Pediatric acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) exhibit favorable survival rates. However, for AML and ALL patients carrying KMT2A gene translocations clinical outcome remains unsatisfactory. Key players in KMT2A-fusion-driven leukemogenesis include menin and DOT1L. Recently, menin inhibitors like revumenib have garnered attention for their potential therapeutic efficacy in treating KMT2A-rearranged acute leukemias. However, resistance to menin inhibition poses challenges, and identifying which patients would benefit from revumenib treatment is crucial. Here, we investigated the in vitro response to revumenib in KMT2A-rearranged ALL and AML. While ALL samples show rapid, dose-dependent induction of leukemic cell death, AML responses are much slower and promote myeloid differentiation. Furthermore, we reveal that acquired resistance to revumenib in KMT2A-rearranged ALL cells can occur either through the acquisition of MEN1 mutations or independently of mutations in MEN1. Finally, we demonstrate significant synergy between revumenib and the DOT1L inhibitor pinometostat in KMT2A-rearranged ALL, suggesting that such drug combinations represent a potent therapeutic strategy for these patients. Collectively, our findings underscore the complexity of resistance mechanisms and advocate for precise patient stratification to optimize the use of menin inhibitors in KMT2A-rearranged acute leukemia. Full article

In the existing literature, direct torque control (DTC) by synthesizing virtual vectors can effectively suppress low-order harmonic currents under the single open-phase fault (OPF) of the five-phase permanent magnet synchronous motor (PMSM), but the sectors and the look-up tables need to be redesigned, which makes the control process more complicated. In order to solve this problem, an indirect correction method of virtual vectors is proposed, and the amplitudes of the virtual vectors are maximized. The fault-tolerant DTC strategy under the OPF ensures that there is no need to re-divide the sectors under the fault. And the selection rules of the look-up tables are consistent with the healthy operation. The difference is that the amplitudes of ten virtual vectors in the faulty operation are reduced, which simplifies the control process and is easy to implement. Finally, the correctness and effectiveness of the proposed control strategy were verified by experiments. Full article

Sulfated marine polysaccharides, so-called fucoidans, have been shown to exhibit anti-inflammatory and immunomodulatory activities in retinal pigment epithelium (RPE). In this study, we tested the effects of different fucoidans (and of fucoidan-treated RPE cells) on retinal microglia to investigate whether its anti-inflammatory effect can be extrapolated to the innate immune cells of the retina. In addition, we tested whether fucoidan treatment influenced the anti-inflammatory effect of RPE cells on retinal microglia. Three fucoidans were tested (FVs from Fucus vesiculosus, Fuc1 and FucBB04 from Laminaria hyperborea) as well as the supernatant of primary porcine RPE treated with fucoidans for their effects on inflammatory activated (using lipopolysaccharide, LPS) microglia cell line SIM-A9 and primary porcine retinal microglia. Cell viability was detected with a tetrazolium assay (MTT), and morphology by Coomassie staining. Secretion of tumor necrosis factor alpha (TNFα), interleukin 1 beta (IL1β) and interleukin 8 (IL8) was detected with ELISA, gene expression (NOS2 (Nitric oxide synthase 2), and CXCL8 (IL8)) with qPCR. Phagocytosis was detected with a fluorescence assay. FucBB04 and FVs slightly reduced the viability of SIM-A9 and primary microglia, respectively. Treatment with RPE supernatants increased the viability of LPS-treated primary microglia. FVs and FucBB04 reduced the size of LPS-activated primary microglia, indicating an anti-inflammatory phenotype. RPE supernatant reduced the size of LPS-activated SIM-A9 cells. Proinflammatory cytokine secretion and gene expression in SIM-A9, as well as primary microglia, were not significantly affected by fucoidans, but RPE supernatants reduced the secretion of LPS-induced proinflammatory cytokine secretion in SIM-A9 and primary microglia. The phagocytosis ability of primary microglia was reduced by FucBB04. In conclusion, fucoidans exhibited only modest effects on inflammatorily activated microglia by maintaining their cell size under stimulation, while the anti-inflammatory effect of RPE cells on microglia irrespective of fucoidan treatment could be confirmed, stressing the role of RPE in regulating innate immunity in the retina. Full article

