The 2023 MDPI Annual Report has
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19 pages, 1994 KiB  
Article
Bibliometric Analysis of Trends and Future Directions of Research and Development of Seed Orchards
by Fatma Yardibi, Kyu-Suk Kang, Alper Ahmet Özbey and Nebi Bilir
Forests 2024, 15(6), 953; https://doi.org/10.3390/f15060953 (registering DOI) - 30 May 2024
Abstract
Seed orchards are important seed resources for producing improved tree crops for future plantations, forest restoration, and forestry practices (i.e., gene conservation) and for transmitting current gene diversity to future generations. Seed orchards are a major sub-division in forest science. The establishment and [...] Read more.
Seed orchards are important seed resources for producing improved tree crops for future plantations, forest restoration, and forestry practices (i.e., gene conservation) and for transmitting current gene diversity to future generations. Seed orchards are a major sub-division in forest science. The establishment and management of a seed orchard involves many steps, from the selection of superior trees to the harvesting of a seed crop. Studying the trends and future directions of seed orchards using different analysis methods is critically important, especially to establish resistant forests via the production of climate-smart, biotic/abiotic-stress-resistant seedling materials. Published papers related to seed orchards should be analyzed to determine the current trends in this field and to contribute to its future directions. Bibliometric analysis has been used for different purposes in various scientific fields. However, it has not been performed for publications in seed orchards. This study was carried out to analyze the current trends of research on seed orchards and to determine the future directions of these orchards based on published papers. For these purposes, 1018 published papers were obtained from the Science Citation Index, Science Citation Index Expanded, and citation index databases of “Web of Science” using the keyword “seed orchard”. The papers were published between 1980 and 2022 and were subjected to bibliometric analysis based on the most prolific contributors, references, countries, and keywords. CiteSpace software 6.1 R6 was applied to visualize information about seed orchard research. The average number of citations per publication was 13.05, and the 4 H-Index of the publication set was 48. The most prolific contributors with the strongest citation bursts, the highest centrality, and the greatest numbers of published papers were from Canada, Sweden, South Korea, Finland, and Czech Republic, while Canada (186 published articles), the USA (140), and Sweden (115), together with China, Brazil, and Germany, were active countries, especially based on citations from recent years. The “keywords” of the papers were the core of the research. “Mating pattern”, “Swedish forestry”, “fertility variation”, “Hymenoscyphus fraxineus”, “threatened Pacific sandalwood”, “outbreeding depression”, “climate change”, “management”, and “growth”, together with others such as “genetic improvement” and “effective size”, were active study areas and keywords, based on results of the analysis. They also guided the literature search and inventory and classification of early studies and served as predictors for future studies. The results of this study are discussed based on the trends and future directions of the research and development of seed orchards. Full article
31 pages, 15181 KiB  
Article
Seasonal Cycle of Southern Hemisphere Explosive Growth and Decay of Storms
by Stacey L. Osbrough and Jorgen S. Frederiksen
Atmosphere 2024, 15(6), 660; https://doi.org/10.3390/atmos15060660 (registering DOI) - 30 May 2024
Abstract
The seasonal variability of Southern Hemisphere (SH) synoptic-scale weather systems is analysed for the 20-year timespan 1997 to 2016. The relationships between the SH jet streams and storm tracks based on lower tropospheric circulation anomalies filtered into the high-pass (periods < 4 days) [...] Read more.
The seasonal variability of Southern Hemisphere (SH) synoptic-scale weather systems is analysed for the 20-year timespan 1997 to 2016. The relationships between the SH jet streams and storm tracks based on lower tropospheric circulation anomalies filtered into the high-pass (periods < 4 days) and band-pass (periods between 4 and 8 days) types are examined based on 6-hourly reanalysis data. Leading Empirical Orthogonal Functions (EOFs) and storm tracks based on all (growing and decaying) disturbances are determined. As well, the structure and standard deviations of streamfunction fluctuations are determined separately in three growth rate and three decay rate bins focusing on explosive growth and decay. In all cases, and in each season, the band-pass storm tracks are more zonally symmetric than the high-pass standard deviations and this is also reflected by the EOFs. Leading EOFs in both bands are monopole wavetrains of highs and lows located in the storm tracks with some band-pass disturbances having dipole structures consistent with blocking and northwest cloud bands. EOFs based on the bin with slow-growing fluctuations are structurally similar to the standard EOFs based on all disturbances. EOFs for moderately and explosively growing disturbances are increasingly displaced equatorward with a larger growth rate. Full article
(This article belongs to the Section Climatology)
23 pages, 6572 KiB  
Article
Spatiotemporal Evolution and Frontier Focus Analysis Based on Coal Fire Control Body of Knowledge
by Dandan Han, Guchen Niu, Bing Liu, Feiran Wang, Yongbo Ren, Chang Su, Yutong Yao and Zining Zhao
Fire 2024, 7(6), 187; https://doi.org/10.3390/fire7060187 (registering DOI) - 30 May 2024
Abstract
Abstract: Mine fire accidents frequently constitute a major threat to mining safety, and their potential consequences are extremely severe, which highlights the urgency of fire prevention and control research. In this study, the CiteSpace software was used to conduct a metrological analysis of [...] Read more.
