The initial Swedish discourse of transnational adoption as a win-win situation has changed over its more than 60-year-long history. This article aims to trace and present some themes in this history, with a particular focus on the public debate and the different narratives that representatives of the adoption triangle—the adoptees, the adoptive parents, and the biological parents—tell when dealing with transnational and transracial adoption as a personal and political phenomenon. The article draws from an ongoing study of discourses and narratives of transnational adoption based, above all, on journalism, memoirs, governmental documents, and previous research. It attempts to present the contradictory perspectives on transnational adoption to create a diffractive pattern. The diffractive analysis makes it possible to show how the investigated narratives and discourses on transnational adoption change in encounters with experiences made, and even more so, made visible and knowledgeable, in social practices. Full article

Sea level rise due to global warming is a continuing and, disappointingly, accelerating process which has already affected and will further impact coastal lowlands and the social and economic activities in these areas. Delos Island, situated in the middle of the Cyclades in the Aegean Sea, was considered the most sacred of all islands in ancient Greek culture and was a trading hub for the entire eastern Mediterranean. Uninhabited since the 7th century AD, and consistently the focus of research and touristic attention, the island is designated as an archaeological site and inscribed on the UNESCO World Heritage List. Previous studies on the relative sea level (rsl) changes suggest a steadily rising rsl during the last 6300 years, starting from a sea level of −4.80 ± 0.20 m in the Late Neolithic. The seafront of the ancient city of Delos is subject to the effects of rsl rise, which have caused significant coastline retreat and exposure to the northerly winds and waves, whereas parts of the coastal lowland, where the remains of the ancient city lie, are inundated, forming extended wetlands. The future impacts of rsl rise on the seafront of ancient Delos are illustrated on very-high-resolution digital surface models, evaluating both the flooding risk under different climatic projections, as provided by the IPCC AR6 report, and the ongoing land subsidence, as recorded by GNSS data. An rsl rise ranging from 87 cm (SSP1-2.6 scenario) to 148 cm (SSP5-8.5 scenario) is anticipated by 2150, requiring both resilience strategies and adaptation solutions as well as mitigation policies to cope with the effects of climate change. Full article

The expression and function of podoplanin (PDPN) in the normal human placenta has been debated in placental evaluation. This study emphasizes the importance of a multimodal approach of PDPN expression in normal human placentas. A complete examination is performed using immunohistochemistry, RNAscope and automated Digital Image examination (DIA) interpretation. QuPath DIA-based analysis automatically generated the stromal and histological scores of PDPN expression for immunohistochemistry and RNAscope stains. The umbilical cord’s isolated fibroblasts and luminal structures expressed PDPN protein and PDPN_mRNA. RNAscope detected PDPN_mRNA upregulation in syncytial placental knots trophoblastic cells, but immunohistochemistry did not certify this at the protein level. The study found a significant correlation between the IHC and RNAscope H-Score (p = 0.033) and Allred Score (p = 0.05). A successful multimodal strategy for PDPN assessment in human placentas confirmed PDPN expression heterogeneity in the full-term human normal placenta and umbilical cord at the protein and mRNA level. In placental syncytial knots trophoblastic cells, PDPN showed mRNA overexpression, suggesting a potential role in placenta maturation. Full article

One of the several differences between Modern European Portuguese (EP) and Modern Brazilian Portuguese (BP) is the prepositional expression of complements licensed by the preposition a. While in EP the preposition a occurs in several contexts, this element has been substituted by other strategies in BP, as is extensively discussed in the literature. The aim of this paper is to investigate the historical behavior of a-marked prepositional accusatives (PP-ACC) in Portuguese. In order to do so, a search was conducted for PP-ACCs in the Historical Portuguese Corpus Tycho Brahe. The results showed an increase of PP-ACCs in the 17th century, followed by a decrease in the 18th century. Thereafter, unmarked accusatives (NP-ACC) were analyzed in the corpus, which resulted in 7756 sentences, contrasting with 624 PP-ACCs in the same contexts. This result shows that the a-marked accusative is far less common than bare accusatives in Historical Portuguese. Psych verbs, however, behaved differently, showing a constant increase in PP-ACCs. In EP, the preposition a still introduces Experiencer arguments in structures with some psych verbs (O vinho agradou ao João—lit. ‘The wine pleased ‘to’ John’). In BP, the preposition a has disappeared in psych predicates (O vinho agradou Ø o João—‘The wine pleased John’). In both Modern EP and BP, most PP-ACCs have become typical unmarked direct objects. In the context of psych verbs, however, structural accusative assignment has shifted to structural dative Case in Modern EP, so as to ascertain the interpretation of the Experiencer in the internal argument via the preposition a. While in Modern BP, the argument is not overtly marked since it receives inherent accusative case in the derivation. Full article

