The 2023 MDPI Annual Report has
been released!
 
14 pages, 2186 KiB  
Article
How the “Olive Oil Polyphenols” Health Claim Depends on Anthracnose and Olive Fly on Fruits
by Fátima Peres, Cecília Gouveia, Conceição Vitorino, Helena Oliveira and Suzana Ferreira-Dias
Foods 2024, 13(11), 1734; https://doi.org/10.3390/foods13111734 (registering DOI) - 1 Jun 2024
Abstract
Olive anthracnose, caused by Colletotrichum fungi, and the olive fruit fly Bactrocera olea are, respectively, the most important fungal disease and pest affecting olive fruits worldwide, leading to detrimental effects on the yield and quality of fruits and olive oil. This study focuses [...] Read more.
Olive anthracnose, caused by Colletotrichum fungi, and the olive fruit fly Bactrocera olea are, respectively, the most important fungal disease and pest affecting olive fruits worldwide, leading to detrimental effects on the yield and quality of fruits and olive oil. This study focuses on the content of hydroxytyrosol (HYT) and its derivatives (the “olive oil polyphenols” health claim) in olive oils extracted from fruits of ‘Galega Vulgar’ and ‘Cobrançosa’ cultivars, naturally affected by olive anthracnose and olive fly. The olives, with different damage levels, were harvested from organic rainfed orchards, located in the center of Portugal, at four harvest times over three years. Galega oils extracted from olives with a higher anthracnose and olive fly incidence showed no conformity for the extra virgin olive oil (EVOO) and virgin olive oil (VOO) categories, presenting high acidity and negative sensory notes accompanied by the disappearance of oleacein. Conversely, no sensory defects were observed in Cobrançosa oils, regardless of disease and pest incidence levels, and quality criteria were still in accordance with the EVOO category. The total HYT and tyrosol (TYR) content (>5 mg/20 g) allows for the use of the “olive oil polyphenols” health claim on the label of all the analyzed Cobrançosa olive oils. Full article
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Article
New Parametrization of the Dark-Energy Equation of State with a Single Parameter
by Jainendra Kumar Singh, Preeti Singh, Emmanuel N. Saridakis, Shynaray Myrzakul and Harshna Balhara
Universe 2024, 10(6), 246; https://doi.org/10.3390/universe10060246 (registering DOI) - 1 Jun 2024
Abstract
We propose a novel dark-energy equation-of-state parametrization, with a single parameter η that quantifies the deviation from ΛCDM cosmology. We first confront the scenario with various datasets, from the Hubble function (OHD), Pantheon, baryon acoustic oscillations (BAO), and their joint observations, and [...] Read more.
We propose a novel dark-energy equation-of-state parametrization, with a single parameter η that quantifies the deviation from ΛCDM cosmology. We first confront the scenario with various datasets, from the Hubble function (OHD), Pantheon, baryon acoustic oscillations (BAO), and their joint observations, and we show that η has a preference for a non-zero value, namely, a deviation from ΛCDM cosmology is favored, although the zero value is marginally inside the 1σ confidence level. However, we find that the present Hubble function value acquires a higher value, namely, H0=66.6240.013+0.011 Km s1 Mpc1, which implies that the H0 tension can be partially alleviated. Additionally, we perform a cosmographic analysis, showing that the universe transits from deceleration to acceleration in the recent cosmological past; nevertheless, in the future, it will not result in a de Sitter phase since it exhibits a second transition from acceleration to deceleration. Finally, we perform the statefinder analysis. The scenario behaves similarly to the ΛCDM paradigm at high redshifts, while the deviation becomes significant at late and recent times and especially in the future. Full article
(This article belongs to the Collection Modified Theories of Gravity and Cosmological Applications)
18 pages, 1158 KiB  
Article
Exploring the Determinants of Quality of Work Life in the Construction Industry: A Quantitative Approach
by M. G. Soundarya Priya and K. S. Anandh
Buildings 2024, 14(6), 1607; https://doi.org/10.3390/buildings14061607 (registering DOI) - 1 Jun 2024
Abstract
This research aims to identify and quantify the factors affecting quality of work life (QWL) among professionals in the Indian construction industry. The study employs a structured questionnaire, distributed to 900 construction professionals, yielding a response rate of 80.44%. The QWL construct was [...] Read more.
This research aims to identify and quantify the factors affecting quality of work life (QWL) among professionals in the Indian construction industry. The study employs a structured questionnaire, distributed to 900 construction professionals, yielding a response rate of 80.44%. The QWL construct was assessed through eight factors: career growth, management, job satisfaction, remuneration and fringe benefits, the work–family interface, emotional intelligence, work culture, and work commitment. Both descriptive and inferential analysis were carried out. The relative importance index method was used to rank these factors based on their relative importance. Work commitment (RII = 0.772) ranked as the most important factor, this was due to work commitment including significant items. The high ranking of this factor suggests that commitment to work is highly valued in the construction industry. The study also employed structural equation modelling to validate the association among these QWL factors. The findings reveal that job satisfaction (t = 0.765) and career growth (t = 0.751) play significant roles in QWL, suggesting that these factors should be prioritized to enhance QWL in the construction industry. The results of this study provide valuable insights for organizations, HR practitioners, and researchers in the construction industry, emphasizing the need to focus on job satisfaction and career growth to enhance QWL. This study contributes to the existing literature by providing a comprehensive analysis of QWL in the construction industry, offering valuable insights for organizations, HR practitioners, and researchers. Future research could adopt longitudinal study designs or qualitative methods to further explore the QWL among construction professionals. Full article
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20 pages, 6268 KiB  
Article
Effectiveness of the Concrete Equivalent Mortar Method for the Prediction of Fresh and Hardened Properties of Concrete
by Haruna Ibrahim, George Wardeh, Hanaa Fares and Elhem Ghorbel
Buildings 2024, 14(6), 1610; https://doi.org/10.3390/buildings14061610 (registering DOI) - 1 Jun 2024
Abstract
Modern concrete mix design is a complex process involving superplasticisers, fine powders, and fibres, requiring time and energy due to the high number of trial tests needed to achieve rheological properties in the fresh state. Concrete batching involves the extensive use of materials, [...] Read more.