Abstract: Mine fire accidents frequently constitute a major threat to mining safety, and their potential consequences are extremely severe, which highlights the urgency of fire prevention and control research. In this study, the CiteSpace software was used to conduct a metrological analysis of 717 relevant studies in the field of mine fire prevention and control (MFPC), aiming to reveal the research trends and trends in this field. This analysis found that the annual number of MFPC articles showed a significant upward trend, indicating that it is in rapid development during the active period. China, the United States, and Australia are the main contributors in this field, and the institutional contribution of China University of Mining and Technology is particularly outstanding, reflecting the regional concentration of research activities. The analysis of cooperation networks reveals the close cross-regional collaboration among European countries. The inhibition effect and evaluation criteria and the inhibition technology under different coal characteristics have become the focus of research. Activation energy, release, and quantum chemistry have become recent hot spots, reflecting the research on the mechanism of forward physicochemical synergistic inhibition and the in-depth exploration of the molecular level. It indicates that future research will focus on the development of temperature-responsive retardant materials, the application of quantum chemistry theory, and the exploration of the microscopic mechanism of coal spontaneous combustion through molecular simulation technology to further optimize the fire prevention strategy. In summary, the findings of this study not only provide a comprehensive picture of current research activities in the MFPC field but also indicate potential directions for future research and have important guiding significance for promoting the development of this field. Full article
(This article belongs to the Special Issue Simulation, Experiment and Modeling of Coal Fires)
14 pages, 6494 KiB  
Article
Marine-Derived Phosphoeleganin and Its Semisynthetic Derivative Decrease IL6 Levels and Improve Insulin Signaling in Human Hepatocellular Carcinoma Cells
by Ayewa L. Agognon, Marcello Casertano, Alessio Vito, Sonia Orso, Serena Cabaro, Federica Mormone, Cristina Morelli, Giuseppe Perruolo, Pietro Formisano, Marialuisa Menna, Concetta Imperatore and Francesco Oriente
Int. J. Mol. Sci. 2024, 25(11), 6039; https://doi.org/10.3390/ijms25116039 (registering DOI) - 30 May 2024
Abstract
Marine natural products constitute a great source of potential new antidiabetic drugs. The aim of this study was to evaluate the role of phosphoeleganin (PE), a polyketide purified from the Mediterranean ascidian Sidnyum elegans, and its derivatives PE/2 and PE/3 on insulin [...] Read more.
Marine natural products constitute a great source of potential new antidiabetic drugs. The aim of this study was to evaluate the role of phosphoeleganin (PE), a polyketide purified from the Mediterranean ascidian Sidnyum elegans, and its derivatives PE/2 and PE/3 on insulin sensitivity in human hepatocellular carcinoma (HepG2) cells. In our experiments, insulin stimulates the phosphorylation of its receptor (INSR) and AKT by 1.5- and 3.5-fold, respectively, whereas in the presence of PE, PE/2, and PE/3, the insulin induced INSR phosphorylation is increased by 2.1-, 2-, and 1.5-fold and AKT phosphorylation by 7.1-, 6.0-, and 5.1-fold, respectively. Interestingly, PE and PE/2 have an additive effect on insulin-mediated reduction of phosphoenolpyruvate carboxykinase (PEPCK) expression. Finally, PE and PE/2, but not PE/3, decrease interleukin 6 (IL6) secretion and expression before and after palmitic acid incubation, while in the presence of high glucose (HG), only PE reduces IL6. Levels of other cytokines are not significantly affected by PE and its derivates. All these data suggest that PE and its synthetic-derived compound, PE/2, significantly decrease IL6 and improve hepatic insulin signaling. As IL6 impairs insulin action, it could be hypothesized that PE and PE/2, by inhibiting IL6, may improve the hepatic insulin pathway. Full article
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8 pages, 1713 KiB  
Brief Report
Response of Tahitian Bridal Veil (Gibasis pellucida) and Small-Leaf Spiderwort (Tradescantia fluminensis) to Postemergence Herbicides under Greenhouse Conditions
by Ping Yu, Stephen Christopher Marble and Patrick Minogue
Plants 2024, 13(11), 1513; https://doi.org/10.3390/plants13111513 (registering DOI) - 30 May 2024
Abstract
Tahitian bridal veil (Gibasis pellucida) and small-leaf spiderwort (Tradescantia fluminensis) are both invasive species in natural areas throughout Florida. However, very little is known regarding herbicide control. To provide land managers with herbicidal control options for both species, postemergence [...] Read more.
Tahitian bridal veil (Gibasis pellucida) and small-leaf spiderwort (Tradescantia fluminensis) are both invasive species in natural areas throughout Florida. However, very little is known regarding herbicide control. To provide land managers with herbicidal control options for both species, postemergence herbicides were evaluated for efficacy in a greenhouse to identify herbicide options that control both species under similar settings. Four herbicides, including triclopyr acid, triclopyr amine + 2,4-D amine, triclopyr amine, and glufosinate were applied at standard label rates and compared to a non-treated control group for efficacy. Visual control ratings were taken at 2, 4, and 8 weeks after treatment (WAT), and shoot dry weights (WAT 8) and regrowth dry weights (WAT 12) were determined. Triclopyr (acid and amine) generally provided the most consistent control of both species as evidenced by the visual control ratings and shoot dry weight data which showed reductions of 76% to 89% in shoot biomass at trial conclusion. Triclopyr + 2,4-D reduced shoot dry weights by 52% to 54% and was the least effective when considering the control of both species. Full article
(This article belongs to the Section Plant Protection and Biotic Interactions)
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14 pages, 910 KiB  
Article
Negative Medium-Voltage Direct Current Discharges in Air under Simulated Sub-Atmospheric Pressures for All-Electric Aircraft
by Sai Pavan Kalakonda, Mohammad Hamidieh, Adil Bhojwani and Mona Ghassemi
Aerospace 2024, 11(6), 444; https://doi.org/10.3390/aerospace11060444 (registering DOI) - 30 May 2024
Abstract
The increase in the global temperature due to greenhouse gas emissions is a major concern to the world. To achieve the goal of zero emissions by 2050 in the USA the practical realization of all-electric vehicles, particularly all-electric aircraft (AEA), is important. For [...] Read more.
