Large quantities of cover crop residues in the soil, combined, or not, with the inoculation of seeds with diazotrophic bacteria, can increase organic matter (OM) and protect soil microorganisms, such as arbuscular mycorrhizal fungi (AMF) and dark septate endophytic (DSE) fungi. Thus, the use of these sustainable biotechnologies can benefit microbial interactions, soil fertility and rice production in the Brazilian Cerrado region. In this study, we evaluated the effects of maize and Urochloa ruziziensis, intercropped or individually, as cover crops and an inoculation of Azospirillum brasilense on the chemical (fertility) and biological (C–microbial biomass and C–CO₂ released) attributes of soil and the effects of root colonization by AMF and DSE on the yield of rice grown in succession in highlands. The experiment was conducted under field conditions, in a typical dystrophic Red Oxisol. The experimental design consisted of randomized blocks arranged in strips, incorporating a combination of eight residual cover crops: ((1) maize, (2) maize–I (I = inoculation of seeds with A. brasilense), (3) Urochloa (U. ruziziensis), (4) Urochloa–I, (5) maize + Urochloa–I, (6) maize + Urochloa–I, (7) maize–I + Urochloa and (8) maize–I + Urochloa–I). This was accompanied by two treatments of rice as a successor crop (inoculated or not with A. brasilense), with four replicates, totaling 64 experimental units. A cover crop and rice seed inoculation prompted increases in OM and AMF relative to DSE, while the inoculation of rice, regardless of the cover crop treatment, increased the soil’s P content. The combination of maize + Urochloa–I and inoculated rice as the next crop generated increases in its sum of bases (SBs) and cation exchange capacity (CEC). There was a 19% increase in rice grain yields when the seed was inoculated. Full article

In this paper, we prove a discrete analog of the Selberg Trace Formula for the group ${\mathrm{GL}}_3\left({\mathbb{F}}_q\right).$ By considering a cubic extension of the finite field ${\mathbb{F}}_q$, we define an analog of the upper half-space and an action of ${\mathrm{GL}}_3\left({\mathbb{F}}_q\right)$ on it. To compute the orbital sums, we explicitly identify the double coset spaces and fundamental domains in our upper half space. To understand the spectral side of the trace formula, we decompose the induced representation $\rho ={\mathrm{Ind}}_{\Gamma }^{G}1$ for $G={\mathrm{GL}}_3\left({\mathbb{F}}_q\right)$ and $\Gamma ={\mathrm{GL}}_3\left({\mathbb{F}}_p\right).$ Full article

The development of novel cathodic materials with tailored nanostructures is crucial for the advancement of electrochromic devices. In this study, we synthesized cobalt-doped titanium dioxide (Ti-Co) thin films using a facile hydrothermal method to investigate the effects of cobalt doping on their structural, morphological, and electrochromic properties. Comprehensive characterization techniques, including X-ray diffraction and Raman analysis, confirmed the highly crystalline nature of the Ti-Co thin films, with specific Raman bands indicating distinct modifications due to cobalt incorporation. The TiO₂ nanorods, optimally doped with cobalt (TC-3), demonstrated enhanced charge transport and mobility, significantly improving the electrochromic performance. Among the various compositions studied, the TC-3 sample exhibited superior lithium-ion accommodation, achieving an optical modulation of 73.6% and a high coloration efficiency of 81.50 cm²/C. It also demonstrated excellent electrochromic stability, maintaining performance for up to 5000 s of coloring/bleaching cycles. These results confirm the beneficial impact of cobalt doping on the structural and functional properties of the host material. Furthermore, the practical effectiveness of the TC-3 thin film was validated through the fabrication of an electrochromic device, which showed efficient coloration and bleaching capabilities. This comprehensive research enhances the understanding and functionality of Ti-Co nanorod architectures, highlighting their promising potential for advanced electrochromic applications. Full article