Modern concrete mix design is a complex process involving superplasticisers, fine powders, and fibres, requiring time and energy due to the high number of trial tests needed to achieve rheological properties in the fresh state. Concrete batching involves the extensive use of materials, time, and the testing of chemical admixtures, with various methodologies proposed. Therefore, in some instances, the required design properties (physical and mechanical) are not achieved, leading to the loss of resources. The concrete equivalent mortar (CEM) method was introduced to anticipate concrete behaviour at fresh and hardened states. Moreover, the CEM method saves time and costs by replacing coarse aggregates with an equivalent sand mass, resulting in an equivalent specific surface area at the mortar scale. This study aims to evaluate the performance of fibre in CEM and concrete and determine the relationships between the CEM and the concrete in fresh and hardened states. Steel and polypropylene fibres were used to design three series of mixtures (CEM and concrete): normal-strength concrete (NSC), high-strength concrete (HSC), high-strength concrete with fly ash (HSCFA), and equivalent normal-strength mortar (NSM), high-strength mortar (HSM), and high-strength mortar with fly ash (HSMFA). This study used three-point bending tests and digital image correlation to evaluate load and crack mouth opening displacement (CMOD) curves. An analytical mode I crack propagation model was developed using a tri-linear stress–crack opening relationship. Post-cracking parameters were optimised using inverse analysis and compared to actual MC2010 characteristic values. The concrete slump is approximately half of the CEM flow; its compressive strength ranges between 78% and 82% of CEM strength, while its flexural strength is 60% of CEM strength. The post-cracking behaviour showed a significant difference attributed to the presence of aggregates in concrete. The fracture energy of concrete is 28.6% of the CEM fracture energy, while the critical crack opening of the concrete is 60% of that of the CEM. Full article
(This article belongs to the Special Issue Innovative Solutions towards Sustainable Precast Concrete Products)
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Review
Obstacle Avoidance and Path Planning Methods for Autonomous Navigation of Mobile Robot
by Kornél Katona, Husam A. Neamah and Péter Korondi
Sensors 2024, 24(11), 3573; https://doi.org/10.3390/s24113573 (registering DOI) - 1 Jun 2024
Abstract
Path planning creates the shortest path from the source to the destination based on sensory information obtained from the environment. Within path planning, obstacle avoidance is a crucial task in robotics, as the autonomous operation of robots needs to reach their destination without [...] Read more.
Path planning creates the shortest path from the source to the destination based on sensory information obtained from the environment. Within path planning, obstacle avoidance is a crucial task in robotics, as the autonomous operation of robots needs to reach their destination without collisions. Obstacle avoidance algorithms play a key role in robotics and autonomous vehicles. These algorithms enable robots to navigate their environment efficiently, minimizing the risk of collisions and safely avoiding obstacles. This article provides an overview of key obstacle avoidance algorithms, including classic techniques such as the Bug algorithm and Dijkstra’s algorithm, and newer developments like genetic algorithms and approaches based on neural networks. It analyzes in detail the advantages, limitations, and application areas of these algorithms and highlights current research directions in obstacle avoidance robotics. This article aims to provide comprehensive insight into the current state and prospects of obstacle avoidance algorithms in robotics applications. It also mentions the use of predictive methods and deep learning strategies. Full article
(This article belongs to the Special Issue Mobile Robots: Navigation, Control and Sensing)
36 pages, 5854 KiB  
Article
Empirical Assessment of the Efficiency of Poland’s Energy Transition Process in the Context of Implementing the European Union’s Energy Policy
by Jarosław Brodny, Magdalena Tutak and Wes Grebski
Energies 2024, 17(11), 2689; https://doi.org/10.3390/en17112689 (registering DOI) - 1 Jun 2024
Abstract
This article addresses one of the contemporary economy’s most challenging endeavors: the energy transition. Specifically, the aim of the study was to assess the effectiveness of Poland’s energy transition process between 2004 and 2021. A comprehensive approach is employed to analyze Poland’s energy [...] Read more.