The frequency of freshwater cyanobacterial blooms is increasing globally due to climate change and eutrophication, particularly in reservoirs. Reservoir ecosystems exhibit unique characteristics, and there is a complex relationship between factors such as light, temperature, nutrient salts, hydrology, and algal growth. The impact of the other factors on algal growth varies significantly among different reservoirs. Thus, it is crucial to assess the effectiveness of various algal control measures implemented in different reservoirs. This study conducted a comprehensive assessment by establishing a eutrophication model for the Shanzi Reservoir in Fuzhou City. The model incorporated meteorology, hydrology, carbon dynamics, nutrient cycling, and biological communities. The effectiveness of diverse management measures was systematically evaluated. The findings demonstrate that increasing the water level, reducing nutrient salts in sediments, and implementing ecological fish stocking effectively suppressed algal growth to varying degrees and improved nitrogen and phosphorus levels. Lower water levels and ecological fish stocking had a significant impact on algal reproduction, while sediment reduction had a minimal effect. Conversely, lower water levels and ecological fish stocking did not significantly improve nitrogen and phosphorus concentrations in the reservoir, whereas sediment reduction had a noticeable effect. Consequently, the management strategies for the Shanzi Reservoir should prioritize external control measures and the implementation of ecological fish stocking. Full article

Goat milk is considered the optimal substitute for human milk and is characterized by variations in the lipid composition of its fat globules across lactation phases. Therefore, the objective of this study was to thoroughly analyze the differences between goat milk during different lactations and human milk, aiming to offer scientific guidance for the production of functional dairy products. Compared with transitional and mature milk, the findings indicated that the total membrane protein content in goat colostrum exhibited greater similarity to that found in human milk. Additionally, goat milk exhibited higher milk fat globule size, as well as a higher total lipid and protein content than human milk. A total of 1461 lipid molecules across 61 subclasses were identified in goat milk and human milk. The contents of glycerides and glycerophospholipids were higher in goat colostrum, whereas sphingolipids and fatty acids were more abundant in human milk. Meanwhile, the compositions of lipid subclasses were inconsistent. There were 584 differentially expressed lipids identified between human and goat milk, including 47 subclasses that were primarily involved in the metabolism of glycerophospholipids, sphingolipids, and triglycerides. In summary, for both the membrane protein and the lipid composition, there were differences between the milk of different goat lactations and human milk. Full article

NeuroHIV affects approximately 30–60% of people living with HIV-1 (PLWH) and is characterized by varying degrees of cognitive impairments, presenting a multifaceted challenge, the underlying cause of which is chronic, low-level neuroinflammation. Such smoldering neuroinflammation is likely an outcome of lifelong reliance on antiretrovirals coupled with residual virus replication in the brains of PLWH. Despite advancements in antiretroviral therapeutics, our understanding of the molecular mechanism(s) driving inflammatory processes in the brain remains limited. Recent times have seen the emergence of non-coding RNAs (ncRNAs) as critical regulators of gene expression, underlying the neuroinflammatory processes in HIV infection, NeuroHIV, and their associated comorbidities. This review explores the role of various classes of ncRNAs and their regulatory functions implicated in HIV infection, neuropathogenesis, and related conditions. The dysregulated expression of ncRNAs is known to exacerbate the neuroinflammatory responses, thus contributing to neurocognitive impairments in PLWH. This review also discusses the diagnostic and therapeutic potential of ncRNAs in HIV infection and its comorbidities, suggesting their utility as non-invasive biomarkers and targets for modulating neuroinflammatory pathways. Understanding these regulatory roles could pave the way for novel diagnostic strategies and therapeutic interventions in the context of HIV and its comorbidities. Full article