The increase in the global temperature due to greenhouse gas emissions is a major concern to the world. To achieve the goal of zero emissions by 2050 in the USA the practical realization of all-electric vehicles, particularly all-electric aircraft (AEA), is important. For the design of electrical power systems (EPSs) in all-electric aircraft, a bipolar medium-voltage direct current (MVDC) system of ±5 kV is being investigated. However, several challenges manifest when using such voltages in a low-pressure environment. One of the main challenges is the partial discharge (PD) behavior of the insulation. It is important to study the PD behavior of the insulation by simulating the aviation environment in the lab. This work aimed to study the partial discharge behavior of air under a negative DC voltage in a needle-to-plane electrode geometry by simulating the aviation pressures in the lab. The partial discharge inception voltage (PDIV) and the breakdown voltage (BDV) show an obvious pressure-dependent variation. Regression analysis was performed to better understand the relationship between the PDIV and pressures. Plots were drawn for the average discharge current at each voltage step until breakdown. This paper’s findings can provide valuable insight into the design of EPS for an AEA. To the best of our knowledge, such a study has not been carried out to date. Full article
(This article belongs to the Special Issue Electric Power Systems and Components for All-Electric Aircraft)
16 pages, 759 KiB  
Article
An Iterated Local Search Heuristic for the Multi-Trip Vehicle Routing Problem with Multiple Time Windows
by Yinghui Wu, Haoran Du and Huixin Song
Mathematics 2024, 12(11), 1712; https://doi.org/10.3390/math12111712 (registering DOI) - 30 May 2024
Abstract
This paper studies the multi-trip vehicle routing problem with multiple time windows, which extends the multi-trip vehicle routing problem by deciding not only the sequence of customers that each vehicle serves but also the service time window of each customer. It also requires [...] Read more.
This paper studies the multi-trip vehicle routing problem with multiple time windows, which extends the multi-trip vehicle routing problem by deciding not only the sequence of customers that each vehicle serves but also the service time window of each customer. It also requires that the delivery service time is within the selected time windows and that the total demand of the customers served by the vehicle on each trip does not exceed the maximum carrying capacity. For solving the studied problem, we develop a mixed integer linear programming model with the objective of minimizing the total travel distance of vehicles and design a tailored iterative local search heuristic. Within the framework of the iterative local search, an improved Solomon greedy insertion algorithm suitable for multiple time windows and multi-trip scenarios is designed to generate the initial solution, and local search operators such as Or-opt and Relocate, as well as Random Exchange perturbation operations, are also developed. The experiment results demonstrate the effectiveness of the proposed model and algorithm and confirm that by providing customers with multiple time windows option, carriers can flexibly plan vehicle routes and select appropriate service time windows, thereby reducing the number of vehicles used and the total distance travelled and improve delivery success. Full article
12 pages, 3082 KiB  
Article
Adsorption Characteristics of Illite and Kerogen Oil Phase: Thermodynamics Experiments
by Xin Tang, Junjie Xiong, Yanming Zhu, Ruiyu He, Xiangru Chen, Qiuqi Chen, Zhangping Yan, Cheng Liu and Litao Ma
Minerals 2024, 14(6), 579; https://doi.org/10.3390/min14060579 (registering DOI) - 30 May 2024
Abstract
In order to study the adsorption process and adsorption characteristics of shale oil at the macro scale, the isothermal adsorption experiments of illite and kerogen on a heptadecane (oil phase) solution were carried out by infrared spectrophotometry and gas chromatography–mass spectrometry. Based on [...] Read more.
In order to study the adsorption process and adsorption characteristics of shale oil at the macro scale, the isothermal adsorption experiments of illite and kerogen on a heptadecane (oil phase) solution were carried out by infrared spectrophotometry and gas chromatography–mass spectrometry. Based on the adsorption isotherm model and adsorption thermodynamic model, the characteristics of heptadecane adsorbed by illite and kerogen at different temperatures and oily solution concentrations were studied. The experimental results show that the concentration and temperature of the alkane solution help to enhance the adsorption and increase the saturated adsorption capacity. The difference is that the concentration will have a certain effect on the adsorption rate, while the temperature will not. Based on the three adsorption isotherm models, it was found that Langmuir and Freundlich were more suitable for describing the adsorption process of the heptadecane solution by illite and kerogen, and the adsorption characteristics of heptadecane molecules at different temperatures and adsorbents were evaluated. Heating leads to an increase in the collision efficiency between adsorbate molecules and adsorbents, thereby accelerating the migration rate of alkanes. Therefore, increasing temperature helps to enhance the adsorption capacity of rocks and increase the saturated adsorption capacity of minerals. The research results clarify the adsorption characteristics of shale oil heavy components from the macro level and fill the research gap in the application of solid–liquid isothermal adsorption physical experiments on the adsorption and occurrence of shale oil. Full article
(This article belongs to the Section Clays and Engineered Mineral Materials)
13 pages, 1358 KiB  
Article
Association between COVID-19 and the Risk of Vascular Dementia: A Mendelian Randomisation Study of the Potential Cognitive Sequela of COVID-19
by Qing Han, Yue Ma and Wenting Ye
Behav. Sci. 2024, 14(6), 465; https://doi.org/10.3390/bs14060465 (registering DOI) - 30 May 2024
Abstract
A growing body of observational studies and Mendelian Randomisation analyses suggest an increased risk of Alzheimer’s disease and dementia following COVID-19 infection. However, evidence on the potential association between COVID-19 and vascular dementia, which is plausible given the vascular complications of COVID-19 infection, [...] Read more.