This article addresses one of the contemporary economy’s most challenging endeavors: the energy transition. Specifically, the aim of the study was to assess the effectiveness of Poland’s energy transition process between 2004 and 2021. A comprehensive approach is employed to analyze Poland’s energy transition process, focusing on the effectiveness of implementation through the Energy Transition Effectiveness Index. This methodology incorporates four dimensions, namely energy security, economic considerations, climate impact, and social aspects, each characterized by 22 sub-indices. The research methodology employs a two-tiered approach based on the multi-criteria decision making methodology. The EDAS method is utilized to determine the indices’ values, while the CRITIC, equal weights, and statistical variance methods and Laplace’s criterion are employed to ascertain sub-indices values and dimension weights, particularly useful for decision making under uncertainty. Moreover, the relationship between these indices, the Energy Transition Effectiveness Index, and Poland’s Gross Domestic Product is explored. By evaluating Poland’s energy transition effectiveness from 2004 to 2021 and comparing the results with other European Union countries, it becomes evident that the effectiveness varies over time. Despite encountering economic and social challenges during the energy sector’s transformation, Poland exhibits positive progress in its energy transition efforts, outperforming certain European Union counterparts. However, there is a pressing need to intensify efforts to curtail emissions and enhance renewable energy utilization. The European Union’s support and coordination are deemed crucial in facilitating these endeavors, alongside fostering the wider adoption of best practices among member states. The developed methodology stands as a valuable tool for ongoing evaluation of transformation processes across European Union nations. Full article
(This article belongs to the Collection Energy Transition towards Carbon Neutrality)
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22 pages, 9345 KiB  
Article
Human Coronavirus 229E Infection Inactivates Pyroptosis Executioner Gasdermin D but Ultimately Leads to Lytic Cell Death Partly Mediated by Gasdermin E
by Xavier Martiáñez-Vendrell, Jonna Bloeme-ter Horst, Roy Hutchinson, Coralie Guy, Andrew G. Bowie and Marjolein Kikkert
Viruses 2024, 16(6), 898; https://doi.org/10.3390/v16060898 (registering DOI) - 1 Jun 2024
Abstract
Human coronavirus 229E (HCoV-229E) is associated with upper respiratory tract infections and generally causes mild respiratory symptoms. HCoV-229E infection can cause cell death, but the molecular pathways that lead to virus-induced cell death as well as the interplay between viral proteins and cellular [...] Read more.
Human coronavirus 229E (HCoV-229E) is associated with upper respiratory tract infections and generally causes mild respiratory symptoms. HCoV-229E infection can cause cell death, but the molecular pathways that lead to virus-induced cell death as well as the interplay between viral proteins and cellular cell death effectors remain poorly characterized for HCoV-229E. Studying how HCoV-229E and other common cold coronaviruses interact with and affect cell death pathways may help to understand its pathogenesis and compare it to that of highly pathogenic coronaviruses. Here, we report that the main protease (Mpro) of HCoV-229E can cleave gasdermin D (GSDMD) at two different sites (Q29 and Q193) within its active N-terminal domain to generate fragments that are now unable to cause pyroptosis, a form of lytic cell death normally executed by this protein. Despite GSDMD cleavage by HCoV-229E Mpro, we show that HCoV-229E infection still leads to lytic cell death. We demonstrate that during virus infection caspase-3 cleaves and activates gasdermin E (GSDME), another key executioner of pyroptosis. Accordingly, GSDME knockout cells show a significant decrease in lytic cell death upon virus infection. Finally, we show that HCoV-229E infection leads to increased lytic cell death levels in cells expressing a GSDMD mutant uncleavable by Mpro (GSDMD Q29A+Q193A). We conclude that GSDMD is inactivated by Mpro during HCoV-229E infection, preventing GSDMD-mediated cell death, and point to the caspase-3/GSDME axis as an important player in the execution of virus-induced cell death. In the context of similar reported findings for highly pathogenic coronaviruses, our results suggest that these mechanisms do not contribute to differences in pathogenicity among coronaviruses. Nonetheless, understanding the interactions of common cold-associated coronaviruses and their proteins with the programmed cell death machineries may lead to new clues for coronavirus control strategies. Full article
(This article belongs to the Special Issue The Role of Cell Death in Viral Infections)
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16 pages, 6004 KiB  
Article
Comparison of Nitriding Behavior for Austenitic Stainless Steel 316Ti and Super Austenitic Stainless Steel 904L
by Stephan Mändl and Darina Manova
Metals 2024, 14(6), 659; https://doi.org/10.3390/met14060659 (registering DOI) - 1 Jun 2024
Abstract
In situ X-ray diffraction (XRD) was used to compare nitrogen low-energy ion implantation (LEII) into austenitic stainless steel 316Ti and super austenitic stainless steel 904L. While the diffusion and layer growth were very similar, as derived from the decreasing intensity of the substrate [...] Read more.
In situ X-ray diffraction (XRD) was used to compare nitrogen low-energy ion implantation (LEII) into austenitic stainless steel 316Ti and super austenitic stainless steel 904L. While the diffusion and layer growth were very similar, as derived from the decreasing intensity of the substrate reflection, strong variations in the observed lattice expansion—as a function of orientation, the steel alloy, and nitriding temperature—were observed. Nevertheless, a similar resulting nitrogen content was measured using time-of-flight secondary ion mass spectrometry (ToF-SIMS). Furthermore, for some conditions, the formation of a double layer with two distinct lattice expansions was observed, especially for steel 904L. Regarding the stability of expanded austenite, 316Ti had already decayed in CrN during nitriding at 500 °C, while no such effect was observed for 904L. Thus, the alloy composition has a strong influence only on the lattice expansion and the stability of expanded austenite—but not the diffusion and nitrogen content. Full article
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22 pages, 14284 KiB  
Article
Case Study of Space Optimization Simulation of Existing Office Buildings Based on Thermal Buffer Effect
by Shenqi Gan, Wenxiang Chen and Jiawang Feng
Buildings 2024, 14(6), 1611; https://doi.org/10.3390/buildings14061611 (registering DOI) - 1 Jun 2024
Abstract
This paper takes an old office building in Hefei as the research object to explore the influence of the thermal buffering performance of the case building buffer space on the air speed and thermal environment of the office space based on the field [...] Read more.