Adolescents with attention deficit hyperactivity disorder (ADHD) face significant driving challenges due to deficits in attention and executive functioning, elevating their road risks. Previous interventions targeting driving safety among this cohort have typically addressed isolated aspects (e.g., cognitive or behavioral factors) or relied on uniform solutions. However, these approaches often overlook this population’s diverse needs. This study introduces the “Drive-Fun” innovative intervention (DFI), aimed at enhancing driving skills among this vulnerable population. The intervention was tested in a pilot study including 30 adolescents aged 15–18, comparing three groups: DFI, an educational intervention, and a control group with no treatment. Assessments included a driving simulator, EEG, and Tobii Pro Glasses 2. Evaluation was conducted pre- and post-intervention and at a 3-month follow-up. Results indicated that the DFI group significantly improved in the simulated driving performance, attentional effort, and focused gaze time. The findings underscore that holistic strategies with personalized, comprehensive approaches for adolescents with ADHD are particularly effective in improving driving performance. These outcomes not only affirm the feasibility of the DFI but also highlight the critical role of sensor technologies in accurately measuring and enhancing simulator driving performance in adolescents with ADHD. Outcomes suggest a promising direction for future research and application. Full article

Endometrial cancer is one of the most common cancer types among women. Many factors can contribute to the development of this disease, including environmental factors and, thus, eating habits. Our study aims to determine the levels of various mycotoxins and their metabolites in the blood serum and endometrial tissue samples of participants with previously proven endometrial cancer and to find possible contributions to cancer development. In the cohort clinical trial, 52 participants aged between 44 and 86 were studied. The participants were divided into two groups: patients or matched controls. All patients had previously histologically diagnosed endometrial cancer. The cancer patients were divided into low-grade endometrioid and low- plus high-grade endometrioid groups. Controls had no history of endometrial malignancy or premalignancy. Blood serum and endometrial tissue samples were obtained from all study patients. We compared the concentrations of total Aflatoxins (Afs), Deoxynivalenol (DON), Ochratoxin-A (OTA), T2-toxin and HT2 toxin (T2/HT2 toxin), Zearalenone (ZEN), alpha-Zearalenol (α-ZOL), and Fumonisin B1 (FB1) in the serum and endometrium between the different study groups. As a result, we can see a significant correlation between the higher levels of Afs and zearalenone and the presence of endometrial cancer. In the case of Afs, DON, OTA, T2/HT2 toxins, ZEN, and alpha-ZOL, we measured higher endometrial concentrations than in serum. Considering the effect of mycotoxins and eating habits on cancer development, our results might lead to further research exploring the relationship between certain mycotoxins and endometrium cancer. Full article

This paper uses Pope Francis’s Fratelli Tutti to develop traditional Catholic depictions of human dignity in both theory and practice. Black sociopolitical thought and social movement organizing are brought into conversation with theologies and philosophies that reflect on what gives life integrity. I posit that the substantialist (ontological) interpretation of human dignity logically extends from individuals to collectives. Further, I suggest religious leaders in the United States should emphasize this collective form of substantialism alongside the relational (Trinitarian) and functional (creative) interpretations of human dignity, thus identifying collectives as thematizing divine likeness and separating the notion of human dignity from individualism. Full article

This study conducts a comparative analysis of Buddhist sacred structures throughout Asia, focusing on the historical development, regional disparities, and the cultural sinification process of stūpas, caityas, and pagodas. Specifically, it delves into the origins, definitions, and terminologies of early Buddhist monuments, such as stūpas/mahācetiyas and caityas/cetiyas, emphasizing their Indian origins. The research further explores the adaptation and reinterpretation of these original Indian concepts as they spread to East Asia, morphing into new forms, such as pagodas and Buddha halls. It examines the subtle shifts in terminology and the altered meanings and functions of these monuments, from their Indian origins to their sinified representations in East Asia. The transformation of Indian Buddhist monuments through local culture and technology into East Asian architectural forms is investigated, offering a detailed perspective on the dynamic transformation of sacred spaces in Buddhism. This illustrates the religion’s adaptability and integration with the local cultures of ancient East Asia. By analyzing the terminologies and symbolic meanings associated with the architectural transition from stūpa to pagoda, the study argues that sinicized ritual spaces in East Asia have adopted architectural types from pre-Buddhist traditions to represent Indian spaces, thereby highlighting the nuanced changes and the continuous adaptation of sacred Buddhist architecture. Full article