A growing body of observational studies and Mendelian Randomisation analyses suggest an increased risk of Alzheimer’s disease and dementia following COVID-19 infection. However, evidence on the potential association between COVID-19 and vascular dementia, which is plausible given the vascular complications of COVID-19 infection, is still limited. In this study, we conducted a two-sample Mendelian Randomisation analysis to examine the potential causal relationship between COVID-19 phenotypes and the risk of vascular dementia, using summary data from large-scale GWASs. The two-sample Mendelian Randomisation analysis did not detect any significant associations of COVID-19 infection, COVID-19 hospitalisation, or critical COVID-19 with the risk of vascular dementia, with weighted average β values of −0.29 (95% CI: −0.84, 0.26; p = 0.301), −0.12 (95% CI: −0.36, 0.13; p = 0.345), and −0.07 (95% CI: −0.23, 0.09; p = 0.374), respectively. Our findings do not support the hypothesis that vascular dementia is one of the long-term sequelae of COVID-19. Full article
(This article belongs to the Special Issue Health Psychology and Behaviors during COVID-19)
16 pages, 23556 KiB  
Article
The Therapeutic Potential of Intra-Articular Injection of Synthetic Deer Antler Peptides in a Rat Model of Knee Osteoarthritis
by Yu-Chou Hung, Li-Jin Chen, Jen-Hung Wang, Tsung-Jung Ho, Guo-Fang Tseng and Hao-Ping Chen
Int. J. Mol. Sci. 2024, 25(11), 6041; https://doi.org/10.3390/ijms25116041 (registering DOI) - 30 May 2024
Abstract
Synthetic deer antler peptides (TSKYR, TSK, and YR) stimulate the proliferation of human chondrocytes and osteoblasts and increase the chondrocyte content of collagen and glycosamino-glycan in vitro. This study investigated the peptide mixture’s pain relief and chondroprotective effect in a rat model of [...] Read more.
Synthetic deer antler peptides (TSKYR, TSK, and YR) stimulate the proliferation of human chondrocytes and osteoblasts and increase the chondrocyte content of collagen and glycosamino-glycan in vitro. This study investigated the peptide mixture’s pain relief and chondroprotective effect in a rat model of collagenase-induced osteoarthritis. Thirty-six adult male Sprague–Dawley rats were divided into three groups: control (saline), positive control (hyaluronic acid), and ex-perimental (peptides). Intra-articular collagenase injections were administered on days 1 and 4 to induce osteoarthritis in the left knees of the rats. Two injections of saline, hyaluronic acid, or the peptides were injected into the same knees of each corresponding group at the beginning of week one and two, respectively. Joint swelling, arthritic pain, and histopathological changes were evaluated. Injection of the peptides significantly reduced arthritic pain compared to the control group, as evidenced by the closer-to-normal weight-bearing and paw withdrawal threshold test results. Histological analyses showed reduced cartilage matrix loss and improved total cartilage degeneration score in the experimental versus the control group. Our findings suggest that intra-articular injection of synthetic deer antler peptides is a promising treatment for osteoarthritis. Full article
(This article belongs to the Special Issue Osteoarthritis Biomarkers, Diagnosis and Treatments)
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17 pages, 2450 KiB  
Article
Effects of Surface IR783 Density on the In Vivo Behavior and Imaging Performance of Liposomes
by Qianqian Long, Xinmin Zhao, Lili Gao, Mengyuan Liu, Feng Pan, Xihui Gao, Changyou Zhan, Yang Chen, Jialei Wang and Jun Qian
Pharmaceutics 2024, 16(6), 744; https://doi.org/10.3390/pharmaceutics16060744 (registering DOI) - 30 May 2024
Abstract
Background: Nanoparticles conjugated with fluorescent probes have versatile applications, serving not only for targeted fluorescent imaging but also for evaluating the in vivo profiles of designed nanoparticles. However, the relationship between fluorophore density and nanoparticle behavior remains unexplored. Methods: The IR783-modified liposomes (IR783-sLip) [...] Read more.
Background: Nanoparticles conjugated with fluorescent probes have versatile applications, serving not only for targeted fluorescent imaging but also for evaluating the in vivo profiles of designed nanoparticles. However, the relationship between fluorophore density and nanoparticle behavior remains unexplored. Methods: The IR783-modified liposomes (IR783-sLip) were prepared through a modified ethanol injection and extrusion method. The cellular uptake efficiency of IR783-sLip was characterized by flow cytometry and fluorescence microscope imaging. The effects of IR783 density on liposomal in vivo behavior were investigated by pharmacokinetic studies, biodistribution studies, and in vivo imaging. The constitution of protein corona was analyzed by the Western blot assay. Results: Dense IR783 modification improved cellular uptake of liposomes in vitro but hindered their blood retention and tumor imaging performance in vivo. We found a correlation between IR783 density and protein corona absorption, particularly IgM, which significantly impacted the liposome performance. Meanwhile, we observed that increasing IR783 density did not consistently improve the effectiveness of tumor imaging. Conclusions: Increasing the density of modified IR783 on liposomes is not always beneficial for tumor near-infrared (NIR) imaging yield. It is not advisable to prematurely evaluate novel nanomaterials through fluorescence dye conjugation without carefully optimizing the density of the modifications. Full article
(This article belongs to the Special Issue Lipid/Polymer-Based Drug Delivery Systems)
28 pages, 2413 KiB  
Article
Waste Plastic in Asphalt Mixtures via the Dry Method: A Bibliometric Analysis
by Isabella M. Bueno and Jamilla E. S. L. Teixeira
Sustainability 2024, 16(11), 4675; https://doi.org/10.3390/su16114675 (registering DOI) - 30 May 2024
Abstract
Although waste plastic (WP) application as a paving material has drawn increasing attention from scholars, there is a lack of studies that summarize the latest development of WP research. Considering there is no standard procedure to incorporate WPs in asphalt mixtures, it is [...] Read more.