One of the most devastating practices to be normalised in modern times is gender-based violence. Women and girls in South Africa can no longer enjoy the freedom that was promised by the country’s Freedom Charter during the dawn of democracy. Rape, killing and other forms of female persecution have become common practices, and the most worrying part of this is that the perpetrators of this violence seem to enjoy more freedom than their victims. Unfortunately, this kind of violence is no longer a secular issue but something that is now encountered in religious circles, places in which most people would hope to be sheltered and protected. The article investigates these kinds of violence within the parameters of religious institutions, specifically Pentecostal churches, and also makes some suggestions as to what kinds of approaches we need as a country to eliminate this pandemic. This article uses a desktop/secondary approach to gather data and to reach the conclusions made as a bases for the argument. Full article

Female undergraduate students have drastically increased in higher education over the last three decades. The increase in the number of students has come during unprecedented cost increases associated with attending a four-year higher education institution. The increases can be related to tuition but are also associated with mandatory fees (fees all students must pay regardless of status). These fees are associated with programs and services that enhance the collegiate experience (academic tutoring, health services, and Game Day activities). Conversely, little is known concerning how holistic experiences (prior experiences) can shape payment methods. Through a quantitative survey analysis that collected female participants’ self-reported data on payment methods across four states, we employed a regression analysis to predict their payment methods. Our findings suggest the (a) demographic characteristics, (b) university knowledge, (c) knowledge and attitudes toward mandatory fees, and (d) several academic capital subsets that shape women’s payment methods. Full article

Intermittent fasting (IF) has recently gained popularity due to its emerging benefits in reducing weight and improving metabolic health. Concurrently, novel agents (NAs) like venetoclax and Bruton tyrosine kinase inhibitors (BTKIs) have revolutionized the treatment of chronic lymphocytic leukemia (CLL). Unfortunately, it is unclear whether the associated risks of tumor lysis syndrome (TLS) and gastrointestinal bleeding (GIB) are increased in IF practitioners receiving NAs. This review explored the literature available on the permissibility of IF in CLL patients undergoing treatment with first-line NAs (FLNAs). Literature was scoped to identify IF patterns and the available data on TLS and GIB risks associated with food and fluid intake in CLL patients receiving FLNAs. Although current evidence is insufficient to recommend IF in this population, it may be possible for patients on venetoclax to conservatively practice fluid-liberal IF, provided that adequate hydration and the consistent administration of food are achieved. In contrast, considering the significant risk of TLS and the pharmacokinetics of venetoclax, patients should be discouraged from practicing fluid-restricted IF, especially during the ramp-up phase. Moreover, patients on BTKIs ought to refrain from IF due to the possible risk of GIB until further data are available. Further research is needed to provide conclusive recommendations. Full article

This paper deals with the ruin problem of an insurance company investing its capital reserve in a risky asset with the price dynamics given by a conditional geometric Brownian motion whose parameters depend on a Markov process describing random variations in the economic and financial environments. We prove a sufficient condition on the distribution of jumps of the business process ensuring the smoothness of the ruin probability as a function of the initial capital and obtain for this function an integro-differential equation. Full article

Since the Organisation for Economic Cooperation and Development presented its comprehensive Innovation Strategy in 2010, numerous countries have been updating their innovation policies. Subsequent to the promulgation, the innovation policies of Japan shifted the focus from discipline-specific to social issue-oriented approaches. This study investigates the response of the Japanese academic sector to this policy shift and the characteristics of the research projects associated with innovation policy by utilizing descriptive statistics from policy documents and the database of Grants-in-Aid for Scientific Research. The findings reveal that Japanese researchers have increasingly aligned their efforts with government-proposed research themes in recent years, with a notable shift toward short-term research projects. Moreover, Japanese universities are undergoing reforms that are transforming them into entrepreneurial institutions by altering incentive structures. Although these reforms may yield short-term research outcomes, they may not always address long-term societal needs. The narrowing focus on research themes could restrict the potential impact of research and impede the development of innovative solutions to societal challenges. From this viewpoint, assessing the relationship between government-proposed research themes and the research productivity of Japan is critical. Universities and public research institutions play a vital social role in broadening the foundational knowledge base through basic research, while private enterprises may lack the motivation to invest in research and development with low appropriability. These results may be beneficial for policymakers in reconsidering the division of labor in industry-academic collaboration in a knowledge-intensive economy. Full article