This paper takes an old office building in Hefei as the research object to explore the influence of the thermal buffering performance of the case building buffer space on the air speed and thermal environment of the office space based on the field measurement and simulation. As the thermal buffer layer of the main space, the buffer space is the layout mode that follows the thermal transfer law. Building buffer space variables were evaluated and compared by orthogonal tests to determine the better combination of buffer space sizes. The results show that when the air speed is taken as the evaluation index, the influence of each buffer space on the indoor environment is ordered: courtyard > corridor > foyer; when the temperature is taken as the evaluation index, the influence of each buffer space on the indoor environment is ordered: courtyard > foyer > corridor. From the perspective of green transformation, this paper selects two better schemes. Through comparison, it is found that when the buffer space size is: corridor (16 m × 2 m × 3.3 m), courtyard (16 m × 12 m) and foyer (7.2 m × 6 m × 3.3 m) is the optimal scheme, the indoor air speed is increased by 0.1 m/s, and the temperature is reduced to 27.0 °C, which is within the thermal comfort range of the human body. It is found that optimizing the buffer space size of the case building can effectively improve its indoor air speed and thermal environment, and provide theoretical basis and reference for the green transformation of existing buildings of the same type in this area. Full article
(This article belongs to the Section Building Energy, Physics, Environment, and Systems)
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17 pages, 2268 KiB  
Review
Tropical Shrimp Biofloc Aquaculture within Greenhouses in the Mediterranean: Preconditions, Perspectives, and a Prototype Description
by Dimitrios K. Papadopoulos, Maria V. Alvanou, Athanasios Lattos, Kosmas Ouroulis and Ioannis A. Giantsis
Fishes 2024, 9(6), 208; https://doi.org/10.3390/fishes9060208 (registering DOI) - 1 Jun 2024
Abstract
Biofloc technology (BFT) offers an innovative eco-friendly approach that is particularly applicable in shrimp farming. Penaeus vannamei is the most important seafood species in terms of global economic value. Nevertheless, its increasing global demand highlights the necessity for sustainable production of P. vannamei [...] Read more.
Biofloc technology (BFT) offers an innovative eco-friendly approach that is particularly applicable in shrimp farming. Penaeus vannamei is the most important seafood species in terms of global economic value. Nevertheless, its increasing global demand highlights the necessity for sustainable production of P. vannamei shrimps outside their native range, assuring the avoidance of genetic pollution risk. Towards this direction, the present study focuses on the feasibility of tropical shrimp species aquaculture in indoor systems evaluating BFT application in temperate zones. The achievability of P. vannamei cultivation inside greenhouses in temperate latitudes is thoroughly examined and a representative experimental biofloc setup for P. vannamei within a greenhouse in Northern Greece is demonstrated. Nevertheless, there are two major limitations, related to economy and ecology, namely the energy demand for high seawater temperature and the fact that most reared shrimps are non-indigenous species setting risk for genetic pollution, respectively. To overcome the former, energy-saving measures such as tank and greenhouse insulation in combination with a microclimate chamber construction were implemented to optimize water temperature at minimal cost. Concerning the latter, there is clear evidence that P. vannamei populations cannot be established in the Mediterranean, setting aside any environmental risk. Overall, based on the developed and tested pilot prototype, employment of optimal management practices, innovative manufacturing and clean energy alternatives, and the utilization of ecosystem services could reduce the environmental impact and maximize the profitability of biofloc operations. These actions could probably permit sustainable and economically viable farming of P. vannamei employing BFT within greenhouses in the Mediterranean. Full article
(This article belongs to the Special Issue Advances in Shrimp Aquaculture)
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Article
Untargeted Metabolome Analyses Revealed Potential Metabolic Mechanisms of Leymus chinensis in Response to Simulated Animal Feeding
by Chunxu Zhou, Ruiqi Zhao, Han Wang, Bao Liu, Yingjie Yu and Lili Jiang
Int. J. Mol. Sci. 2024, 25(11), 6110; https://doi.org/10.3390/ijms25116110 (registering DOI) - 1 Jun 2024
Abstract
Leymus chinensis (Trin.) Tzvel., also known as the “Alkali Grass”, is a major forage grass in the eastern and northeastern steppe vegetation in the Songnen Prairie. It is of great practical significance for grassland management to understand the influence of animal saliva on [...] Read more.
Leymus chinensis (Trin.) Tzvel., also known as the “Alkali Grass”, is a major forage grass in the eastern and northeastern steppe vegetation in the Songnen Prairie. It is of great practical significance for grassland management to understand the influence of animal saliva on L. chinensis during animal feeding. In this study, we used clipping and daubing animal saliva to simulate responses to grazing by L. chinensis, and analyzed the physiological and metabolomic changes in response to simulated animal feeding. Results showed that the effects of animal saliva on physiological and metabolic processes of the treated plants produced a recovery phenomenon. Moreover, the effects of animal saliva produced a large number of differential metabolites related to several known metabolic pathways, among which the flavonoid biosynthesis pathway has undergone significant and persistent changes. We posit that the potential metabolic mechanisms of L. chinensis in response to simulated animal feeding are closely related to flavonoid biosynthesis. Full article
(This article belongs to the Section Molecular Plant Sciences)
Review
Convergence towards High-Speed Steady States Using High-Order Accurate Shock-Capturing Schemes
by Juan C. Assis, Ricardo D. Santos, Mateus S. Schuabb, Carlos E. G. Falcão, Rômulo B. Freitas and Leonardo S. de B. Alves
Fluids 2024, 9(6), 133; https://doi.org/10.3390/fluids9060133 (registering DOI) - 1 Jun 2024
Abstract
Creating time-marching unsteady governing equations for a steady state in high-speed flows is not a trivial task. Residue convergence in time cannot be achieved when using most low- and high-order spatial discretization schemes. Recently, high-order, weighted, essentially non-oscillatory schemes have been specially designed [...] Read more.