The second partial differential equation from the Kaup–Newell hierarchy is considered. This equation can be employed to model pulse propagation in optical fiber, wave propagation in plasma, or high waves in the deep ocean. The integrability of the explored equation in traveling wave variables is investigated using the Painlevé test. Periodic and solitary wave solutions of the studied equation are presented. The investigated equation belongs to the class of generalized nonlinear Schrödinger equations and may be used for the description of optical solitons in a nonlinear medium. Full article

The objective of this study was to evaluate the thermal comfort of Nelore cattle (Bos indicus) managed in silvopastoral and traditional systems associated with rumination behavior in a humid tropical environment in the Eastern Amazon, Brazil. The study was carried out on a rural property in Mojuí dos Campos, Pará, Brazil, during the transition period of the year, from June to July 2023. Over these two months, six consecutive data collection days were held. We selected 20 clinically healthy non-castrated male Nelore cattle, aged between 18 and 20 months, with an average weight of 250 kg and body condition score of 3.5 (1–5). These animals were randomly divided into two groups: traditional system (TS) and silvopastoral system (SS). The physiological variables evaluated included RR, RT and BST. The variables were analyzed using the linear mixed model. For agrometeorological variables, higher values were observed between 10:00 a.m. (33 °C) and 6:00 p.m. (30 °C), with the highest temperature observed at 4:00 p.m. (40 °C). The RR showed interactions (p = 0.0214) between systems and times; in general, higher RR were obtained in the Traditional. The animals’ RT showed no significant difference (p < 0.05) between the production systems, but there was a statistically significant difference in relation to the time of collection (p < 0.0001). In the BGHI, it was possible to observe that there was mild stress in the period from 22:00 at night to 6:00 in the morning and moderate stress in the period of greatest increase in temperature, from 10:00 in the morning to 18:00 at night. BST showed no statistical difference between the regions studied or between the SP (35.6 °C) and TS (36.25 °C) systems. RT in the TS showed a positive correlation with AT (r = 0.31507; p = 0.0477). RT in the SP showed a positive correlation with THI (r = 35583; p = 0.0242). On the other hand, RT in the SP (r = 0.42873; p = 0.0058) and ST (r = 0.51015; p = 0.0008) showed a positive correlation with BGHI. RR in the TS showed a positive correlation with BGHI (r = 0.44908; p = 0.0037). The greatest amounts of rumination were carried out by animals in the SP system, generally ruminating lying down (p < 0.05). With regard to rumination behavior in the morning and afternoon, there were higher numbers of WS and LD in the TS (p > 0.05). Most of the time, the cattle were LD during the morning and afternoon shifts, and at night and dawn they were WS in the TS. Therefore, the SP offers more thermal comfort advantages compared to the TS system. Full article

Veterinary medications are necessary for both contemporary animal husbandry and food production, but their residues can linger in foods obtained from animals and pose a dangerous human risk. In this review, we aim to highlight the sources, occurrence, human exposure pathways, and human health effects of drug residues in food-animal products. Following the usage of veterinary medications, pharmacologically active compounds known as drug residues can be found in food, the environment, or animals. They can cause major health concerns to people, including antibiotic resistance development, the development of cancer, teratogenic effects, hypersensitivity, and disruption of normal intestinal flora. Drug residues in animal products can originate from variety of sources, including water or food contamination, extra-label drug use, and ignoring drug withdrawal periods. This review also examines how humans can be exposed to drug residues through drinking water, food, air, and dust, and discusses various analytical techniques for identifying these residues in food. Furthermore, we suggest some potential solutions to prevent or reduce drug residues in animal products and human exposure pathways, such as implementing withdrawal periods, monitoring programs, education campaigns, and new technologies that are crucial for safeguarding public health. This review underscores the urgency of addressing veterinary drug residues as a significant and emerging public health threat, calling for collaborative efforts from researchers, policymakers, and industry stakeholders to develop sustainable solutions that ensure the safety of the global food supply chain. Full article