This study aims to carry out a comparative analysis between the level of digitization of the Romanian public administration compared to that existing in the most digitally developed states at the European level. Our study identifies the extent to which Romanian citizens have access to non-bureaucratic and transparent public services that support social inclusion and non-discrimination, compared to European citizens from states with the best digitalization of public services. Also, our research studies the relationship between the level of digitalization quantified by the DESI indicator and the level of income for the states considered in the analysis, as well as the relationship between digitalization and bureaucracy, the corruption index, and the digital skills of citizens. Based on the 486 statistical data collected and centralized on the corruption index (CPI), as well as the values for DESI and GNI per capita, for the period 2017–2022 for the 27 EU member states, we performed a statistical analysis using SPSS 28 regarding the existence of a DESI relationship and level of income (GNI per capita) and/or CPI (Corruption Perceptions Index). Our study is on a current issue, as it addresses the issue of digitalization of public administration, in the new post-pandemic and geostrategic context. It has theoretical applicability, by determining a model that can be used to study the relationship between digitalization and the standard of living and corruption, and also practical application, because it can contribute to the awareness of the government in taking measures and adopting strategies to reduce gaps as compared to the most developed digital states. Full article

Ocean energy sources are a promising source of energy. However, simulating a hydrokinetic farm with multiple units requires significant computational resources, while physical experimentation on site is expensive. Therefore, the scientific challenge is to develop analytical and experimental tools that consider real aspects of areas with generation potential in a controlled laboratory environment. This paper presents a theoretical and experimental tool for analysing the interconnection of a hydrokinetic energy farm comprising 20 generation units. The test bench is a Power Hardware in the Loop type, consisting of one physical prototype generator to scale and 19 discrete averaged models operating in real-time. The system allows generators to interact through an amplifier, emulating the impact of power injection in a small electrical network. This is based on the variability of the marine resource, specifically the current velocities in the Cozumel-Mexico channel. Unlike other publications, the most significant contribution of this work is a complete feasible emulation of a marine current plant interconnected to an electrical grid, where the objective is to have a global analysis of the operation of each generation unit and the impact of the interconnection as a whole, considering that such information is of utmost importance for the execution of future projects of power generation from the sea. Full article

Potential celiac disease (PCD) is a clinical condition characterised by the presence of a positive CD-specific serology and a normal intestinal architecture. Asymptomatic PCD patients are generally advised to continue on a gluten-containing diet (GCD), but long-term risks of this approach have never been explored. In the present study, we aimed to investigate nutritional and autoimmune complications possibly developing overtime in a cohort of asymptomatic PCD children on a GCD. We compared children’s parameters of growth, nutritional status, and autoimmunity between the time of diagnosis and on the occasion of their last medical check, after a long-term gluten-containing diet. Altogether, we collected data from 171 PCD children with a mean follow-up time of 3 years (range 0.35–15.3 years). During follow-up, although patients did not reduce their amount of daily gluten intake, their anti-tissue transglutaminase (anti-TG2) antibodies spontaneously and significantly decreased. Most parameters analysed had not changed during follow-up (height centile, ferritin, albumin, cholesterol, calcium, alkaline phosphatase, parathormone, and vitamin D) or even improved significantly (weight and BMI centile, haemoglobin, blood iron, HDL, glycaemia, and HbA1C, p < 0.05), always remaining within the limit of normality. Equally, autoantibodies for other concomitant autoimmune disorders did not increase overtime. Similar results were obtained excluding from analysis patients who had stopped producing anti-TG2 and those with a follow-up time < 3 years. Our pilot study has provided reassuring results regarding the maintenance of a gluten-containing diet in asymptomatic PCD children, even when long-term follow-up was considered. Full article