Dementia, a multifaceted neurological syndrome characterized by cognitive decline, poses significant challenges to daily functioning. The main causes of dementia, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), Lewy body dementia (LBD), and vascular dementia (VD), have different symptoms and etiologies. Genetic regulators, specifically non-coding RNAs (ncRNAs) such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), are known to play important roles in dementia pathogenesis. MiRNAs, small non-coding RNAs, regulate gene expression by binding to the 3′ untranslated regions of target messenger RNAs (mRNAs), while lncRNAs and circRNAs act as molecular sponges for miRNAs, thereby regulating gene expression. The emerging concept of competing endogenous RNA (ceRNA) interactions, involving lncRNAs and circRNAs as competitors for miRNA binding, has gained attention as potential biomarkers and therapeutic targets in dementia-related disorders. This review explores the regulatory roles of ncRNAs, particularly miRNAs, and the intricate dynamics of ceRNA interactions, providing insights into dementia pathogenesis and potential therapeutic avenues. Full article

Major (exo)planetary and satellite bodies seem to concentrate at intermediate areas of the radial distributions of all the objects orbiting in each (sub)system. We show that angular-momentum transport during secular evolution of (exo)planets and satellites necessarily results in the observed intermediate accumulation of the massive objects. We quantify the ‘middle’ as the mean of mean motions (orbital angular velocities) when three or more massive objects are involved. Radial evolution of the orbits is expected to be halted when the survivors settle near mean-motion resonances and angular-momentum transfer between them ceases (gravitational Landau damping). This dynamical behavior is opposite in direction to what has been theorized for viscous and magnetized accretion disks, in which gas spreads out and away from either side of any conceivable intermediate area. We present angular momentum transfer calculations in few-body systems, and we also calculate the tidal dissipation timescales and the physical properties of the mean tidal field in planetary and satellite (sub)systems. Full article

Artificial intelligence (AI), encompassing machine learning (ML) and deep learning (DL), has revolutionized medical research, facilitating advancements in drug discovery and cancer diagnosis. ML identifies patterns in data, while DL employs neural networks for intricate processing. Predictive modeling challenges, such as data labeling, are addressed by transfer learning (TL), leveraging pre-existing models for faster training. TL shows potential in genetic research, improving tasks like gene expression analysis, mutation detection, genetic syndrome recognition, and genotype–phenotype association. This review explores the role of TL in overcoming challenges in mutation detection, genetic syndrome detection, gene expression, or phenotype–genotype association. TL has shown effectiveness in various aspects of genetic research. TL enhances the accuracy and efficiency of mutation detection, aiding in the identification of genetic abnormalities. TL can improve the diagnostic accuracy of syndrome-related genetic patterns. Moreover, TL plays a crucial role in gene expression analysis in order to accurately predict gene expression levels and their interactions. Additionally, TL enhances phenotype–genotype association studies by leveraging pre-trained models. In conclusion, TL enhances AI efficiency by improving mutation prediction, gene expression analysis, and genetic syndrome detection. Future studies should focus on increasing domain similarities, expanding databases, and incorporating clinical data for better predictions. Full article

To investigate the influence of different rhenium contents on the helium desorption behavior in tungsten–rhenium alloys, pure tungsten and tungsten–rhenium alloys were irradiated with helium under the same conditions. All irradiated samples were characterized using TDS and DBS techniques. The results indicate that the addition of rhenium can reduce the total helium desorption quantity in tungsten–rhenium alloys and slightly accelerate the reduction in the concentration of vacancy-type defects accompanying helium dissociation. The desorption activation energy of helium is approximately 2 eV at the low-temperature peak (~785 K) and about 4 eV at the high-temperature peak (~1475 K). An increase in rhenium content causes the desorption peak to shift towards higher temperatures (>1473 K), which is attributed to the formation of the stable complex structures between rhenium and vacancies. Besides, the migration of He-vacancy complexes towards traps and dynamic annealing processes both lead to the recovery of vacancy-type defects, resulting in a decrease in the positron annihilation S parameters. Full article

Risk management involves thinking about what could happen if someone is exposed to a hazard and the likelihood of this event. The vast majority of standards relating to risk management were written in the context of Occupational Health and Safety, as well as Work Health and Safety with the aim of eliminating all risks. In 2023 Standards, Australia published AS ISO 4980:2023: `Benefit-risk assessment for sport and recreational facilities, activities and equipment’. This standard provides a tool for applying risk management in the context of sport and recreation. AS ISO 4980:2023 is a departure from the traditional view of risk management standards in that it presents a view of risk that is not limited to viewing risk only as negative, but rather balances positive benefits with negative risks within the sport and recreation industry. This standard is also different in that it is based specifically on risk to sport and recreational users and not to employees and employers. The benefit that risk provides in the context of sports and recreational activities is placed on an equal footing with the traditional method of assessing risk. There is an expectation in sports and recreational activities that the user is making an implicit trade-off between the benefits and the inherent risks of the activity, including the potential for harm. This implied expectation is that exposure to risk can be positive. Positive risk and learning from making mistakes are not restricted to childhood development where graduated challenges are used but extend throughout our entire life. The goal of this paper is to draw public attention to the new and different perspective of risk on which AS ISO 4980:2023 is based and to provide an understanding of the concept of benefit–risk assessment. The implications of viewing non-workplace risk in a balanced way are discussed. Full article