Creating time-marching unsteady governing equations for a steady state in high-speed flows is not a trivial task. Residue convergence in time cannot be achieved when using most low- and high-order spatial discretization schemes. Recently, high-order, weighted, essentially non-oscillatory schemes have been specially designed for steady-state simulations. They have been shown to be capable of achieving machine precision residues when simulating the Euler equations under canonical coordinates. In the present work, we review these schemes and show that they can also achieve machine residues when simulating the Navier–Stokes equations under generalized coordinates. This is carried out by considering three supersonic flows of perfect fluids, namely the flow upstream a cylinder, the flow over a blunt wedge, and the flow over a compression ramp. Full article
(This article belongs to the Special Issue Recent Advances in Fluid Mechanics: Feature Papers, 2024)
15 pages, 1065 KiB  
Article
Comparative Analysis of Shapley Values Enhances Transcriptomics Insights across Some Common Uterine Pathologies
by José A. Castro-Martínez, Eva Vargas, Leticia Díaz-Beltrán and Francisco J. Esteban
Genes 2024, 15(6), 723; https://doi.org/10.3390/genes15060723 (registering DOI) - 1 Jun 2024
Abstract
Uterine pathologies pose a challenge to women’s health on a global scale. Despite extensive research, the causes and origin of some of these common disorders are not well defined yet. This study presents a comprehensive analysis of transcriptome data from diverse datasets encompassing [...] Read more.
Uterine pathologies pose a challenge to women’s health on a global scale. Despite extensive research, the causes and origin of some of these common disorders are not well defined yet. This study presents a comprehensive analysis of transcriptome data from diverse datasets encompassing relevant uterine pathologies such as endometriosis, endometrial cancer and uterine leiomyomas. Leveraging the Comparative Analysis of Shapley values (CASh) technique, we demonstrate its efficacy in improving the outcomes of the classical differential expression analysis on transcriptomic data derived from microarray experiments. CASh integrates the microarray game algorithm with Bootstrap resampling, offering a robust statistical framework to mitigate the impact of potential outliers in the expression data. Our findings unveil novel insights into the molecular signatures underlying these gynecological disorders, highlighting CASh as a valuable tool for enhancing the precision of transcriptomics analyses in complex biological contexts. This research contributes to a deeper understanding of gene expression patterns and potential biomarkers associated with these pathologies, offering implications for future diagnostic and therapeutic strategies. Full article
(This article belongs to the Special Issue Genetic Causes of Human Infertility)
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12 pages, 1263 KiB  
Article
The Impact of Football Teams’ Transportation on the Carbon Footprint for Away Matches
by Roman Domański
Sustainability 2024, 16(11), 4721; https://doi.org/10.3390/su16114721 (registering DOI) - 1 Jun 2024
Abstract
Problem: Participating in professional sport involves constant travel. From a review of the literature, the issue of transport in sport (passenger transport) in generating a carbon footprint has already been noted. A reliable assessment of the scale of this phenomenon is currently underway. [...] Read more.
Problem: Participating in professional sport involves constant travel. From a review of the literature, the issue of transport in sport (passenger transport) in generating a carbon footprint has already been noted. A reliable assessment of the scale of this phenomenon is currently underway. The aim of this article is to assess the carbon footprint of transporting football players to away matches. It is complemented by a proposal to change the way matches are played using the Sports Centre concept. Methods: A systematic literature review was carried out in the theoretical part. The research part was conducted based on EN 16258 and the centre of gravity method. The objects of this study are five selected football clubs from the Polish Ekstraklasa, and their method of travel (by coach) to away matches. Results: The use of alternative (low-carbon) modes of transport reduces GHG levels from 13 per cent (Pogoń Szczecin) to 34 per cent (Jagiellonia Białystok). An interesting solution, although not yet adapted to the current times, is the implementation of the Sports Centre concept, which allows a 48 per cent reduction in the distance travelled (81,940 kgCO2e per year). Conclusions: Football clubs can neutralise their remaining carbon footprint through investments that indirectly contribute to total carbon neutrality, such as the planting of oxygen trees or the installation of a photovoltaic system to completely neutralise the carbon footprint. Full article
(This article belongs to the Special Issue The Urgency of Decarbonizing the Mobility and Transport System)
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11 pages, 1230 KiB  
Review
RNF213 Polymorphisms in Intracranial Artery Dissection
by Marialuisa Zedde, Ilaria Grisendi, Federica Assenza, Manuela Napoli, Claudio Moratti, Claudio Pavone, Lara Bonacini, Giovanna Di Cecco, Serena D’Aniello, Maria Simona Stoenoiu, Alexandre Persu, Franco Valzania and Rosario Pascarella
Genes 2024, 15(6), 725; https://doi.org/10.3390/genes15060725 (registering DOI) - 1 Jun 2024
Abstract
The ring finger protein 213 gene (RNF213) is involved in several vascular diseases, both intracranial and systemic ones. Some variants are common in the Asian population and are reported as a risk factor for moyamoya disease, intracranial stenosis and intracranial aneurysms. Among intracranial [...] Read more.