Mission scheduling is an essential function of the management control of remote-sensing satellite application systems. With the continuous development of remote-sensing satellite applications, mission scheduling faces significant challenges. Existing work has many inherent shortcomings in dealing with dynamic task scheduling for remote-sensing satellites. In high-load and complex remote sensing task scenarios, there is low scheduling efficiency and a waste of resources. The paper proposes a scheduling method for remote-sensing satellite applications based on dynamic task prioritization. This paper combines the and Bound methodologies with an onboard task queue scheduling band in an active task prioritization context. A purpose-built emotional task priority-based scheduling blueprint is implemented to mitigate the flux and unpredictability characteristics inherent in the traditional satellite scheduling paradigm, improve scheduling efficiency, and fine-tune satellite resource allocation. Therefore, the Branch and Bound method in remote-sensing satellite task scheduling will significantly save space and improve efficiency. The experimental results show that comparing the technique to the three heuristic algorithms (GA, PSO, DE), the BnB method usually performs better in terms of the maximum value of the objective function, always finds a better solution, and reduces about 80% in terms of running time. Full article

Aiming at the cooperative localization problem for the dynamic UAV swarm in an anchor-limited environment, an adaptive Wasserstein filter (AWF) with distance-constrained bare bones self-recovery particles (CBBP) is proposed. Firstly, to suppress the cumulative error from the inertial navigation system (INS), a position-prediction strategy based on transition particles is designed instead of using inertial measurements directly, which ensures that the generated prior particles can better cover the ground truth and provide the uncertainties of nonlinear estimation. Then, to effectively quantify the difference between the observed and the prior data, the Wasserstein measure based on slice segmentation is introduced to update the posterior weights of the particles, which makes the proposed algorithm robust against distance-measurement noise variance under the strongly nonlinear model. In addition, to solve the problem of particle impoverishment caused by traditional resampling, a diversity threshold based on Gini purity is designed, and a fast bare bones particle self-recovery algorithm with distance constraint is proposed to guide the outlier particles to the high-likelihood region, which effectively improves the accuracy and stability of the estimation. Finally, the simulation results show that the proposed algorithm is robust against cumulative error in an anchor-limited environment and achieves more competitive accuracy with fewer particles. Full article

Lower limb amputation is a common surgical procedure performed worldwide. Many individuals require amputation due to various circumstances, with amputations occurring above or below the knee. Surgeons rely on published research to determine the most appropriate technique based on intraoperative and postoperative outcomes. The Gritti–Stokes amputation (GSA) procedure, introduced in 1857, has shown positive results in terms of primary wound healing, reduced mortality rates during and after surgery, and accelerated healing and mobility. However, due to the need for highly trained surgeons and limitations in functional and cosmetic prosthesis fitting, concerns have been raised regarding its utility. Additionally, the procedure is underutilized in cases where it could potentially yield better results. This article provides a comprehensive review of the documented benefits of GSA, suitable candidate selection, limitations, various modifications, and a comparison with traditional approaches to lower limb amputation. The review is focused on evidence published in the last 100 years. Full article

The structural design of steel–titanium composite plates significantly affects their corrosion resistance. To investigate the impact of defects of different shapes and sizes on the corrosion behavior of steel–titanium composite plates, this study designed six types of defects and conducted a series of characterization tests. The results showed that due to the galvanic interaction between carbon steel and titanium alloy, small defects initially accelerate corrosion, resulting in 50% to 200% more corrosion weight loss compared to large defects. However, in the later stages of immersion, the corrosion rate of small defects decreased by up to 35%, which was attributed to the accumulation of protective corrosion products. Additionally, there is an inverse relationship between the corrosion rate and the thickness ratio of the composite plate. The reduction in the area of Q345B also results in additional corrosion loss of up to 32%. Full article