Although waste plastic (WP) application as a paving material has drawn increasing attention from scholars, there is a lack of studies that summarize the latest development of WP research. Considering there is no standard procedure to incorporate WPs in asphalt mixtures, it is important to document the major findings from the available literature to identify knowledge gaps to tackle in future research and advance knowledge on this subject. Using a bibliometric analysis method, this study carries out a holistic review of WP articles published from 2003 to 2023, focusing on incorporating WP in asphalt mixtures via the dry method. This study particularly focused on identifying and evaluating individual types of WP mostly used in asphalt mixtures via the dry method and how their most common characteristics (size, shape, and melting point) affect the mixing procedure and the overall mixture’s performance. The analysis highlighted China, the USA, and India as leading countries in WP-related publications. Typically, low-density polyethylene (LDPE), high-density polyethylene (HDPE), and polyethylene terephthalate (PET) were the most utilized WPs in the dry method. Smaller WP particle sizes (<2.36 mm) were considered more suitable in asphalt mixtures. In general, studies employing procedures involving WP melting, typically by introducing WP to pre-heated aggregates at temperatures surpassing its melting point, resulted in improved asphalt mixtures with enhanced resistance to rutting, cracking, and moisture damage. In this context, positive performance outcomes were notably observed in studies using HDPE or LDPE, potentially because of their low melting point. The key knowledge gaps identified were the lack of a consistent procedure applicable across studies, a feasibility assessment for scaling laboratory-based procedures to field applications, and laboratory evaluations utilizing advanced performance tests as suggested in the Balance Mix Design (BMD) approaches. Full article
(This article belongs to the Special Issue Critical Issue on Waste Management for Environmental Sustainability)
18 pages, 357 KiB  
Article
Decolonial Embodiments: Materiality, Disability, and Black Being in Djaimilia Pereira de Almeida’s Luanda, Lisboa, Paraíso
by Daniel F. Silva
Humanities 2024, 13(3), 83; https://doi.org/10.3390/h13030083 (registering DOI) - 30 May 2024
Abstract
Grounded in, and in dialogue with, Djaimilia Pereira de Almeida’s Luanda, Lisboa, Paraíso of 2018, this paper interrogates a particular time and place of coloniality and racial capital’s reproduction of Black fungibility in late twentieth-century Portugal, after formal decolonization in Africa [...] Read more.
Grounded in, and in dialogue with, Djaimilia Pereira de Almeida’s Luanda, Lisboa, Paraíso of 2018, this paper interrogates a particular time and place of coloniality and racial capital’s reproduction of Black fungibility in late twentieth-century Portugal, after formal decolonization in Africa and in the wake of Black migratory waves from the post/neo-colony (Angola in this case) to the former metropolis. Almeida’s novel provides a literary intervention in grappling with the economic and institutional reinvention of anti-Blackness in Europe after settler colonialism, while also imagining and inscribing modes of Black being within and beyond the materialities of white supremacy. Towards this end and against the racial, gendered, and ableist logics of capital, the Black body in Almeida’s novel becomes a site through which the relationships between humans and matter as well as mind and body are decolonially revised. Full article
(This article belongs to the Special Issue Decolonization in Lusophone Literature)
13 pages, 597 KiB  
Article
Health Professionals’ Experiences with Health-Promoting Dialogues for Older Home-Dwellers—A Qualitative Study
by Liza Wigaard Johansen, Hilde Lausund and Nina Jøranson
Behav. Sci. 2024, 14(6), 464; https://doi.org/10.3390/bs14060464 (registering DOI) - 30 May 2024
Abstract
Home-dwelling older people without healthcare services might develop vulnerability and health-related issues that should be detected proactively by service providers. Health-promoting measures directed towards the target group could facilitate living longer and better at home, as well as delay the need for healthcare [...] Read more.
Home-dwelling older people without healthcare services might develop vulnerability and health-related issues that should be detected proactively by service providers. Health-promoting measures directed towards the target group could facilitate living longer and better at home, as well as delay the need for healthcare services. One approach is through health-promoting dialogues between the municipality and healthcare professionals. This study aims to explore the experiences of healthcare professionals involved in health-promoting dialogues with home-dwellers aged over 75 years without health service decisions in Norway. Data were collected through three focus groups. Thematic analysis was applied to the data resulting in the emergence of one major theme, “challenging dialogues”, comprising three sub-themes: “promote the individual’s perspectives”, “uncovering vulnerability”, and “ambiguity of the dialogues”. The health-promoting dialogue uses a resource perspective for the elderly to remain independent in old age and can reveal vulnerability and underlying needs. The purpose of the dialogue appears ambiguous for the target group, which leads to unclear service expectations and frequent rejections of the offer. Nevertheless, this health-promoting service has a clear purpose of identifying and meeting the needs of the target group in a broader sense during the ageing process. Full article
(This article belongs to the Special Issue Social Participation and Mental Health among Older Adults)
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21 pages, 3833 KiB  
Article
Generation of Rapid and High-Quality Serum by Recombinant Prothrombin Activator Ecarin (RAPClot™)
by Kong-Nan Zhao, Goce Dimeski, Paul Masci, Lambro Johnson, Jingjing Wang, John de Jersey, Michael Grant and Martin F. Lavin
Biomolecules 2024, 14(6), 645; https://doi.org/10.3390/biom14060645 (registering DOI) - 30 May 2024
Abstract
We recently reported the potential application of recombinant prothrombin activator ecarin (RAPClot™) in blood diagnostics. In a new study, we describe RAPClot™ as an additive to develop a novel blood collection prototype tube that produces the highest quality serum for accurate biochemical analyte [...] Read more.