The future of architectural environments in China will serve the needs of, and thus be shaped/re-shaped by, the Chinese Y and Z generations. Although Shan-Shui designs have long been a classic style of architectural environment in China, there is a lack of comprehensive studies on how the Chinese Y and Z generations perceive Shan-Shui designs as an architectural style. Quantitatively analyzing and understanding Chinese YZ generations’ perceived relationships between Shan-Shui designs and architectural environments will have many implications for both the economy and education. In this paper, we present a large-scale study by conducting a questionnaire survey of 441 human subjects representative of both the Y and Z generations. The questionnaires were carefully designed with a focus on understanding the perceptions and cognitions of Shan-Shui designs in the survey group. The survey results were analyzed using the widely adopted SPSS25 method. Our overall analyses show that the Chinese Y and Z generations have a tendency to subconsciously perceive Shan-Shui as a relatively independent form/style from architectural environments. Between the Y and Z generations, our comparative analyses show that the latter has a more positive perception with respect to different aspects of Shan-Shui designs in architectural environments. Full article

Solid electrolyte materials with high structural stability and excellent proton conductivity (σ) have long been a popular and challenging research topic in the fuel cell field. This problem can be addressed because of the crystalline metal–organic frameworks’ (MOFs’) high structural stability, adjustable framework composition, and dense H-bonded networks. Herein, one highly stable Sr(II) MOF, {[Sr(H₂tmidc)₂(H₂O)₃]·4H₂O}_n (1) (H₃tmidc = 2-(1H-tetrazolium-1-methylene)-1H-imidazole-4,5-dicarboxylic acid) was successfully fabricated, which was structurally characterized by single-crystal X-ray diffraction and electrochemically examined by the AC impedance determination. The results demonstrated that the σ of the compound manifested a positive dependence on temperature and humidity, and the optimal proton conductivity is as high as 1.22 × 10⁻² S/cm under 100 °C and 98% relative humidity, which is at the forefront of reported MOFs with ultrahigh σ. The analysis of the proton conduction mechanism reveals that numerous tetrazolium groups, carboxyl groups, coordination, and crystallization water molecules in the framework are responsible for the high efficiency of proton transport. This work offers a fresh perspective on how to create novel crystalline proton conductive materials. Full article

Aging, marked by a gradual decline in physiological function and heightened vulnerability to age-related diseases, remains a complex biological process with multifaceted regulatory mechanisms. Our study elucidates the critical role of poly(ADP–ribose) glycohydrolase (PARG), responsible for catabolizing poly(ADP–ribose) (pADPr) in the aging process by modulating the expression of age-related genes in Drosophila melanogaster. Specifically, we uncover the regulatory function of the uncharacterized PARG C-terminal domain in controlling PARG activity. Flies lacking this domain exhibit a significantly reduced lifespan compared to wild-type counterparts. Furthermore, we observe progressive dysregulation of age-related gene expression during aging, accelerated in the absence of PARG activity, culminating in a premature aging phenotype. Our findings reveal the critical involvement of the pADPr pathway as a key player in the aging process, highlighting its potential as a therapeutic target for mitigating age-related effects. Full article