The ring finger protein 213 gene (RNF213) is involved in several vascular diseases, both intracranial and systemic ones. Some variants are common in the Asian population and are reported as a risk factor for moyamoya disease, intracranial stenosis and intracranial aneurysms. Among intracranial vascular diseases, both moyamoya disease and intracranial artery dissection are more prevalent in the Asian population. We performed a systematic review of the literature, aiming to assess the rate of RNF213 variants in patients with spontaneous intracranial dissections. Four papers were identified, providing data on 53 patients with intracranial artery dissection. The rate of RNF213 variants is 10/53 (18.9%) and it increases to 10/29 (34.5%), excluding patients with vertebral artery dissection. All patients had the RNF213 p.Arg4810Lys variant. RNF213 variants seems to be involved in intracranial dissections in Asian cohorts. The small number of patients, the inclusion of only patients of Asian descent and the small but non-negligible coexistence with moyamoya disease familiarity might be limiting factors, requiring further studies to confirm these preliminary findings and the embryological interpretation. Full article
(This article belongs to the Section Neurogenomics)
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33 pages, 720 KiB  
Review
Ultra-Processed Foods: A Narrative Review of the Impact on the Human Gut Microbiome and Variations in Classification Methods
by Allison L. Brichacek, Melanie Florkowski, Esther Abiona and Karen M. Frank
Nutrients 2024, 16(11), 1738; https://doi.org/10.3390/nu16111738 (registering DOI) - 1 Jun 2024
Abstract
Ultra-processed foods (UPFs) are foods that are industrially processed and are often pre-packaged, convenient, energy-dense, and nutrient-poor. UPFs are widespread in the current Western diet and their proposed contribution to non-communicable diseases such as obesity and cardiovascular disease is supported by numerous studies. [...] Read more.
Ultra-processed foods (UPFs) are foods that are industrially processed and are often pre-packaged, convenient, energy-dense, and nutrient-poor. UPFs are widespread in the current Western diet and their proposed contribution to non-communicable diseases such as obesity and cardiovascular disease is supported by numerous studies. UPFs are hypothesized to affect the body in multiple ways, including by inducing changes in the gut microbiome. This review summarizes the available research on the effect of UPFs on the gut microbiome. We also review current usage of the NOVA food classification system in randomized controlled trials and observational studies and how its implementation effects UPF research. Despite some differences in methodology between studies, results often associate UPF consumption with a number of negative health consequences. There are attempts to standardize a UPF classification system; however, reaching and implementing a consensus is difficult. Future studies focusing on the mechanisms by which UPFs effect the body, including through the microbiome and metabolome, will be essential to refine our understanding of the effects of UPFs on human health. Full article
(This article belongs to the Special Issue The Relationship between Diet, Gut Microbes and Human Health)
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Article
Hysteresis Behavior of RC Beam–Column Joints of Existing Substandard RC Structures Subjected to Seismic Loading–Experimental and Analytical Investigation
by George Kalogeropoulos, Alexander-Dimitrios Tsonos and Pantelis Iakovidis
Buildings 2024, 14(6), 1609; https://doi.org/10.3390/buildings14061609 (registering DOI) - 1 Jun 2024
Abstract
Four exterior reinforced concrete beam–column joint subassemblages with poor reinforcement details and low-quality materials were constructed and subjected to cyclic lateral deformations under constant axial loading of the columns. The longitudinal rebars at the top of the beams were well-anchored in the joint [...] Read more.
Four exterior reinforced concrete beam–column joint subassemblages with poor reinforcement details and low-quality materials were constructed and subjected to cyclic lateral deformations under constant axial loading of the columns. The longitudinal rebars at the top of the beams were well-anchored in the joint region with a 90° hook and transversely welded to prevent premature slippage. The same was true for the longitudinal rebars at the bottom of the beam of the first specimen. Contrarily, the anchorage of the rebars at the bottom of the beam of the other three subassemblages was straight and of insufficient length. One of these specimens (the second) also had deficient lap splices of the column reinforcement, while the other three specimens had continuous column rebars. The third and the fourth subassemblage were designed with different joint aspect ratio and beam shear span/depth ratio values. The overall seismic performance of the specimens was evaluated and compared. The failure mode of the subassemblages was accurately predicted by the proposed analytical model. It was clearly demonstrated that the anchorage of the rebars, the length of the lap splices, the joint aspect ratio and the shear span/depth of the beam ratio value crucially affect the cyclic response of beam–column joints and, hence, may cause a severe detrimental impact to the overall structural integrity. Full article
(This article belongs to the Section Building Materials, and Repair & Renovation)
15 pages, 1447 KiB  
Review
Microbubble-Enhanced Focused Ultrasound for Infiltrating Gliomas
by Alexandra A. Seas, Adarsha P. Malla, Nima Sharifai, Jeffrey A. Winkles, Graeme F. Woodworth and Pavlos Anastasiadis
Biomedicines 2024, 12(6), 1230; https://doi.org/10.3390/biomedicines12061230 (registering DOI) - 1 Jun 2024
Abstract
Infiltrating gliomas are challenging to treat, as the blood-brain barrier significantly impedes the success of therapeutic interventions. While some clinical trials for high-grade gliomas have shown promise, patient outcomes remain poor. Microbubble-enhanced focused ultrasound (MB-FUS) is a rapidly evolving technology with demonstrated safety [...] Read more.
Infiltrating gliomas are challenging to treat, as the blood-brain barrier significantly impedes the success of therapeutic interventions. While some clinical trials for high-grade gliomas have shown promise, patient outcomes remain poor. Microbubble-enhanced focused ultrasound (MB-FUS) is a rapidly evolving technology with demonstrated safety and efficacy in opening the blood-brain barrier across various disease models, including infiltrating gliomas. Initially recognized for its role in augmenting drug delivery, the potential of MB-FUS to augment liquid biopsy and immunotherapy is gaining research momentum. In this review, we will highlight recent advancements in preclinical and clinical studies that utilize focused ultrasound to treat gliomas and discuss the potential future uses of image-guided precision therapy using focused ultrasound. Full article
(This article belongs to the Special Issue Gliomas: Signaling Pathways, Molecular Mechanisms and Novel Therapies)
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14 pages, 6081 KiB  
Review
Struma Ovarii during Pregnancy
by Gabriela Dumachița-Șargu, Răzvan Socolov, Teodora Ana Balan, Dumitru Gafițanu, Mona Akad and Raluca Anca Balan
Diagnostics 2024, 14(11), 1172; https://doi.org/10.3390/diagnostics14111172 (registering DOI) - 1 Jun 2024
Abstract
Struma ovarii is a rare type of ovarian teratoma primarily composed of over 50% thyroid tissue. Its occurrence is reported in 2–5% of all ovarian teratomas, with approximately 0.5% to 10% showing malignant transformation. Managing it during pregnancy poses significant challenges as pregnancy [...] Read more.