The PHLDA (pleckstrin homology-like domain family) gene family is popularly known as a potential biomarker for cancer identification, and members of the PHLDA family have become considered potentially viable targets for cancer treatments. The PHLDA gene family consists of PHLDA1, PHLDA2, and PHLDA3. The predictive significance of PHLDA genes in cancer remains unclear. To determine the role of pleckstrin as a prognostic biomarker in human cancers, we conducted a systematic multiomics investigation. Through various survival analyses, pleckstrin expression was evaluated, and their predictive significance in human tumors was discovered using a variety of online platforms. By analyzing the protein–protein interactions, we also chose a collection of well-known functional protein partners for pleckstrin. Investigations were also carried out on the relationship between pleckstrins and other cancers regarding mutations and copy number alterations. The cumulative impact of pleckstrin and their associated genes on various cancers, Gene Ontology (GO), and pathway analyses were used for their evaluation. Thus, the expression profiles of PHLDA family members and their prognosis in various cancers may be revealed by this study. During this multiomics analysis, we found that among the PHLDA family, PHLDA1 may be a therapeutic target for several cancers, including kidney, colon, and brain cancer, while PHLDA2 can be a therapeutic target for cancers of the colon, esophagus, and pancreas. Additionally, PHLDA3 may be a useful therapeutic target for ovarian, renal, and gastric cancer. Full article

In the Pistoia Nursery-Ornamental Rural District (Italy), a leader in Europe in ornamental nurseries covering over 5200 hectares with over 2500 different species of plant, plant-parasitic nematodes represent a serious concern. The potential efficacy of a pot cultivation system using commercial substrates to control plant-parasitic nematodes was assessed. On two different plant species, two different pot cultivation managements, potted plants, and potted plants previously cultivated in natural soil were compared to plants only cultivated in natural soil. The entire soil nematode structure with and without plants was evaluated. The relationship between soil properties and soil nematode community was investigated. All the studied substrates were free from plant-parasitic nematodes. Regarding free-living nematodes, Peat–Pumice showed nematode assemblage established by colonizer and extreme colonizer bacterial feeders, whereas Peat–Perlite included both bacterial and fungal feeders, and, finally, coconut fiber also included omnivores and predators. In farming, the substrates rich in organic matter such as coconut fiber could still play an important role in suppressing plant-parasitic nematodes because of the abundance of free-living nematodes. In fact, they are of crucial importance in both the mineralization of organic matter and the antagonistic control of plant-parasitic nematodes. Potting systems equally reduce virus-vector nematodes and improve the prey/predator ratio favoring natural control. Full article

This paper proposes a novel algorithm, termed Mixed Riccati–Lyapunov Balanced Truncation (MRLBT), tailored for order reduction of Linear Time-Invariant Continuous-Time Descriptor Systems (LTI-CTD), commonly encountered in electrical and electronic circuit modeling. The MRLBT approach synergistically combines the advantages of balanced truncation (BT) and positive-real balanced truncation (PRBT) techniques while mitigating their limitations. Unlike BT, which preserves stability but not passivity, and PRBT, which retains passivity at the expense of larger reduction errors, MRLBT ensures the preservation of both stability and passivity inherent in the original system. Additionally, MRLBT achieves reduced computational complexity and minimized order reduction errors compared to PRBT. The proposed algorithm transforms the system into an equivalent Mixed Riccati–Lyapunov Balanced form, enabling the construction of a reduced-order model that retains the critical physical properties. Theoretical analysis and proofs are provided, establishing an upper bound on the global order reduction error. The efficacy of MRLBT is demonstrated through a numerical example involving an RLC ladder network, showcasing its superior performance over BT and PRBT in terms of reduced errors in the time and frequency domains. Full article

In this experimental study, diverse water-soluble Fe(III) complexes were synthesized and employed to catalyze the aquathermolysis of heavy oil. A ternary reaction system comprising heavy oil, water, and methanol was established to facilitate the process. Viscometry, thermogravimetric analysis, DSC, and elemental analysis were utilized to thoroughly investigate the treated heavy oil. The findings reveal that, under optimal conditions of water, catalyst, and methanol dosage, the viscosity of heavy oil can be significantly reduced by up to 88.22% after reacting at 250 °C for 12 h. Notably, apart from viscosity reduction, the catalytic aquathermolysis also effectively removes heteroatoms such as sulfur, nitrogen, and oxygen, enabling in situ modification and viscosity reduction of heavy oil. This study demonstrates the potential of water-soluble Fe(III) complexes in enhancing the efficiency of heavy oil extraction and processing. Full article