A novel method for finding the eigenvalues of a Sturm–Liouville problem is developed. Following the minimalist approach, the problem is transformed to a single first-order differential equation with appropriate boundary conditions. Although the resulting equation is nonlinear, its form allows us to find the general solution by adding a second part to a particular solution. This splitting of the general solution into two parts involves the Schwarzian derivative: hence, the name of the approach. The eigenvalues that correspond to acceptable solutions can be found by requiring the second part to correct the asymptotically diverging behavior of the particular solution. The method can be applied to many different areas of physics, such as the Schrödinger equation in quantum mechanics and stability problems in fluid dynamics. Examples are presented. Full article

Cold chain packaging faces high levels of uncertainty due to its complex nature and dynamic environments during transportation, and the importance of safety and risk management. This study aims to propose a risk assessment model for cold chain packaging based on a fuzzy Bayesian Network. A case study on vaccine cold chain shipping containers is conducted for the illustration of the risk management model, and risk factors like container risk, packaging risk, monitoring risk and handling risk, occupational and product safety risk have been identified and assessed. This paper will add new knowledge to the field of cold chain packaging, which still lacks research attention, and will be useful for industry managers to gain a better understand of the dynamics and risks of cold chain packaging. Full article

The global prevalence of obesity presents a pressing challenge to public health and healthcare systems, necessitating accurate prediction and understanding for effective prevention and management strategies. This article addresses the need for improved obesity prediction models by conducting a comprehensive analysis of existing machine learning (ML) and deep learning (DL) approaches. This study introduces a novel hybrid model, Attention-based Bi-LSTM (ABi-LSTM), which integrates attention mechanisms with bidirectional Long Short-Term Memory (Bi-LSTM) networks to enhance interpretability and performance in obesity prediction. Our study fills a crucial gap by bridging healthcare and urban planning domains, offering insights into data-driven approaches to promote healthier living within urban environments. The proposed ABi-LSTM model demonstrates exceptional performance, achieving a remarkable accuracy of 96.5% in predicting obesity levels. Comparative analysis showcases its superiority over conventional approaches, with superior precision, recall, and overall classification balance. This study highlights significant advancements in predictive accuracy and positions the ABi-LSTM model as a pioneering solution for accurate obesity prognosis. The implications extend beyond healthcare, offering a precise tool to address the global obesity epidemic and foster sustainable development in smart cities. Full article

Many patients experience vertical root fractures, and clinicians often consider conservative treatment options like reattaching the fractured root segments. The study investigated the impact of different bonding agents on the fracture resistance of rebonded vertically fractured teeth with various alveolar bone defects. Human premolar teeth with a single root were sectioned and reattached using dual-cure resin cement (DCRC), resin-modified glass ionomer (RMGI), and cyanoacrylate. The reattached teeth were then restored with a resin fiber post, composite resin core, and full veneer metal copings. These teeth were embedded in acrylic blocks with angular, V-shaped, and step-shaped bone defects to simulate various alveolar bone conditions. After subjecting the samples to thermal cycling, the fracture resistance was evaluated using a universal testing machine. Teeth samples reattached with RMGI exhibited a higher average fracture resistance. The study also found that DCRC proved to be an effective bonding agent for VRF teeth. However, cyanoacrylate-rebonded teeth exhibited the lowest fracture resistance. The V-shaped defects had a significant impact on the fracture resistance of reattached VRF teeth, with largely unfavorable fractures observed in these cases. Predominantly favorable fractures were observed in the teeth treated with RMGI. The fracture loads in both RMGI and DCRC groups exceeded the expected masticatory load. Full article

