the result of a small sample size. Nevertheless, a sub-analysis revealed that specific high-frequency pre-transplant non-HLA antibodies such as GSTT, CXCL11, CXCL10, and HNR, detected by LIFECODES, were associated with rejection (Fisher’s exact test with Bonferroni correction, p < 0.001). Most pre-transplant non-HLA antibody levels were reduced after transplantation, which was attributed to immunosuppression. Conclusion: The ‘high frequency’ non-HLA antibodies displayed an association with graft rejection, though the overall associations between the burden of non-HLA antibodies and rejection episodes remain inconclusive. Further work is needed to establish the rebound phenomenon of non-HLA antibodies, the development of de novo non-HLA antibodies in the long run, and their implications on graft survival. Full article

Background: To date, only a few population-representative studies have been carried out on the rare Merkel cell carcinoma (MCC). We provide incidence and survival estimates of MCC, including the conditional relative survival. Methods: We analyzed data from the cancer registry of North Rhine-Westphalia, Germany, 2008–2021, covering a population of 18 million. We included all newly diagnosed MCCs and calculated age-standardized (old European Standard population) incidence rates and unconditional and conditional relative survival. Results: Our analysis included 2164 MCC patients. The age-standardized incidence of MCC was 5.2 (men) and 3.8 (women) per million person-years. The 5-year relative survival was 58.8% (men) and 70.7% (women). Survival was lower among men than women in all age–sex groups and was highest for MCC of the upper extremity in both men (68.2%) and women (79.3%). The sex difference in survival is particularly due to the better survival of women with MCC of the head and neck. In terms of survival, the first two years are particularly critical. Conclusions: Our data validate the worse survival among men and highlights a more favorable prognosis for MCCs located on the limbs. The first two years after diagnosis of MCC are the years with the highest excess mortality. Full article

Vaginally administered postbiotics derived from Lactobacillus were recently demonstrated to be effective in alleviating bacterial vaginosis and increasing pregnancy rates. However, their potential effect on sperm quality has not been well investigated. This controlled in vitro study aimed to assess the dose- and time-dependent effects of postbiotics derived from Lactobacillus rhamnosus PB01 (DSM 14870) on sperm quality parameters. The experiment was conducted in vitro to eliminate potential confounding factors from the female reproductive tract and vaginal microbiota. Sperm samples from 18 healthy donors were subjected to analysis using Computer-Aided Sperm Analysis (CASA) in various concentrations of postbiotics and control mediums at baseline, 60 min, and 90 min of incubation. Results indicated that lower postbiotic concentration (PB5) did not adversely affect sperm motility, kinematic parameters, sperm DNA fragmentation, and normal morphology at any time. However, concentrations exceeding 15% demonstrated a reduction in progressively motile sperm and a negative correlation with non-progressively motile sperm at all time points. These findings underscore the importance of balancing postbiotic dosage to preserve sperm motility while realizing the postbiotics’ vaginal health benefits. Further research is warranted to understand the underlying mechanisms and refine practical applications in reproductive health. Full article

Assistance during calving and cesarean section (C-section) are important risk factors for the failure of transfer of passive immunity (FTPI) in beef calves, which increases the risk of morbidity and mortality in beef calves during the preweaning period. Colostrum replacement recommendations for beef calves, and especially for those delivered by C-section, are unavailable. The objective of this study was to determine whether or not colostrum replacement or supplementation with a commercially available product could increase serum IgG concentrations in beef calves delivered by elective C-section, compared to beef calves that nursed colostrum naturally. An elective C-section was performed in 32 pregnant beef cows and first-calf heifers. Immediately after delivery, newborn calves were randomly assigned to one of three different treatment groups. Group A calves (n = 7) were fed one packet of a commercial colostrum replacer (CR) product providing 60 g of IgG within 30 min of life. A second packet of the same CR was fed at 6 h of life. Group B calves (n = 13) were fed the same CR at the same frequency as group A; however, these calves were reunited with their dams after the second CR feeding to allow additional nursing of maternal colostrum. Group C calves (n = 12) were united with their dams immediately after surgery without colostrum intervention. Serum IgG levels at 48 h of life were greater in group C calves and in calves born to multiparous cows. Based on the results of this study, neither colostrum replacement nor supplementation result in higher serum IgG concentrations in beef calves delivered by elective C-section compared with natural nursing. Full article