Cardiovascular disease represents the foremost cause of mortality and morbidity worldwide, with a steadily increasing incidence due to the growth of the ageing population. Cardiac dysfunction leading to heart failure may arise from acute myocardial infarction (MI) as well as inflammatory- and cancer-related chronic cardiomyopathy. Despite pharmacological progress, effective cardiac repair represents an unmet clinical need, with heart transplantation being the only option for end-stage heart failure. The functional profiling of the biological activity of extracellular vesicles (EVs) has recently attracted increasing interest in the field of translational research for cardiac regenerative medicine. The cardioprotective and cardioactive potential of human progenitor stem/cell-derived EVs has been reported in several preclinical studies, and EVs have been suggested as promising paracrine therapy candidates for future clinical translation. Nevertheless, some compelling aspects must be properly addressed, including optimizing delivery strategies to meet patient needs and enhancing targeting specificity to the cardiac tissue. Therefore, in this review, we will discuss the most relevant aspects of the therapeutic potential of EVs released by human progenitors for cardiovascular disease, with a specific focus on the strategies that have been recently implemented to improve myocardial targeting and administration routes. Full article

This paper proposes a flexible travel recommender model (FTRM) that emphasizes the symmetry between user preferences and travel constraints, addressing key challenges in the field such as the integration of diverse constraint types and the customization of travel itineraries. The key contribution of the proposed model lies in its integration with the item constraints data model (ICDM), which effectively manages a plethora of constraint types. Additionally, this study develops a novel algorithm inspired by ant colony optimization (ACO) principles, demonstrating performance metrics that are comparable to state-of-the-art algorithms in this field. A comprehensive set of systematic experimental analyses is conducted, employing various models across diverse situational contexts, with the primary goal of illustrating the capabilities of the proposed symmetrical FTRM using real-world data from the Durham dataset. The obtained results highlight the model’s ability to accommodate diverse constraint types, facilitating the customization of travel itineraries to suit individual user preferences and achieve a balanced and symmetrical travel experience. Specifically, our model outperforms existing models in terms of flexibility and customization, showing significant improvements in user satisfaction and itinerary efficiency. Full article

Objectives: To show the superiority of eccentric versus concentric strengthening in terms of improving quadriceps strength in knee osteoarthritis (OA), a randomized controlled study was conducted to perform 12 sessions of either eccentric or concentric isokinetic muscle strengthening over 6 weeks. Methods: We recruited males and females, aged between 40 and 70 years, with predominantly unilateral femorotibial OA. Exclusion criteria were having a prosthesis, inflammatory arthritis or flare-up of OA, symptomatic patellofemoral OA, cardiovascular or pulmonary disease that could be a contraindication to the study treatment, and any pathology that could cause muscle weakness. The primary endpoint was the between-group difference in change in maximum concentric isokinetic knee extension peak torque (PT) at 60°/s on the OA side at 6 weeks. Secondary endpoints were between-group difference in change in concentric hamstring PT at 60°/s; eccentric quadriceps and hamstring PT at 30°/s; 10 m and 200 m walking speeds; pain and functional status (WOMAC score) at 6 weeks and 6 months. Results: The sample consisted of 11 females and 27 males, with a mean age of 57.7 ± 7.52 years and a body mass index (BMI) of 25.95 ± 3.93 kg/m². Quadriceps strength increased more at 6 weeks in the concentric than the eccentric group with no statistical difference. There was a rate of 25% major adverse events in the eccentric group. Conclusions: Eccentric training resulted in a smaller improvement in quadriceps strength than concentric training and was associated with a high risk of muscle injury, particularly to the hamstring muscles. Full article

In this paper, a series of low-temperature CVN (Charpy V-notch impact test) and DWTT (drop-weight tear test) experiments were carried out to deal with the intensifying contradiction of strength and toughness of ultra-high-strength pipeline steel. The fracture behavior and toughening mechanisms of ultra-high-strength pipeline steel were investigated using scanning electron microscopy, transmission electron microscopy and backscattered electron diffraction systems. The results show that DWTT fractures in ultra-high-strength pipeline steel had a variety of unconventional morphological features compared to CVN fractures, including ridge protrusion in ductile fracture conditions and a large-size fracture platform in brittle fracture conditions. Therefore, DWTT fractures contained more information about the material fracturing process, and could better reflect the actual process of material fracturing. In ultra-high-strength pipeline steel, fine-grained granular bainite caused cracks to undergo large deflections or frequent small transitions, which consumed additional energy and improved toughness. In contrast, large-sized granular bainite, which consisted of low-angle grain boundaries, did not effectively prevent crack propagation when it encountered cracks, which was not conducive to improved toughness. Moreover, the M/A constituents in large-sized granular bainite aggregated, cracked, or fell off, which could easily lead to the formation of microcracks and was also detrimental to toughening. Full article