Vibrio fluvialis is an emerging foodborne pathogenic bacterium that can cause severe cholera-like diarrhea and various extraintestinal infections, posing challenges to public health and food safety worldwide. The arginine deiminase (ADI) pathway plays an important role in bacterial environmental adaptation and pathogenicity. However, the biological functions and regulatory mechanisms of the pathway in V. fluvialis remain unclear. In this study, we demonstrate that L-arginine upregulates the expression of the ADI gene cluster and promotes the growth of V. fluvialis. The ADI gene cluster, which we proved to be comprised of two operons, arcD and arcACB, significantly enhances the survival of V. fluvialis in acidic environments both in vitro (in culture medium and in macrophage) and in vivo (in mice). The mRNA level and reporter gene fusion analyses revealed that ArgR, a transcriptional factor, is necessary for the activation of both arcD and arcACB transcriptions. Bioinformatic analysis predicted the existence of multiple potential ArgR binding sites at the arcD and arcACB promoter regions that were further confirmed by electrophoretic mobility shift assay, DNase I footprinting, or point mutation analyses. Together, our study provides insights into the important role of the ArgR-ADI pathway in the survival of V. fluvialis under acidic conditions and the detailed molecular mechanism. These findings will deepen our understanding of how environmental changes and gene expression interact to facilitate bacterial adaptations and virulence. Full article

Cigarette butts (CBs) are non-biodegradable harmful residues of synthetic origin and are widespread in marine environments around the world. Although environmental factors are often primarily responsible for the fragmentation of microplastics in the marine environment, biotic factors have recently been shown to be equally important in plastic debris. This study evaluates the role of the Hediste diversicolor polychaete in the fragmentation of CBs in the marine environment. Polychaetes were exposed to three concentrations of CB (0 (as the control), 0.25, and 1 butt L⁻¹) at two different temperatures (15 °C and 23 °C) for 28 days. At each temperature, aquaria without polychaetes were used to study the effect of the burrowing activity of the polychaete on CB fragmentation. Toxicants analysed from exposed sediments increased their concentration in a dose-dependent manner to the CB concentration at a temperature of 15 °C but not at 23 °C. CBs did not directly decrease Hediste survival, but prolonged elevated temperatures increased the polychaetes’ susceptibility. The negative effects of CBs on burial success and burrowing behaviour could not be offset by the reduced start time caused by elevated temperatures. Regardless of temperature, both the weight loss and physical fragmentation of CBs buried in polychaete-contaminated sediments were significantly higher than those without Hediste, with no differences between the two concentrations tested. FTIR-ATR analysis used to evaluate CB degradation in relation to cellulose acetate decomposition showed a greater degradation of this compound in treatments with Hediste than in those without polychaetes (~2.75 times), but these differences were not significant. This study is a promising initial step for future research, as any factor that facilitates the fragmentation of this prevalent and hazardous waste must be carefully studied to extract the maximum benefit to help to reduce CBs in the marine environment. Full article

Alport syndrome is a hereditary disease caused by mutations in the genes encoding the alpha 3, alpha 4, and alpha 5 chains of type IV collagen. It is characterized by hematuria, proteinuria, progressive renal dysfunction, hearing loss, and ocular abnormalities. The main network of type IV collagen in the glomerular basement membrane is composed of α3α4α5 heterotrimer. Mutations in these genes can lead to the replacement of this network by an immature network composed of the α1α1α2 heterotrimer. Unfortunately, this immature network is unable to provide normal physical support, resulting in hematuria, proteinuria, and progressive renal dysfunction. Current treatment options for Alport syndrome include angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, which aim to alleviate glomerular filtration pressure, reduce renal injury, and delay the progression of renal dysfunction. However, the effectiveness of these treatments is limited, highlighting the need for novel therapeutic strategies and medications to improve patient outcomes. Gene therapy, which involves the use of genetic material to prevent or treat diseases, holds promise for the treatment of Alport syndrome. This approach may involve the insertion or deletion of whole genes or gene fragments to restore or disrupt gene function or the editing of endogenous genes to correct genetic mutations and restore functional protein synthesis. Recombinant adeno-associated virus (rAAV) vectors have shown significant progress in kidney gene therapy, with several gene therapy drugs based on these vectors reaching clinical application. Despite the challenges posed by the structural characteristics of the kidney, the development of kidney gene therapy using rAAV vectors is making continuous progress. This article provides a review of the current achievements in gene therapy for Alport syndrome and discusses future research directions in this field. Full article