Struma ovarii is a rare type of ovarian teratoma primarily composed of over 50% thyroid tissue. Its occurrence is reported in 2–5% of all ovarian teratomas, with approximately 0.5% to 10% showing malignant transformation. Managing it during pregnancy poses significant challenges as pregnancy can promote the growth of malignant struma ovarii due to elevated levels of ovarian and pregnancy-related hormones, including estrogen, progesterone, and human chorionic gonadotrophin (hCG). Most ovarian tumors, including struma ovarii, are detected during routine ultrasonography in the first and second trimesters, often as acute emergencies. Diagnosis during pregnancy is rare, with some cases incidentally discovered during cesarean section when inspecting the adnexa for ovarian cysts. This review explores the diagnostic, management, and therapeutic approaches to struma ovarii during pregnancy. Full article
(This article belongs to the Special Issue Advancements in Maternal–Fetal Medicine)
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10 pages, 631 KiB  
Article
Intraoperative Oxygen Consumption and Postoperative Immune Response in Colorectal Oncological Surgery: A Prospective, Monocentric Pilot Study
by Robert Ivascu, Madalina Dutu, Sandica Bucurica, Dan Corneci and Cornelia Nitipir
J. Pers. Med. 2024, 14(6), 594; https://doi.org/10.3390/jpm14060594 (registering DOI) - 1 Jun 2024
Abstract
Surgical resection is the key treatment for colorectal cancer, but the extent of surgical trauma has been implied as a key factor for the oncologic outcome. The immune stress response to surgical trauma generates a cascade of immunological events implying neutrophils’ perioperative change [...] Read more.
Surgical resection is the key treatment for colorectal cancer, but the extent of surgical trauma has been implied as a key factor for the oncologic outcome. The immune stress response to surgical trauma generates a cascade of immunological events implying neutrophils’ perioperative change generating NETosis, N killer decrease, and platelets’ activation that may influence postoperative surgical outcome, tumor cell growth, and future oncogenesis. The present study aimed to investigate the correlation between intraoperative oxygen consumption (VO2) and the dynamic variation of neutrophils, lymphocytes, and platelets in the perioperative period to identify an intraoperative tool that could predict the postoperative immune response. Twenty-six colorectal oncological surgical patients were enrolled in an observational, prospective, monocentric study, over 18 months. Serum neutrophils, lymphocytes, and thrombocytes values were collected in the preoperative period and on the third postoperative day, oxygen consumption was measured and recorded every 15 min during surgery using indirect calorimetry. We compared oxygen consumption measurements registered 30 min after induction of anesthesia (VO2a) and the first value registered after abdominal wall closure (VO2b) to perioperative variation of absolute neutrophils (VNC), lymphocytes (VLC), and platelets (VPC) count. Our results proved a significant correlation between VO2 variation and neutrophils’ perioperative dynamic assessed by VNC (correlation coefficient = 0.547, p < 0.01, 95% confidence interval (CI) =0.175, 0.783). We also noticed a correlation between VPC and VO2 (correlation coefficient = −0.603, p < 0.01, 95% CI = −0.815, −0.248). No correlation could be shown between VO2 and VLC variation (p = 0.39). In conclusion, intraoperative VO2 variation measured by indirect calorimetry correlates well with perioperative neutrophils and platelets count dynamic variations and can be used as an early prognosis marker of postoperative immune response and surgical outcome in colorectal oncological surgery. Full article
(This article belongs to the Section Methodology, Drug and Device Discovery)
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26 pages, 2075 KiB  
Review
Reducing Heavy Metal Contamination in Soil and Water Using Phytoremediation
by Yryszhan Zhakypbek, Bekzhan D. Kossalbayev, Ayaz M. Belkozhayev, Toktar Murat, Serik Tursbekov, Elaman Abdalimov, Pavel Pashkovskiy, Vladimir Kreslavski, Vladimir Kuznetsov and Suleyman I. Allakhverdiev
Plants 2024, 13(11), 1534; https://doi.org/10.3390/plants13111534 (registering DOI) - 1 Jun 2024
Abstract
The increase in industrialization has led to an exponential increase in heavy metal (HM) soil contamination, which poses a serious threat to public health and ecosystem stability. This review emphasizes the urgent need to develop innovative technologies for the environmental remediation of intensive [...] Read more.