We recently reported the potential application of recombinant prothrombin activator ecarin (RAPClot™) in blood diagnostics. In a new study, we describe RAPClot™ as an additive to develop a novel blood collection prototype tube that produces the highest quality serum for accurate biochemical analyte determination. The drying process of the RAPClot™ tube generated minimal effect on the enzymatic activity of the prothrombin activator. According to the bioassays of thrombin activity and plasma clotting, γ-radiation (>25 kGy) resulted in a 30–40% loss of the enzymatic activity of the RAPClot™ tubes. However, a visual blood clotting assay revealed that the γ-radiation-sterilized RAPClot™ tubes showed a high capacity for clotting high-dose heparinized blood (8 U/mL) within 5 min. This was confirmed using Thrombelastography (TEG), indicating full clotting efficiency under anticoagulant conditions. The storage of the RAPClot™ tubes at room temperature (RT) for greater than 12 months resulted in the retention of efficient and effective clotting activity for heparinized blood in 342 s. Furthermore, the enzymatic activity of the RAPClot™ tubes sterilized with an electron-beam (EB) was significantly greater than that with γ-radiation. The EB-sterilized RAPClot™ tubes stored at RT for 251 days retained over 70% enzyme activity and clotted the heparinized blood in 340 s after 682 days. Preliminary clinical studies revealed in the two trials that 5 common analytes (K, Glu, lactate dehydrogenase (LD), Fe, and Phos) or 33 analytes determined in the second study in the γ-sterilized RAPClot™ tubes were similar to those in commercial tubes. In conclusion, the findings indicate that the novel RAPClot™ blood collection prototype tube has a significant advantage over current serum or lithium heparin plasma tubes for routine use in measuring biochemical analytes, confirming a promising application of RAPClot™ in clinical medicine. Full article
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11 pages, 455 KiB  
Article
Robotic Major Hepatectomy in Elderly Patient
by Antonella Delvecchio, Maria Conticchio, Riccardo Inchingolo, Francesca Ratti, Paolo Magistri, Andrea Belli, Graziano Ceccarelli, Francesco Izzo, Marcello Giuseppe Spampinato, Nicola De’ Angelis, Patrick Pessaux, Tullio Piardi, Fabrizio Di Benedetto, Luca Aldrighetti and Riccardo Memeo
Cancers 2024, 16(11), 2083; https://doi.org/10.3390/cancers16112083 (registering DOI) - 30 May 2024
Abstract
Background: the role of minimally invasive liver surgery has been progressively developed, with the practice increasing in safety and feasibility also with respect to major liver resections. The aim of this study was to analyze the feasibility and safety of major liver resection [...] Read more.
Background: the role of minimally invasive liver surgery has been progressively developed, with the practice increasing in safety and feasibility also with respect to major liver resections. The aim of this study was to analyze the feasibility and safety of major liver resection in elderly patients. Methods: data from a multicentric retrospective database including 1070 consecutive robotic liver resections in nine European hospital centers were analyzed. Among these, 131 were major liver resections. Patients were also divided in two groups (<65 years old and ≥65 years old) and perioperative data were compared between the two groups. Results: a total of 131 patients were included in the study. Operative time was 332 ± 125 min. Postoperative overall complications occurred in 27.1% of patients. Severe complications (Clavien Dindo ≥ 3) were 9.9%. Hospital stay was 6.6 ± 5.3 days. Patients were divided into two groups based on their age: 75 patients < 65 years old and 56 patients ≥ 65 years old. Prolonged pain, lung infection, intensive care stay, and 90-day readmission were worse in the elderly group. The two groups were matched for ASA and Charlson comorbidity score and, after statistical adjustment, postoperative data were similar between two groups. Conclusions: robotic major liver resection in elderly patients was associated with satisfying short-term outcomes. Full article
11 pages, 1347 KiB  
Article
Antibiotic Resistance Trends in Uropathogens during the COVID-19 Pandemic in Western Romania: A Cross-Sectional Study
by Elena Hogea, Alexandra Cristina Muntean, Felix Bratosin, Iulia Georgiana Bogdan, Oana Plavitu, Adelina Fratutu, Cristian Oancea, Mihai Calin Bica, Delia Muntean, Ingrid Hrubaru, Zoran Laurentiu Popa and Adrian Cosmin Ilie
Antibiotics 2024, 13(6), 512; https://doi.org/10.3390/antibiotics13060512 (registering DOI) - 30 May 2024
Abstract
The emergence and spread of antimicrobial resistance have been significant global health challenges, exacerbated by the COVID-19 pandemic. As healthcare systems faced unprecedented pressures, the management of non-COVID conditions, including urinary tract infections (UTIs), also encountered obstacles due to changes in microbial flora [...] Read more.
The emergence and spread of antimicrobial resistance have been significant global health challenges, exacerbated by the COVID-19 pandemic. As healthcare systems faced unprecedented pressures, the management of non-COVID conditions, including urinary tract infections (UTIs), also encountered obstacles due to changes in microbial flora and antibiotic usage patterns. This cross-sectional study aimed to characterize the antimicrobial resistance trends among bacterial uropathogens isolated from patients in the Western region of Romania, between January 2020 and December 2022. The objectives were to map the resistance patterns and observe the pandemic’s influence on antimicrobial resistance, particularly among enterobacterial Gram-negative species, to guide treatment and infection control strategies. From a total of 2472 urine samples collected during the study period, 378 positive samples were analyzed. This study found that Escherichia coli was the most commonly isolated uropathogen, making up 46.3% of the cases (n = 175), with Klebsiella pneumoniae at 20.6% (n = 78). There was a high resistance of Klebsiella pneumoniae to several antibiotics, while carbapenemase production increased to 52.5% and extended-spectrum beta-lactamase (ESBL) present in 24.3% of the strains. Escherichia coli showed high resistance rates to amoxicillin–clavulanic acid (from 45.4% in 2020 to 53.8% in 2022) and trimethoprim/sulfamethoxazole (from 27.5% in 2020 to 47.2% in 2022). The increasing trend of antimicrobial resistance noted during the pandemic, especially in Gram-negative enterobacterial species, highlights the urgent need for robust infection control measures and rational antibiotic use. This study underscores the critical importance of continuous surveillance to adapt antibiotic therapies effectively and prevent the further spread of resistance, thereby ensuring effective management of UTIs in the evolving healthcare landscape influenced by the pandemic. Full article
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13 pages, 1905 KiB  
Article
Machine Learning Identifies Key Proteins in Primary Sclerosing Cholangitis Progression and Links High CCL24 to Cirrhosis
by Tom Snir, Raanan Greenman, Revital Aricha, Matthew Frankel, John Lawler, Francesca Saffioti, Massimo Pinzani, Douglas Thorburn, Adi Mor and Ilan Vaknin
Int. J. Mol. Sci. 2024, 25(11), 6042; https://doi.org/10.3390/ijms25116042 (registering DOI) - 30 May 2024
Abstract
Abstract: Primary sclerosing cholangitis (PSC) is a rare, progressive disease, characterized by inflammation and fibrosis of the bile ducts, lacking reliable prognostic biomarkers for disease activity. Machine learning applied to broad proteomic profiling of sera allowed for the discovery of markers of disease [...] Read more.