The segmentation analysis of the Golding–Cox mRNA dataset clarifies the description of these trajectories as a Fractional Lévy Stable Motion (FLSM). The FLSM method has several important advantages. Using only a few parameters, it allows for the detection of jumps in segmented trajectories with non-Gaussian confined parts. The value of each parameter indicates the contribution of confined segments. Non-Gaussian features in mRNA trajectories are attributed to trajectory segmentation. Each segment can be in one of the following diffusion modes: free diffusion, confined motion, and immobility. When free diffusion segments alternate with confined or immobile segments, the mean square displacement of the segmented trajectory resembles subdiffusion. Confined segments have both Gaussian (normal) and non-Gaussian statistics. If random trajectories are estimated as FLSM, they can exhibit either subdiffusion or Lévy diffusion. This approach can be useful for analyzing empirical data with non-Gaussian behavior, and statistical classification of diffusion trajectories helps reveal anomalous dynamics. Full article

Carbon (δ¹³C) and nitrogen (δ¹⁵N) isotopes were used to evaluate spatial, temporal, and interspecific differences in trophic relationships of four fish species (Paralichthys dentatus, Anchoa mitchilli, Leiostomus xanthurus, and Bairdiella chrysoura) in Maryland’s coastal bays. The δ¹³C values for all species were more enriched in 2017 than in 2018, a year of higher-than-average rainfall that likely caused higher amounts of terrestrial carbon to enter the estuary. There were significant differences among species in the δ¹³C values, with L. xanthurus being the least depleted (−17.2‰ in 2017; −18.8‰ in 2018). Spatially, the δ¹³C values of the species, particularly P. dentatus and B. chrysoura, were more depleted in the northern bays, which have a higher nutrient content and receive more freshwater inflow directly from tributaries, than the southern bays. The observed δ¹³C values (−19.5 ± 0.2‰ to –17.2 ± 0.3‰), however, indicate that marine phytoplankton was the primary carbon source of the fishes. Overall, A. mitchilli was the most enriched in δ¹⁵N (13.0‰), and L. xanthurus was the most depleted (10.2‰). δ¹⁵N was more enriched in fish from the more human-impacted northern bays than in fish from the southern bays, though this might also have stemmed from the differences in the diet composition of the species in the northern and southern bays. A. mitchilli had the highest trophic level, while L. xanthurus and P. dentatus had the lowest trophic levels. Niche breadth was widest in L. xanthurus compared to the other fish species, suggesting a higher variability in diets among L. xanthurus individuals, leading to specialized diets. There was a high niche overlap between B. chrysoura, A. mitchilli, and L. xanthurus, which indicates they fed on similar prey resources. Full article

One of the promising raw materials for the synthesis of geopolymers is perlite, which is a natural low-calcium aluminosilicate. This research studied the physical, mechanical and microstructural characteristics of perlite-based geopolymers modified with different mineral additives that were prepared using different methods of introducing the alkali components and curing conditions. The experimental results of the consolidated perlite-based geopolymer pastes showed that curing conditions and the method of introducing the alkali component into the geopolymer matrix had a minimal effect on the average density while demonstrating a significant boost in compressive strength. So, after thermal treatment, the compressive strength increased by 0.63 to 11.4 times for the mixes when fresh alkali solution was used and by 0.72 to 12.8 times for the mixes with the 24 h conditioned alkali solution. Maximum-strength spikes from 1.1 MPa to 13.2 MPa and from 0.7 MPa to 9.7 MPa were observed for the mixes with kaolin when prepared with fresh and conditioned alkali solutions, respectively. It was also observed that thermal treatment facilitates the compaction of the matrix structure by 18% and 1% for the non-modified mix and the mix modified with Portland cement. Perlite-based geopolymers modified with Portland cement and citrogypsum demonstrated a significant reduction in the initial and final setting times with both methods of introducing the alkali solution. On the surface of mixes modified with citrogypsum, regardless of the curing conditions and method of introducing the alkali component, an efflorescence substance was observed. The microstructural analysis of the consolidated geopolymer perlite-based pastes containing citrogypsum demonstrated a loose structure and the presence of efflorescence, which can be associated with a retardation in interaction processes between alkali cations and the aluminosilicate component. EDS analysis demonstrated that the presence of such elements as oxygen, sodium and sulfur may indicate the efflorescence of unreacted sodium hydroxide (NaOH), citrogypsum (CaSO₄) and the products of their interaction in the form of crystalline hydrates of sodium sulfate (Na₂SO₄). Full article