The increase in industrialization has led to an exponential increase in heavy metal (HM) soil contamination, which poses a serious threat to public health and ecosystem stability. This review emphasizes the urgent need to develop innovative technologies for the environmental remediation of intensive anthropogenic pollution. Phytoremediation is a sustainable and cost-effective approach for the detoxification of contaminated soils using various plant species. This review discusses in detail the basic principles of phytoremediation and emphasizes its ecological advantages over other methods for cleaning contaminated areas and its technical viability. Much attention has been given to the selection of hyperaccumulator plants for phytoremediation that can grow on heavy metal-contaminated soils, and the biochemical mechanisms that allow these plants to isolate, detoxify, and accumulate heavy metals are discussed in detail. The novelty of our study lies in reviewing the mechanisms of plant–microorganism interactions that greatly enhance the efficiency of phytoremediation as well as in discussing genetic modifications that could revolutionize the cleanup of contaminated soils. Moreover, this manuscript discusses potential applications of phytoremediation beyond soil detoxification, including its role in bioenergy production and biodiversity restoration in degraded habitats. This review concludes by listing the serious problems that result from anthropogenic environmental pollution that future generations still need to overcome and suggests promising research directions in which the integration of nano- and biotechnology will play an important role in enhancing the effectiveness of phytoremediation. These contributions are critical for environmental scientists, policy makers, and practitioners seeking to utilize phytoremediation to maintain the ecological stability of the environment and its restoration. Full article
(This article belongs to the Section Plant–Soil Interactions)
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7 pages, 1262 KiB  
Article
The Effect of Two Different Wavelengths of Diode Laser on the Shear Bond Strength of Composite to Dental Enamel after Bleaching Process: An In Vitro Study
by Reza Pourmahmoudian, Luca Solimei, Stefano Benedicenti, Sogol Saberi and Sima Shahabi
Bioengineering 2024, 11(6), 559; https://doi.org/10.3390/bioengineering11060559 (registering DOI) - 1 Jun 2024
Abstract
Introduction: In recent years, tooth whitening has become one of the most popular ways of achieving the original tooth color. The effect of whitening gel can be improved through heat, light or laser. The bond strength between the enamel and the composite can [...] Read more.
Introduction: In recent years, tooth whitening has become one of the most popular ways of achieving the original tooth color. The effect of whitening gel can be improved through heat, light or laser. The bond strength between the enamel and the composite can be reduced through bleaching and laser radiation. The purpose of this study is to assess the shear bond strength of resin composite to enamel after a bleaching process using hydrogen peroxide, with and without a laser (970 nm and 445 nm lasers). Method: This study used 51 extracted anterior teeth without caries that were divided into three groups. A 40% hydrogen peroxide gel was used on the enamel of all teeth. The control group received bleaching without a laser. Both the second and third treatment groups received bleaching with a laser, one with 970 nm and the other with 445 nm. After the bleaching process, all groups had etching, bonding and curing of the composite performed. Lastly, the shear bond strength between the enamel and the composite was measured and the failure modes were recorded. The data were compared using a one-way ANOVA test. Results: The mean shear bond strength between the enamel and the composite in the 445 nm group three (445 nanometer) was significantly lower than the other groups (p < 0.05). There was no significant difference between the control and the 970 nm groups (p = 0.2). Conclusion: According to the laser wavelengths and parameters that were used in this study and the results of this study, office bleaching with a 445 nm laser weakened the shear bond strength between the enamel and the composite. Full article
(This article belongs to the Section Biomedical Engineering and Biomaterials)
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21 pages, 2658 KiB  
Article
Energetic, Exergetic, and Techno-Economic Analysis of A Bioenergy with Carbon Capture and Utilization Process via Integrated Torrefaction–CLC–Methanation
by Enrico Alberto Cutillo, Claudio Tregambi, Piero Bareschino, Erasmo Mancusi, Gaetano Continillo and Francesco Pepe
Energies 2024, 17(11), 2690; https://doi.org/10.3390/en17112690 (registering DOI) - 1 Jun 2024
Abstract
Bioenergy with carbon capture and storage (BECCS) or utilization (BECCU) allows net zero or negative carbon emissions and can be a breakthrough technology for climate change mitigation. This work consists of an energetic, exergetic, and economic analysis of an integrated process based on [...] Read more.
Bioenergy with carbon capture and storage (BECCS) or utilization (BECCU) allows net zero or negative carbon emissions and can be a breakthrough technology for climate change mitigation. This work consists of an energetic, exergetic, and economic analysis of an integrated process based on chemical looping combustion of solar-torrefied agro-industrial residues, followed by methanation of the concentrated CO2 stream with green H2. Four agro-industrial residues and four Italian site locations are considered. Depending on the considered biomass, the integrated plant processes about 18–93 kg h−1 of raw biomass and produces 55–70 t y−1 of synthetic methane. Global exergetic efficiencies ranged within 45–60% and 67–77% when neglecting and considering, respectively, the valorization of torgas. Sugar beet pulp and grape marc required a non-negligible input exergy flow for the torrefaction, due to the high moisture content of the raw biomasses. However, for these biomasses, the water released during drying/torrefaction and CO2 methanation could be recycled to the electrolyzer to eliminate external water consumption, thus allowing for a more sustainable use of water resources. For olive stones and hemp hurd, this water recycling brings, instead, a reduction of approximately 65% in water needs. A round-trip electric efficiency of 28% was estimated assuming an electric conversion efficiency of 40%. According to the economic analysis, the total plant costs ranged within 3–5 M€ depending on the biomass and site location considered. The levelized cost of methane (LCOM) ranged within 4.3–8.9 € kgCH4−1 but, if implementing strategies to avoid the use of a large temporary H2 storage vessel, can be decreased to 2.6–5.3 € kgCH4−1. Lower values are obtained when considering hemp hurd and grape marc as raw biomasses, and when locating the PV field in the south of Italy. Even in the best scenario, values of LCOM are out of the market if compared to current natural gas prices, but they might become competitive with the introduction of a carbon tax or through government incentives for the purchase of the PV field and/or electrolyzer. Full article
(This article belongs to the Section A: Sustainable Energy)
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