Abstract: Primary sclerosing cholangitis (PSC) is a rare, progressive disease, characterized by inflammation and fibrosis of the bile ducts, lacking reliable prognostic biomarkers for disease activity. Machine learning applied to broad proteomic profiling of sera allowed for the discovery of markers of disease presence, severity, and cirrhosis and the exploration of the involvement of CCL24, a chemokine with fibro-inflammatory activity. Sera from 30 healthy controls and 45 PSC patients were profiled with proximity extension assay, quantifying the expression of 2870 proteins, and used to train an elastic net model. Proteins that contributed most to the model were tested for correlation to enhanced liver fibrosis (ELF) score and used to perform pathway analysis. Statistical modeling for the presence of cirrhosis was performed with principal component analysis (PCA), and receiver operating characteristics (ROC) curves were used to assess the useability of potential biomarkers. The model successfully predicted the presence of PSC, where the top-ranked proteins were associated with cell adhesion, immune response, and inflammation, and each had an area under receiver operator characteristic (AUROC) curve greater than 0.9 for disease presence and greater than 0.8 for ELF score. Pathway analysis showed enrichment for functions associated with PSC, overlapping with pathways enriched in patients with high levels of CCL24. Patients with cirrhosis showed higher levels of CCL24. This data-driven approach to characterize PSC and its severity highlights potential serum protein biomarkers and the importance of CCL24 in the disease, implying its therapeutic potential in PSC. Full article
(This article belongs to the Special Issue Machine Learning Applications in Bioinformatics and Biomedicine 2.0)
14 pages, 3301 KiB  
Article
Sheep Wool Waste Availability for Potential Sustainable Re-Use and Valorization: A GIS-Based Model
by Giusi Midolo, Simona M. C. Porto, Giovanni Cascone and Francesca Valenti
Agriculture 2024, 14(6), 872; https://doi.org/10.3390/agriculture14060872 (registering DOI) - 30 May 2024
Abstract
Worldwide, 1.3 to 2.1 billion tons of agricultural waste are generated yearly, including livestock wastes (i.e., sheep wool), which create several critical environmental issues if not properly treated. In order to reduce the environmental issues related to the management and disposal, their use [...] Read more.
Worldwide, 1.3 to 2.1 billion tons of agricultural waste are generated yearly, including livestock wastes (i.e., sheep wool), which create several critical environmental issues if not properly treated. In order to reduce the environmental issues related to the management and disposal, their use as natural fibers for green building components has notably developed over the last years. Indeed, sheep wool, which is a natural animal fiber that comes from shearing sheep fleece, is considered to be a problem of increasing concern due to its complex and difficult disposal management. Recently, several researchers have demonstrated that “low-quality wool” (i.e., not appropriate for textile uses) is suitable for the thermal and acoustic insulation of buildings. Indeed, thanks to its thermo-hygrometric and acoustic characteristics, it can be used as a reinforcing fiber for composite materials. In this study, a Geographic Information System (GIS)-based model to locate and quantify both the yearly amount of livestock waste, i.e., sheep wool, and the territorial distribution of sheep farms through their Global Positioning System (GPS) coordinates, was developed and applied within the selected study area (i.e., the Sicily region). The aim was to identify the territorial areas highly characterized by this kind of waste and therefore most suitable for localizing new shared sheep wool collection centers to sustainably manage the reuse of this waste as a potential green building component. Full article
(This article belongs to the Special Issue Innovations in Precision Farming for Sustainable Agriculture)
16 pages, 1425 KiB  
Article
Adhesion Properties and Stability of Polar Polymers Treated by Air Atmospheric Pressure Plasma
by Roxana Ciobanu, Ilarion Mihăilă, Cătălin Borcia and Gabriela Borcia
Polymers 2024, 16(11), 1552; https://doi.org/10.3390/polym16111552 (registering DOI) - 30 May 2024
Abstract
This study continues the discussion on the surface modification of polymers using an atmospheric pressure plasma (APP) reactor in air. These results complement prior research focusing on nonpolar polymers. Polymers, such as polyethylene terephthalate, polyetheretherketone, and polymethyl methacrylate, containing structurally bonded oxygen are [...] Read more.