In recent years, multi-functional lecture halls have developed rapidly and become a symbol of contemporary public spaces and places. This kind of spatial facility that brings together the advantages of land intensiveness and multi-functional integration also faces feedback such as poor acoustic effects. However, current research rarely involves the architectural design perspective, which is actually the root consideration of this problem; that is, how to set up corresponding spatial layout measures to optimize acoustic performance in a relatively economical and simple way. This study uses the academic lecture hall of the School of Architecture and Planning of Yunnan University as a case to try to solve these problems. The research is based on holistic considerations, starting from site selection, architectural design, aesthetic considerations, and environmental noise assessment, and combining simulation results with actual measurement results. Using a prediction–comparison–verification method, key acoustic parameters such as speech intelligibility, loudness, and reverberation time were calculated and evaluated to understand the acoustic design problems of the hall. The study found that the out-of-control reverberation time was the main cause of poor acoustic feedback, and based on this, optimization and transformation were carried out from an architectural perspective. Finally, a renovation suggestion was made that the application of sound-absorbing materials on the rear wall can achieve better acoustic effects inside the hall. Among the space combination methods, the combination of “rear wall, central ceiling, and front ceiling” has the best effect. Practical insights are provided for improving the acoustic performance of the multi-functional lecture halls while taking into account the acoustic design and feasible requirements. Full article

This investigation sought to discern the risk factors for atrial fibrillation within Shanghai’s Chongming District, analyzing data from 678 patients treated at a tertiary hospital in Chongming District, Shanghai, from 2020 to 2023, collecting information on season, C-reactive protein, hypertension, platelets, and other relevant indicators. The researchers introduced a novel dual feature-selection methodology, combining hierarchical clustering with Fisher scores (HC-MFS), to benchmark against four established methods. Through the training of five classification models on a designated dataset, the most effective model was chosen for method performance evaluation, with validation confirmed by test set scores. Impressively, the HC-MFS approach achieved the highest accuracy and the lowest root mean square error in the classification model, at 0.9118 and 0.2970, respectively. This provides a higher performance compared to existing methods, thanks to the combination and interaction of the two methods, which improves the quality of the feature subset. The research identified seasonal changes that were strongly associated with atrial fibrillation (pr = 0.31, FS = 0.11, and DCFS = 0.33, ranked first in terms of correlation); LDL cholesterol, total cholesterol, C-reactive protein, and platelet count, which are associated with inflammatory response and coronary heart disease, also indirectly contribute to atrial fibrillation and are risk factors for AF. Conclusively, this study advocates that machine-learning models can significantly aid clinicians in diagnosing individuals predisposed to atrial fibrillation, which shows a strong correlation with both pathological and climatic elements, especially seasonal variations, in the Chongming District. Full article

Biologics, including monoclonal antibodies (mAb), have proved to be effective and successful therapeutic agents, particularly in the treatment of cancer and immune-inflammatory conditions, as well as allergies and infections. However, their use carries an inherent risk of an immune-mediated adverse drug reaction. In this study, we describe the use of a novel pre-clinical human in vitro skin explant test for predicting skin sensitization and adverse immune reactions. The skin explant test was used to investigate the effects of therapeutic antibodies, which are known to cause a limited reaction in a small number of patients or more severe reactions. Material and Methods: Immune responses were determined by T cell proliferation and multiplex cytokine analysis, as well as histopathological analysis of skin damage (grades I–IV in increasing severity), predicting a negative (grade I) or positive (grade ≥ II) response for an adverse skin sensitization effect. Results: T cell proliferation responses were significantly increased in the positive group (p < 0.004). Multiplex cytokine analysis showed significantly increased levels of IFNγ, TNFα, IL-10, IL-12, IL-13, IL-1β, and IL-4 in the positive response group compared with the negative response group (p < 0.0001, p < 0.0001, p < 0.002, p < 0.01, p < 0.04, p < 0.006, and p < 0.004, respectively). Conclusions: Overall, the skin explant test correctly predicted the clinical outcome of 13 out of 16 therapeutic monoclonal antibodies with a correlation coefficient of 0.770 (p = 0.0001). This assay therefore provides a valuable pre-clinical test for predicting adverse immune reactions, including T cell proliferation and cytokine release, both associated with skin sensitization to monoclonal antibodies. Full article