This numerical investigation explores the enhanced control of the 3D natural convection (NC) within a cubic cavity filled with graphene–water nanofluids, utilizing a bottom-center-located tree-shaped obstacle and a horizontal magnetic field (MF). The analysis includes the effects of the Rayleigh number (Ra), the solid volume fraction of graphene ($\mathsf{\phi }$), the Hartmann number (Ha), and the fins’ length (W). The results show complex flow patterns and thermal behavior within the cavity, indicating the interactive effects of nanofluid properties, the tree-shaped obstacle, and magnetic field effects. The MHD effects reduce the convection, while the addition of graphene improves the thermal conductivity of the fluid, which enhances the heat transfer observed with increasing Rayleigh numbers. The increase in the fins’ length on the heat transfer efficiency is found to be slightly negative, which is attributed to the complex interplay between the enhanced heat transfer surface area and fluid flow disruption. This study presents an original combination of non-destructive methods (magnetic field) and a destructive method (tree-shaped obstacle) for the control of the fluid flow and heat transfer characteristics in a 3D cavity filled with graphene–water nanofluids. In addition, it provides valuable information for optimizing heat transfer control strategies, with applications in electronic cooling, renewable energy systems, and advanced thermal management solutions. The application of a magnetic field was found to reduce the maximum velocity and total entropy generation by about 82% and 76%, respectively. The addition of graphene nanoparticles was found to reduce the maximum velocity by about 5.5% without the magnetic field and to increase it by 1.12% for Ha = 100. Varying the obstacles’ length from W = 0.2 to W = 0.8 led to a reduction in velocity by about 23.6%. Full article

Injury is the leading cause of death and disability amongst those between 0 and 16 years of age. Routinely associated with a social gradient of health, childhood injury is reportedly higher in rural and regional areas. A retrospective cross-sectional study collected deidentified emergency injury presentation data from nine health services in regional Victoria for children aged 0–14 years between 2017 and 2022. Emergency injury presentation incidence rates and predictor variables were analysed using hierarchical multiple regression. Significance was determined at p < 0.05. Amongst the 15,884 emergency injury presentations, 35.2% (n = 5597) occurred at health services that did not routinely report data to government datasets. Although some findings are consistent with current research, this study highlights specific factors that are predictive of injury amongst 0–4-year-old children who require deeper investigation, including general practitioner access and health literacy-related elements such as preschool health assessment attendance rates, parent education levels, and overseas birth. These findings provide more comprehensive insights for healthcare workers and policymakers as they seek to support people with injuries and accurately address health inequities. Full article

The primary research question driving this paper is the following: “What are the schooling experiences of young people who are at risk of or experiencing homelessness?” Through interviews with 28 young people in two cities in Ontario, Canada, the authors identified several common experiences, including the following: lack of available information that could help them cope with their housing difficulties; prejudice and bullying from other students, sometimes stemming from their housing problems but also due to factors such as racialization, gender identity, poverty, and substance use; and individual support from some teachers and support staff, although this was dependent on being in school. They proposed changes to help young people still in school, including the inclusion of non-judgmental information and guidance on dealing with poverty and homelessness in school curricula, educating school staff about the ‘symptoms’ of homelessness to help them identify students at risk, and creating more safe and supportive school environments overall. Full article

The environmental impact of tire wear emissions has become increasingly apparent, and efforts to reduce their impact on the environment are on the rise. To minimise the generation of tire wear, it is essential to consider the influencing factors. However, as it cannot be entirely prevented, measures to reduce immissions are also necessary. This paper summarises possible measures derived from the literature, stakeholder workshops, and the authors’ own conclusions, taking into account the different perspectives: tire, vehicle, road, sustainable mobility and emissions treatment. The presentation of the entry paths of tire wear into the environment and the hotspots of generation can be used to prioritise reduction measures. Measures should be implemented at a political level, technical solutions applied, and awareness raised among the general public. It is evident that reducing tire wear is a complex task that requires a transdisciplinary approach. Full article