Dyslexia is classed as a neurobiological difficulty and is referred to as a Specific Learning Disability (SPLD) that primarily affects reading, writing, working memory (WM), and organisational skills. Positive psychology interventions (PPIs) have been found to increase self-esteem, self-efficacy, and confidence and lower anxiety among students with dyslexia. Therefore, to summarise the current evidence on PPIs, a narrative review was undertaken. The review synthesised the findings from six studies that investigated PPIs for dyslexic individuals across various education settings. Four key themes emerged: (1) characteristics and effectiveness of PPIs, (2) level of education, (3) gender differences, and (4) PPIs differences in Western and Eastern countries. The analysis revealed that group interventions in secondary schools positively impacted self-esteem and social skills among dyslexic pupils, while the efficacy of sunflower therapy for dyslexic children showed inconclusive results on academic performance but potential psychological benefits. Socioemotional wellbeing programmes for dyslexic children yielded mixed outcomes, with temporary increases in self-esteem post-programme. Mindfulness meditation demonstrated promise in improving reading accuracy and attention functions in adults with dyslexia. Positive psychology group interventions effectively enhanced subjective wellbeing, academic self-concept, and achievement among dyslexic children. Early interventions showed promise in improving coping strategies, perceived control, and overall wellbeing among students with dyslexia. This review highlights the potential benefits of diverse interventions across different educational settings, emphasising the importance of early support and targeted interventions for individuals with dyslexia. Full article

Locating shared electric micro-mobility stations in urban environments involves balancing multiple objectives, including accessibility, profitability, sustainability, operational costs, and social considerations. This study investigates traveler preferences regarding shared electric micro-mobility stations, focusing on factors influencing their location decisions. The study used the Analytic Hierarchy Process (AHP) model to analyze the criteria and determine their relative importance in influencing the location decisions of shared electric micro-mobility stations as evaluated by experts in transportation fields. The examined criteria are proximity to public transportation, accessibility to key destinations, demographics (e.g., age, and income), safety, land use, and pedestrian and cyclist infrastructure. Using the AHP model, the importance and ranking of each criterion were established. Results indicate that the availability and quality of sidewalks and bike lanes in the vicinity, along with the proximity to popular destinations like shopping centers and tourist attractions, emerge as the most influential criteria. The least important criteria were the demographics such as the young age percentage in the area and the average income of the surrounding population. These findings underscore the critical importance of well-maintained infrastructure for pedestrian and cyclist mobility, as well as the need for convenient access to high-traffic areas. Such insights provide valuable guidance for informed decision making regarding the optimal placement of shared electric micro-mobility stations. Full article

Ransomware is one of the most extended cyberattacks. It consists of encrypting a user’s files or locking the smartphone in order to blackmail a victim. The attacking software is ordered on the infected device from the attacker’s remote server, known as command and control. In this work, we propose a method to recover from a Locker.CB!tr ransomware attack after it has infected and hit a smartphone. The novelty of our approach lies on exploiting the communication between the ransomware on the infected device and the attacker’s command and control server as a point to reverse disruptive actions like screen locking or file encryption. For this purpose, we carried out both a dynamic and a static analysis of decompiled Locker.CB!tr ransomware source code to understand its operation principles and exploited communication patterns from the IP layer to the application layer to fully impersonate the command and control server. This way, we gained full control over the Locker.CB!tr ransomware instance. From that moment, we were able to command the Locker.CB!tr ransomware instance on the infected device to unlock the smartphone or decrypt the files. The contributions of this work are a novel method to recover the mobile phone after ransomware attack based on the analysis of the ransomware communication with the C&C server; and a mechanism for impersonating the ransomware C&C server and thus gaining full control over the ransomware instance. Full article

Economic globalization and the rapid development of the Internet make logistics systems more and more diversified, people and enterprises have greatly increased their requirements for logistics systems, and fourth party logistics has received more and more attention from people and related enterprises. In order to further study the routing problem under uncertain stochastic environments, this paper considers the fourth party logistics routing problem from a single manufacturer to multiple distributors with uncertain times and random supplies under the complete information symmetry scenario and symmetric transportation volume decision space. Then, an uncertain stochastic programming model is established with the minimum total cost as its core objective, and the total transportation time, manufacturer’s supply, and distributor’s demand as constraints. In order to solve the optimal path of the above problems, this paper transforms the uncertain stochastic programming model into a classical mathematical programming model based on the distribution functions of uncertain time and random supply. Finally, two numerical examples are given to verify the effectiveness of the proposed model. Full article