This study continues the discussion on the surface modification of polymers using an atmospheric pressure plasma (APP) reactor in air. These results complement prior research focusing on nonpolar polymers. Polymers, such as polyethylene terephthalate, polyetheretherketone, and polymethyl methacrylate, containing structurally bonded oxygen are studied, representing a range of properties such as oxygen content, crystalline/amorphous structure, polarity, functionality, and aliphatic/aromatic structure. APP induces superior wetting properties on the hydrophilic polymer surfaces with rapid and uniform modification within 0.5 s of exposure. The amorphous structures undergo additional modification for longer exposure. Moreover, the aliphatic chain structures require longer plasma exposure to reach surface modification equilibrium. The polar polymers reach a limit level of modification corresponding to a minimum water contact angle of about 50°. The surface polarity increases on average by a factor of approximately two. The equilibrium values of the adhesion work attained after post-processing recovery fall within a limited range of about 100–120 mJ/m2. The enhancement of surface functionality through the creation of oxidized groups primarily depends on the initial oxygen content and reaches a limit of about 40 at.% oxygen. The surface properties of the treated polar surfaces exhibit good stability, comparable to that of the previously tested nonpolar polymers. Full article
(This article belongs to the Special Issue Plasma Processing of Polymers, 2nd Edition)
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24 pages, 5383 KiB  
Article
Investigation of Crack Propagation and Failure of Liquid-Filled Cylindrical Shells Damaged in High-Pressure Environments
by Hongshuo Zhang, Dapeng Tan, Shicheng Xu, Tiancheng Hu, Huan Qi and Lin Li
J. Mar. Sci. Eng. 2024, 12(6), 921; https://doi.org/10.3390/jmse12060921 (registering DOI) - 30 May 2024
Abstract
Cylindrical shell structures have excellent structural properties and load-bearing capacities in fields such as aerospace, marine engineering, and nuclear power. However, under high-pressure conditions, cylindrical shells are prone to cracking due to impact, corrosion, and fatigue, leading to a reduction in structural strength [...] Read more.
Cylindrical shell structures have excellent structural properties and load-bearing capacities in fields such as aerospace, marine engineering, and nuclear power. However, under high-pressure conditions, cylindrical shells are prone to cracking due to impact, corrosion, and fatigue, leading to a reduction in structural strength or failure. This paper proposes a static modeling method for damaged liquid-filled cylindrical shells based on the extended finite element method (XFEM). It investigated the impact of different initial crack angles on the crack propagation path and failure process of liquid-filled cylindrical shells, overcoming the difficulties of accurately simulating stress concentration at crack tips and discontinuities in the propagation path encountered in traditional finite element methods. Additionally, based on fluid‒structure interaction theory, a dynamic model for damaged liquid-filled cylindrical shells was established, analyzing the changes in pressure and flow state of the fluid during crack propagation. Experimental results showed that although the initial crack angle had a slight effect on the crack propagation path, the crack ultimately extended along both sides of the main axis of the cylindrical shell. When the initial crack angle was 0°, the crack propagation path was more likely to form a through-crack, with the highest penetration rate, whereas when the initial crack angle was 75°, the crack propagation speed was slower. After fluid entered the cylindrical shell, it spurted along the crack propagation path, forming a wave crest at the initial ejection position. Full article
7 pages, 191 KiB  
Brief Report
Chatting: Family Carers’ Perspectives on Receiving Support from Dementia Crisis Teams
by Marcus Redley, Fiona Poland, Juanita Hoe, Tom Dening, Miriam Stanyon, Jen Yates, Amy Streater, Dons Coleston-Shields and Martin Orrell
Healthcare 2024, 12(11), 1122; https://doi.org/10.3390/healthcare12111122 (registering DOI) - 30 May 2024
Abstract
Family caregivers are vital to enabling people with dementia to live longer in their own homes. For these caregivers, chatting with clinicians—being listened to empathetically and receiving reassurance—can be seen as not incidental but important to supporting them. This paper considers and identifies [...] Read more.
Family caregivers are vital to enabling people with dementia to live longer in their own homes. For these caregivers, chatting with clinicians—being listened to empathetically and receiving reassurance—can be seen as not incidental but important to supporting them. This paper considers and identifies the significance of this relational work for family carers by re-examining data originally collected to document caregivers’ perspectives on quality in crisis response teams. This reveals that chatting, for family caregivers, comprises three related features: (i) that family caregivers by responding to a person’s changing and sometimes challenging needs and behaviors inhabit a precarious equilibrium; (ii) that caregivers greatly appreciate ‘chatting’ with visiting clinicians; and (iii) that while caregivers appreciate these chats, they can be highly critical of the institutionalized character of a crisis response team’s involvement with them. Full article
(This article belongs to the Special Issue Dementia Caregivers’ Wellbeing—Challenges and Opportunities)
22 pages, 1697 KiB  
Article
Process Optimization and Distortion Prediction in Directed Energy Deposition
by Adem Ben Hammouda, Hatem Mrad, Haykel Marouani, Ahmed Frikha and Tikou Belem
J. Manuf. Mater. Process. 2024, 8(3), 116; https://doi.org/10.3390/jmmp8030116 (registering DOI) - 30 May 2024
Abstract
Directed energy deposition (DED), a form of additive manufacturing (AM), is gaining traction for its ability to produce complex metal parts with precise geometries. However, defects like distortion, residual stresses, and porosity can compromise part quality, leading to rejection. This research addresses this [...] Read more.
Directed energy deposition (DED), a form of additive manufacturing (AM), is gaining traction for its ability to produce complex metal parts with precise geometries. However, defects like distortion, residual stresses, and porosity can compromise part quality, leading to rejection. This research addresses this challenge by emphasizing the importance of monitoring process parameters (overlayer distance, powder feed rate, and laser path/power/spot size) to achieve desired mechanical properties. To improve DED quality and reliability, a numerical approach is presented and compared with an experimental work. The parametric finite element model and predictive methods are used to quantify and control material behavior, focusing on minimizing residual stresses and distortions. Numerical simulations using the Abaqus software 2022 are validated against experimental results to predict distortion and residual stresses. A coupled thermomechanical analysis model is employed to understand the impact of thermal distribution on the mechanical responses of the parts. Finally, new strategies based on laser scan trajectory and power are proposed to reduce residual stresses and distortions, ultimately enhancing the quality and reliability of DED-manufactured parts. Full article

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